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  1. Programmed cell death 1 ligand 1 (PD-L1) is the ligand for programmed death protein-1 (PD-1), is associated with immunosuppression. Signaling via PD-1/PD-L1 will transmits negative regulatory signals to T cell...

    Authors: Jiaxing Liu, Xueqiang Peng, Shuo Yang, Xinyu Li, Mingyao Huang, Shibo Wei, Sheng Zhang, Guangpeng He, Hongyu Zheng, Qing Fan, Liang Yang and Hangyu Li

    Citation: Cell Communication and Signaling 2022 20:14

    Content type: Review

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  2. Glioblastoma multiforme (GBM), as a deadly and almost incurable brain cancer, is the most invasive form of CNS tumors that affects both children and adult population. It accounts for approximately half of all ...

    Authors: Raziyeh Salami, Marziyeh Salami, Alireza Mafi, Omid Vakili and Zatollah Asemi

    Citation: Cell Communication and Signaling 2022 20:13

    Content type: Review

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  3. Endoplasmic reticulum (ER) stress has been found to foster the escape of cancer cells from immune surveillance and upregulate PD-L1 expression. However, the underlying mechanisms are unknown.

    Authors: Yi Yuan, Pengfei Jiao, Zeyu Wang, Mengqi Chen, Hongming Du, Liang Xu, Juanyong Xu, Youjin Dai, Fu-gen Wu, Yaqin Zhang and Heming Wu

    Citation: Cell Communication and Signaling 2022 20:12

    Content type: Research

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  4. A universal adaptor protein, MyD88, orchestrates the innate immune response by propagating signals from toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R). Receptor activation seeds MyD88 dependent ...

    Authors: Katarzyna Pustelny, Katarzyna Kuska, Andrzej Gorecki, Bogdan Musielak, Ewelina Dobosz, Benedykt Wladyka, Joanna Koziel, Anna Czarna, Tad Holak and Grzegorz Dubin

    Citation: Cell Communication and Signaling 2022 20:10

    Content type: Research

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  5. Pancreatic cancer is one of the most common malignancies. Unfortunately, the lack of effective methods of treatment and diagnosis has led to poor prognosis coupled with a very high mortality rate. So far, the ...

    Authors: Huan Zhang, Juan Xing, Zhujiang Dai, Daorong Wang and Dong Tang

    Citation: Cell Communication and Signaling 2022 20:9

    Content type: Review

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  6. The cycad neurotoxin beta-methylamino-l-alanine (L-BMAA), one of the environmental trigger factor for amyotrophic lateral sclerosis/Parkinson-dementia complex (ALS/PDC), may cause neurodegeneration by disrupting ...

    Authors: Tiziana Petrozziello, Francesca Boscia, Valentina Tedeschi, Anna Pannaccione, Valeria de Rosa, Angela Corvino, Beatrice Severino, Lucio Annunziato and Agnese Secondo

    Citation: Cell Communication and Signaling 2022 20:8

    Content type: Research

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  7. Glioblastomas are lethal brain tumors under the current combinatorial therapeutic strategy that includes surgery, chemo- and radio-therapies. Extensive changes in the tumor microenvironment is a key reason for...

    Authors: Jiabin Pan, Shiyang Sheng, Ling Ye, Xiaonan Xu, Yizhao Ma, Xuanran Feng, Lisha Qiu, Zhaohuan Fan, Yi Wang, Xiaohuan Xia and Jialin C. Zheng

    Citation: Cell Communication and Signaling 2022 20:7

    Content type: Research

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  8. Several studies have shown that members of the tumor necrosis factor (TNF) family play an important role in cancer immunoregulation, and trials targeting these molecules are already underway. Our study aimed t...

    Authors: Qiang-Wei Wang, Wei-Wei Lin and Yong-Jian Zhu

    Citation: Cell Communication and Signaling 2022 20:6

    Content type: Research

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  9. G protein-coupled receptors (GPCRs) usually regulate cellular processes via activation of intracellular signaling pathways. However, we have previously shown that in several cell lines, GqPCRs induce immediate...

    Authors: Guy Nadel, Zhong Yao, Ehud Wainstein, Izel Cohen, Ido Ben-Ami, Amir Schajnovitz, Galia Maik-Rachline, Zvi Naor, Benjamin A. Horwitz and Rony Seger

    Citation: Cell Communication and Signaling 2022 20:5

    Content type: Research

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  10. Research is revealing the complex coordination between cell signaling systems as they adapt to genetic and epigenetic changes. Tools to uncover these highly complex functional linkages will play an important r...

