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  1. Cancer is a major cause of high morbidity and mortality worldwide. Several environmental, genetic and lifestyle factors are associated with the development of cancer in humans and result in suboptimal treatmen...

    Authors: Hao Ji, Zhengting Jiang, Chen Wei, Yichao Ma, Jiahao Zhao, Fei Wang, Bin Zhao, Daorong Wang and Dong Tang
    Citation: Cell Communication and Signaling 2023 21:164
    Content type: Review Published on:

  2. Adherens junctions (AJs) facilitate cell–cell contact and contribute to cellular communication as well as signaling under physiological and pathological conditions. Aberrant expression of AJ proteins is frequ...

    Authors: Yingyue Tang, Lena Thiess, Sofia M. E. Weiler, Marcell Tóth, Fabian Rose, Sabine Merker, Thomas Ruppert, Peter Schirmacher and Kai Breuhahn
    Citation: Cell Communication and Signaling 2023 21:162
    Content type: Research Published on:

  3. Breast cancer (BC) is the second most frequent type of cancer in the world and most common among women, configuring a major challenge to global health. BC is a complex and heterogeneous disease that can be sub...

    Authors: Diandra Zipinotti dos Santos, Josiany Carlos de Souza, Tatiana Massariol Pimenta, Bárbara da Silva Martins, Roberto Silva Ribeiro Junior, Solenny Maria Silva Butzene, Nayara Gusmão Tessarolo, Paulo Morais Lyra Cilas Jr, Ian Victor Silva and Leticia B. A. Rangel
    Citation: Cell Communication and Signaling 2023 21:161
    Content type: Review Published on:

  4. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling has been known to play a critical role in maintaining cellular and tissue homeostasis, which also has an essential role in the inflammat...

    Authors: Tao Yang, Xiaoye Qu, Jiaying Zhao, Xiao Wang, Qian Wang, Jingjing Dai, Chuanlong Zhu, Jun Li and Longfeng Jiang
    Citation: Cell Communication and Signaling 2023 21:160
    Content type: Research Published on:

  5. Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and metastasis. Therefore, clarification of the mechanisms involved in CSC stemness maintenance and cell fate determination would ...

    Authors: Mengchen Fan, Ying Shi, Jumei Zhao and Ling Li
    Citation: Cell Communication and Signaling 2023 21:159
    Content type: Review Published on:

  6. Bone marrow (BM) is progressively filled with adipocytes during aging process. Thus, BM adipocytes-derived adiponectin (APN) affects the function of bone marrow-derived mesenchymal stem cells (BMSCs). However,...

    Authors: Sujung Soh, Sora Han, Hye In Ka, Se Hwan Mun, Woojung Kim, Gaeun Oh and Young Yang
    Citation: Cell Communication and Signaling 2023 21:158
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2023 21:194

  7. Breast cancer is one of the most common cancers with a high mortality rate, underscoring the need to identify new therapeutic targets. Here we report that non-POU domain-containing octamer-binding (NONO) prote...

    Authors: Bilal Ahmad Lone, Fouzia Siraj, Ira Sharma, Shweta Verma, Shibendra Kumar Lal Karna, Faiz Ahmad, Preeti Nagar, Chetana Sachidanandan and Yuba Raj Pokharel
    Citation: Cell Communication and Signaling 2023 21:157
    Content type: Research Published on:

  8. Golgi apparatus (GA) is assembled as a crescent-like ribbon in mammalian cells under immunofluorescence microscope without knowing the shaping mechanisms. It is estimated that roughly 1/5 of the genes encodin...

    Authors: Shao-Chih Chiu, Xin-Ting Yang, Tong-You Wade Wei, Yu-Ting Amber Liao, Jo-Mei Maureen Chen, Yi-Chun Kuo, Chun-Chih Jared Liu, Chiao-Yun Cheng, Yu-Ting Jenny Huang, Yun-Ru Jaoying Huang, He-Lian Joe Wu, Chang-Xin Wan, Jia-Rung Tsai and Chang-Tze Ricky Yu
    Citation: Cell Communication and Signaling 2023 21:156
    Content type: Research Published on:

  9. Coronary artery disease (CAD) is a multi-factor complex trait and is heritable, especially in early-onset families. However, the genetic factors affecting the susceptibility of early-onset CAD are not fully ch...

    Authors: Ting-Ting Wu, Ying-Ying Zheng, Xiang Ma, Wen-Juan Xiu, Hai-Tao Yang, Xian-Geng Hou, Yi Yang, You Chen, Yi-Tong Ma and Xiang Xie
    Citation: Cell Communication and Signaling 2023 21:155
    Content type: Research Published on:

  10. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12964-022-00833-3.

