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  1. Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in regulating mitochondrial transcription and oxidative phospho...

    Authors: Meng-Jia Huan, Ping-ping Fu, Xia Chen, Zhao-Xia Wang, Zhou-rui Ma, Shi-zhong Cai, Qin Jiang and Qian Wang
    Citation: Cell Communication and Signaling 2024 22:343
  2. Mechanical unloading of the knee articular cartilage results in cartilage matrix atrophy, signifying the osteoarthritic-inductive potential of mechanical unloading. In contrast, mechanical loading stimulates c...

    Authors: Zhiyao Ma, David Xinzheyang Li, Xiaoyi Lan, Adam Bubelenyi, Margaret Vyhlidal, Melanie Kunze, Mark Sommerfeldt and Adetola B. Adesida
    Citation: Cell Communication and Signaling 2024 22:342
  3. Pseudomonas aeruginosa (PA) is an opportunistic pathogen that can cause sight threatening infections in the eye and fatal infections in the cystic fibrosis airway. Extracellular vesicles (EVs) are released by hos...

    Authors: Rajalakshmy Ayilam Ramachandran, Andrew Lemoff and Danielle M. Robertson
    Citation: Cell Communication and Signaling 2024 22:341
  4. Triple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breast cancer. A high circulating neutrophil-to-lymphocyte ratio (NLR) is strongly linked to...

    Authors: Chenghui Yang, Lili Li, Zhiqiang Ye, Anqi Zhang, Yunjia Bao, Xue Wu, Guohong Ren, Chao Jiang, Ouchen Wang and Zhen Wang
    Citation: Cell Communication and Signaling 2024 22:340
  5. Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal. Characterization of mechanisms underlying aberrant AR pathway activat...

    Authors: Jiajia Wang, Hui Liu, Zeyuan Yu, Qianqian Zhou, Feifei Sun, Jingying Han, Lin Gao, Baokai Dou, Hanwen Zhang, Jiawei Fu, Wenqiao Jia, Weiwen Chen, Jing Hu and Bo Han
    Citation: Cell Communication and Signaling 2024 22:339
  6. Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor expressed predominantly in NK and T-cell subsets that downregulates the activation and proliferation of immune cells and participate...

    Authors: Yakun Zhang, Shuang Chen, Xinyi Tang, Yu Peng, Tingting Jiang, Xiaomei Zhang, Jun Li, Yao Liu and Zailin Yang
    Citation: Cell Communication and Signaling 2024 22:337
  7. Excessive scar formation such as hypertrophic scars and keloids, resulting from trauma or surgical procedures, present a widespread concern for causing disfigurement, discomfort, and functional limitations. Ma...

    Authors: Julei Zhang, Zeliang He, Chenlu Xiong, Yuanyuan Yao, Chengliang Zhang, Wende Yao, Sihan Yang, Xiaodong Li and Yan Han
    Citation: Cell Communication and Signaling 2024 22:336
  8. Kappa opioid receptor (KOR) signaling is involved in joint development and inflammation in Osteoarthritis (OA), while the biochemical mechanism remains unclarified. This study aims to investigate downstream mo...

    Authors: Haixia Liu, Renhuan Huang, Ziang Zhuo, Xinru Zhang, Ling Wu, Zhen Guo, Fuping Wen, Liwei An, Hang Yuan, Yiming Zhang and Yuanzhi Xu
    Citation: Cell Communication and Signaling 2024 22:335
  9. Balloon flower root-derived exosome-like nanoparticles (BDEs) have recently been proposed as physiologically active molecules with no cytotoxicity. However, the therapeutic effects of drug-induced hepatotoxici...

    Authors: Jisu Kim, Chao Gao, Pengcheng Guo, Jianyong Sheng and Jianxin Wang
    Citation: Cell Communication and Signaling 2024 22:334
  10. Glioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis even under the current first-line treatment, with a 5-year survival rate less than 7%. Therefore, it is important to under...

