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  1. Exosomes are small vesicles released by cells, which have crucial functions in intercellular communication. Exosomes originated from cell membrane invagination and are released followed by multivesicular bodie...

    Authors: Xiaotong Cen, Qing Chen, Bin Wang, Hongjie Xu, Xu Wang, Yixia Ling, Xiaofei Zhang and Dajiang Qin
    Citation: Cell Communication and Signaling 2022 20:191
  2. TGF-β superfamily signaling is indispensable for bone homeostasis. However, the global expression profiles of all the genes that make up this signaling module in bone and bone-related diseases have not yet bee...

    Authors: Ying-Wen Wang, Wen-Yu Lin, Fang-Ju Wu and Ching-Wei Luo
    Citation: Cell Communication and Signaling 2022 20:190
  3. Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE machinery STX17 to form autolysosome for degradati...

    Authors: Yunash Maharjan, Raghbendra Kumar Dutta, Jinbae Son, Xiaofan Wei, Channy Park, Hyug Moo Kwon and Raekil Park
    Citation: Cell Communication and Signaling 2022 20:189
  4. Pancreatic cancer (PC) is a highly lethal malignancy regarding digestive system, which is the fourth leading factor of cancer-related mortalities in the globe. Prognosis is poor due to diagnosis at advanced di...

    Authors: Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin and Dachuan Qi
    Citation: Cell Communication and Signaling 2022 20:188
  5. Current therapeutic management of advanced melanoma patients largely depends on their BRAF mutation status. However, the vast heterogeneity of the tumors hampers the success of therapies targeting the MAPK/ERK...

    Authors: Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar and Melanie Boerries
    Citation: Cell Communication and Signaling 2022 20:187
  6. Innate and adaptive immune cells patrol and survey throughout the human body and sometimes reside in the tumor microenvironment (TME) with a variety of cell types and nutrients that may differ from those in wh...

    Authors: Hamidreza Zalpoor, Fatemeh Aziziyan, Mahsa Liaghat, Maryam Bakhtiyari, Abdullatif Akbari, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani and Nima Rezaei
    Citation: Cell Communication and Signaling 2022 20:186
  7. The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aime...

    Authors: Bing-Xi Yan, Xue-Yan Chen, Zhao-Yuan Wang, Ying-Zhe Cui, Lilla Landeck, Ni-Chang Fu, Xing-Yu Yang, Fan Xu, Yuan Zhou, Jia-Qi Chen and Xiao-Yong Man
    Citation: Cell Communication and Signaling 2022 20:185
  8. CD6 is one of many cell surface receptors known to regulate signal transduction upon T cell activation. However, whether CD6 mediates costimulatory or inhibitory signals is controversial. When T cells engage w...

    Authors: Sónia N. Henriques, Liliana Oliveira, Rita F. Santos and Alexandre M. Carmo
    Citation: Cell Communication and Signaling 2022 20:184
  9. Hyperoxia-induced acute lung injury (HALI) is a critical life-threatening disorder characterized by severe infiltration immune cells and death of type II alveolar epithelial cells (AECII). However, little is k...

    Authors: Baoyue Guo, Zhongfu Zuo, Xingwei Di, Ying Huang, Gu Gong, Bo Xu, Lulu Wang, Xiaoyu Zhang, Zhuang Liang, Yang Hou, Xuezheng Liu and Zhansheng Hu
    Citation: Cell Communication and Signaling 2022 20:183
  10. Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in the modulation of volta...

    Authors: Martyna Sochacka, Radoslaw Karelus, Lukasz Opalinski, Daniel Krowarsch, Martyna Biadun, Jacek Otlewski and Malgorzata Zakrzewska
    Citation: Cell Communication and Signaling 2022 20:182
  11. Although a lack of functional PTEN contributes to tumorigenesis in a wide spectrum of human malignancies, little is known about the functional role of its overexpression in the tumors. The current study focuse...

    Authors: Ako Yokoi, Marina Minami, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Yoshinori Hasegawa, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa and Makoto Saegusa
    Citation: Cell Communication and Signaling 2022 20:181
  12. Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated...

    Authors: Genmao Cao, Xuezhen Xuan, Jie Hu, Ruijing Zhang, Haijiang Jin and Honglin Dong
    Citation: Cell Communication and Signaling 2022 20:180
  13. Bicalutamide is a nonsteroidal antiandrogen widely used as a first-line clinical treatment for advanced prostate cancer (PCa). Although patients initially show effective responses to bicalutamide treatment, re...

    Authors: Lei Tian, Yanfei Peng, Kuo Yang, Jiasong Cao, Xiaoling Du, Zhixian Liang, Jiandang Shi and Ju Zhang
    Citation: Cell Communication and Signaling 2022 20:178
  14. Loss-of-function (LOF) mutations of JAK1, a member of the JAK kinase family, were frequently observed in EC, indicating that JAK1 may act as a tumor suppressor, at least in EC. However, the mechanism of JAK1 m...

