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  1. Research

    Metabolic shift in density-dependent stem cell differentiation

    Vascular progenitor cells (VPCs) derived from embryonic stem cells (ESCs) are a valuable source for cell- and tissue-based therapeutic strategies. During the optimization of endothelial cell (EC) inductions fr...

    Simar J. Singh, William Turner, Drew E. Glaser, Kara E. McCloskey and Fabian V. Filipp

    Cell Communication and Signaling 2017 15:44

    Published on: 20 October 2017

  2. Research

    A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells

    In previous research, we found that cell secretion from the adult lamprey supraneural body tissues possesses cytocidal activity against tumor cells, but the protein with cytocidal activity was unidentified.

    Yue Pang, Changzhi Li, Shiyue Wang, Wei Ba, Tao Yu, Guangying Pei, Dan Bi, Hongfang Liang, Xiong Pan, Ting Zhu, Meng Gou, Yinglun Han and Qingwei Li

    Cell Communication and Signaling 2017 15:42

    Published on: 16 October 2017

  3. Research

    Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4

    Human cancer cells often exhibit impaired IGF2 expression and the underlying mechanisms are multifaceted and complex. Besides the well-known imprinting control region IGF2/H19-ICR, the involvement of a differenti...

    Undraga Schagdarsurengin, Angela Lammert, Natalie Schunk, Diana Sheridan, Stefan Gattenloehner, Klaus Steger, Florian Wagenlehner and Temuujin Dansranjavin

    Cell Communication and Signaling 2017 15:40

    Published on: 10 October 2017

  4. Research

    NF-κB potentiates tumor growth by suppressing a novel target LPTS

    Chronic inflammation is causally linked to the carcinogenesis and progression of most solid tumors. LPTS is a well-identified tumor suppressor by inhibiting telomerase activity and cancer cell growth. However,...

    Dongbo Liu, Hongping Miao, Yuanyin Zhao, Xia Kang, Shenglan Shang, Wei Xiang, Rongchen Shi, Along Hou, Rui Wang, Kun Zhao, Yingzhe Liu, Yue Ma, Huan Luo, Hongming Miao and Fengtian He

    Cell Communication and Signaling 2017 15:39

    Published on: 10 October 2017

  5. Research

    CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway

    Chloride channel accessory 1 (CLCA1) belongs to the calcium-sensitive chloride conductance protein family, which is mainly expressed in the colon, small intestine and appendix. This study was conducted to inve...

    Xiaofen Li, Wangxiong Hu, Jiaojiao Zhou, Yanqin Huang, Jiaping Peng, Ying Yuan, Jiekai Yu and Shu Zheng

    Cell Communication and Signaling 2017 15:38

    Published on: 3 October 2017

  6. Research

    Crosstalk between glial and glioblastoma cells triggers the “go-or-grow” phenotype of tumor cells

    Glioblastoma (GBM), the most malignant primary brain tumor, leads to poor and unpredictable clinical outcomes. Recent studies showed the tumor microenvironment has a critical role in regulating tumor growth by...

    Ana Isabel Oliveira, Sandra I. Anjo, Joana Vieira de Castro, Sofia C. Serra, António J. Salgado, Bruno Manadas and Bruno M. Costa

    Cell Communication and Signaling 2017 15:37

    Published on: 2 October 2017

  7. Short report

    ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis

    The small GTPase ARF1 mediates membrane trafficking mostly from the Golgi, and is essential for the G protein-coupled receptor (GPCR)-mediated chemotaxis of neutrophils. In this process, ARF1 is activated by t...

    Yuichi Mazaki, Yasuhito Onodera, Tsunehito Higashi, Takahiro Horinouchi, Tsukasa Oikawa and Hisataka Sabe

    Cell Communication and Signaling 2017 15:36

    Published on: 2 October 2017

  8. Review

    The emerging roles of phosphatases in Hedgehog pathway

    Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad ...

    Long Zhao, Liguo Wang, Chunli Chi, Wenwen Lan and Ying Su

    Cell Communication and Signaling 2017 15:35

    Published on: 20 September 2017

  9. Research

    Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling

    Meningiomas are the most common primary intracranial tumors in adults. While a majority of meningiomas are slow growing neoplasms that may cured by surgical resection, a subset demonstrates more aggressive beh...

