Articles

Correction to: Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract

Following publication of the original article [1], it was reported that Fig. 1c was not entirely readable due to overlapping Fig. 1d. The publishers apologise for this error.

Authors: Subhayan Sur, Hiroshi Nakanishi, Colin Flaveny, Joseph E. Ippolito, Jane McHowat, David A. Ford and Ratna B. Ray

Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein

Authors: Rachel NeMoyer, Arindam Mondal, Mehul Vora, Elaine Langenfeld, Danea Glover, Michael Scott, Lauren Lairson, Christopher Rongo, David J. Augeri, Youyi Peng, Salma K. Jabbour and John Langenfeld

TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1

In recent years, copper complexes have gradually become the focus of potential anticancer drugs due to their available redox properties and low toxicity. In this study, a novel mitochondrion-targeting copper (...

Authors: Jiangjuan Shao, Mengmeng Li, Zijian Guo, Chun Jin, Feng Zhang, Chunyan Ou, Yaochen Xie, Shanzhong Tan, Zhenyi Wang, Shizhong Zheng and Xiaoyong Wang

Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer ...

Authors: Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi and Päivi J. Koskinen

The regulatory roles of neutrophils in adaptive immunity

Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly supported the direct and indirect regulatory effects of ne...

Authors: Yang Li, Wei Wang, Fan Yang, Yanan Xu, Chang Feng and Yong Zhao

Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk

Successful establishment of pregnancy hinges on appropriate communication between the embryo and the uterus prior to implantation, but the nature of this communication remains poorly understood. Here, we teste...

Authors: Masoumeh Es-Haghi, Kasun Godakumara, Annika Häling, Freddy Lättekivi, Arina Lavrits, Janeli Viil, Aneta Andronowska, Tamer Nafee, Victoria James, Ülle Jaakma, Andres Salumets and Alireza Fazeli

Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis

Notch1 signalling is a stem-cell-related pathway that is essential for embryonic development, tissue regeneration and organogenesis. However, the role of Notch1 in the formation of myofibroblasts and fibrosis ...

Authors: Weilong Hong, Ge Zhang, Hong Lu, Yangyang Guo, Shizhang Zheng, Hengyue Zhu, Yanyi Xiao, Akuetteh Percy David Papa, Cunzao Wu, Linxiao Sun, Bicheng Chen and Yongheng Bai

ATM controls DNA repair and mitochondria transfer between neighboring cells

Intercellular communication is essential for multicellular tissue vitality and homeostasis. We show that healthy cells message protective signals through direct cell–cell connections to adjacent DNA–damaged ce...

Authors: Sha Jin and Nils Cordes

Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling

Excessive TGF-β signalling has been shown to underlie pulmonary hypertension (PAH). Human pulmonary artery smooth muscle cells (HPASMCs) can release extracellular vesicles (EVs) but their contents and signific...

Authors: Fernando de la Cuesta, Ilaria Passalacqua, Julie Rodor, Raghu Bhushan, Laura Denby and Andrew H. Baker

Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway

Integrin-mediated platelet-tumor cell contacting plays an important role in promoting epithelial-mesenchymal transition (EMT) transformation of tumor cells and cancer metastasis, but whether it occurs in breas...

Authors: Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang and Yong-gang Shi

Loss-of-function phenotype of a PKCθ^T219A knockin mouse strain

Protein kinase C θ has been established as an important signaling intermediate in T-effector-cell activation and survival pathways by controlling activity of the key transcription factors NF-κB and NFAT. Previ...

Authors: Nikolaus Thuille, Kerstin Siegmund, Victoria Klepsch, Jacqueline Schörgenhuber, Sarah Danklmaier, Michael Leitges and Gottfried Baier

GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients

In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of...

Authors: Ulrike Neckmann, Camilla Wolowczyk, Martina Hall, Eivind Almaas, Jiang Ren, Sen Zhao, Bjarne Johannessen, Rolf I. Skotheim, Geir Bjørkøy, Peter ten Dijke and Toril Holien

Flipping the dogma – phosphatidylserine in non-apoptotic cell death

The exposure of phosphatidylserine (PS) on the outer plasma membrane has long been considered a unique feature of apoptotic cells. Together with other “eat me” signals, it enables the recognition and phagocyto...

Authors: Inbar Shlomovitz, Mary Speir and Motti Gerlic

Correction to: Transcriptional activation of CBFβ by CDK11^p110 is necessary to promote osteosarcoma cell proliferation

Following publication of the original article [1], it was reported that Figs. 4 and 5 were not updated during the production process.

