Haque Z, Wang D. How cardiomyocytes sense pathophysiological stresses for cardiac remodeling. Cell Mol Life Sci: CMLS. 2017;74:983–1000.
Article
CAS
Google Scholar
Liu C, Tang W. Epigenetics in cardiac hypertrophy and heart failure. JACC Basic Transl Sci. 2019;4:976–93.
Article
Google Scholar
Wu Q, Xiao Y, Yuan Y, Ma Z, Liao H, Liu C, Zhu J, Yang Z, Deng W, Tang Q. Mechanisms contributing to cardiac remodelling. Clin Sci (London, England: 1979). 2017;131:2319–45.
Article
CAS
Google Scholar
Lee H, Oh SH, Cho H, Cho HJ, Kang HY. Prevalence and socio-economic burden of heart failure in an aging society of South Korea. BMC Cardiovasc Disord. 2016;16:215.
Article
Google Scholar
Schirone L, Forte M, Palmerio S, Yee D, Nocella C, Angelini F, Pagano F, Schiavon S, Bordin A, Carrizzo A, et al. A review of the molecular mechanisms underlying the development and progression of cardiac remodeling. Oxid Med Cell Longev. 2017;2017:3920195.
Article
Google Scholar
Nishida K, Otsu K. Autophagy during cardiac remodeling. J Mol Cell Cardiol. 2016;95:11–8.
Article
CAS
Google Scholar
Li L, Xu J, He L, Peng L, Zhong Q, Chen L, Jiang Z. The role of autophagy in cardiac hypertrophy. Acta Biochim Biophys Sin. 2016;48:491–500.
Article
CAS
Google Scholar
Petrasek J, Iracheta-Vellve A, Csak T, Satishchandran A, Kodys K, Kurt-Jones E, Fitzgerald K, Szabo G. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proc Natl Acad Sci USA. 2013;110:16544–9.
Article
CAS
Google Scholar
Moretti J, Roy S, Bozec D, Martinez J, Chapman J, Ueberheide B, Lamming D, Chen Z, Horng T, Yeretssian G, et al. STING senses microbial viability to orchestrate stress-mediated autophagy of the endoplasmic reticulum. Cell. 2017;171:809-823.e813.
Article
CAS
Google Scholar
Prabakaran T, Bodda C, Krapp C, Zhang B, Christensen M, Sun C, Reinert L, Cai Y, Jensen S, Skouboe M, et al. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1. EMBO J. 2018;37:e97858.
Article
Google Scholar
Gui X, Yang H, Li T, Tan X, Shi P, Li M, Du F, Chen Z. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature. 2019;567:262–6.
Article
CAS
Google Scholar
Li N, Zhou H, Wu H, Wu Q, Duan M, Deng W, Tang Q. STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. Redox Biol. 2019;24:101215.
Article
CAS
Google Scholar
Wu Q, Xiao Y, Liu C, Duan M, Cai Z, Xie S, Yuan Y, Wu H, Deng W, Tang Q. The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling. J Mol Cell Cardiol. 2019;128:160–78.
Article
CAS
Google Scholar
Li N, Zhou H, Ma Z, Zhu J, Liu C, Song P, Kong C, Wu H, Deng W, Tang Q. in vivoGeniposide alleviates isoproterenol-induced cardiac fibrosis partially via SIRT1 activation and. Front Pharmacol. 2018;9:854.
Article
Google Scholar
Ma Z, Yuan Y, Zhang X, Xu S, Wang S, Tang Q. Piperine attenuates pathological cardiac fibrosis via PPAR-γ/AKT pathways. EBioMedicine. 2017;18:179–87.
Article
Google Scholar
Wu Q, Yuan Y, Jiang X, Xiao Y, Yang Z, Ma Z, Liao H, Liu Y, Chang W, Bian Z, Tang Q. OX40 regulates pressure overload-induced cardiac hypertrophy and remodelling via CD4+ T-cells. Clin Sci (London, England: 1979). 2016;130:2061–71.
Article
Google Scholar
Rahman MA, Cho Y, Nam G, Rhim H. Antioxidant compound, oxyresveratrol, inhibits APP production through the AMPK/ULK1/mTOR-mediated autophagy pathway in mouse cortical astrocytes. Antioxidants (Basel, Switzerland). 2021;10:408.
CAS
Google Scholar
Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem. 2010;285:13107–20.
Article
CAS
Google Scholar
Torii S, Yamaguchi H, Nakanishi A, Arakawa S, Honda S, Moriwaki K, Nakano H, Shimizu S. Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy. Nat Commun. 2020;11:1754.
Article
CAS
Google Scholar
Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell. 2010;40:280–93.