    Authors: Qin Lin, Zheng Chen, Wei Shi, Zeheng Lv, Xiaoping Wan and Kun Gao
    Citation: Cell Communication and Signaling 2022 20:177
  15. Serous ovarian carcinoma is the most frequent histological subgroup of ovarian cancer and the leading cause of death among gynecologic tumors. The tumor microenvironment and cancer-associated fibroblasts (CAFs...

    Authors: Robson Francisco Carvalho, Luisa Matos do Canto, Cecilie Abildgaard, Mads Malik Aagaard, Monica Søgaard Tronhjem, Marianne Waldstrøm, Lars Henrik Jensen, Karina Dahl Steffensen and Silvia Regina Rogatto
    Citation: Cell Communication and Signaling 2022 20:176
  16. Spermine is frequently elevated in tumor tissues and body fluids of cancer patients and is critical for cancer cell proliferation, migration and invasion. However, the immune functions of spermine in hepatocel...

    Authors: Hong-Xiang Shi, Chao Liang, Chao-Yan Yao, Zi-Xuan Gao, Jia Qin, Jin-Lan Cao, Ming-Zhu Zhang, Ying-Ying Li, Meng-Qing Wang, Hua Sun, Song-Qiang Xie and Dong Fang
    Citation: Cell Communication and Signaling 2022 20:175
  17. Recurrence, metastasis, and drug resistance are still big challenges in breast cancer therapy. Internal and external stresses have been proven to substantially facilitate breast cancer progression through mole...

    Authors: Di Xu, Zhen Liu, Ming-Xing Liang, Yin-Jiao Fei, Wei Zhang, Yang Wu and Jin-Hai Tang
    Citation: Cell Communication and Signaling 2022 20:174
  18. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been growing swiftly worldwide. Patients with background chronic pulmonary inflammations such as asthma or chronic obstructive pu...

    Authors: Hadi Rajabi, Deniz Mortazavi, Nur Konyalilar, Gizem Tuse Aksoy, Sinem Erkan, Seval Kubra Korkunc, Ozgecan Kayalar, Hasan Bayram and Reza Rahbarghazi
    Citation: Cell Communication and Signaling 2022 20:173
  19. Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival characterized by abnormal cell proliferation and differentiation. Despite advances in treatment, AML still has a low comple...

    Authors: Hamidreza Zalpoor, Maryam Bakhtiyari, Abdullatif Akbari, Fatemeh Aziziyan, Hooriyeh Shapourian, Mahsa Liaghat, Zahra Zare-Badie, Sheida Yahyazadeh, Vahideh Tarhriz and Mazdak Ganjalikhani-Hakemi
    Citation: Cell Communication and Signaling 2022 20:172
  20. Presently, more than half of cancer patients receive radiotherapy to cure localized cancer, palliate symptoms, or control the progression of cancer. However, radioresistance and radiation-induced bystander eff...

    Authors: Zhenyi Yang, Wen Zhong, Liang Yang, Ping Wen, Yixuan Luo and Chunli Wu
    Citation: Cell Communication and Signaling 2022 20:171
  21. Molecule interacting with CasL-like protein 2 (MICALL2) is believed to regulate cytoskeleton dynamics, tight junction formation, and neurite outgrowth. However, its biological role and the underlying mechanism...

    Authors: Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang and Jing Gao
    Citation: Cell Communication and Signaling 2022 20:170
  22. Myelodysplastic syndrome (MDS) is a clonal disease of hematopoietic cells, characterized by hematopoietic cell hematopoiesis and a high risk of transformation into acute myeloid leukemia (AML). Although the un...

    Authors: Zhaoyun Liu, Yixuan Guo, Lei Huang, Yue Jia, Hui Liu, Fengping Peng, Lixiang Duan, Hongkai Zhang and Rong Fu
    Citation: Cell Communication and Signaling 2022 20:169
  23. DNA methyltransferase 3A (DNMT3A) often mutate on arginine 882 (DNMT3AR882) in acute myeloid leukemia (AML). AML patients with DNMT3A R882 mutation are usually resistant to daunorubicin treatment; however, the as...

    Authors: Xuan Chu, Liang Zhong, Wenran Dan, Xiao Wang, Zhonghui Zhang, Zhenyan Liu, Yang Lu, Xin Shao, Ziwei Zhou, Shuyu Chen and Beizhong Liu
    Citation: Cell Communication and Signaling 2022 20:168
  24. Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devot...