    Authors: Tingyu Liang, Lingui Gu, Xiaoman Kang, Junlin Li, Yixuan Song, Yu Wang and Wenbin Ma
    Citation: Cell Communication and Signaling 2024 22:333
  11. HRASKO/NRASKO double knockout mice exhibit exceedingly high rates of perinatal lethality due to respiratory failure caused by a significant lung maturation delay. The few animals that reach adulthood have a norma...

    Authors: Rocío Fuentes-Mateos, Rósula García-Navas, Cristina Fernández-Infante, Luis Hernández-Cano, Nuria Calzada-Nieto, Andrea Olarte-San Juan, Carmen Guerrero, Eugenio Santos and Alberto Fernández-Medarde
    Citation: Cell Communication and Signaling 2024 22:332
  12. Biomechanical attributes have emerged as novel markers, providing a reliable means to characterize cellular and subcellular fractions. Numerous studies have identified correlations between these factors and pa...

    Authors: Behrouz Aghajanloo, Hanieh Hadady, Fatemeh Ejeian, David W. Inglis, Michael Pycraft Hughes, Alireza Fadaei Tehrani and Mohammad Hossein Nasr-Esfahani
    Citation: Cell Communication and Signaling 2024 22:331
  13. Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously inhibiting the opposite pathway. In mice, the WNT/β-catenin...

    Authors: Malene Lundgaard Riis, Gaspard Delpouve, John E. Nielsen, Cecilie Melau, Lea Langhoff Thuesen, Kristine Juul Hare, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Jakob Albrethsen, Hanne Frederiksen, Anders Juul, Paolo Giacobini and Anne Jørgensen
    Citation: Cell Communication and Signaling 2024 22:330
  14. Respiratory disorders are among the conditions that affect the respiratory system. The healthcare sector faces challenges due to the emergence of drug resistance to prescribed medications for these illnesses. ...

    Authors: Bashdar Mahmud Hussen, Zana Baqi Najmadden, Snur Rasool Abdullah, Mohammed Fatih Rasul, Suhad A. Mustafa, Soudeh Ghafouri-Fard and Mohammad Taheri
    Citation: Cell Communication and Signaling 2024 22:329
  15. Kawasaki disease (KD) is an immune vasculitis of unknown origin, characterized by transient inflammation. The activation of the cGAS-STING pathway, triggered by mitochondrial DNA (mtDNA) release, has been impl...

    Authors: Ke Wei, Tao Chen, Hao Fang, Xianjuan Shen, Zhiyuan Tang and Jianmei Zhao
    Citation: Cell Communication and Signaling 2024 22:328
  16. Authors: Xiyue Huang, Xiao Yang, Jinglin Huang, Ling Wei, Yanhua Mao, Changjiang Li, Yingfeng Zhang, Qiuhong Chen, Shasha Wu, Lele Xie, Congcong Sun, Wenwen Zhang and Jia Wang
    Citation: Cell Communication and Signaling 2024 22:326

    The original article was published in Cell Communication and Signaling 2024 22:301

  17. Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will in...

    Authors: Qihong Yang, Kenneth Kin Wah To, Guilin Hu, Kai Fu, Chuan Yang, Shuangli Zhu, Can Pan, Fang Wang, Kewang Luo and Liwu Fu
    Citation: Cell Communication and Signaling 2024 22:325
  18. KRAS-mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS-G12C selective inhibitors, leading to short median progression-free survival, and overal...

    Authors: Rafael Rosell, Eloisa Jantus-Lewintre, Peng Cao, Xueting Cai, Baojuan Xing, Masaoki Ito, Jose Luis Gomez-Vazquez, Mireia Marco-Jordán, Silvia Calabuig-Fariñas, Andrés Felipe Cardona, Jordi Codony-Servat, Jessica Gonzalez, Kevin València-Clua, Andrés Aguilar, Carlos Pedraz-Valdunciel, Zahra Dantes…
    Citation: Cell Communication and Signaling 2024 22:324
  19. Mesenchymal stem cells (MSCs) are widely used in the development of therapeutic tools in regenerative medicine. However, their quality decreases during in vitro expansion because of heterogeneity and acquired ...