    Authors: Han-Ming Huang, Xin-Hua He, Xiao-Yu Huang, Guo-Yun Wang, Qiao-Xi Xia, Ze-Peng Du and Yong-Fa Zhang
    Citation: Cell Communication and Signaling 2023 21:154
    Content type: Retraction Note Published on:

  12. Prostate cancer (PC) is the most common neoplasm and is the second leading cause of cancer-related deaths in men worldwide. The Hippo tumor suppressor pathway is highly conserved in mammals and plays an import...

    Authors: Longxiang Wu, Zhenyu Ou, Peihua Liu, Cheng Zhao, Shiyu Tong, Ruizhe Wang, Yangle Li, Junbin Yuan, Minfeng Chen, Benyi Fan, Xiongbing Zu, Yongjie Wang and Jianing Tang
    Citation: Cell Communication and Signaling 2023 21:152
    Content type: Research Published on:

  13. Diabetes mellitus (DM), currently affecting more than 537 million people worldwide is a chronic disease characterized by impaired glucose metabolism resulting from a defect in insulin secretion, action, or bot...

    Authors: Abdoulaye Diane, Layla Ibrahim Mohammed and Heba H. Al-Siddiqi
    Citation: Cell Communication and Signaling 2023 21:151
    Content type: Review Published on:

  14. Multiple studies have shown that extracellular vesicles (EVs) play a key role in the process of information transfer and material transport between cells. EVs are classified into different types according to t...

    Authors: Xiaoyu Fu, Junlong Song, Wei Yan, Bradley M. Downs, Weixing Wang and Juanjuan Li
    Citation: Cell Communication and Signaling 2023 21:150
    Content type: Review Published on:

  15. The Hippo pathway plays a critical role in controlled cell proliferation. The tumor suppressor Merlin and large tumor suppressor kinase 1 (LATS1) mediate activation of Hippo pathway, consequently inhibiting th...

    Authors: Truc Phan Hoang Le, Nga Thi Thanh Nguyen, Duong Duy Thai Le, Muhammad Ayaz Anwar and Sang Yoon Lee
    Citation: Cell Communication and Signaling 2023 21:149
    Content type: Research Published on:

  16. Myoblast differentiation requires metabolic reprogramming driven by increased mitochondrial biogenesis and oxidative phosphorylation. The canonical GH-GHR-IGFs axis in liver exhibits a great complexity in resp...

    Authors: Bowen Hu, Changbin Zhao, Xiangchun Pan, Haohui Wei, Guodong Mo, Mingjian Xian, Wen Luo, Qinghua Nie, Hongmei Li and Xiquan Zhang
    Citation: Cell Communication and Signaling 2023 21:148
    Content type: Research Published on:

  17. Fluoropyridine-based chemotherapy remains the most widely used treatment for colorectal cancer (CRC). In this study, we investigated the mechanism by which the natural product Scutellaria baicalensis (Huang Qin; ...

    Authors: Haizhou Liu, Hui Liu, Zhiyi Zhou, Jessica Chung, Guojing Zhang, Jin Chang, Robert A. Parise, Edward Chu and John C. Schmitz
    Citation: Cell Communication and Signaling 2023 21:147
    Content type: Research Published on:

  18. Mesenchymal stem cells (MSCs) therapies are emerging as a promising approach to therapeutic regeneration. Therapeutic persistence and reduced functional stem cells following cell delivery remain critical hurdl...

    Authors: Tao Zhang, Yuqian He, Xin Shu, Xiaoyu Ma, Jiaqi Wu, Zuoqin Du, Jin Xu, Ni Chen, Jingcan You, Yaofang Liu, Tian Li and Jianbo Wu
    Citation: Cell Communication and Signaling 2023 21:146
    Content type: Brief Report Published on:

  19. The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in surviving the cell as well as defendi...

    Authors: Eunus S. Ali, Brototi Chakrabarty, Sarker Ramproshad, Banani Mondal, Neloy Kundu, Chandan Sarkar, Javad Sharifi-Rad, Daniela Calina and William C. Cho
    Citation: Cell Communication and Signaling 2023 21:145
    Content type: Review Published on:

  20. Ovarian cancer, particularly epithelial ovarian cancer (EOC), is the leading cause of cancer-related mortality among women. Our previous study revealed that high HMGB3 levels are associated with poor prognosis...

