Articles

Extracellular vesicle PD-L1 in reshaping tumor immune microenvironment: biological function and potential therapy strategies

Programmed cell death 1 ligand 1 (PD-L1) is the ligand for programmed death protein-1 (PD-1), is associated with immunosuppression. Signaling via PD-1/PD-L1 will transmits negative regulatory signals to T cell...

Authors: Jiaxing Liu, Xueqiang Peng, Shuo Yang, Xinyu Li, Mingyao Huang, Shibo Wei, Sheng Zhang, Guangpeng He, Hongyu Zheng, Qing Fan, Liang Yang and Hangyu Li

Circular RNAs and glioblastoma multiforme: focus on molecular mechanisms

Glioblastoma multiforme (GBM), as a deadly and almost incurable brain cancer, is the most invasive form of CNS tumors that affects both children and adult population. It accounts for approximately half of all ...

Authors: Raziyeh Salami, Marziyeh Salami, Alireza Mafi, Omid Vakili and Zatollah Asemi

Endoplasmic reticulum stress promotes the release of exosomal PD-L1 from head and neck cancer cells and facilitates M2 macrophage polarization

Endoplasmic reticulum (ER) stress has been found to foster the escape of cancer cells from immune surveillance and upregulate PD-L1 expression. However, the underlying mechanisms are unknown.

Authors: Yi Yuan, Pengfei Jiao, Zeyu Wang, Mengqi Chen, Hongming Du, Liang Xu, Juanyong Xu, Youjin Dai, Fu-gen Wu, Yaqin Zhang and Heming Wu

Correction to: Regulators of glucose uptake in thyroid cancer cell lines

Authors: Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour and Mehdi Hedayati

Mechanism of MyD88S mediated signal termination

A universal adaptor protein, MyD88, orchestrates the innate immune response by propagating signals from toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R). Receptor activation seeds MyD88 dependent ...

Authors: Katarzyna Pustelny, Katarzyna Kuska, Andrzej Gorecki, Bogdan Musielak, Ewelina Dobosz, Benedykt Wladyka, Joanna Koziel, Anna Czarna, Tad Holak and Grzegorz Dubin

Exosomes: the key of sophisticated cell–cell communication and targeted metastasis in pancreatic cancer

Pancreatic cancer is one of the most common malignancies. Unfortunately, the lack of effective methods of treatment and diagnosis has led to poor prognosis coupled with a very high mortality rate. So far, the ...

Authors: Huan Zhang, Juan Xing, Zhujiang Dai, Daorong Wang and Dong Tang

Na⁺/Ca²⁺ exchanger isoform 1 takes part to the Ca²⁺-related prosurvival pathway of SOD1 in primary motor neurons exposed to beta-methylamino-l-alanine

The cycad neurotoxin beta-methylamino-l-alanine (L-BMAA), one of the environmental trigger factor for amyotrophic lateral sclerosis/Parkinson-dementia complex (ALS/PDC), may cause neurodegeneration by disrupting ...

Authors: Tiziana Petrozziello, Francesca Boscia, Valentina Tedeschi, Anna Pannaccione, Valeria de Rosa, Angela Corvino, Beatrice Severino, Lucio Annunziato and Agnese Secondo

Extracellular vesicles derived from glioblastoma promote proliferation and migration of neural progenitor cells via PI3K-Akt pathway

Glioblastomas are lethal brain tumors under the current combinatorial therapeutic strategy that includes surgery, chemo- and radio-therapies. Extensive changes in the tumor microenvironment is a key reason for...

Authors: Jiabin Pan, Shiyang Sheng, Ling Ye, Xiaonan Xu, Yizhao Ma, Xuanran Feng, Lisha Qiu, Zhaohuan Fan, Yi Wang, Xiaohuan Xia and Jialin C. Zheng

Comprehensive analysis of a TNF family based-signature in diffuse gliomas with regard to prognosis and immune significance

Several studies have shown that members of the tumor necrosis factor (TNF) family play an important role in cancer immunoregulation, and trials targeting these molecules are already underway. Our study aimed t...

