Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP. Functional antagonism between sall4 and plzf define germline progenitors. Cell Stem Cell. 2012;10:284–98.
Balk SP. Androgen receptor as a target in androgen-independent prostate cancer. Urology. 2002;60:132–8.
Krutskikh A, De Gendt K, Sharp V, Verhoeven G, Poutanen M, Huhtaniemi I. Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology. 2011;152:689–96.
Zhu C, Luong R, Zhuo M, Johnson DT, McKenney JK, Cunha GR, Sun Z. Conditional expression of the androgen receptor induces oncogenic transformation of the mouse prostate. J Biol Chem. 2011;286:33478–33,488.
Kimura N, Mizokami A, Oonuma T, Sasano H, Nagura H. Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues. J Histochem Cytochem. 1993;41:671–8.
Vornberger W, Prins G, Musto NA, Suarez-Quian CA. Androgen receptor distribution in rat testis: New implications for androgen regulation of spermatogenesis. Endocrinology. 1994;134:2307–16.
Takeda H, Chodak G, Mutchnik S, Nakamoto T, Chang C. Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor. J Endocrinol. 1990;126:17–NP.
Tsai M-Y, Yeh S-D, Wang R-S, Yeh S, Zhang C, Lin H-Y, Tzeng C-R, Chang C. Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells. Proc Natl Acad Sci U S A. 2006;103:18975–18,980.
Xu Q, Lin H-Y, Yeh S-D, Yu IC, Wang R-S, Chen Y-T, Zhang C, Altuwaijri S, Chen L-M, Chuang K-H, Chiang H-S, Yeh S, Chang C. Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in leydig cells. Endocr. 2007;32:96–106.
Karel DG, Swinnen JV, Saunders PTK, Luc S, Mieke D, Ann D, Karen T, Nina A, Frank C, Charlotte L. A sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A. 2004;101:1327–32.
Zhou Q, Nie R, Prins GS, Saunders PTK, Katzenellenbogen BS, Hess RA. Localization of androgen and estrogen receptors in adult male mouse reproductive tract. J Androl. 2002;23:870–81.
Chen L-Y, Brown PR, Willis WB, Eddy EM. Peritubular myoid cells participate in male mouse spermatogonial stem cell maintenance. Endocrinology. 2014;155:4964–74.
Chen L-Y, Willis WD, Eddy EM. Targeting the gdnf gene in peritubular myoid cells disrupts undifferentiated spermatogonial cell development. Proc Nat Acad Sci U S A. 2016;113:1829–34.
Wang ZY, Chen Z, Huang W, Li XS, Lu JX, Huang LA, Zhang FQ, Gu LJ, Ouyang RR, Chen SJ. Problems existing in differentiation therapy of acute promyelocytic leukemia (apl) with all-trans retinoic acid (atra). Blood Cells. 1993;19:633–41 discussion 642–637.
Costoya JA, Hobbs RM, Maria B, Giorgio C, Katia M, Meena S, Orwig KE, Wolgemuth DJ, Pier Paolo P. Essential role of plzf in maintenance of spermatogonial stem cells. Nat Genet. 2004;36:551–3.
Hermann BP, Sukhwani M, Lin CC, Yi S, Tomko J, Rodriguez M, Shuttleworth JJ, Mcfarland D, Hobbs RM, Pandolfi PP. Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. Stem Cells. 2007;25:2330–8.
Filipponi D, Hobbs RM, Ottolenghi S, Rossi P, Jannini EA, Pandolfi PP, Dolci S. Repression of kit expression by plzf in germ cells. Mol Cell Biol. 2007;27:6770–81.
Payne C, Braun RE. Histone lysine trimethylation exhibits a distinct perinuclear distribution in plzf-expressing spermatogonia. Dev Biol. 2006;293:461–72.
Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP. Plzf regulates germline progenitor self-renewal by opposing mtorc1. Cell. 2010;142:468–79.
Feng J, Zhou W. Identification and characterization of plzf as a prostatic androgen-responsive gene. Prostate. 2004;59:426–35.
Yang J, Su Q, Martina T, Ling W, Alexandr K, Landsmo GM, Haiying K, Tianzhou Z, Carmen J, Teixeira MR. Molecular circuit involving klk4 integrates androgen and mtor signaling in prostate cancer. Proc Natl Acad Sci U S A. 2013;110:E2572–81. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710885/.
Chen XG, Cheng HY, Pan TF, Yi L, Yang S, Ren CP, Huang DK, Zha XJ, Liang CZ. Mtor regulate emt through rhoa and rac1 pathway in prostate cancer. Mol Carcinog. 2015;54:1086–95.
