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  1. Content type: Review

    In favor of their outgrowth, cancer cells must resist immune surveillance and edit the immune response. Cancer immunoediting is characterized by fundamental changes in the cellular composition and the inflamma...

    Authors: Richard Greil, Evelyn Hutterer, Tanja Nicole Hartmann and Lisa Pleyer

    Citation: Cell Communication and Signaling 2017 15:5

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  2. Content type: Research

    Uric acid (UA) is an antioxidant found in human serum. However, high UA levels may also have pro-oxidant functions. According to previous research, aldose reductase (AR) plays a vital role in the oxidative str...

    Authors: Zhiyong Huang, Quan Hong, Xueguang Zhang, Wenzhen Xiao, Liyuan Wang, Shaoyuan Cui, Zhe Feng, Yang Lv, Guangyan Cai, Xiangmei Chen and Di Wu

    Citation: Cell Communication and Signaling 2017 15:3

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  3. Content type: Review

    The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoi...

    Authors: Kemal Catakovic, Eckhard Klieser, Daniel Neureiter and Roland Geisberger

    Citation: Cell Communication and Signaling 2017 15:1

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  4. Content type: Research

    Cell migration including collective cell movement and individual cell migration are crucial factors in embryogenesis. During the spreading/migration of cells, several types of adhesive structures physically in...

    Authors: Xiaoli Shen, Zanhui Jia, Donato D’Alonzo, Xinggang Wang, Elisabeth Bruder, Fabienne Hélène Emch, Christian De Geyter and Hong Zhang

    Citation: Cell Communication and Signaling 2017 15:2

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  5. Content type: Research

    STAT3 is increasingly becoming known for its non-transcriptional regulation of mitochondrial bioenergetic function upon activation of its S727 residue (S727-STAT3). Lengthy mitochondrial dysfunction can lead t...

    Authors: Nishant P. Visavadiya, Matthew P. Keasey, Vladislav Razskazovskiy, Kalpita Banerjee, Cuihong Jia, Chiharu Lovins, Gary L. Wright and Theo Hagg

    Citation: Cell Communication and Signaling 2016 14:32

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    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:11

  6. Content type: Research

    Some herpesviruses like human cytomegalovirus (HCMV) encode viral G protein-coupled receptors that cause reprogramming of cell signaling to facilitate dissemination of the virus, prevent immune surveillance an...

    Authors: Theresa Frank, Anna Reichel, Olav Larsen, Anne-Charlotte Stilp, Mette M. Rosenkilde, Thomas Stamminger, Takeaki Ozawa and Nuska Tschammer

    Citation: Cell Communication and Signaling 2016 14:31

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  7. Content type: Research

    The serine proteases HtrA/DegP secreted by the human gastrointestinal pathogens Helicobacter pylori (H. pylori) and Campylobacter jejuni (C. jejuni) cleave the mammalian cell adhesion protein E-cadherin to open i...

    Authors: Carmen M. Abfalter, Maria Schubert, Camilla Götz, Thomas P. Schmidt, Gernot Posselt and Silja Wessler

    Citation: Cell Communication and Signaling 2016 14:30

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  8. Content type: Short report

    Squamous cell carcinoma of the tongue (tongue SCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer under current therapeutics. ARF6 and its effector AMAP1 ar...

    Authors: Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Kiyoshi Fukunaga, Kanako C. Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Satoshi Fukuda and Hisataka Sabe

    Citation: Cell Communication and Signaling 2016 14:28

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  9. Content type: Research

    Chemokines and their receptors play a decisive role in tumor progression and metastasis. We recently found a new signaling mechanism in malignant glioma cells mediated by transmembrane chemokines that we terme...

    Authors: Kirsten Hattermann, Kareen Bartsch, Henrike H. Gebhardt, H. Maximilian Mehdorn, Michael Synowitz, Anne Dorothée Schmitt, Rolf Mentlein and Janka Held-Feindt

    Citation: Cell Communication and Signaling 2016 14:26

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  10. Content type: Research

    ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. Growing evidence suggests interplay between ErbB2 and insulin-like growth factor (IGF) signa...