Authors: Qiang-Wei Wang, Wei-Wei Lin and Yong-Jian Zhu

GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch

G protein-coupled receptors (GPCRs) usually regulate cellular processes via activation of intracellular signaling pathways. However, we have previously shown that in several cell lines, GqPCRs induce immediate...

Authors: Guy Nadel, Zhong Yao, Ehud Wainstein, Izel Cohen, Ido Ben-Ami, Amir Schajnovitz, Galia Maik-Rachline, Zvi Naor, Benjamin A. Horwitz and Rony Seger

Functional signaling test identifies HER2 negative breast cancer patients who may benefit from c-Met and pan-HER combination therapy

Research is revealing the complex coordination between cell signaling systems as they adapt to genetic and epigenetic changes. Tools to uncover these highly complex functional linkages will play an important r...

Authors: Ian A. MacNeil, Salmaan A. Khan, Adrish Sen, Sajjad M. Soltani, David J. Burns, Brian F. Sullivan and Lance G. Laing

CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngioma

Calcification of adamantinomatous craniopharyngioma (ACP) often causes problems with tumor resection, leading to a high incidence of deadly complications and tumor recurrence. Histone acetyltransferase (HAT) a...

Authors: Xiaorong Yan, Dezhi Kang, Yuanxiang Lin, Songtao Qi and Changzhen Jiang

Scavenger receptors in host defense: from functional aspects to mode of action

Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain. They are ...

Authors: Qamar Taban, Peerzada Tajamul Mumtaz, Khalid Z. Masoodi, Ehtishamul Haq and Syed Mudasir Ahmad

Small extracellular vesicles: from mediating cancer cell metastasis to therapeutic value in pancreatic cancer

Pancreatic cancer is a highly malignant tumor and, is extremely difficult to diagnose and treat. Metastasis is one of the critical steps in the development of cancer and uses cell to cell communication to medi...

Authors: Wenjie Zhang, Juan Xing, Tian Liu, Jie Zhang, Zhujiang Dai, Huan Zhang, Daorong Wang and Dong Tang

Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts

Vemurafenib (PLX4032) is one of the most frequently used treatments for late-stage melanoma patients with the BRAF^V600E mutation; however, acquired resistance to the drug poses as a major challenge. It remains to...

Authors: Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Silke Kowar, Manching Ku, Tilman Brummer and Melanie Boerries

Interleukin-1 receptor antagonist inhibits metastatic potential by down-regulating CXCL12/CXCR4 signaling axis in colorectal cancer

The aim of this study was to investigate the co-operative role of CXCR4/CXCL12 axis and IL-1Ra in metastatic processes mechanism by interactions between colorectal cancer cells and stromal cells in their micro...

Authors: Jiachi Ma, Wanqing Liang, Yaosheng Qiang, Lei Li, Jun Du, Chengwu Pan, Bangling Chen, Chensong Zhang, Yuzhong Chen and Qingkang Wang

Cytoplasmic eIF6 promotes OSCC malignant behavior through AKT pathway

Eukaryotic translation initiation factor 6 (eIF6), also known as integrin β4 binding protein, is involved in ribosome formation and mRNA translation, acting as an anti-association factor. It is also essential ...

Authors: Zechen Zhao, Weiming Chu, Yang Zheng, Chao Wang, Yuemei Yang, Teng Xu, Xueming Yang, Wei Zhang, Xu Ding, Gang Li, Hongchuang Zhang, Junbo Zhou, Jinhai Ye, Heming Wu, Xiaomeng Song and Yunong Wu

Regulated cell death: discovery, features and implications for neurodegenerative diseases

Regulated cell death (RCD) is a ubiquitous process in living organisms that is essential for tissue homeostasis or to restore biological balance under stress. Over the decades, various forms of RCD have been r...

