Skip to main content

Articles

Page 1 of 24

  1. Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-...

    Authors: Shannon M. Weber, Nicole M. Brossier, Amanda Prechtl, Stephen Barnes, Landon S. Wilson, Stephanie N. Brosius, Jody Fromm Longo and Steven L. Carroll

    Citation: Cell Communication and Signaling 2021 19:95

    Content type: Research

    Published on:

  2. Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an...

    Authors: Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Michal Komorowski, Steffen Waldherr, Fred Schaper and Anna Dittrich

    Citation: Cell Communication and Signaling 2021 19:94

    Content type: Research

    Published on:

  3. Exosomes mediated crosstalk between tumor cells and other stromal cells including tumor associated macrophages plays an essential role in reprogramming tumor microenvironment (TME) to facilitate tumor progress...

    Authors: Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang and Jinjian Yang

    Citation: Cell Communication and Signaling 2021 19:93

    Content type: Research

    Published on:

  4. Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal trans...

    Authors: John C. Charpentier and Philip D. King

    Citation: Cell Communication and Signaling 2021 19:92

    Content type: Review

    Published on:

  5. Autophagy is catabolic process by degradation of intracellular components in lysosome including proteins, lipids, and mitochondria in response to nutrient deficiency or stress such as hypoxia or chemotherapy. ...

    Authors: Yalan Duan, Xiaoqing Tian, Qian Liu, Jianhua Jin, Juanjuan Shi and Yongzhong Hou

    Citation: Cell Communication and Signaling 2021 19:91

    Content type: Review

    Published on:

  6. Metastasis represents the leading cause of death in patients with breast cancer. Traditional Chinese medicine is particularly appreciated for metastatic diseases in Asian countries due to its benefits for surv...

    Authors: Jing Li, Shengqi Wang, Neng Wang, Yifeng Zheng, Bowen Yang, Xuan Wang, Juping Zhang, Bo Pan and Zhiyu Wang

    Citation: Cell Communication and Signaling 2021 19:89

    Content type: Research

    Published on:

  7. For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured pro...

    Authors: Sarah E. Bondos, A. Keith Dunker and Vladimir N. Uversky

    Citation: Cell Communication and Signaling 2021 19:88

    Content type: Editorial

    Published on:

  8. Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development and tissue homeostasis in adults. This pathway can be defin...

    Authors: Juan A. Godoy, Jasson Espinoza-Caicedo and Nibaldo C. Inestrosa

    Citation: Cell Communication and Signaling 2021 19:87

    Content type: Research

    Published on:

  9. Maspin (SERPINB5) is a potential tumor suppressor gene with pleiotropic biological activities, including regulation of cell proliferation, death, adhesion, migration and gene expression. Several studies indica...

    Authors: M. T. Longhi, L. E. Silva, M. Pereira, M. Magalhães, J. Reina, F. N. L. Vitorino, B. M. Gumbiner, J. P. C. da Cunha and N. Cella

    Citation: Cell Communication and Signaling 2021 19:86

    Content type: Research

    Published on:

  10. Vitamin D receptor (VDR) plays a vital protective role in oral and colonic epithelial cells. Albeit we know that VDR expression is reduced in the mucosal epithelial layers of autoimmune diseases, the mechanism...

    Authors: Xiangyu Wang, Xuejun Ge, Wang Liao, Yong Cao, Ran Li, Fang Zhang, Bin Zhao and Jie Du

    Citation: Cell Communication and Signaling 2021 19:85

    Content type: Research

    Published on:

  11. RNA base editing is potential for cellular function research and genetic diseases treating. There are two main RNA base editors, REPAIR and RESCUE, for in vitro use. REPAIR was developed by fusing inactivated ...

    Authors: Guo Li, Yihan Wang, Xiangyang Li, Yuzhe Wang, Xingxu Huang, Jianen Gao and Xiaoxiang Hu

    Citation: Cell Communication and Signaling 2021 19:84

    Content type: Research

    Published on:

  12. The positive transcription elongation factor b (P-TEFb) kinase activity is involved in the process of transcription. Cyclin-dependent kinase 9 (CDK9), a core component of P-TEFb, regulates the process of trans...