    Authors: Ha Yeong Kim and Han Su Kim
    Citation: Cell Communication and Signaling 2024 22:323
  20. Bone resorption is driven through osteoclast differentiation by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-Β ligand (RANKL). We noted that a disintegrin and met...

    Authors: Aaron Babendreyer, Julia Kieselhorst, Cindy Rinkens, Anastasia M. Lyashenko, Stefan Düsterhöft, Holger Jahr, Rogerio B. Craveiro, Michael Wolf and Andreas Ludwig
    Citation: Cell Communication and Signaling 2024 22:322
  21. Huntington’s disease (HD) is a neurological disorder caused by a CAG expansion in the Huntingtin gene (HTT). HD pathology mostly affects striatal medium-sized spiny neurons and results in an altered cortico-stria...

    Authors: Júlia Solana-Balaguer, Pol Garcia-Segura, Genís Campoy-Campos, Almudena Chicote-González, Joaquín Fernández-Irigoyen, Enrique Santamaría, Esther Pérez-Navarro, Mercè Masana, Jordi Alberch and Cristina Malagelada
    Citation: Cell Communication and Signaling 2024 22:321
  22. Multiple Myeloma (MM), a cancer of terminally differentiated plasma cells, is the second most prevalent hematological malignancy and is incurable due to the inevitable development of drug resistance. Intense p...

    Authors: Yanmeng Wang, Niels Vandewalle, Kim De Veirman, Karin Vanderkerken, Eline Menu and Elke De Bruyne
    Citation: Cell Communication and Signaling 2024 22:320
  23. Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and membrane-bound enzyme-linked receptors, such as receptor tyrosi...

    Authors: Emanuele Murgo, Giorgia Falco, Gaetano Serviddio, Gianluigi Mazzoccoli and Tommaso Colangelo
    Citation: Cell Communication and Signaling 2024 22:319
  24. Interleukin 33 (IL-33) is a crucial inflammatory factor that functions as an alarm signal in endometriosis (EMs). Epithelial-mesenchymal transition (EMT), a process related to inflammatory signals, intracellul...

    Authors: Jingyao Ruan, Qi Tian, Siting Li, Xiaoyu Zhou, Qianzhi Sun, Yuning Wang, Yinping Xiao, Mingqing Li, Kaikai Chang and Xiaofang Yi
    Citation: Cell Communication and Signaling 2024 22:318
  25. Alzheimer’s disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. Although neuronal loss is a primary hallmark of Alzheimer’s d...

    Authors: Tabea M. Soelter, Timothy C. Howton, Amanda D. Clark, Vishal H. Oza and Brittany N. Lasseigne
    Citation: Cell Communication and Signaling 2024 22:317
  26. Authors: Mengqi Gu, Pengzheng Chen, Dongmei Zeng, Xiaotong Jiang, Qingfeng Lv, Yuchen Li, Fengyuan Zhang, Shuting Wan, Qian Zhou, Yuan Lu, Xietong Wang and Lei Li
    Citation: Cell Communication and Signaling 2024 22:316

    The original article was published in Cell Communication and Signaling 2023 21:336

  27. Aberrant inflammatory responses drive the initiation and progression of various diseases, and hyperactivation of NLRP3 inflammasome is a key pathogenetic mechanism. Pharmacological inhibitors of NLRP3 represen...

    Authors: Wenhao Liao, Yuchen Li, Jingwen Liu, Yu Mou, Mei Zhao, Juan Liu, Tianxin Zhang, Qin Sun, Jianyuan Tang and Zhilei Wang
    Citation: Cell Communication and Signaling 2024 22:315
  28. Abnormally expressed BCR/ABL protein serves as the basis for the development of chronic myeloid leukaemia (CML). The F-actin binding domain (FABD), which is a crucial region of the BCR/ABL fusion protein, is a...

    Authors: Renren Zheng, Wei Wei, Suotian Liu, Dachuan Zeng, Zesong Yang, Jie Tang, Jinfeng Tan, Zhenglan Huang and Miao Gao
    Citation: Cell Communication and Signaling 2024 22:314
  29. Non-small-cell lung cancer (NSCLC) accounts for 80–85% of all lung cancer and is the leading cause of cancer-related deaths globally. Although various treatment strategies have been introduced, the 5-year surv...