Authors: Juntao Cui, Suhan Zhao, Yinghui Li, Danyang Zhang, Bingjing Wang, Junxia Xie and Jun Wang

PDIA3 inhibits mitochondrial respiratory function in brain endothelial cells and C. elegans through STAT3 signaling and decreases survival after OGD

Protein disulfide isomerase A3 (PDIA3, also named GRP58, ER-60, ERp57) is conserved across species and mediates protein folding in the endoplasmic reticulum. PDIA3 is, reportedly, a chaperone for STAT3. Howeve...

Authors: Matt. P. Keasey, V. Razskazovskiy, C. Jia, E. D. Peterknecht, P. C. Bradshaw and T. Hagg

γ-Enolase enhances Trk endosomal trafficking and promotes neurite outgrowth in differentiated SH-SY5Y cells

Neurotrophins can activate multiple signalling pathways in neuronal cells through binding to their cognate receptors, leading to neurotrophic processes such as cell survival and differentiation. γ-Enolase has ...

Authors: Anja Pišlar and Janko Kos

Immune checkpoint inhibition for pancreatic ductal adenocarcinoma: limitations and prospects: a systematic review

Pancreatic cancer is an extremely malignant tumor with the lowest 5-year survival rate among all tumors. Pancreatic ductal adenocarcinoma (PDAC), as the most common pathological subtype of pancreatic cancer, u...

Authors: Hong-Bo Li, Zi-Han Yang and Qing-Qu Guo

Multiomic analysis on human cell model of wolfram syndrome reveals changes in mitochondrial morphology and function

Wolfram syndrome (WFS) is a rare autosomal recessive syndrome in which diabetes mellitus and neurodegenerative disorders occur as a result of Wolframin deficiency and increased ER stress. In addition, WFS1 def...

Authors: Agnieszka Zmyslowska, Miljan Kuljanin, Beata Malachowska, Marcin Stanczak, Dominika Michalek, Aneta Wlodarczyk, Dagmara Grot, Joanna Taha, Bartłomiej Pawlik, Magdalena Lebiedzińska-Arciszewska, Hanna Nieznanska, Mariusz R. Wieckowski, Piotr Rieske, Joseph D. Mancias, Maciej Borowiec, Wojciech Mlynarski…

The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis

It is well known that sepsis is a prevalent severe disease caused by infection and the treatment strategies are limited. Recently pericyte-derived microvesicles (PMVs) were confirmed to be therapeutic in many ...

Authors: Henan Zhou, Danyang Zheng, Hongchen Wang, Yue Wu, Xiaoyong Peng, Qinghui Li, Tao Li and Liangming Liu

Estradiol increases risk of topoisomerase IIβ-mediated DNA strand breaks to initiate Xp11.2 translocation renal cell carcinoma

Xp11.2 translocation renal cell carcinoma (tRCC) is defined by translocation of the transcription factor E3 (TFE3) gene located on chromosome Xp11.2. Due to the high incidence in women, 17β-estradiol (E2) may be ...

Authors: Qiancheng Shi, Ning Liu, Lei Yang, Yi Chen, Yanwen Lu, Hongqian Guo, Xiaodong Han, Dongmei Li and Weidong Gan

Correction to: Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration

Authors: Jing Li, Shengqi Wang, Neng Wang, Yifeng Zheng, Bowen Yang, Xuan Wang, Juping Zhang, Bo Pan and Zhiyu Wang

Presenilin1 inhibits glioblastoma cell invasiveness via promoting Sortilin cleavage

Alzheimer’s disease (AD) and glioblastoma are the most common and devastating diseases in the neurology and neurosurgery departments, respectively. Our previous research reports that the AD-related protein Pre...

Authors: Wei Yang, Yan Xiang, Mao-Jun Liao, Peng-Fei Wu, Lin Yang, Guo-Hao Huang, Bao-Zhong Shi, Liang Yi and Sheng-Qing Lv

Correction to: Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression

Authors: Ya Fan, Jia Wang, Yuemei Xu, Yipin Wang, Tao Song, Xiubin Liang, Feng Jin and Dongming Su

Communication between cells: exosomes as a delivery system in prostate cancer

Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low ri...

