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  1. Content type: Research

    Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel invol...

    Authors: Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, Kelly Galbraith Kawabata, F. David Horgen, Toshihiko Kawamori, Reinhold Penner and Andrea Fleig

    Citation: Cell Communication and Signaling 2017 15:30

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    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:31

  2. Content type: Research

    C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-termina...

    Authors: Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin and Heung-Chin Cheng

    Citation: Cell Communication and Signaling 2017 15:29

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  3. Content type: Research

    Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunit...

    Authors: Kirsten Bucher, Fee Schmitt, Benedikt Mothes, Carolin Blumendeller, Daniel Schäll, Roland Piekorz, Emilio Hirsch, Bernd Nürnberg and Sandra Beer-Hammer

    Citation: Cell Communication and Signaling 2017 15:28

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  4. Content type: Review

    Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has em...

    Authors: Angela J. Lowrey, Wyatt Cramblet and Gretchen L. Bentz

    Citation: Cell Communication and Signaling 2017 15:27

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  5. Content type: Research

    Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract....

    Authors: Sylvain Lecomte, Frederic Chalmel, François Ferriere, Frederic Percevault, Nicolas Plu, Christian Saligaut, Claire Surel, Marie Lelong, Theo Efstathiou and Farzad Pakdel

    Citation: Cell Communication and Signaling 2017 15:26

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  6. Content type: Research

    Hematopoietic stem cell (HSC) maintenance requires a specific microenvironment. HSC niches can be activated by tissue damaging chemotherapeutic drugs and various cell signaling molecules such as SDF-1 and FGF,...

    Authors: Kyung-Ae Yoon, YeonSung Son, Young-Jin Choi, Joo-Hyun Kim and Je-Yoel Cho

    Citation: Cell Communication and Signaling 2017 15:25

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  7. Content type: Research

    In mammalian intestines, Notch signaling plays a critical role in mediating cell fate decisions; it promotes the absorptive (or enterocyte) cell fate, while concomitantly inhibiting the secretory cell fate (i....

    Authors: Shaiya C. Robinson, Kristina Klobucar, Christina C. Pierre, Amna Ansari, Svetlana Zhenilo, Egor Prokhortchouk and Juliet M. Daniel

    Citation: Cell Communication and Signaling 2017 15:24

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  8. Content type: Review

    The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarizati...

    Authors: Farhad Seif, Majid Khoshmirsafa, Hossein Aazami, Monireh Mohsenzadegan, Gholamreza Sedighi and Mohammadali Bahar

    Citation: Cell Communication and Signaling 2017 15:23

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  9. Content type: Short report

    The pathogenesis of human basal-like breast cancer (BLBC) is not well understood and patients with BLBC have a poor prognosis. Expression of the epidermal growth factor receptor (EGFR) and nuclear factor-κB (N...

    Authors: Stacey Chung, Yanli Jin, Bingchen Han, Ying Qu, Bowen Gao, Armando E. Giuliano and Xiaojiang Cui

    Citation: Cell Communication and Signaling 2017 15:22

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  10. Content type: Research

    LASP2 (LIM and SH3 Protein 2) is a small focal adhesion protein belongs to nebulin protein family. As the newest member of nebulette family, the function of LASP2 remains to be identified.

    Authors: Bin Wang, Lanzhi Zhang, Liying Zhao, Rui Zhou, Yanqing Ding, Guoxin Li and Liang Zhao

    Citation: Cell Communication and Signaling 2017 15:21

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  11. Content type: Review

    This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The aggressive nature of these tumor typ...

    Authors: Catharina Melzer, Ralf Hass, Juliane von der Ohe, Hendrik Lehnert and Hendrik Ungefroren

    Citation: Cell Communication and Signaling 2017 15:19

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  12. Content type: Research

    Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms hav...

    Authors: You-Take Oh, Ping Yue and Shi-Yong Sun

    Citation: Cell Communication and Signaling 2017 15:18

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  13. Content type: Research

    There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attr...