    Authors: Ian A. MacNeil, Salmaan A. Khan, Adrish Sen, Sajjad M. Soltani, David J. Burns, Brian F. Sullivan and Lance G. Laing

    Citation: Cell Communication and Signaling 2022 20:4

    Content type: Research

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  11. Calcification of adamantinomatous craniopharyngioma (ACP) often causes problems with tumor resection, leading to a high incidence of deadly complications and tumor recurrence. Histone acetyltransferase (HAT) a...

    Authors: Xiaorong Yan, Dezhi Kang, Yuanxiang Lin, Songtao Qi and Changzhen Jiang

    Citation: Cell Communication and Signaling 2022 20:3

    Content type: Research

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  12. Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain. They are ...

    Authors: Qamar Taban, Peerzada Tajamul Mumtaz, Khalid Z. Masoodi, Ehtishamul Haq and Syed Mudasir Ahmad

    Citation: Cell Communication and Signaling 2022 20:2

    Content type: Review

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  13. Pancreatic cancer is a highly malignant tumor and, is extremely difficult to diagnose and treat. Metastasis is one of the critical steps in the development of cancer and uses cell to cell communication to medi...

    Authors: Wenjie Zhang, Juan Xing, Tian Liu, Jie Zhang, Zhujiang Dai, Huan Zhang, Daorong Wang and Dong Tang

    Citation: Cell Communication and Signaling 2022 20:1

    Content type: Review

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  14. Vemurafenib (PLX4032) is one of the most frequently used treatments for late-stage melanoma patients with the BRAFV600E mutation; however, acquired resistance to the drug poses as a major challenge. It remains to...

    Authors: Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Silke Kowar, Manching Ku, Tilman Brummer and Melanie Boerries

    Citation: Cell Communication and Signaling 2021 19:123

    Content type: Research

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  15. The aim of this study was to investigate the co-operative role of CXCR4/CXCL12 axis and IL-1Ra in metastatic processes mechanism by interactions between colorectal cancer cells and stromal cells in their micro...

    Authors: Jiachi Ma, Wanqing Liang, Yaosheng Qiang, Lei Li, Jun Du, Chengwu Pan, Bangling Chen, Chensong Zhang, Yuzhong Chen and Qingkang Wang

    Citation: Cell Communication and Signaling 2021 19:122

    Content type: Research

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  16. Eukaryotic translation initiation factor 6 (eIF6), also known as integrin β4 binding protein, is involved in ribosome formation and mRNA translation, acting as an anti-association factor. It is also essential ...

    Authors: Zechen Zhao, Weiming Chu, Yang Zheng, Chao Wang, Yuemei Yang, Teng Xu, Xueming Yang, Wei Zhang, Xu Ding, Gang Li, Hongchuang Zhang, Junbo Zhou, Jinhai Ye, Heming Wu, Xiaomeng Song and Yunong Wu

    Citation: Cell Communication and Signaling 2021 19:121

    Content type: Research

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  17. Regulated cell death (RCD) is a ubiquitous process in living organisms that is essential for tissue homeostasis or to restore biological balance under stress. Over the decades, various forms of RCD have been r...

    Authors: Juntao Cui, Suhan Zhao, Yinghui Li, Danyang Zhang, Bingjing Wang, Junxia Xie and Jun Wang

    Citation: Cell Communication and Signaling 2021 19:120

    Content type: Review

    Published on:

  18. Protein disulfide isomerase A3 (PDIA3, also named GRP58, ER-60, ERp57) is conserved across species and mediates protein folding in the endoplasmic reticulum. PDIA3 is, reportedly, a chaperone for STAT3. Howeve...

    Authors: Matt. P. Keasey, V. Razskazovskiy, C. Jia, E. D. Peterknecht, P. C. Bradshaw and T. Hagg

    Citation: Cell Communication and Signaling 2021 19:119

    Content type: Research

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  19. Pancreatic cancer is an extremely malignant tumor with the lowest 5-year survival rate among all tumors. Pancreatic ductal adenocarcinoma (PDAC), as the most common pathological subtype of pancreatic cancer, u...

    Authors: Hong-Bo Li, Zi-Han Yang and Qing-Qu Guo

    Citation: Cell Communication and Signaling 2021 19:117

    Content type: Review

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  20. Wolfram syndrome (WFS) is a rare autosomal recessive syndrome in which diabetes mellitus and neurodegenerative disorders occur as a result of Wolframin deficiency and increased ER stress. In addition, WFS1 def...

    Authors: Agnieszka Zmyslowska, Miljan Kuljanin, Beata Malachowska, Marcin Stanczak, Dominika Michalek, Aneta Wlodarczyk, Dagmara Grot, Joanna Taha, Bartłomiej Pawlik, Magdalena Lebiedzińska-Arciszewska, Hanna Nieznanska, Mariusz R. Wieckowski, Piotr Rieske, Joseph D. Mancias, Maciej Borowiec, Wojciech Mlynarski…

    Citation: Cell Communication and Signaling 2021 19:116

    Content type: Research

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  21. It is well known that sepsis is a prevalent severe disease caused by infection and the treatment strategies are limited. Recently pericyte-derived microvesicles (PMVs) were confirmed to be therapeutic in many ...