Kanatsu-Shinohara M, Miki H, Inoue K, Ogonuki N, Toyokuni S, Ogura A, Shinohara T. Germline niche transplantation restores fertility in infertile mice. Hum Reprod. 2005;20:2376–82.
Kanatsu-Shinohara M, Takehashi M, Takashima S, Lee J, Morimoto H, Chuma S, Raducanu A, Nakatsuji N, Fässler R, Shinohara T. Homing of mouse spermatogonial stem cells to germline niche depends on β1integrin. Cell Stem Cell. 2008;3:533–42.
Ruey-Sheng W, Shuyuan Y, Lu-Min C, Hung-Yun L, Caixia Z, Jing N, Cheng-Chia W, P Anthony DSA, Demesy-Bentley KL, Chii-Ruey T. Androgen receptor in sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes. Endocrinology. 2006;147:5624–33.
Rio-Tsonis KD, Covarrubias L, Kent J, Hastie ND, Tsonis PA. Regulation of the wilms’ tumor gene during spermatogenesis. Dev Dyn. 1996;207:372.
Myers M, Ebling FJ, Nwagwu M, Boulton R, Wadhwa K, Stewart J, Kerr JB. Atypical development of sertoli cells and impairment of spermatogenesis in the hypogonadal (hpg) mouse. J Anat. 2006;207:797–811.
Zaia A, Fraizer G, Piantanelli L, Saunders G. Transcriptional regulation of the androgen signaling pathway by the wilms’ tumor suppressor gene wt1. Anticancer Res. 2001;21:1–10.
McLean DJ, Friel PJ, Johnston DS, Griswold MD. Characterization of spermatogonial stem cell maturation and differentiation in neonatal mice. Biol Reprod. 2003;69:2085–91.
Wu J, Zhang Y, Tian GG, Zou K, Lee CM, Yu Q, Yuan Z. Short-type pb-cadherin promotes self-renewal of spermatogonial stem cells via multiple signaling pathways. Cell Signal. 2008;20:1052–60.
Ks VDW, Johnson EW, Dirami G, Dym TM, Hofmann MC. Immunomagnetic isolation and long-term culture of mouse type a spermatogonia. J Androl. 2001;22:696–704.
Galdieri M, Ziparo E, Palombi F, Russo MA, Stefanini M. Pure sertoli cell cultures: A new model for the study of somatic—germ cell interactions. J Androl. 1981;2:249–54.
Zhang XL, Wu J, Jian W, Shen T, Hua L, Lu J, Gu Y, Kang Y, Wong CH, Ngan CY. Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells. Genome Biol. 2016;17:162.
Bolger AM, Lohse M, Usadel B. Trimmomatic: A flexible trimmer for illumina sequence data. Bioinformatics. 2014;30:2114–20.
Li H. Aligning sequence reads, clone sequences and assembly contigs with bwa-mem; 2013. p. 1303.
Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W. Model-based analysis of chip-seq (macs). Genome Biol. 2008;9:R137.
Jin R, Yamashita H, Yu X, Wang J, Franco OE, Wang Y, Hayward SW, Matusik RJ. Inhibition of nf-kappa b signaling restores responsiveness of castrate resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor variants expression. Oncogene. 2015;34:3700–10.
Zou K, Yuan Z, Yang Z, Luo H, Sun K, Zhou L, Xiang J, Shi L, Yu Q, Zhang Y. Production of offspring from a germline stem cell line derived from neonatal ovaries. Nat Cell Biol. 2009;11:631–6.
Schefe JH, Mario M, Jana R, Karin E, Hobbs RM, Pier Paolo P, Patricia R, Thomas U, Heiko FK. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res. 2006;99:1355–66.
Zeng Q, Guo Y, Liu Y, Li R, Zhang X, Liu L, Wang Y, Zhang X, Zou X. Integrin-β1, not integrin-β5, mediates osteoblastic differentiation and ecm formation promoted by mechanical tensile strain. Biol Res. 2015;48:25.
Jing Z, Yuan WJ, Yi-Feng ZG. Down-regulation of wt1 activates wnt/β-catenin signaling through modulating endocytic route of lrp6 in podocyte dysfunction in vitro. Cell Signal. 2015;27:1772–80.
Anne-Laure S, Anne G, Bruno Q, Christian B. Jo?Lle CT, Jean-No?L L: Gata2-induced silencing and lim-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat gnrh receptor gene. Mol Endocrinol. 2013;27:74–91.