    Authors: Paola Ortiz-Montero, Arturo Londoño-Vallejo and Jean-Paul Vernot

    Citation: Cell Communication and Signaling 2017 15:17

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  14. Content type: Research

    Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One import...

    Authors: Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher and Sebastian Heikaus

    Citation: Cell Communication and Signaling 2017 15:16

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  15. Content type: Review

    Infections with the human pathogen Helicobacter pylori (H. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. Drastic changes in...

    Authors: Silja Wessler, Linda M. Krisch, Dominik P. Elmer and Fritz Aberger

    Citation: Cell Communication and Signaling 2017 15:15

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  16. Content type: Research

    Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA se...

    Authors: Fabia Fricke, Jennifer Lee, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Meggy Suarez-Carmona, Niels Halama, Martina Schnölzer, Jürgen Kopitz and Johannes Gebert

    Citation: Cell Communication and Signaling 2017 15:14

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  17. Content type: Review

    Hypomethylating agents (HMAs) have been widely used over the last decade, approved for use in myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). The propos...

    Authors: Florian Wolff, Michael Leisch, Richard Greil, Angela Risch and Lisa Pleyer

    Citation: Cell Communication and Signaling 2017 15:13

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  18. Content type: Review

    Cancer represents heterogeneous and aberrantly proliferative manifestations composed of (epi)genetically and phenotypically distinct cells with a common clonal origin. Cancer stem cells (CSC) make up a rare su...

    Authors: Wolfgang Gruber, Tamara Scheidt, Fritz Aberger and Christian G. Huber

    Citation: Cell Communication and Signaling 2017 15:12

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  19. Content type: Review

    C-Met is a receptor tyrosine kinase with multiple functions throughout embryonic development, organogenesis and wound healing and is expressed in various epithelia. The ligand of c-Met is Hepatocyte Growth Fac...

    Authors: Ralf Hass, Susanne Jennek, Yuanyuan Yang and Karlheinz Friedrich

    Citation: Cell Communication and Signaling 2017 15:10

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  20. Content type: Research

    Translationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. TCTP may be involved in protec...

    Authors: Ulrich-Axel Bommer, Kara L. Vine, Prianka Puri, Martin Engel, Lisa Belfiore, Karen Fildes, Marijka Batterham, Alistair Lochhead and Morteza Aghmesheh

    Citation: Cell Communication and Signaling 2017 15:9

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  21. Content type: Review

    Treatment of acute myeloid leukemia (AML), an aggressive and heterogeneous hematological malignancy, remains a challenge. Despite advances in our understanding of the complex genetics and biology of AML pathop...

    Authors: Fritz Aberger, Evelyn Hutterer, Christina Sternberg, Pedro J. del Burgo and Tanja N. Hartmann

    Citation: Cell Communication and Signaling 2017 15:8

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  22. Content type: Research

    The mammalian target of rapamycin (mTOR) is a regulator of cell proliferation, cell growth and apoptosis working through two distinct complexes: mTORC1 and mTORC2. Although much is known about the activation a...

    Authors: Kirsten Thobe, Christine Sers and Heike Siebert

    Citation: Cell Communication and Signaling 2017 15:6

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  23. Content type: Review

    In favor of their outgrowth, cancer cells must resist immune surveillance and edit the immune response. Cancer immunoediting is characterized by fundamental changes in the cellular composition and the inflamma...

    Authors: Richard Greil, Evelyn Hutterer, Tanja Nicole Hartmann and Lisa Pleyer

    Citation: Cell Communication and Signaling 2017 15:5

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  24. Content type: Research

    Uric acid (UA) is an antioxidant found in human serum. However, high UA levels may also have pro-oxidant functions. According to previous research, aldose reductase (AR) plays a vital role in the oxidative str...

