Skip to main content
Fig. 5 | Cell Communication and Signaling

Fig. 5

From: STING protects against cardiac dysfunction and remodelling by blocking autophagy

Fig. 5

STING blocked cardiomyocyte hypertrophy and cardiac fibroblast activation in vitro. A Representative western blot of STING in primary cardiomyocytes transfected with Ad-STING (n = 6) *P < 0.05 vs Ad-Ctrl. B, C The mRNA level of hypertrophic markers (BNP and ANP) (n = 6). D Immunofluorescence staining and analysis of α-actin in cardiomyocytes exposed to AngII and infected with Ad-STING (n = 6) *P < 0.05 vs PBS + Ad-Ctrl group, #P < 0.05 vs AngII + Ad-Ctrl group. E Representative western blot of STING in cardiac fibroblasts transfected with Ad-STING (n = 6) *P < 0.05 vs Ad-Ctrl. F, G The mRNA level of fibrotic markers (Collagen1 and Collagen3) (n = 6). H Immunofluorescence staining and analysis of α-SMA in cardiac fibroblasts exposed to TGF-β and infected with Ad-STING (n = 6), *P < 0.05 vs PBS + Ad-Ctrl group, #P < 0.05 vs AngII + Ad-Ctrl group

Back to article page