    Yu Mei, Ziming Du, Changchen Hu, Noah F. Greenwald, Malak Abedalthagafi, Nathalie Y.R. Agar, Gavin P. Dunn, Wenya Linda Bi, Sandro Santagata and Ian F. Dunn

    Cell Communication and Signaling 2017 15:34

    Published on: 18 September 2017

  10. Research

    CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens

    Antimicrobial peptides are important components of the host defence with a broad range of functions including direct antimicrobial activity and modulation of inflammation. Lack of cathelin-related antimicrobia...

    Eugenia Kress, Julika Merres, Lea-Jessica Albrecht, Sven Hammerschmidt, Thomas Pufe, Simone C. Tauber and Lars-Ove Brandenburg

    Cell Communication and Signaling 2017 15:32

    Published on: 16 September 2017

  11. Erratum

    Erratum to: Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

    Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, Kelly Galbraith Kawabata, F. David Horgen, Toshihiko Kawamori, Reinhold Penner and Andrea Fleig

    Cell Communication and Signaling 2017 15:31

    Published on: 11 September 2017

    The original article was published in Cell Communication and Signaling 2017 15:30

  12. Research

    Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

    Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel invol...

    Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, Kelly Galbraith Kawabata, F. David Horgen, Toshihiko Kawamori, Reinhold Penner and Andrea Fleig

    Cell Communication and Signaling 2017 15:30

    Published on: 15 August 2017

    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:31

  13. Research

    Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

    C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-termina...

    Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin and Heung-Chin Cheng

    Cell Communication and Signaling 2017 15:29

    Published on: 7 August 2017

  14. Research

    Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

    Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunit...

    Kirsten Bucher, Fee Schmitt, Benedikt Mothes, Carolin Blumendeller, Daniel Schäll, Roland Piekorz, Emilio Hirsch, Bernd Nürnberg and Sandra Beer-Hammer

    Cell Communication and Signaling 2017 15:28

    Published on: 19 July 2017

  15. Review

    Viral manipulation of the cellular sumoylation machinery

    Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has em...

    Angela J. Lowrey, Wyatt Cramblet and Gretchen L. Bentz

    Cell Communication and Signaling 2017 15:27

    Published on: 14 July 2017

  16. Research

    Glyceollins trigger anti-proliferative effects through estradiol-dependent and independent pathways in breast cancer cells

    Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract....

    Sylvain Lecomte, Frederic Chalmel, François Ferriere, Frederic Percevault, Nicolas Plu, Christian Saligaut, Claire Surel, Marie Lelong, Theo Efstathiou and Farzad Pakdel

    Cell Communication and Signaling 2017 15:26

    Published on: 30 June 2017

  17. Research

    Fibroblast growth factor 2 supports osteoblastic niche cells during hematopoietic homeostasis recovery after bone marrow suppression

    Hematopoietic stem cell (HSC) maintenance requires a specific microenvironment. HSC niches can be activated by tissue damaging chemotherapeutic drugs and various cell signaling molecules such as SDF-1 and FGF,...

    Kyung-Ae Yoon, YeonSung Son, Young-Jin Choi, Joo-Hyun Kim and Je-Yoel Cho

    Cell Communication and Signaling 2017 15:25

    Published on: 29 June 2017

  18. Review

    The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells

    The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarizati...

    Farhad Seif, Majid Khoshmirsafa, Hossein Aazami, Monireh Mohsenzadegan, Gholamreza Sedighi and Mohammadali Bahar

    Cell Communication and Signaling 2017 15:23

    Published on: 21 June 2017

  19. Research

    Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells

    In mammalian intestines, Notch signaling plays a critical role in mediating cell fate decisions; it promotes the absorptive (or enterocyte) cell fate, while concomitantly inhibiting the secretory cell fate (i....

    Shaiya C. Robinson, Kristina Klobucar, Christina C. Pierre, Amna Ansari, Svetlana Zhenilo, Egor Prokhortchouk and Juliet M. Daniel

    Cell Communication and Signaling 2017 15:24

    Published on: 21 June 2017

  20. Short report

    Identification of EGF-NF-κB-FOXC1 signaling axis in basal-like breast cancer

    The pathogenesis of human basal-like breast cancer (BLBC) is not well understood and patients with BLBC have a poor prognosis. Expression of the epidermal growth factor receptor (EGFR) and nuclear factor-κB (N...

    Stacey Chung, Yanli Jin, Bingchen Han, Ying Qu, Bowen Gao, Armando E. Giuliano and Xiaojiang Cui

    Cell Communication and Signaling 2017 15:22

    Published on: 19 June 2017

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