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Featured article: SOX2 as a novel contributor of oxidative metabolism in melanoma cells

In light of recent research illuminating the role of sex-determining region Y (SRY) BOX2 (SOX2) in cancer, the authors of this article sought to evaluate whether SOX2 modulation is correlated with metabolic shift toward oxidative phosphorylation taking place under acidic tumor microenvironment. Their results suggest that SOX2 does promote an oxidative metabolism that correlates with more aggressive and drug resistant tumor phenotypes with enhanced metastatic ability.


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Aims and scope

Cell Communication and Signaling is an open access journal that encompasses all basic and translational aspects of cellular communications and signaling pathways in normal and pathological conditions.

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New Content Item
Beginning in January of 2019, Cell Communication and Signaling is pleased to announce their new affiliation with the International Cell Death Society

Upcoming Conferences

New Content ItemICDS 25th Annual Meeting
June 27-30, 2019
New York, New York

The 'International Lecture Series on Disease Biology and Molecular Medicine' has a series of ongoing meetings organized by the Medical Faculty of the Martin-Luther-University Halle-Wittenberg with support from the City of Halle. The International Lecture Series on Disease Biology and Molecular Medicine showcases a wide range of biomedical research areas and fosters collaboration in the scientific community.

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Editor's profile

New Content Item (1)Raymond Birge, Editor-in-Chief

Raymond Birge, PhD., is a Professor at Rutgers, The State University of New Jersey and member of the New Jersey Medical School Cancer Center. Dr. Birge joined UMDNJ-New Jersey Medical School in 2000 and currently holds a position of Professor and Vice Chair for Research in the Department of Microbiology, Biochemistry and Molecular Biology. Dr. Birge also has joint appointments at the New Jersey Medical School Cancer Center (Newark) and the Cancer Institute of New Jersey (New Brunswick).  

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