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Featured article: A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control

Tunneling nanotubes (TNTs) play critical role in coordination of both physiological and pathological conditions between distant cells by allowing transit of the cytoplasmic components. Here, we uncover the unknown role of RASSF1A/GEFH1 signaling as a novel candidate required for TNTs formation through control of Rab11 accumulation and subsequent exosome release. Accordingly, we postulate that targeting TNTs formation in hypermethylated RASSF1A cells, will be a promising therapeutic strategy for preventing intercellular communication in tumor microenvironment.


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Cell Communication and Signaling is an open access journal that encompasses all basic and translational aspects of cellular communications and signaling pathways in normal and pathological conditions.

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New Content ItemASCB-EMBO 2018
Dec 8-12, 2018
San Diego, California

New Content ItemICDS 25th Annual Meeting
June 27-30, 2019
New York, New York

The 'International Lecture Series on Disease Biology and Molecular Medicine' has a series of ongoing meetings organized by the Medical Faculty of the Martin-Luther-University Halle-Wittenberg with support from the City of Halle. The International Lecture Series on Disease Biology and Molecular Medicine showcases a wide range of biomedical research areas and fosters collaboration in the scientific community.

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Editor's profile

New Content Item (1)Raymond Birge, Editor-in-Chief

Raymond Birge, PhD., is a Professor at Rutgers, The State University of New Jersey and member of the New Jersey Medical School Cancer Center. Dr. Birge joined UMDNJ-New Jersey Medical School in 2000 and currently holds a position of Professor and Vice Chair for Research in the Department of Microbiology, Biochemistry and Molecular Biology. Dr. Birge also has joint appointments at the New Jersey Medical School Cancer Center (Newark) and the Cancer Institute of New Jersey (New Brunswick).  

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