    Authors: Zhengyan Wu, Min Jiao, Chenying Shu, Saiqun Zhang, Jiajia Wang, Jianhong Pu, Jianjie Zhu, Yuanyuan Zeng, Yehan Zhu and Zeyi Liu
    Citation: Cell Communication and Signaling 2024 22:313
  30. African American (AA) women are twice as likely to develop triple-negative breast cancer (TNBC) as women of European descent. Additionally, AA women with TNBC present a much more aggressive disease course than...

    Authors: Chakravarthy Garlapati, Shriya Joshi, Chunhua Yang, Darshan Shimoga Chandrashekar, Padmashree Rida and Ritu Aneja
    Citation: Cell Communication and Signaling 2024 22:312
  31. Neuroinflammation is widely acknowledged as a characteristic feature of almost all neurological disorders and specifically in depression- and anxiety-like disorders. In recent years, there has been significant...

    Authors: Daiki Wakasugi, Shinji Kondo, Farhana Ferdousi, Seiya Mizuno, Akira Yada, Kenichi Tominaga, Satoru Takahashi and Hiroko Isoda
    Citation: Cell Communication and Signaling 2024 22:309
  32. Gasdermin D (GSDMD) is emerging as an important player in autoimmune diseases, but its exact role in lupus nephritis (LN) remains controversial. Here, we identified markedly elevated GSDMD in human and mouse L...

    Authors: Jiani Shen, Feng Li, Xu Han, Dongying Fu, Yiping Xu, Changjian Zhu, Zhou Liang, Ziwen Tang, Ruilin Zheng, Xinrong Hu, Ruoni Lin, Qiaoqiao Pei, Jing Nie, Ning Luo, Xiaoyan Li, Wei Chen…
    Citation: Cell Communication and Signaling 2024 22:308
  33. Interleukin 24 (IL-24) has been implicated in the nociceptive signaling. However, direct evidence and the precise molecular mechanism underlying IL-24’s role in peripheral nociception remain unclear.

    Authors: Hua Cai, Siyu Chen, Yufang Sun, Tingting Zheng, Yulu Liu, Jin Tao and Yuan Zhang
    Citation: Cell Communication and Signaling 2024 22:307
  34. Dysregulation in histone acetylation, a significant epigenetic alteration closely associated with major pathologies including cancer, promotes tumorigenesis, inactivating tumor-suppressor genes and activating ...

    Authors: Botao Pan, Can Liu, Jiyan Su and Chenglai Xia
    Citation: Cell Communication and Signaling 2024 22:306

    The Correction to this article has been published in Cell Communication and Signaling 2024 22:327

  35. As a major component of innate immunity and a positive regulator of interferons, the Stimulator of interferon gene (STING) has an immunotherapy potential to govern a variety of infectious diseases. Despite the...

    Authors: Aysa Rezabakhsh, M. Reza Sadaie, Alireza Ala, Yousef Roosta, Solomon Habtemariam, Adeleh Sahebnasagh and Mohammad Rafi Khezri
    Citation: Cell Communication and Signaling 2024 22:305
  36. Elevated concentrations of palmitate in serum of obese individuals can impair endothelial function, contributing to development of cardiovascular disease. Although several molecular mechanisms of palmitate-ind...

    Authors: Igor Kovacevic, Paula Henriette Schmidt, Annkatrin Kowalski, Bernd J. Helms, Chris H. A. van de Lest, Alexander Kluttig and Guido Posern
    Citation: Cell Communication and Signaling 2024 22:304
  37. While previous studies have primarily focused on Glucose transporter type 1 (GLUT1) related glucose metabolism signaling, we aim to discover if GLUT1 promotes tumor progression through a non-metabolic pathway.