    Authors: Hanlin Ma, Gonghua Qi, Fang Han, Panpan Gai, Jiali Peng and Beihua Kong
    Citation: Cell Communication and Signaling 2023 21:144
    Content type: Research Published on:

  21. In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mec...

    Authors: Sara Razi, Amin Haghparast, Sepide Chodari Khameneh, Amin Ebrahimi Sadrabadi, Fatemeh Aziziyan, Maryam Bakhtiyari, Mohsen Nabi-Afjadi, Vahideh Tarhriz, Arsalan Jalili and Hamidreza Zalpoor
    Citation: Cell Communication and Signaling 2023 21:143
    Content type: Review Published on:

  22. LRRC6 is an assembly factor for dynein arms in the cytoplasm of motile ciliated cells, and when mutated, dynein arm components remained in the cytoplasm. Here, we demonstrate the role of LRRC6 in the active nu...

    Authors: Dong Yun Kim, Yu Jin Sub, Hye-Youn Kim, Kyeong Jee Cho, Won Il Choi, Yo Jun Choi, Min Goo Lee, Friedhelm Hildebrandt and Heon Yung Gee
    Citation: Cell Communication and Signaling 2023 21:142
    Content type: Research Published on:

  23. Metabolic reprogramming is a critical event for cell fate and function, making it an attractive target for clinical therapy. The function of metabolic reprogramming in Helicobacter pylori (H. pylori)-infected gas...

    Authors: Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong and Wanfu Xu
    Citation: Cell Communication and Signaling 2023 21:141
    Content type: Research Published on:

  24. We previously reported that miR-195 exerts neuroprotection by inhibiting Sema3A and cerebral miR-195 levels decreased with age, both of which urged us to explore the role of miR-195 and miR-195-regulated Sema3...

    Authors: Chien-Yuan Chen, Yung-Mei Chao, Ching-Chang Cho, Cheng-Sheng Chen, Wei-Yong Lin, Yi-Hung Chen, Marlène Cassar, Cecilia S. Lu, Jenq-Lin Yang, Julie Y. H. Chan and Suh-Hang H. Juo
    Citation: Cell Communication and Signaling 2023 21:140
    Content type: Research Published on:

  25. The identification of contributing factors leading to the development of Colorectal Cancer (CRC), as the third fatal malignancy, is crucial. Today, the tumor microenvironment has been shown to play a key role ...

    Authors: Zahra Kalaei, Reyhaneh Manafi-Farid, Bentolhoda Rashidi, Fariba Karoon Kiani, Asieh Zarei, Mehrdad Fathi and Farhad Jadidi-Niaragh
    Citation: Cell Communication and Signaling 2023 21:139
    Content type: Review Published on:

  26. Immunotherapy targeting programmed death-ligand 1 (PD-L1) or PD-1 in solid tumors has been shown to be clinically beneficial. However, in colorectal cancer (CRC), only a subset of patients benefit from PD-1/PD...

    Authors: Shakti Ranjan Satapathy, Souvik Ghatak and Anita Sjölander
    Citation: Cell Communication and Signaling 2023 21:138
    Content type: Research Published on:

  27. Osteoarthritis is an age-related disease that currently faces a lack of symptomatic treatment. Inflammation, which is mainly sustained by pro-inflammatory cytokines such as IL-1b, TNF, and IL-6, plays an impor...

    Authors: Anais Defois, Nina Bon, Alexandre Charpentier, Melina Georget, Nicolas Gaigeard, Frederic Blanchard, Antoine Hamel, Denis Waast, Jean Armengaud, Ophelie Renoult, Claire Pecqueur, Yves Maugars, Marie-Astrid Boutet, Jerome Guicheux and Claire Vinatier
    Citation: Cell Communication and Signaling 2023 21:137
    Content type: Research Published on:

  28. The dimerization of RAF kinases represents a key event in their activation cycle and in RAS/ERK pathway activation. Genetic, biochemical and structural approaches provided key insights into this process defini...

    Authors: Lino Rohrer, Corinna Spohr, Carina Beha, Ricarda Griffin, Sandra Braun, Sebastian Halbach and Tilman Brummer
    Citation: Cell Communication and Signaling 2023 21:136
    Content type: Research Published on:

  29. Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We inves...

    Authors: Jin Seok Woo, Sun-Hee Hwang, SeungCheon Yang, Kun Hee Lee, Yeon Su Lee, Jeong Won Choi, Jin-Sil Park, JooYeon Jhun, Sung-Hwan Park and Mi-La Cho
    Citation: Cell Communication and Signaling 2023 21:135
    Content type: Research Published on:

  30. Age-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the leading cause of irreversible vision impairment among the elderly. RPE s...

