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  1. Breast cancer is a common malignancy with varying clinical behaviors and for the more aggressive subtypes, novel and more efficient therapeutic approaches are needed. Qualities of the tumor microenvironment as...

    Authors: Emma Persson, Pernilla Gregersson, Anna Gustafsson, Paul Fitzpatrick, Sara Rhost, Anders Ståhlberg and Göran Landberg

    Citation: Cell Communication and Signaling 2021 19:66

    Content type: Research

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  2. Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization. Proteins that drive the f...

    Authors: Ryan J. Emenecker, Alex S. Holehouse and Lucia C. Strader

    Citation: Cell Communication and Signaling 2021 19:65

    Content type: Research

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  3. Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia forma...

    Authors: Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti and Daniela Corda

    Citation: Cell Communication and Signaling 2021 19:64

    Content type: Research

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  4. miR-1250 is localised to the second intron of AATK at chromosome 17q25. As a CpG island is present at the putative promoter region of its host gene, AATK, we postulated that the intronic miR-1250-5p is a tumor...

    Authors: Min Yue Zhang, Lu Qian Wang and Chor Sang Chim

    Citation: Cell Communication and Signaling 2021 19:62

    Content type: Research

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  5. Chronic superphysiological glucose and insulin concentrations are known to trigger several tissue and organ failures, including insulin resistance, oxidative stress and chronic low-grade inflammation. Hence, t...

    Authors: Anna Kowalczuk, Nabila Bourebaba, Katarzyna Kornicka-Garbowska, Eliza Turlej, Krzysztof Marycz and Lynda Bourebaba

    Citation: Cell Communication and Signaling 2021 19:61

    Content type: Research

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  6. Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition...

    Authors: Juane Lu, Tao Wu, Biao Zhang, Suke Liu, Wenjun Song, Jianjun Qiao and Haihua Ruan

    Citation: Cell Communication and Signaling 2021 19:60

    Content type: Review

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  7. The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that A...

    Authors: Jillian Hattaway Luttman, Ashley Colemon, Benjamin Mayro and Ann Marie Pendergast

    Citation: Cell Communication and Signaling 2021 19:59

    Content type: Review

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  8. Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator of interferon gene...

    Authors: Lu Zhou, Yi-Fei Zhang, Fu-Hua Yang, Han-Qing Mao, Zhi Chen and Lu Zhang

    Citation: Cell Communication and Signaling 2021 19:58

    Content type: Research

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  9. The human family of Potassium (K+) Channel Tetramerization Domain (KCTD) proteins counts 25 members, and a significant number of them are still only partially characterized. While some of the KCTDs have been link...

    Authors: Annapaola Angrisani, Annamaria Di Fiore, Enrico De Smaele and Marta Moretti

    Citation: Cell Communication and Signaling 2021 19:56

    Content type: Review

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  10. The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied in cancer, especially ovarian cancer. These large cytoskeletal proteins have primary roles in the m...

    Authors: Tamsin Wesley, Stuart Berzins, George Kannourakis and Nuzhat Ahmed

    Citation: Cell Communication and Signaling 2021 19:55

    Content type: Review

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  11. Many clinical trials are being conducted to clarify effective combinations of various drugs for immune checkpoint blockade (ICB) therapy. However, although extensive studies from multiple aspects have been con...

    Authors: Ari Hashimoto, Haruka Handa, Soichiro Hata, Akio Tsutaho, Takao Yoshida, Satoshi Hirano, Shigeru Hashimoto and Hisataka Sabe

    Citation: Cell Communication and Signaling 2021 19:54

    Content type: Commentary

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  12. Neurodegenerative diseases like Alzheimer’s, Parkinson’s and Huntington’s disease involves abnormal aggregation and accumulation of toxic proteins aggregates. Post-translational modifications (PTMs) of the cau...

    Authors: Abhishek Ankur Balmik and Subashchandrabose Chinnathambi

    Citation: Cell Communication and Signaling 2021 19:51

    Content type: Review

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  13. Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed the tumor microenvironment (TME) immune cells to functionally affect the development and progression of br...