    Authors: Huldani Huldani, Ahmed Ibraheem Rashid, Khikmatulla Negmatovich Turaev, Maria Jade Catalan Opulencia, Walid Kamal Abdelbasset, Dmitry Olegovich Bokov, Yasser Fakri Mustafa, Moaed E. Al-Gazally, Ali Thaeer Hammid, Mustafa M. Kadhim and Seyed Hossein Ahmadi
    Citation: Cell Communication and Signaling 2022 20:167
  25. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the epidermal growth factor (EGF) family of growth factors. HB-EGF and its receptors, epidermal growth factor receptor (EGFR) and ...

    Authors: Jung-Chien Cheng, Xiaoyu Han, Qingxue Meng, Yanjie Guo, Boqun Liu, Tinglin Song, Yuanyuan Jia, Lanlan Fang and Ying-Pu Sun
    Citation: Cell Communication and Signaling 2022 20:166
  26. Postmenopausal bone loss, mainly caused by excessive bone resorption mediated by osteoclasts, has become a global public health burden. Metformin, a hypoglycemic drug, has been reported to have beneficial effe...

    Authors: Xudong Xie, Liangcong Hu, Bobin Mi, Hang Xue, Yiqiang Hu, Adriana C. Panayi, Yori Endo, Lang Chen, Chenchen Yan, Ze Lin, Hui Li, Wu Zhou and Guohui Liu
    Citation: Cell Communication and Signaling 2022 20:165
  27. Triple negative breast cancer (TNBC) is one of the most lethal breast cancer subtypes. Due to a lack of effective therapeutic targets, chemotherapy is still the main medical treatment for TNBC patients. Thus, ...

    Authors: Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao, Huijie Yang, Xin Li, Xiao Yang, Yan Xia, Chenmiao Zhang, Mingxi Fu, Dehai Wang, Ye Zhang, Shu Zhuo, Jian Zhu and Ting Zhuang
    Citation: Cell Communication and Signaling 2022 20:164
  28. Nesfatin-1 and -2 are produced from a reaction in which the N-terminus of human Nucleobindin-2 undergoes proteolytical processing. To date, Nucleobindin-2 and/or nesfatin-1 have only been shown to act as pepti...

    Authors: Rafał Lenda, Michał Padjasek, Artur Krężel, Andrzej Ożyhar and Dominika Bystranowska
    Citation: Cell Communication and Signaling 2022 20:163
  29. Frameshift mutations in LRPAP1 are responsible for autosomal recessive high myopia in human beings but its underlying mechanism remains elusive. This study aims to investigate the effect of LRPAP1 defect on ocula...

    Authors: Shanshan Liu, Ting Chen, Binghao Chen, Yijun Liu, Xiaohe Lu and Jiali Li
    Citation: Cell Communication and Signaling 2022 20:162
  30. High-altitude cerebral edema (HACE) is a serious and potentially fatal brain injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the main pathological factor of this condition. H...

    Authors: Yan Xue, Xueting Wang, Baolan Wan, Dongzhi Wang, Meiqi Li, Kang Cheng, Qianqian Luo, Dan Wang, Yapeng Lu and Li Zhu
    Citation: Cell Communication and Signaling 2022 20:160
  31. We mourn, and briefly describe the life and contributions of, Andrew H. Wyllie, who was a co-author of the first paper to describe apoptosis, and a primary proponent of the concept.

    Authors: Zahra Zakeri and Richard A. Lockshin
    Citation: Cell Communication and Signaling 2022 20:159
  32. Ongoing differentiation processes characterize the mammary gland during sexual development and reproduction. In contrast, defective remodelling is assumed to be causal for breast tumorigenesis. We have shown r...

    Authors: Marie-Luise Melcher, Ines Block, Karolin Kropf, Anurag Kumar Singh and Guido Posern
    Citation: Cell Communication and Signaling 2022 20:158
  33. In acute pancreatitis, activation of inflammatory signaling, including the nuclear factor-kappa B (NF-κB) pathway, within acinar cells is known to be an early intracellular event occurring in parallel with pat...

    Authors: Jing Yang, Xujiao Tang, Baiqiang Li and Jinsong Shi
    Citation: Cell Communication and Signaling 2022 20:157
  34. EGFR mutations in non-small cell lung cancer (NSCLC) are associated with a poor response to immune checkpoint inhibitors (ICIs), and only 20% of NSCLC patients harboring EGFR mutations benefit from immunotherapy....

    Authors: Dantong Sun, Haili Qian, Jinsong Wang, Tongji Xie, Fei Teng, Junling Li and Puyuan Xing
    Citation: Cell Communication and Signaling 2022 20:156
  35. Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to...