    Authors: Zhiyong Huang, Quan Hong, Xueguang Zhang, Wenzhen Xiao, Liyuan Wang, Shaoyuan Cui, Zhe Feng, Yang Lv, Guangyan Cai, Xiangmei Chen and Di Wu

    Citation: Cell Communication and Signaling 2017 15:3

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  25. Content type: Research

    Cell migration including collective cell movement and individual cell migration are crucial factors in embryogenesis. During the spreading/migration of cells, several types of adhesive structures physically in...

    Authors: Xiaoli Shen, Zanhui Jia, Donato D’Alonzo, Xinggang Wang, Elisabeth Bruder, Fabienne Hélène Emch, Christian De Geyter and Hong Zhang

    Citation: Cell Communication and Signaling 2017 15:2

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  26. Content type: Review

    The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoi...

    Authors: Kemal Catakovic, Eckhard Klieser, Daniel Neureiter and Roland Geisberger

    Citation: Cell Communication and Signaling 2017 15:1

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  27. Content type: Research

    STAT3 is increasingly becoming known for its non-transcriptional regulation of mitochondrial bioenergetic function upon activation of its S727 residue (S727-STAT3). Lengthy mitochondrial dysfunction can lead t...

    Authors: Nishant P. Visavadiya, Matthew P. Keasey, Vladislav Razskazovskiy, Kalpita Banerjee, Cuihong Jia, Chiharu Lovins, Gary L. Wright and Theo Hagg

    Citation: Cell Communication and Signaling 2016 14:32

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    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:11

  28. Content type: Research

    Some herpesviruses like human cytomegalovirus (HCMV) encode viral G protein-coupled receptors that cause reprogramming of cell signaling to facilitate dissemination of the virus, prevent immune surveillance an...

    Authors: Theresa Frank, Anna Reichel, Olav Larsen, Anne-Charlotte Stilp, Mette M. Rosenkilde, Thomas Stamminger, Takeaki Ozawa and Nuska Tschammer

    Citation: Cell Communication and Signaling 2016 14:31

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  29. Content type: Research

    The serine proteases HtrA/DegP secreted by the human gastrointestinal pathogens Helicobacter pylori (H. pylori) and Campylobacter jejuni (C. jejuni) cleave the mammalian cell adhesion protein E-cadherin to open i...

    Authors: Carmen M. Abfalter, Maria Schubert, Camilla Götz, Thomas P. Schmidt, Gernot Posselt and Silja Wessler

    Citation: Cell Communication and Signaling 2016 14:30

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  30. Content type: Short report

    Squamous cell carcinoma of the tongue (tongue SCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer under current therapeutics. ARF6 and its effector AMAP1 ar...

    Authors: Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Kiyoshi Fukunaga, Kanako C. Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Satoshi Fukuda and Hisataka Sabe

    Citation: Cell Communication and Signaling 2016 14:28

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  31. Content type: Research

    Chemokines and their receptors play a decisive role in tumor progression and metastasis. We recently found a new signaling mechanism in malignant glioma cells mediated by transmembrane chemokines that we terme...

    Authors: Kirsten Hattermann, Kareen Bartsch, Henrike H. Gebhardt, H. Maximilian Mehdorn, Michael Synowitz, Anne Dorothée Schmitt, Rolf Mentlein and Janka Held-Feindt

    Citation: Cell Communication and Signaling 2016 14:26

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  32. Content type: Research

    ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. Growing evidence suggests interplay between ErbB2 and insulin-like growth factor (IGF) signa...

    Authors: Susan M. Farabaugh, Bonita T. Chan, Xiaojiang Cui, Robert K. Dearth and Adrian V. Lee

    Citation: Cell Communication and Signaling 2016 14:25

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  33. Content type: Research

    Reports of exocrine-to-endocrine reprogramming through expression or stabilization of the transcription factor neurogenin 3 (NGN3) have generated renewed interest in harnessing pancreatic plasticity for therap...

    Authors: Michael J. Shamblott, Marci L. O’Driscoll, Danielle L. Gomez and Dustin L. McGuire

    Citation: Cell Communication and Signaling 2016 14:23

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  34. Content type: Commentary

    Under physiological conditions, endothelial cells and the endothelial nitric oxide (NO) synthase (eNOS) are the main source of NO in the cardiovascular system. However, several other cell types have also been ...

