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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times. Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

Announcing the launch of In Review

Cell Communication and Signaling, in partnership with Research Square, is now offering In Review. Authors choosing this free optional service will be able to:

  • Share their work with fellow researchers to read, comment on, and cite even before publication
  • Showcase their work to funders and others with a citable DOI while it is still under review
  • Track their manuscript - including seeing when reviewers are invited, and when reports are received

Aims and Scope

Cell Communication and Signaling (CCS) is an open access journal that encompasses all basic and translational aspects of cellular communications and signaling pathways in normal and pathological conditions.

Beginning in January of 2019, CCS is pleased to announce their affiliation with the International Cell Death Society

The journal encourages submissions in all aspects of cell death, that include apoptotic and non-apoptotic mechanisms of cell death, cell death in model systems, autophagy, clearance of dying cells, as well as the immunological and pathological consequences of dying cells in the tissue microenvironment. 

Read more


Thematic Series
Biology of phosphatidylserine: basic physiology and implications in immunology, infectious disease, and cancer
Edited by Raymond Birge and David Calianese

Thematic Series
25th Anniversary of the ICDS Cell Death collection
Edited by Raymond Birge

Collaboration Series
Pluripotent Stem Cells: Research Review

Review Series
Tumor Cell-Microenvironment Communication
Edited by Silja Wessler

Review series
Short linear motifs - the unexplored frontier of the eukaryotic proteome
Edited by Norman Davey

Review series
Bacterial pathogen - host cell interactions
Edited by Silja Wessler

Review series
Systems Biology and Medicine
Edited by Stephan Feller and Fred Schaper

Thematic series
Interaction of Helicobacter pylori with its host cell
Edited by Silja Wessler

Thematic series
Cancer cell motility and microenvironment

Call for papers

Kinases, adaptor proteins, and actin cytoskeleton rearrangements in EMT and cancer
Edited by Dr. Leszek Kotula and Dr. Patrycja Dubielecka-Sczerba

The roles of intrinsically disordered proteins and regions (IDPs and IDRs) in cell communication and cell signaling
Edited by Dr. Sarah Bondos, Dr. A. Keith Dunker and Dr. Vladimir Uversky

Biology of phosphatidylserine (PS): basic physiology and implications in immunology, infectious disease, and cancer
Edited by Dr. Raymond Birge and Dr. David Calianese

Video Bytes are here

At Cell Communication and Signaling, we are passionate about the dissemination of research.

We are pleased to announce that as of the 12th August 2019, all authors whose papers are accepted will receive a Video Byte.

Created by our partners, Research Square, a Video Byte is a 1-2 minute video summary of a paper that will be incorporated into the abstract of the paper and published on the journal website. Authors will also receive a shareable version of their Video Byte.

Featured Collection

Cell Death Collection Image ©  © CIPhotos / Getty Images / iStock

25th Anniversary of the International Cell Death Society Collection

Curated by Editor-in-Chief Raymond Birge, we're celebrating the 25th anniversary of the ICDS with a collection highlighting the most important Cell Death papers published in Cell Communication and Signaling in the last decade.

Featured Article

PenalozaFig6Higher sensitivity of female cells to ethanol: Methylation of DNA lowers Cyp2e1, generating more ROS.

In a recent paper, Penaloza et al demonstrated that the higher sensitivity of female cells to ethanol, present even before sex differentiation, derives from sex-differential methylation of detoxifying enzymes. Females, with less methylation of CpG islands for Cyp2e1, produce more message for this gene, part of a subsidiary pathway producing more reactive oxygen species, while males produce more glutathione to reduce these oxidants. The combination renders the ethanol more toxic to female cells.

Editor's profile

New Content Item (1)Raymond Birge, Editor-in-Chief

Raymond Birge, PhD., is a Professor at Rutgers, The State University of New Jersey and member of the New Jersey Medical School Cancer Center. Dr. Birge joined UMDNJ-New Jersey Medical School in 2000 and currently holds a position of Professor and Vice Chair for Research in the Department of Microbiology, Biochemistry and Molecular Biology. Dr. Birge also has joint appointments at the New Jersey Medical School Cancer Center (Newark) and the Cancer Institute of New Jersey (New Brunswick). 

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