    Authors: Pengfei Zhan, Yuqing Cui, Yujuan Cao, Xun Bao, Meili Wu, Qian Yang, Jiahui Yang, Haohan Zheng, Jian Zou, Tianhua Xie, Jiping Cai, Yong Yao and Xiaolu Wang
    Citation: Cell Communication and Signaling 2022 20:155
  36. Insulin resistance (IR) is a condition in which the response of organs to insulin is impaired. IR is an early marker of metabolic dysfunction. However, IR also appears in physiological contexts during critical...

    Authors: Rosa Isela Ortiz-Huidobro, Carlos Larqué, Myrian Velasco, Juan Pablo Chávez-Maldonado, Jean Sabido, Yuriko Itzel Sanchez-Zamora and Marcia Hiriart
    Citation: Cell Communication and Signaling 2022 20:154
  37. Cardiovascular disease is one of the leading causes of human mortality worldwide, mainly due to atherosclerosis (AS), and the phenotypic transition of vascular smooth muscle cells (VSMCs) is a key event in the...

    Authors: Jiali Yao, Linqian Cai, Yingrui Chen, Jie Zhang, Wenwen Zhuang, Jingyan Liang and Hongliang Li
    Citation: Cell Communication and Signaling 2022 20:153
  38. Tumorigenic phenotype of M2 tumor-associated macrophages promote tumor progression in response to exosomes cues imposed by tumor cells. However, the effect and underlying mechanisms of clear cell renal cell ca...

    Authors: Tianyi Shen, Suqin Miao, Yulin Zhou, Xiaoming Yi, Song Xue, Bowen Du, Chaopeng Tang, Le Qu, Dian Fu, Ruipeng Jia and Haowei He
    Citation: Cell Communication and Signaling 2022 20:152
  39. Anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibodies (mAbs) are of great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) patients. However, the generation of primary a...

    Authors: Shanshan Wei, Wenwei Hu, Jun Feng and Yiting Geng
    Citation: Cell Communication and Signaling 2022 20:150
  40. Tumor cells detachment from primary lesions is an early event for hepatocellular carcinoma (HCC) metastasis, in which cell adhesion molecules play an important role. The role of mechanical crowding has attract...

    Authors: Ping Han, Yu Lei, Jingmei Liu, Jiqiao Liu, Huanjun Huang, Dean Tian and Wei Yan
    Citation: Cell Communication and Signaling 2022 20:149
  41. Middle ear cholesteatoma (MEC), is a destructive, and locally invasive lesion in the middle ear driven by inflammation with an annual incidence of 10 per 100,000. Surgical extraction/excision remains the only ...

    Authors: Matthias Schürmann, Peter Goon and Holger Sudhoff
    Citation: Cell Communication and Signaling 2022 20:148
  42. Ubiquitin-specific protease 22 (USP22), a putative cancer stem cell marker, is frequently upregulated in cancers, and USP22 overexpression is associated with aggressive growth, metastasis, and therapy resistan...

    Authors: Ting Sun, Keqiang Zhang, Wendong Li, Yunze Liu, Rajendra P. Pangeni, Aimin Li, Leonidas Arvanitis and Dan J. Raz
    Citation: Cell Communication and Signaling 2022 20:147
  43. Keratinocytes constitute a major part of the melanoma microenvironment, considering their protective role towards melanocytes in physiological conditions. However, their interactions with tumor cells following...

    Authors: Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Magdalena Kot, Katarzyna Pietraszek-Gremplewicz, Dominika Wilk, Marcin Ziętek, Rafał Matkowski and Dorota Nowak
    Citation: Cell Communication and Signaling 2022 20:146
  44. Notch signaling is highly conserved and critically involved in cell differentiation, immunity, and survival. Activation of the Notch pathway modulates immune cell functions during the inflammatory response. Ho...

    Authors: Dongwei Xu, Xiaoye Qu, Yizhu Tian, Zhao Jie, Zhifeng Xi, Feng Xue, Xueyun Ma, Jianjun Zhu and Qiang Xia
    Citation: Cell Communication and Signaling 2022 20:144
  45. Spatiotemporal regulation of subcellular protein kinase A (PKA) activity for precise substrate phosphorylation is essential for cellular responses to hormonal stimulation. Ryanodine receptor 2 (RyR2) and (sarc...

    Authors: Bing Xu, Ying Wang, Sherif M. F. M. Bahriz, Meimi Zhao, Chaoqun Zhu and Yang K. Xiang
    Citation: Cell Communication and Signaling 2022 20:143
  46. Multidrug resistance (MDR) is a complex phenomenon that frequently leads to chemotherapy failure during cancer treatment. The overexpression of ATP-binding cassette (ABC) transporters represents the major mech...

    Authors: Yuchen Zhang, Cheukfai Li, Chenglai Xia, Keneth Kin Wah To, Zhixing Guo, Chongyang Ren, Lingzhu Wen, Fang Wang, Liwu Fu and Ning Liao
    Citation: Cell Communication and Signaling 2022 20:142

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