Authors: Pia Giovannelli, Marzia Di Donato, Giovanni Galasso, Alessandra Monaco, Fabrizio Licitra, Bruno Perillo, Antimo Migliaccio and Gabriella Castoria

STING protects against cardiac dysfunction and remodelling by blocking autophagy

Heart failure, which is characterized by cardiac remodelling, is one of the most common chronic diseases in the aged. Stimulator of interferon genes (STING) acts as an indispensable molecule modulating immune ...

Authors: Rui Xiong, Ning Li, Lei Chen, Wei Wang, Bo Wang, Wenyang Jiang and Qing Geng

Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells

High temperature requirement A (HtrA) is an active serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expre...

Authors: Sabine Bernegger, Robert Vidmar, Marko Fonovic, Gernot Posselt, Boris Turk and Silja Wessler

Beclin1 controls caspase-4 inflammsome activation and pyroptosis in mouse myocardial reperfusion-induced microvascular injury

Myocardial reperfusion injury is often accompanied by cell death and inflammatory reactions. Recently, pyroptosis is gradually recognized as pivotal role in cardiovascular disease. However, little is known abo...

Authors: Wenjing Sun, Hongquan Lu, Shujuan Dong, Rui Li, Yingjie Chu, Nan Wang, Yu Zhao, Yabin Zhang, Limeiting Wang, Lin Sun and Di Lu

Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells

Protein tyrosine phosphatase 1B (PTP1B) and low molecular weight protein tyrosine phosphatase (LMPTP) are implicated in the development of metabolic disorders. Yet, their role in progenitor stem cell adipogeni...

Authors: Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken and Krzysztof Marycz

Perturbation of PI3K/Akt signaling affected autophagy modulation in dystrophin-deficient myoblasts

The absence of dystrophin has gave a massive impact on myotube development in Muscular Dystrophy pathogenesis. One of the conserved signaling pathways involved in skeletal muscle differentiation is the PI3K/Ak...

Authors: Muhammad Dain Yazid and Chen Hung-Chih

Extracellular vesicles: mediators of intercellular communication in tissue injury and disease

Intercellular communication is a critical process that ensures cooperation between distinct cell types and maintains homeostasis. EVs, which were initially described as cellular debris and devoid of biological...

Authors: Greg Berumen Sánchez, Kaitlyn E. Bunn, Heather H. Pua and Marjan Rafat

Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension

Transcription factor CREB is involved in the development of pulmonary hypertension (PH). However, little is known about the role and regulatory signaling of CREB in PH.

Authors: Genfa Xiao, Guili Lian, Tingjun Wang, Weixiao Chen, Wei Zhuang, Li Luo, Huajun Wang and Liangdi Xie

Opportunities and challenges of glioma organoids

Glioma is the most common primary brain tumor and its prognosis is poor. Despite surgical removal, glioma is still prone to recurrence because it grows rapidly in the brain, is resistant to chemotherapy, and i...

Authors: Xiangdong Xu, Lingfei Li, Linting Luo, Lingling Shu, Xiaoli Si, Zhenzhen Chen, Wenqing Xia, Jinyu Huang, Yang Liu, Anwen Shao and Yiquan Ke

EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression

During pregnancy, trophoblast cell invasion needs to be finely controlled. Aberrant trophoblast cell invasion is associated with placental diseases. Epidermal growth factor (EGF) and its receptor, EGFR, are ex...

Authors: Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng and Ying-Pu Sun

Extracellular vesicles from maternal uterine cells exposed to risk factors cause fetal inflammatory response

Fetal cell-derived exosomes (extracellular vesicles, 40–160 nm) are communication channels that can signal parturition by inducing inflammatory changes in maternal decidua and myometrium. Little is known about...