    Authors: Henan Zhou, Danyang Zheng, Hongchen Wang, Yue Wu, Xiaoyong Peng, Qinghui Li, Tao Li and Liangming Liu

    Citation: Cell Communication and Signaling 2021 19:115

    Content type: Research

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  22. Xp11.2 translocation renal cell carcinoma (tRCC) is defined by translocation of the transcription factor E3 (TFE3) gene located on chromosome Xp11.2. Due to the high incidence in women, 17β-estradiol (E2) may be ...

    Authors: Qiancheng Shi, Ning Liu, Lei Yang, Yi Chen, Yanwen Lu, Hongqian Guo, Xiaodong Han, Dongmei Li and Weidong Gan

    Citation: Cell Communication and Signaling 2021 19:114

    Content type: Research

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  23. Alzheimer’s disease (AD) and glioblastoma are the most common and devastating diseases in the neurology and neurosurgery departments, respectively. Our previous research reports that the AD-related protein Pre...

    Authors: Wei Yang, Yan Xiang, Mao-Jun Liao, Peng-Fei Wu, Lin Yang, Guo-Hao Huang, Bao-Zhong Shi, Liang Yi and Sheng-Qing Lv

    Citation: Cell Communication and Signaling 2021 19:112

    Content type: Research

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  24. Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low ri...

    Authors: Pia Giovannelli, Marzia Di Donato, Giovanni Galasso, Alessandra Monaco, Fabrizio Licitra, Bruno Perillo, Antimo Migliaccio and Gabriella Castoria

    Citation: Cell Communication and Signaling 2021 19:110

    Content type: Review

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  25. Heart failure, which is characterized by cardiac remodelling, is one of the most common chronic diseases in the aged. Stimulator of interferon genes (STING) acts as an indispensable molecule modulating immune ...

    Authors: Rui Xiong, Ning Li, Lei Chen, Wei Wang, Bo Wang, Wenyang Jiang and Qing Geng

    Citation: Cell Communication and Signaling 2021 19:109

    Content type: Research

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  26. High temperature requirement A (HtrA) is an active serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expre...

    Authors: Sabine Bernegger, Robert Vidmar, Marko Fonovic, Gernot Posselt, Boris Turk and Silja Wessler

    Citation: Cell Communication and Signaling 2021 19:108

    Content type: Research

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  27. Myocardial reperfusion injury is often accompanied by cell death and inflammatory reactions. Recently, pyroptosis is gradually recognized as pivotal role in cardiovascular disease. However, little is known abo...

    Authors: Wenjing Sun, Hongquan Lu, Shujuan Dong, Rui Li, Yingjie Chu, Nan Wang, Yu Zhao, Yabin Zhang, Limeiting Wang, Lin Sun and Di Lu

    Citation: Cell Communication and Signaling 2021 19:107

    Content type: Research

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  28. Protein tyrosine phosphatase 1B (PTP1B) and low molecular weight protein tyrosine phosphatase (LMPTP) are implicated in the development of metabolic disorders. Yet, their role in progenitor stem cell adipogeni...

    Authors: Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken and Krzysztof Marycz

    Citation: Cell Communication and Signaling 2021 19:106

    Content type: Research

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  29. Intercellular communication is a critical process that ensures cooperation between distinct cell types and maintains homeostasis. EVs, which were initially described as cellular debris and devoid of biological...

    Authors: Greg Berumen Sánchez, Kaitlyn E. Bunn, Heather H. Pua and Marjan Rafat

    Citation: Cell Communication and Signaling 2021 19:104

    Content type: Review

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  30. Transcription factor CREB is involved in the development of pulmonary hypertension (PH). However, little is known about the role and regulatory signaling of CREB in PH.

    Authors: Genfa Xiao, Guili Lian, Tingjun Wang, Weixiao Chen, Wei Zhuang, Li Luo, Huajun Wang and Liangdi Xie

    Citation: Cell Communication and Signaling 2021 19:103

    Content type: Research

    Published on:

  31. Glioma is the most common primary brain tumor and its prognosis is poor. Despite surgical removal, glioma is still prone to recurrence because it grows rapidly in the brain, is resistant to chemotherapy, and i...