Authors: Yong Feng, Yunfei Liao, Jianming Zhang, Jacson Shen, Zengwu Shao, Francis Hornicek and Zhenfeng Duan

Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma

p21-activated kinase 1 (PAK1) stimulates growth and metastasis in non-small cell lung cancer (NSCLC). Protein kinase C iota (PKCι) is an enzyme highly expressed in NSCLC, regulating PAK1 signaling. In the pres...

Authors: Masaoki Ito, Carles Codony-Servat, Jordi Codony-Servat, David Lligé, Imane Chaib, Xiaoyan Sun, Jing Miao, Rongwei Sun, Xueting Cai, Alberto Verlicchi, Morihito Okada, Miguel Angel Molina-Vila, Niki Karachaliou, Peng Cao and Rafael Rosell

The PPAR-γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice

Osteoclasts are key determinant cellular components implicated in the development and progression of disorders driven by bone damage. Herein, we studied the upshot of T007, an antagonist of peroxisome prolifer...

Authors: Xiang Li, Lei Ning, Jianjun Ma, Ziang Xie, Xiangde Zhao, Gangliang Wang, Xinyu Wan, Pengcheng Qiu, Teng Yao, Haoming Wang, Shunwu Fan and Shuanglin Wan

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signa...

Authors: Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller and Fred Schaper

Notch1-ADAM8 positive feed-back loop regulates the degradation of chondrogenic extracellular matrix and osteoarthritis progression

Osteoarthritis (OA) is one of the most prevalent joint disease, and there are still no effective therapeutic agents or clinical methods for the cure of this disease to date. The degradation of cartilage extrac...

Authors: Biao Duan, Yan Liu, He Hu, Fu-Guo Shi, Ya-Long Liu, Hao Xue, Xin-Yu Yun, Ming-Yu Yan, Xi-Rui Han, An-Fu Chen, Yong Wang and Zhe-Hai Li

Notch pathway: a bistable inducer of biological noise?

Notch signalling pathway is central to development of metazoans. The pathway codes a binary fate switch. Upon activation, downstream signals contribute to resolution of fate dichotomies such as proliferation/d...

Authors: Filip Vujovic, Neil Hunter and Ramin M. Farahani

Roles of phosphatidylserine exposed on the viral envelope and cell membrane in HIV-1 replication

Phosphatidylserine (PtdSer) is usually present only in the inner leaf of the lipid bilayers of the cell membrane, but is exposed on the outer leaf when cells are activated and/or die. Exposure of PtdSer has ph...

Authors: Bernadette Anne Chua, Jamie Ann Ngo, Kathy Situ and Kouki Morizono

Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract

Metabolic reprogramming is one of the hallmarks of cancer which favours rapid energy production, biosynthetic capabilities and therapy resistance. In our previous study, we showed bitter melon extract (BME) pr...

Authors: Subhayan Sur, Hiroshi Nakanishi, Colin Flaveny, Joseph E. Ippolito, Jane McHowat, David A. Ford and Ratna B. Ray

Correction to: MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling

Following publication of the original article [1], the authors reported that the given name of Qinhao Wang was incorrectly published as Qinghao Wang. The original article has been corrected.

Authors: Guang Yan, Yi Ru, Fengqi Yan, Xin Xiong, Wei Hu, Tao Pan, Jianming Sun, Chi Zhang, Qinhao Wang and Xia Li

Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

While regulated WNT activity is required for normal development and stem cell maintenance, mutations that lead to constitutive activation of the WNT pathway cause cellular transformation and drive colorectal c...

Authors: Yi-Heng Hao, M. Carmen Lafita-Navarro, Lauren Zacharias, Nofit Borenstein-Auerbach, Min Kim, Spencer Barnes, Jiwoong Kim, Jerry Shay, Ralph J. DeBerardinis and Maralice Conacci-Sorrell

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure

Linoleic acid is the major fatty acid moiety of cardiolipin, which is central to the assembly of components involved in mitochondrial oxidative phosphorylation (OXPHOS). Although linoleic acid is an essential ...

Authors: Satoshi Maekawa, Shingo Takada, Hideo Nambu, Takaaki Furihata, Naoya Kakutani, Daiki Setoyama, Yasushi Ueyanagi, Dongchon Kang, Hisataka Sabe and Shintaro Kinugawa

Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phlore...

Authors: Sarita Saraswati, Abdulqader Alhaider, Abdelgalil Mohamed Abdelgadir, Pooja Tanwer and Hesham M. Korashy

Distribution, dynamics and functional roles of phosphatidylserine within the cell

Phosphatidylserine (PtdSer), an essential constituent of eukaryotic membranes, is the most abundant anionic phospholipid in the eukaryotic cell accounting for up to 10% of the total cellular lipid. Much of wha...