    Authors: Jing Jin, Yi Li, Qijie Zhao, Yue Chen, Shaozhi Fu and JingBo Wu

    Citation: Cell Communication and Signaling 2021 19:50

    Content type: Review

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  14. Microtubule-associated protein Tau undergoes aggregation in Alzheimer`s disease (AD) and a group of other related diseases collectively known as Tauopathies. In AD, Tau forms aggregates, which are deposited in...

    Authors: Abhishek Ankur Balmik, Shweta Kishor Sonawane and Subashchandrabose Chinnathambi

    Citation: Cell Communication and Signaling 2021 19:49

    Content type: Research

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  15. The G-protein-coupled receptor GPR55 has been implicated in multiple biological activities, which has fuelled interest in its functional targeting. Its controversial pharmacology and often species-dependent re...

    Authors: Maria Giovanna Mosca, Maria Mangini, Stefania Cioffi, Pasquale Barba and Stefania Mariggiò

    Citation: Cell Communication and Signaling 2021 19:48

    Content type: Research

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  16. Myocardial fibrosis is caused by the adverse and powerful remodeling of the heart secondary to the death of cardiomyocytes after myocardial infarction. Regulators of G protein Signaling (RGS) 4 is involved in ...

    Authors: Jing Guo, Pengzhou Hang, Jie Yu, Wen Li, Xiuye Zhao, Yue Sun, Ziyi Fan and Zhimin Du

    Citation: Cell Communication and Signaling 2021 19:46

    Content type: Research

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  17. Toll-like receptors (TLRs) are critical sensors for the detection of potentially harmful microbes. They are instrumental in initiating innate and adaptive immune responses against pathogenic organisms. However...

    Authors: Clovis H. T. Seumen, Tanja M. Grimm and Christof R. Hauck

    Citation: Cell Communication and Signaling 2021 19:45

    Content type: Review

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  18. Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. A minority of affected patients develops inflammation, subsequently f...

    Authors: Marco Raffaele, Kristina Kovacovicova, Jan Frohlich, Oriana Lo Re, Sebastiano Giallongo, Jude A. Oben, Martin Faldyna, Lenka Leva, Antonino Giulio Giannone, Daniela Cabibi and Manlio Vinciguerra

    Citation: Cell Communication and Signaling 2021 19:44

    Content type: Short report

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  19. Phosphotyrosine kinase (PTK)-mediated phospholipase C-γ1 (PLC-γ1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for sever...

    Authors: Helena M. Stricker, Nadine Rommerswinkel, Silvia Keil, Sandina A. Gnoth, Bernd Niggemann and Thomas Dittmar

    Citation: Cell Communication and Signaling 2021 19:43

    Content type: Research

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  20. Progesterone receptor membrane component 1 (Pgrmc1) is a non-classical progesterone receptor associated with the development of the mammary gland and xenograft-induced breast cancer. Importantly, Pgrmc1 is ass...

    Authors: Sang R. Lee, Young Ho Lee, Seong Lae Jo, Jun H. Heo, Globinna Kim, Geun-Shik Lee, Beum-Soo An, In-Jeoung Baek and Eui-Ju Hong

    Citation: Cell Communication and Signaling 2021 19:42

    Content type: Research

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  21. The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a sca...

    Authors: Yu Fang, Angelina Olegovna Zekiy, Farhoodeh Ghaedrahmati, Anton Timoshin, Maryam Farzaneh, Amir Anbiyaiee and Seyed Esmaeil Khoshnam

    Citation: Cell Communication and Signaling 2021 19:41

    Content type: Review

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  22. Lysosome-associated membrane protein type 2A (LAMP-2A) is the key component of chaperone-mediated autophagy (CMA), a cargo-selective lysosomal degradation pathway. Aberrant LAMP-2A expression and CMA activatio...

    Authors: Yongjie Wang, Buyi Zhang, Jianli Wang, Haijian Wu, Shenbin Xu, Jianmin Zhang and Lin Wang

    Citation: Cell Communication and Signaling 2021 19:40

    Content type: Research

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  23. Tumor angiogenesis, an essential process for cancer proliferation and metastasis, has a critical role in prognostic of kidney renal clear cell carcinoma (KIRC), as well as a target in guiding treatment with an...