    Authors: Yingjie Qing, Xiangyuan Wang, Hongzheng Wang, Po Hu, Hui Li, Xiaoxuan Yu, Mengyuan Zhu, Zhanyu Wang, Yu Zhu, Jingyan Xu, Qinglong Guo and Hui Hui

    Citation: Cell Communication and Signaling 2021 19:83

    Content type: Research

    Published on:

  13. As a ubiquitous second messenger, calcium (Ca2+) can interact with numerous cellular proteins to regulate multiple physiological processes and participate in a variety of diseases, including hepatitis B virus ...

    Authors: Fanyun Kong, Fulong Zhang, Xiangye Liu, Suping Qin, Xiaoying Yang, Delong Kong, Xiucheng Pan, Hongjuan You, Kuiyang Zheng and Renxian Tang

    Citation: Cell Communication and Signaling 2021 19:82

    Content type: Review

    Published on:

  14. The currently available RESCUE RNA base editing system demonstrates considerable potential for the treatment of genetic diseases at the transcriptional level. However, the relatively high incidence of off-targ...

    Authors: Yihan Wang, Guo Li, Xiangyang Li, Yuzhe Wang, Xingxu Huang, Xiaoxiang Hu and Jianen Gao

    Citation: Cell Communication and Signaling 2021 19:81

    Content type: Research

    Published on:

  15. Hhex(human hematopoietically expressed homeobox), also known as PRH, is originally considered as a transcription factor to regulate gene expression due to its homebox domain. Increasing studies show that Hhex ...

    Authors: Xiaopeng Li, Guilin Ma, Wenjie Guo, Ning Mu, Yingying Wang, Xiangguo Liu and Ling Su

    Citation: Cell Communication and Signaling 2021 19:80

    Content type: Research

    Published on:

  16. The urinary tract is highly innervated by autonomic nerves which are essential in urinary tract development, the production of growth factors, and the control of homeostasis. These neural signals may become dy...

    Authors: M. Archer, N. Dogra, Z. Dovey, T. Ganta, H.-S. Jang, J. A. Khusid, A. Lantz, M. Mihalopoulos, J. A. Stockert, A. Zahalka, L. Björnebo, S. Gaglani, M. R. Noh, S. A. Kaplan, R. Mehrazin, K. K. Badani…

    Citation: Cell Communication and Signaling 2021 19:78

    Content type: Review

    Published on:

  17. CMTM7 is a tumor suppressor that positively regulates EGFR degradation by promoting Rab5 activation, and plays a vital role in tumor progression. Rab5 forms complexes with Beclin1 and VPS34, and acts in the ea...

    Authors: Baocai Liu, Yinliang Lu, Tingting Zhang, Xinyue Yu, Qian Wang, Yunbo Chi, Shunzi Jin and Guanghui Cheng

    Citation: Cell Communication and Signaling 2021 19:77

    Content type: Research

    Published on:

  18. Small extracellular vesicles (sEVs) mediate intercellular communication by transferring RNA, proteins, and lipids to recipient cells. These cargo molecules are selectively loaded into sEVs and mirror the physi...

    Authors: Xuan Luo, Renée Jean-Toussaint, Ahmet Sacan and Seena K. Ajit

    Citation: Cell Communication and Signaling 2021 19:75

    Content type: Research

    Published on:

  19. Our murine cancer model studies have demonstrated that Plasmodium infection activates the immune system that has been inhibited by cancer cells, counteracts tumor immunosuppressive microenvironment, inhibits tumo...

    Authors: Xiaoping Chen, Li Qin, Wen Hu and Dickson Adah

    Citation: Cell Communication and Signaling 2021 19:74

    Content type: Review

    Published on:

  20. The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has become an ongoing pandemic. Understanding the respiratory immune microenvironment whi...