Authors: Jason G. Kay and Gregory D. Fairn

Transcriptional activation of CBFβ by CDK11^p110 is necessary to promote osteosarcoma cell proliferation

Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation. However, the molecular mechanisms of CDK11 and CDK11 t...

Authors: Yong Feng, Yunfei Liao, Jianming Zhang, Jacson Shen, Zengwu Shao, Francis Hornicek and Zhenfeng Duan

Identification of Cancer–associated metabolic vulnerabilities by modeling multi-objective optimality in metabolism

Cancer cells undergo global reprogramming of cellular metabolism to satisfy demands of energy and biomass during proliferation and metastasis. Computational modeling of genome-scale metabolic models is an effe...

Authors: Ziwei Dai, Shiyu Yang, Liyan Xu, Hongrong Hu, Kun Liao, Jianghuang Wang, Qian Wang, Shuaishi Gao, Bo Li and Luhua Lai

Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system

The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular ...

Authors: Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Groß, Anette Kaiser and Simone Prömel

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

Prostate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease. ABI1, a memb...

Authors: Disharee Nath, Xiang Li, Claudia Mondragon, Dawn Post, Ming Chen, Julie R. White, Anita Hryniewicz-Jankowska, Tiffany Caza, Vladimir A. Kuznetsov, Heidi Hehnly, Tamara Jamaspishvili, David M. Berman, Fan Zhang, Sonia H. Y. Kung, Ladan Fazli, Martin E. Gleave…

cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα, part of the GPIb-IX-V complex, has several physiolog...

Authors: Stephanie Makhoul, Katharina Trabold, Stepan Gambaryan, Stefan Tenzer, Daniele Pillitteri, Ulrich Walter and Kerstin Jurk

Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review

Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate of metastasis and low rate of survival. Despite the advances in understanding this devastating disease, PC still accounts for 3% o...

Authors: Jiang-Jiang Qin, Xiang-Dong Cheng, Jia Zhang and Wei-Dong Zhang

Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling

Stromal-derived CXCL12 play an important role which influence the proliferation and invasiveness of colon cancer in microenvironment. The present study aimed to analyze the underlying mechanism by which CXCL12...

Authors: Jiachi Ma, Xiaowen Sun, Yimin Wang, Bangling Chen, Liyu Qian and Yaguo Wang

CXCL1-LCN2 paracrine axis promotes progression of prostate cancer via the Src activation and epithelial-mesenchymal transition

Mechanisms driving the progression of castration-resistant prostate cancer are believed to relate substantially to the tumor microenvironment. However, the cross-talks between tumor epithelial cell, stromal ce...

Authors: Yongning Lu, Baijun Dong, Fan Xu, Yunze Xu, Jiahua Pan, Jiajia Song, Jin Zhang, Yiran Huang and Wei Xue

Nonlytic exocytosis of Cryptococcus neoformans from neutrophils in the brain vasculature

Cryptococcus neoformans (C. neoformans) is an encapsulated budding yeast that causes life-threatening meningoencephalitis in immunocompromised individuals, especially those with acquired immunodeficiency syndrome...

Authors: Xiaofan Yang, Huijuan Wang, Fan Hu, Xichen Chen and Mingshun Zhang

Ventricular Zone Expressed PH Domain Containing 1 (VEPH1): an adaptor protein capable of modulating multiple signaling transduction pathways during normal and pathological development

Ventricular Zone Expressed PH Domain-Containing 1 (VEPH1) is an 833-amino acid protein encoded by an evolutionarily conserved single-copy gene that emerged with pseudocoelomates. This gene has no paralog in an...

Authors: Theodore J. Brown, Alexandra Kollara, Premalatha Shathasivam and Maurice J. Ringuette

4.1B suppresses cancer cell proliferation by binding to EGFR P13 region of intracellular juxtamembrane segment

Gastric cancer (GC) has high incidence and mortality worldwide. However, the underlying mechanisms that regulate gastric carcinogenesis are largely undefined. 4.1B is an adaptor protein found at the interface ...

Authors: Fumin Xue, Chao An, Lixiang Chen, Gang Liu, Feifei Ren, Xinhua Guo, Haibin Sun, Lu Mei, Xiangdong Sun, Jinpeng Li, Youcai Tang, Xiuli An and Pengyuan Zheng

N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells

KIT tyrosine kinase is expressed in mast cells, interstitial cells of Cajal, and hematopoietic cells. Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leu...

Authors: Yuuki Obata, Yasushi Hara, Isamu Shiina, Takatsugu Murata, Yasutaka Tasaki, Kyohei Suzuki, Keiichi Ito, Shou Tsugawa, Kouhei Yamawaki, Tsuyoshi Takahashi, Koji Okamoto, Toshirou Nishida and Ryo Abe

Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals

C-Type Lectin Domain Family 3 Member B (CLEC3B), is down-regulated in serum and tumor tissues in different cancers including hepatocellular carcinoma (HCC). However, the functions of CLEC3B in HCC remains eluc...