Article
CAS
Google Scholar
Luo Q, Song Y, Kang J, Wu Y, Wu F, Li Y, Dong Q, Wang J, Song C, Guo H. mtROS-mediated Akt/AMPK/mTOR pathway was involved in Copper-induced autophagy and it attenuates Copper-induced apoptosis in RAW264.7 mouse monocytes. Redox biology. 2021;41:101912.
Article
CAS
Google Scholar
Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007;13:619–24.
Article
CAS
Google Scholar
Oyabu J, Yamaguchi O, Hikoso S, Takeda T, Oka T, Murakawa T, Yasui H, Ueda H, Nakayama H, Taneike M, et al. Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading. Biochem Biophys Res Commun. 2013;441:787–92.
Article
CAS
Google Scholar
Saito T, Asai K, Sato S, Hayashi M, Adachi A, Sasaki Y, Takano H, Mizuno K, Shimizu W. Autophagic vacuoles in cardiomyocytes of dilated cardiomyopathy with initially decompensated heart failure predict improved prognosis. Autophagy. 2016;12:579–87.
Article
CAS
Google Scholar
Zhu H, Tannous P, Johnstone J, Kong Y, Shelton J, Richardson J, Le V, Levine B, Rothermel B, Hill J. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Investig. 2007;117:1782–93.
Article
CAS
Google Scholar
Su F, Shi M, Zhang J, Zheng Q, Zhang D, Zhang W, Wang H, Li X. Simvastatin protects heart from pressure overload injury by inhibiting excessive autophagy. Int J Med Sci. 2018;15:1508–16.
Article
CAS
Google Scholar
Xu Y, Yang S, Huang J, Ruan S, Zheng Z, Lin J. Tgf-β1 induces autophagy and promotes apoptosis in renal tubular epithelial cells. Int J Mol Med. 2012;29:781–90.
CAS
PubMed
Google Scholar
Kim S, Na H, Ding Y, Wang Z, Lee S, Choi M. Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1. J Biol Chem. 2012;287:11677–88.
Article
CAS
Google Scholar
Ghavami S, Cunnington R, Gupta S, Yeganeh B, Filomeno K, Freed D, Chen S, Klonisch T, Halayko A, Ambrose E, et al. Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts. Cell Death Dis. 2015;6:e1696.
Article
CAS
Google Scholar
Mao Y, Luo W, Zhang L, Wu W, Yuan L, Xu H, Song J, Fujiwara K, Abe J, LeMaire S, et al. STING-IRF3 triggers endothelial inflammation in response to free fatty acid-induced mitochondrial damage in diet-induced obesity. Arterioscler Thromb Vasc Biol. 2017;37:920–9.
Article
CAS
Google Scholar
King K, Aguirre A, Ye Y, Sun Y, Roh J, Ng R, Kohler R, Arlauckas S, Iwamoto Y, Savol A, et al. IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017;23:1481–7.
Article
CAS
Google Scholar
Dickhout J, Carlisle R, Austin R. Interrelationship between cardiac hypertrophy, heart failure, and chronic kidney disease: endoplasmic reticulum stress as a mediator of pathogenesis. Circ Res. 2011;108:629–42.
Article
CAS
Google Scholar
Guan H, Shangguan H, Shang Z, Yang L, Meng X, Qiao S. Endoplasmic reticulum stress caused by left ventricular hypertrophy in rats: effects of telmisartan. Am J Med Sci. 2011;342:318–23.
Article
Google Scholar
Xie F, Wu D, Huang S, Cao J, Li H, He L, Liu M, Li L, Chen L. The endoplasmic reticulum stress-autophagy pathway is involved in apelin-13-induced cardiomyocyte hypertrophy in vitro. Acta Pharmacol Sin. 2017;38:1589–600.
Article
CAS
Google Scholar
Kemp M, Lindsey-Boltz L, Sancar A. UV light potentiates STING (Stimulator of Interferon Genes)-dependent innate immune signaling through deregulation of ULK1 (Unc51-like Kinase 1). J Biol Chem. 2015;290:12184–94.
Article
CAS
Google Scholar
Konno H, Konno K, Barber G. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell. 2013;155:688–98.
Article
CAS
Google Scholar
Zhang Y, Chen W, Wang Y. STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress. Biomed Pharmacother. 2020;125:110022.
Article
CAS
Google Scholar
Wang S, Wang L, Qin X, Turdi S, Sun D, Culver B, Reiter R, Wang X, Zhou H, Ren J. ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy. Signal Transduct Target Ther. 2020;5:119.
Article
CAS
Google Scholar
Motwani M, Pesiridis S, Fitzgerald K. DNA sensing by the cGAS-STING pathway in health and disease. Nat Rev Genet. 2019;20:657–74.
Article
CAS
Google Scholar
Feng X, Liu D, Li Z, Bian J. Bioactive modulators targeting STING adaptor in cGAS-STING pathway. Drug Discov Today. 2020;25:230–7.
Article
CAS
Google Scholar