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Research
Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel invol...
Cell Communication and Signaling 2017 15:30
Published on: 15 August 2017
Research
C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-termina...
Cell Communication and Signaling 2017 15:29
Published on: 7 August 2017
Research
Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunit...
Cell Communication and Signaling 2017 15:28
Published on: 19 July 2017
Review
Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has em...
Cell Communication and Signaling 2017 15:27
Published on: 14 July 2017
Research
Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract....
Cell Communication and Signaling 2017 15:26
Published on: 30 June 2017
Research
Hematopoietic stem cell (HSC) maintenance requires a specific microenvironment. HSC niches can be activated by tissue damaging chemotherapeutic drugs and various cell signaling molecules such as SDF-1 and FGF,...
Cell Communication and Signaling 2017 15:25
Published on: 29 June 2017
Review
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarizati...
Cell Communication and Signaling 2017 15:23
Published on: 21 June 2017
Research
In mammalian intestines, Notch signaling plays a critical role in mediating cell fate decisions; it promotes the absorptive (or enterocyte) cell fate, while concomitantly inhibiting the secretory cell fate (i....
Cell Communication and Signaling 2017 15:24
Published on: 21 June 2017
Short report
The pathogenesis of human basal-like breast cancer (BLBC) is not well understood and patients with BLBC have a poor prognosis. Expression of the epidermal growth factor receptor (EGFR) and nuclear factor-κB (N...
Cell Communication and Signaling 2017 15:22
Published on: 19 June 2017
Research
LASP2 (LIM and SH3 Protein 2) is a small focal adhesion protein belongs to nebulin protein family. As the newest member of nebulette family, the function of LASP2 remains to be identified.
Cell Communication and Signaling 2017 15:21
Published on: 12 June 2017
Editorial
Cell Communication and Signaling 2017 15:20
Published on: 2 June 2017
Review
This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The aggressive nature of these tumor typ...
Cell Communication and Signaling 2017 15:19
Published on: 12 May 2017
Research
Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms hav...
Cell Communication and Signaling 2017 15:18
Published on: 8 May 2017
Research
There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attr...
Cell Communication and Signaling 2017 15:17
Published on: 4 May 2017
Research
Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One import...
Cell Communication and Signaling 2017 15:16
Published on: 2 May 2017
Review
Infections with the human pathogen Helicobacter pylori (H. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. Drastic changes in...
Cell Communication and Signaling 2017 15:15
Published on: 20 April 2017
Research
Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA se...
Cell Communication and Signaling 2017 15:14
Published on: 4 April 2017
Review
Hypomethylating agents (HMAs) have been widely used over the last decade, approved for use in myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). The propos...
Cell Communication and Signaling 2017 15:13
Published on: 31 March 2017
Review
Cancer represents heterogeneous and aberrantly proliferative manifestations composed of (epi)genetically and phenotypically distinct cells with a common clonal origin. Cancer stem cells (CSC) make up a rare su...
Cell Communication and Signaling 2017 15:12
Published on: 29 March 2017
Erratum
Cell Communication and Signaling 2017 15:11
Published on: 27 March 2017
The original article was published in Cell Communication and Signaling 2016 14:32
Review
C-Met is a receptor tyrosine kinase with multiple functions throughout embryonic development, organogenesis and wound healing and is expressed in various epithelia. The ligand of c-Met is Hepatocyte Growth Fac...
Cell Communication and Signaling 2017 15:10
Published on: 17 February 2017
Research
Translationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. TCTP may be involved in protec...
Cell Communication and Signaling 2017 15:9
Published on: 1 February 2017
Review
Treatment of acute myeloid leukemia (AML), an aggressive and heterogeneous hematological malignancy, remains a challenge. Despite advances in our understanding of the complex genetics and biology of AML pathop...
Cell Communication and Signaling 2017 15:8
Published on: 25 January 2017
Review
Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif. During development, th...
Cell Communication and Signaling 2017 15:7
Published on: 25 January 2017
Research
The mammalian target of rapamycin (mTOR) is a regulator of cell proliferation, cell growth and apoptosis working through two distinct complexes: mTORC1 and mTORC2. Although much is known about the activation a...
Cell Communication and Signaling 2017 15:6
Published on: 19 January 2017