    Authors: Wenzhong Zheng, Shiqiang Zhang, Huan Guo, Xiaobao Chen, Zhangcheng Huang, Shaoqin Jiang and Mengqiang Li

    Citation: Cell Communication and Signaling 2021 19:39

    Content type: Research

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  24. CP12 is a small chloroplast protein that is widespread in various photosynthetic organisms and is an actor of the redox signaling pathway involved in the regulation of the Calvin Benson Bassham (CBB) cycle. Th...

    Authors: Hui Shao, Wenmin Huang, Luisana Avilan, Véronique Receveur-Bréchot, Carine Puppo, Rémy Puppo, Régine Lebrun, Brigitte Gontero and Hélène Launay

    Citation: Cell Communication and Signaling 2021 19:38

    Content type: Research

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  25. The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various g...

    Authors: Zhen Zhang, Puhua Zeng, Wenhui Gao, Qing Zhou, Ting Feng and Xuefei Tian

    Citation: Cell Communication and Signaling 2021 19:37

    Content type: Review

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  26. The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type pl...

    Authors: Daisuke Ito, Hiroyasu Ito, Takayasu Ideta, Ayumu Kanbe, Soranobu Ninomiya and Masahito Shimizu

    Citation: Cell Communication and Signaling 2021 19:36

    Content type: Research

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  27. The mechanism underlying endothelial dysfunction leading to cardiovascular disease in type 2 diabetes mellitus (T2DM) remains unclear. Here, we show that inhibition of histone deacetylase 3 (HDAC3) reduced inf...

    Authors: Shuai Huang, Gen Chen, Jia Sun, Yunjie Chen, Nan Wang, Yetong Dong, Enzhao Shen, Zhicheng Hu, Wenjie Gong, Litai Jin and Weitao Cong

    Citation: Cell Communication and Signaling 2021 19:35

    Content type: Research

    Published on:

  28. Prostate cancer (PCa) is one of the most commonly diagnosed human cancers in males. Nearly 191,930 new cases and 33,330 new deaths of PCa are estimated in 2020. Androgen and androgen receptor pathways played e...

    Authors: Dexin Shen, Lingao Ju, Fenfang Zhou, Mengxue Yu, Haoli Ma, Yi Zhang, Tongzu Liu, Yu Xiao, Xinghuan Wang and Kaiyu Qian

    Citation: Cell Communication and Signaling 2021 19:34

    Content type: Review

    Published on:

  29. Hepatitis B virus (HBV) X protein (HBX) has been reported to be responsible for the epithelial-mesenchymal transition (EMT) in HBV-related hepatocellular carcinoma (HCC). Vimentin is an EMT-related molecular m...

    Authors: Hongjuan You, Dongchen Yuan, Yanwei Bi, Ning Zhang, Qi Li, Tao Tu, Xiao Wei, Qi Lian, Tong Yu, Delong Kong, Xiaoying Yang, Xiangye Liu, Xiaomei Liu, Fanyun Kong, Kuiyang Zheng and Renxian Tang

    Citation: Cell Communication and Signaling 2021 19:33

    Content type: Research

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  30. Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique chara...

    Authors: Jason D. Domogauer, Sonia M. de Toledo, Roger W. Howell and Edouard I. Azzam

    Citation: Cell Communication and Signaling 2021 19:30

    Content type: Research

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  31. Neurodegeneration, an early event in the pathogenesis of diabetic retinopathy (DR), precedes clinically detectable microvascular damage. Autophagy dysregulation is considered a potential cause of neuronal cell...

    Authors: Sanjar Batirovich Madrakhimov, Jin Young Yang, Jin Ha Kim, Jung Woo Han and Tae Kwann Park

    Citation: Cell Communication and Signaling 2021 19:29

    Content type: Research

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  32. Alzheimer’s disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal transduction in neurons and other glia cells. The pathologica...