    Authors: Zhiqing Zhou, Yu Li, Sijie Chen, Zhangrong Xie, Yuhui Du, Yue Liu, Yuxuan Shi, Xiangyi Lin, Xiaofei Zeng, Huijie Zhao and Guoan Chen
    Citation: Cell Communication and Signaling 2024 22:303
  38. The ubiquitination-mediated protein degradation exerts a vital role in the progression of multiple tumors. NEDD4L, which belongs to the E3 ubiquitin ligase NEDD4 family, is related to tumor genesis, metastasis...

    Authors: Yijun Shi, Na Fang, Yutong Wu, Huiwen Xu, Anhui Ning, Wendi Zhang, Yiran Liu, Xiaobo Tao, Qiong Chen, Tian Tian, Lei Zhang, Minjie Chu and Jiahua Cui
    Citation: Cell Communication and Signaling 2024 22:302
  39. Intrauterine adhesion (IUA) is one of the most severe causes of infertility in women of childbearing age with injured endometrium secondary to uterine performance. Stem cell therapy is effective in treating da...

    Authors: Xiyue Huang, Xiao Yang, Jinglin Huang, Ling Wei, Yanhua Mao, Changjiang Li, Yingfeng Zhang, Qiuhong Chen, Shasha Wu, Lele Xie, Congcong Sun, Wenwen Zhang and Jia Wang
    Citation: Cell Communication and Signaling 2024 22:301

    The Correction to this article has been published in Cell Communication and Signaling 2024 22:326

  40. Optimizing the efficiency of definitive endoderm (DE) differentiation is necessary for the generation of diverse organ-like structures. In this study, we used the small molecule inhibitor saracatinib (SAR) to ...

    Authors: Ruiyang Ma, Huanjing Bi, Ying Wang, Jingwen Wang, Jiangwei Zhang, Xiaoyang Yu, Zuhan Chen, Jiale Wang, Cuinan Lu, Jin Zheng, Yang Li and Xiaoming Ding
    Citation: Cell Communication and Signaling 2024 22:300
  41. Eph receptors constitute the largest family of receptor tyrosine kinases, comprising 14 distinct members classified into two subgroups: EphAs and EphBs.. Despite their essential functions in normal physiologic...

    Authors: Xiaoting Guo, Yanyi Yang, Jingqun Tang and Juanjuan Xiang
    Citation: Cell Communication and Signaling 2024 22:299
  42. Nucleobindin-2 (Nucb2) and nesfatin-1 (N1) are widely distributed hormones that regulate numerous physiological processes, from energy homeostasis to carcinogenesis. However, the role of nesfatin-2 (N2), the s...

    Authors: Rafał Lenda, Lilia Zhukova, Andrzej Ożyhar and Dominika Bystranowska
    Citation: Cell Communication and Signaling 2024 22:298
  43. Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of the very low-density lipoprotein (VLDL) receptor (VLDLR) promote hepatic steatosis by increasing the delivery of triglyceride-rich ...

    Authors: Mona Peyman, Anna Babin-Ebell, Rosalía Rodríguez-Rodríguez, Matilde Rigon, David Aguilar-Recarte, Joan Villarroya, Anna Planavila, Francesc Villarroya, Xavier Palomer, Emma Barroso and Manuel Vázquez-Carrera
    Citation: Cell Communication and Signaling 2024 22:297
  44. The SARS-CoV-2 virus causes severe COVID-19 in one-fifth of patients. In addition to high mortality, infection may induce respiratory failure and cardiovascular complications associated with inflammation. Acut...

    Authors: Wojciech M. Ciszewski, Lucyna A. Woźniak and Katarzyna Sobierajska
    Citation: Cell Communication and Signaling 2024 22:296
  45. Colorectal cancer (CRC) commonly exhibits tolerance to cisplatin treatment, but the underlying mechanisms remain unclear. Within the tumor microenvironment, macrophages play a role in resisting the cytotoxic e...

    Authors: Zhixin Ma, Yu Sun, Yang Yu, Wenjun Xiao, Zhijie Xiao, Tianyu Zhong, Xi Xiang and Zhigang Li
    Citation: Cell Communication and Signaling 2024 22:295

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