Call for papers
Extracellular vesicles in infectious disease
Edited by Dr. Nicole-Meisner Kober and Dr Silja Wessler
Submission Deadline: March 1, 2022
Kinases, adaptor proteins, and actin cytoskeleton rearrangements in EMT and cancer
Edited by Dr. Leszek Kotula and Dr. Patrycja Dubielecka-Sczerba
Submission Deadline: December 31, 2021
The roles of intrinsically disordered proteins and regions (IDPs and IDRs) in cell communication and cell signaling
Edited by Dr. Sarah Bondos, Dr. A. Keith Dunker and Dr. Vladimir Uversky
Submission Deadline: July 1, 2021
Submit your manuscript here.
Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage
In a recent review article, Ternet & Kiel highlight the role of KRAS in the intestinal epithelium and in colorectal cancer for processes such as cell proliferation, cell junction formation and remodelling, hypoxia, the immune system, inflammation, and metabolism. As KRAS is considered undruggable, they discuss the suitability of targeting pathways downstream of KRAS as well as alterations of cell extrinsic/ microenvironmental factors as possible targets for modulating signaling pathways in colorectal cancer.
L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness
By combining biological methods with computational modeling, this study has investigated the signaling network leading to Ser5 phosphorylation of the actin-bundling protein L-plastin. Machado et al.'s approach has revealed that L-plastin is a target of both the ERK/MAPK and the PI3K signaling pathways. Downstream of PI3K, SGK3 was identified as a novel kinase able to phosphorylate L-plastin on Ser5. Furthermore, our results have illustrated that Ser5 phosphorylation promotes the recruitment of L-plastin to invadopodia, increases extracellular matrix degradation and enhances invasion of breast cancer cells. The authors propose L-plastin Ser5 phosphorylation as a therapeutic target to reduce breast cancer cell invasiveness.
Video Bytes are here
At Cell Communication and Signaling, we are passionate about the dissemination of research.
We are pleased to announce that as of the 12th August 2019, all authors whose papers are accepted will receive a Video Byte.
Created by our partners, Research Square, a Video Byte is a 1-2 minute video summary of a paper that will be incorporated into the abstract of the paper and published on the journal website. Authors will also receive a shareable version of their Video Byte.