    Authors: Lei He, Quan Zhang, Yue Zhang, Yixian Fan, Fahu Yuan and Songming Li

    Citation: Cell Communication and Signaling 2021 19:73

    Content type: Research

    Published on:

  21. The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with trans...

    Authors: Yuanjie Ding, Yuanchun Yao, Xingmu Gong, Qi Zhuo, Jinhua Chen, Miao Tian and Maryam Farzaneh

    Citation: Cell Communication and Signaling 2021 19:72

    Content type: Review

    Published on:

  22. The fusion oncoprotein Bcr-Abl is mostly located in the cytoplasm, which causes chronic myeloid leukemia (CML). After moving into the nucleus, the fusion protein can induce apoptosis of CML cells. The coiled-c...

    Authors: Yuhang Peng, Zhenglan Huang, Fangzhu Zhou, Teng Wang, Ke Mou and Wenli Feng

    Citation: Cell Communication and Signaling 2021 19:71

    Content type: Research

    Published on:

  23. Intercellular communications are important for maintaining normal physiological processes. An important intercellular communication is mediated by the exchange of membrane-enclosed extracellular vesicles. Amon...

    Authors: Yi-Wei Lin, Jennifer Nhieu, Chin-Wen Wei, Yu-Lung Lin, Hiroyuki Kagechika and Li-Na Wei

    Citation: Cell Communication and Signaling 2021 19:69

    Content type: Short report

    Published on:

  24. The oncogenic PIM kinases and the tumor-suppressive LKB1 kinase have both been implicated in the regulation of cell growth and metabolism, albeit in opposite directions. Here we investigated whether these kina...

    Authors: Kwan Long Mung, William B. Eccleshall, Niina M. Santio, Adolfo Rivero-Müller and Päivi J. Koskinen

    Citation: Cell Communication and Signaling 2021 19:68

    Content type: Research

    Published on:

  25. Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progre...

    Authors: Maria A. Ortiz, Tatiana Mikhailova, Xiang Li, Baylee A. Porter, Alaji Bah and Leszek Kotula

    Citation: Cell Communication and Signaling 2021 19:67

    Content type: Review

    Published on:

  26. Breast cancer is a common malignancy with varying clinical behaviors and for the more aggressive subtypes, novel and more efficient therapeutic approaches are needed. Qualities of the tumor microenvironment as...

    Authors: Emma Persson, Pernilla Gregersson, Anna Gustafsson, Paul Fitzpatrick, Sara Rhost, Anders Ståhlberg and Göran Landberg

    Citation: Cell Communication and Signaling 2021 19:66

    Content type: Research

    Published on:

  27. Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization. Proteins that drive the f...

    Authors: Ryan J. Emenecker, Alex S. Holehouse and Lucia C. Strader

    Citation: Cell Communication and Signaling 2021 19:65

    Content type: Research

    Published on:

  28. Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia forma...

    Authors: Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti and Daniela Corda

    Citation: Cell Communication and Signaling 2021 19:64

    Content type: Research

    Published on:

  29. miR-1250 is localised to the second intron of AATK at chromosome 17q25. As a CpG island is present at the putative promoter region of its host gene, AATK, we postulated that the intronic miR-1250-5p is a tumor...

    Authors: Min Yue Zhang, Lu Qian Wang and Chor Sang Chim

    Citation: Cell Communication and Signaling 2021 19:62

    Content type: Research

    Published on:

  30. Chronic superphysiological glucose and insulin concentrations are known to trigger several tissue and organ failures, including insulin resistance, oxidative stress and chronic low-grade inflammation. Hence, t...

    Authors: Anna Kowalczuk, Nabila Bourebaba, Katarzyna Kornicka-Garbowska, Eliza Turlej, Krzysztof Marycz and Lynda Bourebaba

    Citation: Cell Communication and Signaling 2021 19:61

    Content type: Research

    Published on:

  31. Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition...

