Skip to main content
Fig. 6 | Cell Communication and Signaling

Fig. 6

From: STING protects against cardiac dysfunction and remodelling by blocking autophagy

Fig. 6

The cardioprotective effect of STING was mediated by autophagy inhibition. A Representative western blot and analysis of Beclin-1, Atg7, Atg12 and LC3I/II (n = 6). *P < 0.05 vs the Sham + WT group, #P < 0.05 vs the AB + WT group. B Immunohistochemistry analysis of LC3B in indicated groups. C Representative western blot and analysis of Beclin-1 in STING TG mice with AB and rapamycin (n = 6). D, E Ejection fraction and fractional shortening in STING TG mice with AB and rapamycin via echocardiography (n = 12). F The mRNA level of hypertrophic markers (ANP) (n = 6). G Representative image of the heart with H&E staining and Picrosirius Red (PSR) staining and statistical results (n = 6). H The mRNA level of fibrotic markers (Collagen1) (n = 6), *P < 0.05 vs AB-TG group

Back to article page