    Authors: Xiangdong Xu, Lingfei Li, Linting Luo, Lingling Shu, Xiaoli Si, Zhenzhen Chen, Wenqing Xia, Jinyu Huang, Yang Liu, Anwen Shao and Yiquan Ke

    Citation: Cell Communication and Signaling 2021 19:102

    Content type: Review

    Published on:

  32. During pregnancy, trophoblast cell invasion needs to be finely controlled. Aberrant trophoblast cell invasion is associated with placental diseases. Epidermal growth factor (EGF) and its receptor, EGFR, are ex...

    Authors: Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng and Ying-Pu Sun

    Citation: Cell Communication and Signaling 2021 19:101

    Content type: Research

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  33. Fetal cell-derived exosomes (extracellular vesicles, 40–160 nm) are communication channels that can signal parturition by inducing inflammatory changes in maternal decidua and myometrium. Little is known about...

    Authors: Megan C. Shepherd, Enkhtuya Radnaa, Ourlad Alzeus Tantengco, Talar Kechichian, Rheanna Urrabaz-Garza, Ananth Kumar Kammala, Samantha Sheller-Miller and Ramkumar Menon

    Citation: Cell Communication and Signaling 2021 19:100

    Content type: Research

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  34. The calcium (Ca2+)/calmodulin (CAM)-activated kinase kinase 2 (CAMKK2)-signaling regulates several physiological processes, for example, glucose metabolism and energy homeostasis, underlying the pathogenesis o...

    Authors: Mohammad Golam Sabbir, Carla G. Taylor and Peter Zahradka

    Citation: Cell Communication and Signaling 2021 19:98

    Content type: Research

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  35. Recent studies have shown that bone morphogenetic protein receptor 2 (BMPR2) regulates cell survival signaling events in cancer cells independent of the BMP type 1 receptor (BMPR1) or the Smad-1/5 transcriptio...

    Authors: Arindam Mondal, Rachel NeMoyer, Mehul Vora, Logan Napoli, Zoya Syed, Elaine Langenfeld, Dongxuan Jia, Youyi Peng, John Gilleran, Jacques Roberge, Christopher Rongo, Salma K. Jabbour and John Langenfeld

    Citation: Cell Communication and Signaling 2021 19:97

    Content type: Research

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  36. Notch signaling drives many aspects of neoplastic phenotype. Here, we report that the Integrator complex (INT) is a new component of the Notch transcriptional supercomplex. Together with Notch Activation Compl...

    Authors: Elena Shersher, Mohini Lahiry, Annamil Alvarez-Trotta, Giulia Diluvio, David J. Robbins, Ramin Shiekhattar and Anthony J. Capobianco

    Citation: Cell Communication and Signaling 2021 19:96

    Content type: Research

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  37. Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-...

    Authors: Shannon M. Weber, Nicole M. Brossier, Amanda Prechtl, Stephen Barnes, Landon S. Wilson, Stephanie N. Brosius, Jody Fromm Longo and Steven L. Carroll

    Citation: Cell Communication and Signaling 2021 19:95

    Content type: Research

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  38. Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an...

    Authors: Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Michal Komorowski, Steffen Waldherr, Fred Schaper and Anna Dittrich

    Citation: Cell Communication and Signaling 2021 19:94

    Content type: Research

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  39. Exosomes mediated crosstalk between tumor cells and other stromal cells including tumor associated macrophages plays an essential role in reprogramming tumor microenvironment (TME) to facilitate tumor progress...

    Authors: Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang and Jinjian Yang

    Citation: Cell Communication and Signaling 2021 19:93

    Content type: Research

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  40. Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal trans...

    Authors: John C. Charpentier and Philip D. King

    Citation: Cell Communication and Signaling 2021 19:92

    Content type: Review

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  41. Autophagy is catabolic process by degradation of intracellular components in lysosome including proteins, lipids, and mitochondria in response to nutrient deficiency or stress such as hypoxia or chemotherapy. ...

    Authors: Yalan Duan, Xiaoqing Tian, Qian Liu, Jianhua Jin, Juanjuan Shi and Yongzhong Hou

    Citation: Cell Communication and Signaling 2021 19:91

    Content type: Review

    Published on:

  42. Metastasis represents the leading cause of death in patients with breast cancer. Traditional Chinese medicine is particularly appreciated for metastatic diseases in Asian countries due to its benefits for surv...

    Authors: Jing Li, Shengqi Wang, Neng Wang, Yifeng Zheng, Bowen Yang, Xuan Wang, Juping Zhang, Bo Pan and Zhiyu Wang

    Citation: Cell Communication and Signaling 2021 19:89

    Content type: Research

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    The Correction to this article has been published in Cell Communication and Signaling 2021 19:113

  43. For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured pro...

    Authors: Sarah E. Bondos, A. Keith Dunker and Vladimir N. Uversky

    Citation: Cell Communication and Signaling 2021 19:88

    Content type: Editorial

    Published on:

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