Authors: Wenjuan Dai, Yilin Wang, Tianxiao Yang, Jing Wang, Weicheng Wu and Jianxin Gu

Correction to: Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury

Following publication of the original article [1], the authors reported that the given name of Liqing Wang was incorrectly published as Liqiang Wang. The original article has been updated.

Authors: Yueying Zheng, Liqing Wang, Manli Chen, Lu Liu, Aijie Pei, Rong Zhang, Shuyuan Gan and Shengmei Zhu

Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo

Overexpression of ATP-binding cassette (ABC) transporters, such as ABCB1 and ABCG2, has been proved to be a major trigger for multidrug resistance (MDR) in certain types of cancer. A promising approach to reve...

Authors: Zhiqiang Zhang, Chunling Ma, Peng Li, Min Wu, Shengnan Ye, Liwu Fu and Jianhua Xu

Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) cells rely on an un...

Authors: Weiguang Sun, Shanshan Luan, Changxing Qi, Qingyi Tong, Shan Yan, Hua Li and Yonghui Zhang

WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling

Breast cancer is the leading cause of cancer-related death in women worldwide. Metastatic disease remains the primary cause of death in patients with breast cancer. Basal-like breast cancer (BLBC) is associate...

Authors: Shaojie Jiang, Miaofeng Zhang, Yanhua Zhang, Weiping Zhou, Tao Zhu, Qing Ruan, Hui Chen, Jie Fang, Fei Zhou, Jihong Sun and Xiaoming Yang

¹H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma

Glioma is the most common and primary brain tumors in adults. Despite the available multimodal therapies, glioma patients appear to have a poor prognosis. The Hedgehog (Hh) signaling is involved in tumorigenes...

Authors: Giuseppina D’Alessandro, Deborah Quaglio, Lucia Monaco, Clotilde Lauro, Francesca Ghirga, Cinzia Ingallina, Michela De Martino, Sergio Fucile, Alessandra Porzia, Maria Amalia Di Castro, Federica Bellato, Francesca Mastrotto, Mattia Mori, Paola Infante, Paola Turano, Stefano Salmaso…

Immature O-glycans recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells

Ligands of the C-type lectin CLEC10A such as Tn and sialyl-Tn representing early intermediates of O-glycosylation are hallmarks of many human malignancies. A variety of regulatory mechanisms underlying their e...

Authors: Anna-Katharina Kurze, Sophia Buhs, Dennis Eggert, Leticia Oliveira-Ferrer, Volkmar Müller, Axel Niendorf, Christoph Wagener and Peter Nollau

ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

HER3/ErbB3 receptor deletion or blockade leads to tumor cell apoptosis, whereas its overexpression confers anti-cancer drug resistance through upregulation of protective mechanisms against apoptosis. We produc...

Authors: Christophe Le Clorennec, Yassamine Lazrek, Olivier Dubreuil, Carla Sampaio, Christel Larbouret, Romain Lanotte, Marie-Alix Poul, Jean-Marc Barret, Jean-François Prost, André Pèlegrin and Thierry Chardès

Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction

Breast cancer is a life-threatening disease in females and the leading cause of mortality among the female population, presenting huge challenges for prognosis and treatment. ITM2A is a member of the BRICHOS s...

Authors: Cefan Zhou, Ming Wang, Jing Yang, Hui Xiong, Yefu Wang and Jingfeng Tang

Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation

Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase complex and is associated with hepatic lipid accumulation...

Authors: Dong Hun Lee, Mi Hee Park, Chul Ju Hwang, Youngsoo Kim, Dae Yeon Hwang, Sang Bae Han and Jin Tae Hong

Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury

The T cell Ig domain and mucin domain (TIM)-1 protein expressed on the surface of Th2 cells regulates the immune response by modulating cytokine production. The present study aimed to investigate the role and ...

Authors: Yueying Zheng, Liqing Wang, Manli Chen, Lu Liu, Aijie Pei, Rong Zhang, Shuyuan Gan and Shengmei Zhu

Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213

Androgen receptor (AR) plays important role in the development, progression, and metastasis of prostate cancer (PCa). Caffeic acid phenethyl ester (CAPE) is the main component of honey bee propolis. We determi...

Authors: Ying-Yu Kuo, Chieh Huo, Ching-Yu Lin, Hui-Ping Lin, Jai-Shin Liu, Wen-Ching Wang, Chuang-Rung Chang and Chih-Pin Chuu