    Authors: Juane Lu, Tao Wu, Biao Zhang, Suke Liu, Wenjun Song, Jianjun Qiao and Haihua Ruan

    Citation: Cell Communication and Signaling 2021 19:60

    Content type: Review

    Published on:

  32. The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that A...

    Authors: Jillian Hattaway Luttman, Ashley Colemon, Benjamin Mayro and Ann Marie Pendergast

    Citation: Cell Communication and Signaling 2021 19:59

    Content type: Review

    Published on:

  33. Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator of interferon gene...

    Authors: Lu Zhou, Yi-Fei Zhang, Fu-Hua Yang, Han-Qing Mao, Zhi Chen and Lu Zhang

    Citation: Cell Communication and Signaling 2021 19:58

    Content type: Research

    Published on:

  34. The human family of Potassium (K+) Channel Tetramerization Domain (KCTD) proteins counts 25 members, and a significant number of them are still only partially characterized. While some of the KCTDs have been link...

    Authors: Annapaola Angrisani, Annamaria Di Fiore, Enrico De Smaele and Marta Moretti

    Citation: Cell Communication and Signaling 2021 19:56

    Content type: Review

    Published on:

  35. The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied in cancer, especially ovarian cancer. These large cytoskeletal proteins have primary roles in the m...

    Authors: Tamsin Wesley, Stuart Berzins, George Kannourakis and Nuzhat Ahmed

    Citation: Cell Communication and Signaling 2021 19:55

    Content type: Review

    Published on:

  36. Many clinical trials are being conducted to clarify effective combinations of various drugs for immune checkpoint blockade (ICB) therapy. However, although extensive studies from multiple aspects have been con...

    Authors: Ari Hashimoto, Haruka Handa, Soichiro Hata, Akio Tsutaho, Takao Yoshida, Satoshi Hirano, Shigeru Hashimoto and Hisataka Sabe

    Citation: Cell Communication and Signaling 2021 19:54

    Content type: Commentary

    Published on:

  37. Neurodegenerative diseases like Alzheimer’s, Parkinson’s and Huntington’s disease involves abnormal aggregation and accumulation of toxic proteins aggregates. Post-translational modifications (PTMs) of the cau...

    Authors: Abhishek Ankur Balmik and Subashchandrabose Chinnathambi

    Citation: Cell Communication and Signaling 2021 19:51

    Content type: Review

    Published on:

  38. Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed the tumor microenvironment (TME) immune cells to functionally affect the development and progression of br...

    Authors: Jing Jin, Yi Li, Qijie Zhao, Yue Chen, Shaozhi Fu and JingBo Wu

    Citation: Cell Communication and Signaling 2021 19:50

    Content type: Review

    Published on:

  39. Microtubule-associated protein Tau undergoes aggregation in Alzheimer`s disease (AD) and a group of other related diseases collectively known as Tauopathies. In AD, Tau forms aggregates, which are deposited in...

    Authors: Abhishek Ankur Balmik, Shweta Kishor Sonawane and Subashchandrabose Chinnathambi

    Citation: Cell Communication and Signaling 2021 19:49

    Content type: Research

    Published on:

  40. The G-protein-coupled receptor GPR55 has been implicated in multiple biological activities, which has fuelled interest in its functional targeting. Its controversial pharmacology and often species-dependent re...

    Authors: Maria Giovanna Mosca, Maria Mangini, Stefania Cioffi, Pasquale Barba and Stefania Mariggiò

    Citation: Cell Communication and Signaling 2021 19:48

    Content type: Research

    Published on:

  41. Myocardial fibrosis is caused by the adverse and powerful remodeling of the heart secondary to the death of cardiomyocytes after myocardial infarction. Regulators of G protein Signaling (RGS) 4 is involved in ...

    Authors: Jing Guo, Pengzhou Hang, Jie Yu, Wen Li, Xiuye Zhao, Yue Sun, Ziyi Fan and Zhimin Du

    Citation: Cell Communication and Signaling 2021 19:46

    Content type: Research

    Published on:

Annual Journal Metrics