    Authors: Wenchang Xu, Xinqi Liu, Wenjuan Han, Keling Wu, Minglei Zhao, Tingfang Mei, Bizhi Shang, Jinwen Wu, Jingyi Luo, Yuhua Lai, Boyu Yang, Yehong Zhuo, Lin Lu, Yizhi Liu, Xiao-li Tian and Ling Zhao
    Citation: Cell Communication and Signaling 2023 21:134
    Content type: Research Published on:

  31. Multiple drug resistance poses a significant threat to public health worldwide, with a substantial increase in morbidity and mortality rates. Consequently, searching for novel strategies to control microbial p...

    Authors: Nourhan G. Naga, Dalia E. El-Badan, Khaled M. Ghanem and Mona I. Shaaban
    Citation: Cell Communication and Signaling 2023 21:133
    Content type: Review Published on:

  32. Neuronal networks receive and deliver information to regulate bodily functions while the vascular network provides oxygen, nutrients, and signaling molecules to tissues. Neurovascular interactions are vital fo...

    Authors: Lotta Isosaari, Hanna Vuorenpää, Alma Yrjänäinen, Fikret Emre Kapucu, Minna Kelloniemi, Toni-Karri Pakarinen, Susanna Miettinen and Susanna Narkilahti
    Citation: Cell Communication and Signaling 2023 21:132
    Content type: Research Published on:

  33. Elraglusib (formerly 9-ING-41) is an ATP-competitive inhibitor of glycogen synthase kinase-3β (GSK3β) undergoing clinical trials for the treatment of various cancers including non-Hodgkin lymphoma (NHL). The d...

    Authors: Josh T. Coats, Sudhir Tauro and Calum Sutherland
    Citation: Cell Communication and Signaling 2023 21:131
    Content type: Brief Report Published on:

  34. Colorectal cancer (CRC) is the third most common malignancy worldwide. CRC cells are situated in an adipocyte-rich microenvironment, which leads to interactions between adipocytes and CRC cells. Upon exposure ...

    Authors: Joanna Olszańska, Katarzyna Pietraszek-Gremplewicz, Mikołaj Domagalski and Dorota Nowak
    Citation: Cell Communication and Signaling 2023 21:130
    Content type: Research Published on:

  35. Authors: Aleksandra Gedaj, Dominika Zukowska, Natalia Porebska, Marta Pozniak, Mateusz Krzyscik, Aleksandra Czyrek, Daniel Krowarsch, Malgorzata Zakrzewska, Jacek Otlewski and Lukasz Opalinski
    Citation: Cell Communication and Signaling 2023 21:129
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2023 21:122

  37. The School of Life Sciences at the Jawaharlal Nehru University in New Delhi, India held an International Symposium on Mitochondria, Cell Death and Human Diseases on February 18–19, 2023. The meeting provided a...

    Authors: Rana P. Singh, Raymond B. Birge and Dhyan Chandra
    Citation: Cell Communication and Signaling 2023 21:127
    Content type: Editorial Published on:

  38. Microglial cells play an important role in the immune system in the brain. Activated microglial cells are not only injurious but also neuroprotective. We confirmed marked lectin-like oxidized low-density lipop...

    Authors: Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka and Masayuki Itoh
    Citation: Cell Communication and Signaling 2023 21:126
    Content type: Research Published on:

  39. Atherosclerosis is an underlying pathology of many vascular diseases as a result of cellular, structural and molecular dysfunctions within the sub-endothelial space. This review deals with the events involved ...

    Authors: Elmira Mahdinia, Nafiseh Shokri, Abdolkarim Talebi Taheri, Sahar Asgharzadeh, Mohammad Elahimanesh and Mohammad Najafi
    Citation: Cell Communication and Signaling 2023 21:125
    Content type: Review Published on:

  40. It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage membrane or whether mVDR is associated with lipopolysaccharide (LPS) tolerance. Herein, we report that interfering with caveola...

    Authors: Yu Zhang, Jun Zhou, Ling Hua, Pan Li, Jiaqi Wu, Shenglan Shang, Fei Deng, Jing Luo, Mengling Liao, Nuoyan Wang, Xichun Pan, Yue Yuan, Yue Zheng, Yonglin Lu, Yasi Huang, Jiang Zheng…
    Citation: Cell Communication and Signaling 2023 21:124
    Content type: Research Published on:

  41. Idiosyncratic drug-induced liver injury (IDILI) is common in hepatology practices and, in some cases, lethal. Increasing evidence show that tricyclic antidepressants (TCAs) can induce IDILI in clinical applica...