Hidetoshi M, Lo AT, Inman JL, Jordi A, Ghajar CM, Mott JD, Nelson CM, Chen CS, Hui Z, Bascom JL. Transmembrane/cytoplasmic, rather than catalytic, domains of mmp14 signal to mapk activation and mammary branching morphogenesis via binding to integrin β1. Development. 2013;140:343–52.
Bremner WJ, Millar MR, Sharpe RM, Saunders PT. Immunohistochemical localization of androgen receptors in the rat testis: Evidence for stage-dependent expression and regulation by androgens. Endocrinology. 1994;135:1227–34.
Greenbaum MP, Yan W, Wu MH, Lin YN, Agno JE, Sharma M, Braun RE, Rajkovic A, Matzuk MM. Tex14 is essential for intercellular bridges and fertility in male mice. Proc Natl Acad Sci U S A. 2006;103:4982–7.
Furuhata A, Murakami M, Ito H, Gao S, Yoshida K, Sobue S, Kikuchi R, Iwasaki T, Takagi A, Kojima T, Suzuki M, Abe A, Naoe T, Murate T. Gata-1 and gata-2 binding to 3′ enhancer of wt1 gene is essential for its transcription in acute leukemia and solid tumor cell lines. Leukemia. 2009;23:1270–7.
Wang XN, Li ZS, Ren Y, Jiang T, Wang YQ, Chen M, Zhang J, Hao JX, Wang YB, Sha RN, Huang Y, Liu X, Hu JC, Sun GQ, Li HG, Xiong CL, Xie J, Jiang ZM, Cai ZM, Wang J, Wang J, Huff V, Gui YT, Gao F. The wilms tumor gene, wt1, is critical for mouse spermatogenesis via regulation of sertoli cell polarity and is associated with non-obstructive azoospermia in humans. PLoS Genet. 2013;9:e1003645.
Salanova M, Stefanini M, Curtis ID, Palombi F. Integrin receptor alpha 6 beta 1 is localized at specific sites of cell-to-cell contact in rat seminiferous epithelium. Biol Reprod. 1995;52:79–87.
Salanova M, Ricci G, Boitani C, Stefanini M, De GS, Palombi F. Junctional contacts between sertoli cells in normal and aspermatogenic rat seminiferous epithelium contain alpha6beta1 integrins, and their formation is controlled by follicle-stimulating hormone. Biol Reprod. 1998;58:371–8.
Merlet J, Racine C, Moreau E, Moreno SG, Habert R. Male fetal germ cells are targets for androgens that physiologically inhibit their proliferation. Proc Natl Acad Sci U S A. 2007;104:3615–20.
Kaufmann S, Sauter M, Schmitt M, Baumert B, Best B, Boese A, Roemer K, Mueller-Lantzsch N. Human endogenous retrovirus protein rec interacts with the testicular zinc-finger protein and androgen receptor. J Gen Virol. 2010;91:1494–502.
Furu K, Klungland A. Tzfp represses the androgen receptor in mouse testis. PLoS ONE. 2013;8:e62314.
Cheng CY, Lie PP, Mok KW, Cheng YH, Wong EW, Mannu J, Mathur PP, Yan HH, Mruk DD. Interactions of laminin β3 fragment with β1-integrin receptor: A revisit of the apical ectoplasmic specialization-blood-testis-barrier-hemidesmosome functional axis in the testis. Spermatogenesis. 2011;1:174–85.
An J, Zheng Y, Dann CT. Mesenchymal to epithelial transition mediated by cdh1 promotes spontaneous reprogramming of male germline stem cells to pluripotency. Stem Cell Rep. 2016;8:446–59.
Mazaud-Guittot S, Meugnier E, Pesenti S, Wu X, Vidal H, Gow A, Le Magueresse-Battistoni B. Claudin 11 deficiency in mice results in loss of the sertoli cell epithelial phenotype in the testis. Biol Reprod. 2010;82:202–13.
Meng J, Holdcraft RW, Shima JE, Griswold MD, Braun RE. Androgens regulate the permeability of the blood–testis barrier. Proc Natl Acad Sci U S A. 2005;102:16696–16,700.
Smith BE, Braun RE. Germ cell migration across sertoli cell tight junctions. Science. 2012;338:798–802.
Mueller S, Rosenquist TA, Takai Y, Bronson RA, Wimmer E. Loss of nectin-2 at sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration. Biol Reprod. 2003;69:1330–40.