Authors: Megan C. Shepherd, Enkhtuya Radnaa, Ourlad Alzeus Tantengco, Talar Kechichian, Rheanna Urrabaz-Garza, Ananth Kumar Kammala, Samantha Sheller-Miller and Ramkumar Menon

Pathophysiological role of calcium channels and transporters in the multiple myeloma

Multiple myeloma (MM) is a common malignant tumor of plasma cells. Despite several treatment approaches in the past two decades, MM remains an aggressive and incurable disease in dire need of new treatment str...

Authors: Tingting Li, Junmin Chen and Zhiyong Zeng

CAMKK2 regulates mitochondrial function by controlling succinate dehydrogenase expression, post-translational modification, megacomplex assembly, and activity in a cell-type-specific manner

The calcium (Ca2+)/calmodulin (CAM)-activated kinase kinase 2 (CAMKK2)-signaling regulates several physiological processes, for example, glucose metabolism and energy homeostasis, underlying the pathogenesis o...

Authors: Mohammad Golam Sabbir, Carla G. Taylor and Peter Zahradka

Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells

Recent studies have shown that bone morphogenetic protein receptor 2 (BMPR2) regulates cell survival signaling events in cancer cells independent of the BMP type 1 receptor (BMPR1) or the Smad-1/5 transcriptio...

Authors: Arindam Mondal, Rachel NeMoyer, Mehul Vora, Logan Napoli, Zoya Syed, Elaine Langenfeld, Dongxuan Jia, Youyi Peng, John Gilleran, Jacques Roberge, Christopher Rongo, Salma K. Jabbour and John Langenfeld

NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis

Notch signaling drives many aspects of neoplastic phenotype. Here, we report that the Integrator complex (INT) is a new component of the Notch transcriptional supercomplex. Together with Notch Activation Compl...

Authors: Elena Shersher, Mohini Lahiry, Annamil Alvarez-Trotta, Giulia Diluvio, David J. Robbins, Ramin Shiekhattar and Anthony J. Capobianco

R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells

Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-...

Authors: Shannon M. Weber, Nicole M. Brossier, Amanda Prechtl, Stephen Barnes, Landon S. Wilson, Stephanie N. Brosius, Jody Fromm Longo and Steven L. Carroll

The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling

Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an...

Authors: Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Michal Komorowski, Steffen Waldherr, Fred Schaper and Anna Dittrich

Cancer derived exosomes induce macrophages immunosuppressive polarization to promote bladder cancer progression

Exosomes mediated crosstalk between tumor cells and other stromal cells including tumor associated macrophages plays an essential role in reprogramming tumor microenvironment (TME) to facilitate tumor progress...

Authors: Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang and Jinjian Yang

Mechanisms and functions of endocytosis in T cells

Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal trans...

Authors: John C. Charpentier and Philip D. King

Role of autophagy on cancer immune escape

Autophagy is catabolic process by degradation of intracellular components in lysosome including proteins, lipids, and mitochondria in response to nutrient deficiency or stress such as hypoxia or chemotherapy. ...

Authors: Yalan Duan, Xiaoqing Tian, Qian Liu, Jianhua Jin, Juanjuan Shi and Yongzhong Hou

TLR4 signaling in the development of colitis-associated cancer and its possible interplay with microRNA-155

Ulcerative colitis (UC) has closely been associated with an increased risk of colorectal cancer. However, the exact mechanisms underlying colitis-associated cancer (CAC) development remain unclear. As a classi...

Authors: Jie Guo, Mengfan Liao and Jun Wang

Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration

Metastasis represents the leading cause of death in patients with breast cancer. Traditional Chinese medicine is particularly appreciated for metastatic diseases in Asian countries due to its benefits for surv...

Authors: Jing Li, Shengqi Wang, Neng Wang, Yifeng Zheng, Bowen Yang, Xuan Wang, Juping Zhang, Bo Pan and Zhiyu Wang

On the roles of intrinsically disordered proteins and regions in cell communication and signaling

For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured pro...

Authors: Sarah E. Bondos, A. Keith Dunker and Vladimir N. Uversky