    Authors: Smita Eknath Desale and Subashchandrabose Chinnathambi

    Citation: Cell Communication and Signaling 2021 19:28

    Content type: Review

    Published on:

  33. The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy. Abl also is a critical regulator of normal development, playing c...

    Authors: Edward M. Rogers, S. Colby Allred and Mark Peifer

    Citation: Cell Communication and Signaling 2021 19:27

    Content type: Research

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  34. Over the past years, Human Amnion Epithelial Cells (hAECs), a placental stem cell, are gaining higher attention from the scientific community as they showed several advantages over other types of stem cells, i...

    Authors: Meriem Bejaoui, Farhana Ferdousi, Yun-Wen Zheng, Tatsuya Oda and Hiroko Isoda

    Citation: Cell Communication and Signaling 2021 19:26

    Content type: Short report

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  35. Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found. No pharmaceutical treatment is available today and r...

    Authors: Matthias Schürmann, Felix Oppel, Senyao Shao, Verena Volland-Thurn, Christian Kaltschmidt, Barbara Kaltschmidt, Lars-Uwe Scholtz and Holger Sudhoff

    Citation: Cell Communication and Signaling 2021 19:25

    Content type: Research

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  36. The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance. Inhibition of the Otub1/c-Maf axis is a promising therape...

    Authors: Tong Sun, Yujia Xu, Zhuan Xu, Biyin Cao, Zubin Zhang, Qi Wang, Yan Kong and Xinliang Mao

    Citation: Cell Communication and Signaling 2021 19:24

    Content type: Research

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  37. Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysio...

    Authors: Zhu Liang, Andreas Damianou, Elena Di Daniel and Benedikt M. Kessler

    Citation: Cell Communication and Signaling 2021 19:23

    Content type: Review

    Published on:

  38. Metastasis is the predominant cause for cancer morbidity and mortality accounting for approximatively 90% of cancer deaths. The actin-bundling protein L-plastin has been proposed as a metastatic marker and pho...

    Authors: Raquel A. C. Machado, Dunja Stojevski, Sébastien De Landtsheer, Philippe Lucarelli, Alexandre Baron, Thomas Sauter and Elisabeth Schaffner-Reckinger

    Citation: Cell Communication and Signaling 2021 19:22

    Content type: Research

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  39. Frizzled (FZD) proteins function as receptors for WNT ligands. Members in FZD family including FZD2, FZD4, FZD7, FZD8 and FZD10 have been demonstrated to mediate cancer cell epithelial-mesenchymal transition (...

    Authors: Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao and Wei Wang

    Citation: Cell Communication and Signaling 2021 19:21

    Content type: Research

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  40. Intercellular communication is crucial for breast cancer progression and metastasis. However, the role of cancer-derived exosomes and their crucial microRNA (miRNA) cargoes mediating intercellular communicatio...

    Authors: Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou and Qiang Sun

    Citation: Cell Communication and Signaling 2021 19:20

    Content type: Research

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  41. Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and more aggressive clones that contri...

    Authors: Yuan Li, Zhenning Wang, Jaffer A. Ajani and Shumei Song

    Citation: Cell Communication and Signaling 2021 19:19

    Content type: Review

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  42. Our previous studies have shown that the E3 ubiquitin ligase of HMG-CoA reductase degradation 1 (HRD1) functions as a tumor suppressor, as overexpression of HRD1 suppressed breast cancer proliferation and inva...

    Authors: Ya Fan, Jia Wang, Yuemei Xu, Yipin Wang, Tao Song, Xiubin Liang, Feng Jin and Dongming Su

    Citation: Cell Communication and Signaling 2021 19:18

    Content type: Research

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  43. Vascular endothelial barrier function is maintained by cell-to-cell junctional proteins and contributes to vascular homeostasis. Various risk factors such as inflammation disrupt barrier function through down-...

    Authors: Kayo Kunimura, Satomi Miki, Miyuki Takashima and Jun-ichiro Suzuki

    Citation: Cell Communication and Signaling 2021 19:17

    Content type: Research

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