    Authors: Peter M. Benz and Ingrid Fleming

    Citation: Cell Communication and Signaling 2016 14:22

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  35. Content type: Research

    Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to the vascular wall. αIIbβ3 is the main inte...

    Authors: Peter M. Benz, Hebatullah Laban, Joana Zink, Lea Günther, Ulrich Walter, Stepan Gambaryan and Karim Dib

    Citation: Cell Communication and Signaling 2016 14:21

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  36. Content type: Review

    Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. imm...

    Authors: Catharina Melzer, Yuanyuan Yang and Ralf Hass

    Citation: Cell Communication and Signaling 2016 14:20

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  37. Content type: Research

    Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigene...

    Authors: Stanley G. Kimani, Sushil Kumar, Viralkumar Davra, Yun-Juan Chang, Canan Kasikara, Ke Geng, Wen-I Tsou, Shenyan Wang, Mainul Hoque, Andrej Boháč, Anita Lewis-Antes, Mariana S. De Lorenzo, Sergei V. Kotenko and Raymond B. Birge

    Citation: Cell Communication and Signaling 2016 14:19

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  38. Content type: Research

    The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα) leading to proliferation of human uterine leiomyoma cells....

    Authors: Linda Yu, Kyle Ham, Xiaohua Gao, Lysandra Castro, Yitang Yan, Grace E. Kissling, Charles J. Tucker, Norris Flagler, Ray Dong, Trevor K. Archer and Darlene Dixon

    Citation: Cell Communication and Signaling 2016 14:18

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  39. Content type: Research

    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASK...

    Authors: Ekaterina Smirnova, Jamie J. Kwan, Ryan Siu, Xin Gao, Georg Zoidl, Borries Demeler, Vivian Saridakis and Logan W. Donaldson

    Citation: Cell Communication and Signaling 2016 14:17

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  40. Content type: Research

    Direct interaction between Red blood cells (RBCs) and platelets is known for a long time. The bleeding time is prolonged in anemic patients independent of their platelet count and could be corrected by transfu...

    Authors: Stepan Gambaryan, Hariharan Subramanian, Linda Kehrer, Igor Mindukshev, Julia Sudnitsyna, Cora Reiss, Natalia Rukoyatkina, Andreas Friebe, Iraida Sharina, Emil Martin and Ulrich Walter

    Citation: Cell Communication and Signaling 2016 14:16

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  41. Content type: Research

    Canonical Wnt signals, transduced by stabilized β-catenin, play similar roles across animals in maintaining stem cell pluripotency, regulating cell differentiation, and instructing normal embryonic development...

    Authors: William Q. Gillis, Arif Kirmizitas, Yasuno Iwasaki, Dong-Hyuk Ki, Jonathan M. Wyrick and Gerald H. Thomsen

    Citation: Cell Communication and Signaling 2016 14:15

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  42. Content type: Research

    The serine/threonine protein kinase C (PKC) theta has been firmly implicated in T cell-mediated immunity. Because its role in macrophages has remained undefined, we employed PKCtheta-deficient (PKCtheta ...

    Authors: Christa Pfeifhofer-Obermair, Karin Albrecht-Schgoer, Sebastian Peer, Manfred Nairz, Kerstin Siegmund, Victoria Klepsch, David Haschka, Nikolaus Thuille, Natascha Hermann-Kleiter, Thomas Gruber, Günter Weiss and Gottfried Baier

    Citation: Cell Communication and Signaling 2016 14:14

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  43. Content type: Review

    Extracellular vesicles are cell-derived vesicles, which can transport various cargos out of cells. From their cell of origin, the content molecules (proteins, non-coding RNAs including miRNAs, DNA and others) ...

    Authors: Giulia Cesi, Geoffroy Walbrecq, Christiane Margue and Stephanie Kreis

    Citation: Cell Communication and Signaling 2016 14:13

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