    Authors: Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai and Xiaohe Xiao
    Citation: Cell Communication and Signaling 2023 21:123
    Content type: Research Published on:

  42. Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis of the human body. Most of FGFs are released by cells using t...

    Authors: Aleksandra Gedaj, Dominika Zukowska, Natalia Porebska, Marta Pozniak, Mateusz Krzyscik, Aleksandra Czyrek, Daniel Krowarsch, Malgorzata Zakrzewska, Jacek Otlewski and Lukasz Opalinski
    Citation: Cell Communication and Signaling 2023 21:122
    Content type: Brief Report Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2023 21:129

  43. It is well-established that most Hepatocellular carcinoma (HCC) patients die of metastasis, yet the potential mechanisms orchestrating metastasis remain poorly understood. Current evidence suggests that the dy...

    Authors: Bowen Liu, Jinling Cao, Biting Wu, Kaixuan Hao, Xiangyun Wang, Xin Chen and Zhifa Shen
    Citation: Cell Communication and Signaling 2023 21:121
    Content type: Research Published on:

  44. Extracellular vesicles (EVs) are important mediators of intercellular communication in the tumour microenvironment. Many studies suggest that cancer cells release higher amounts of EVs exposing phosphatidylser...

    Authors: Klara Hanelova, Martina Raudenska, Monika Kratochvilova, Jiri Navratil, Tomas Vicar, Maria Bugajova, Jaromir Gumulec, Michal Masarik and Jan Balvan
    Citation: Cell Communication and Signaling 2023 21:120
    Content type: Research Published on:

  45. Until the advent of immune checkpoint inhibitors (ICIs), definitive radiotherapy (RT) concurrently with chemotherapy was recommended for unresectable, locally advanced non-small cell lung cancer (LA-NSCLC). Th...

    Authors: Leilei Wu, Zhenshan Zhang, Menglin Bai, Yujie Yan, Jinming Yu and Yaping Xu
    Citation: Cell Communication and Signaling 2023 21:119
    Content type: Review Published on:

  46. Blood–brain barrier (BBB) interface with multicellular structure controls strictly the entry of varied circulating macromolecules from the blood-facing surface into the brain parenchyma. Under several patholog...

    Authors: Leila Salimi, Fatemehsadat Seyedaghamiri, Mohammad Karimipour, Halimeh Mobarak, Narges Mardi, Maryam Taghavi and Reza Rahbarghazi
    Citation: Cell Communication and Signaling 2023 21:118
    Content type: Review Published on:

  47. Cancer-associated anemia promotes tumor progression, leads to poor quality of life in patients with cancer, and even obstructs the efficacy of immune checkpoint inhibitors therapy. However, the precise mechani...

    Authors: Ting Yuan, Qingzhu Jia, Bo Zhu, Degao Chen and Haixia Long
    Citation: Cell Communication and Signaling 2023 21:117
    Content type: Review Published on:

  48. Metastasis, the spread of a tumor or cancer from the primary site of the body to a secondary site, is a multi-step process in cancer progression, accounting for various obstacles in cancer treatment and most c...

    Authors: Chuwen Jiang, Zhengting Jiang, Gengyu Sha, Daorong Wang and Dong Tang
    Citation: Cell Communication and Signaling 2023 21:116
    Content type: Review Published on:

  49. Glioma is a common primary tumor of the central nervous system (CNS), with glioblastoma multiforme (GBM) being the most malignant, aggressive, and drug resistant. Most drugs are designed to induce cancer cell ...

    Authors: Sicheng Wan, Guanghui Zhang, Ruochen Liu, Muhammad Nadeem Abbas and Hongjuan Cui
    Citation: Cell Communication and Signaling 2023 21:115
    Content type: Review Published on:

  50. Zika virus (ZIKV), an arbovirus of global concern, has been associated with neurological complications including microcephaly in newborns and Guillain–Barré syndrome in adults. Like other flaviviruses, ZIKV de...

    Authors: Gloria Stoyanova, Sidra Jabeen, Joselyn Landazuri Vinueza, Sounak Ghosh Roy, Richard A. Lockshin and Zahra Zakeri
    Citation: Cell Communication and Signaling 2023 21:114
    Content type: Research Published on:
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