    Authors: Susan M. Farabaugh, Bonita T. Chan, Xiaojiang Cui, Robert K. Dearth and Adrian V. Lee

    Citation: Cell Communication and Signaling 2016 14:25

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  11. Content type: Research

    Reports of exocrine-to-endocrine reprogramming through expression or stabilization of the transcription factor neurogenin 3 (NGN3) have generated renewed interest in harnessing pancreatic plasticity for therap...

    Authors: Michael J. Shamblott, Marci L. O’Driscoll, Danielle L. Gomez and Dustin L. McGuire

    Citation: Cell Communication and Signaling 2016 14:23

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  12. Content type: Commentary

    Under physiological conditions, endothelial cells and the endothelial nitric oxide (NO) synthase (eNOS) are the main source of NO in the cardiovascular system. However, several other cell types have also been ...

    Authors: Peter M. Benz and Ingrid Fleming

    Citation: Cell Communication and Signaling 2016 14:22

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  13. Content type: Research

    Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to the vascular wall. αIIbβ3 is the main inte...

    Authors: Peter M. Benz, Hebatullah Laban, Joana Zink, Lea Günther, Ulrich Walter, Stepan Gambaryan and Karim Dib

    Citation: Cell Communication and Signaling 2016 14:21

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  14. Content type: Review

    Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. imm...

    Authors: Catharina Melzer, Yuanyuan Yang and Ralf Hass

    Citation: Cell Communication and Signaling 2016 14:20

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  15. Content type: Research

    Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigene...

    Authors: Stanley G. Kimani, Sushil Kumar, Viralkumar Davra, Yun-Juan Chang, Canan Kasikara, Ke Geng, Wen-I Tsou, Shenyan Wang, Mainul Hoque, Andrej Boháč, Anita Lewis-Antes, Mariana S. De Lorenzo, Sergei V. Kotenko and Raymond B. Birge

    Citation: Cell Communication and Signaling 2016 14:19

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  16. Content type: Research

    The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα) leading to proliferation of human uterine leiomyoma cells....

    Authors: Linda Yu, Kyle Ham, Xiaohua Gao, Lysandra Castro, Yitang Yan, Grace E. Kissling, Charles J. Tucker, Norris Flagler, Ray Dong, Trevor K. Archer and Darlene Dixon

    Citation: Cell Communication and Signaling 2016 14:18

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  17. Content type: Research

    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASK...

    Authors: Ekaterina Smirnova, Jamie J. Kwan, Ryan Siu, Xin Gao, Georg Zoidl, Borries Demeler, Vivian Saridakis and Logan W. Donaldson

    Citation: Cell Communication and Signaling 2016 14:17

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  18. Content type: Research

    Direct interaction between Red blood cells (RBCs) and platelets is known for a long time. The bleeding time is prolonged in anemic patients independent of their platelet count and could be corrected by transfu...

    Authors: Stepan Gambaryan, Hariharan Subramanian, Linda Kehrer, Igor Mindukshev, Julia Sudnitsyna, Cora Reiss, Natalia Rukoyatkina, Andreas Friebe, Iraida Sharina, Emil Martin and Ulrich Walter

    Citation: Cell Communication and Signaling 2016 14:16

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  19. Content type: Research

    Canonical Wnt signals, transduced by stabilized β-catenin, play similar roles across animals in maintaining stem cell pluripotency, regulating cell differentiation, and instructing normal embryonic development...

    Authors: William Q. Gillis, Arif Kirmizitas, Yasuno Iwasaki, Dong-Hyuk Ki, Jonathan M. Wyrick and Gerald H. Thomsen

    Citation: Cell Communication and Signaling 2016 14:15

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  20. Content type: Research

    The serine/threonine protein kinase C (PKC) theta has been firmly implicated in T cell-mediated immunity. Because its role in macrophages has remained undefined, we employed PKCtheta-deficient (PKCtheta ...

    Authors: Christa Pfeifhofer-Obermair, Karin Albrecht-Schgoer, Sebastian Peer, Manfred Nairz, Kerstin Siegmund, Victoria Klepsch, David Haschka, Nikolaus Thuille, Natascha Hermann-Kleiter, Thomas Gruber, Günter Weiss and Gottfried Baier

    Citation: Cell Communication and Signaling 2016 14:14

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  21. Content type: Review

    Extracellular vesicles are cell-derived vesicles, which can transport various cargos out of cells. From their cell of origin, the content molecules (proteins, non-coding RNAs including miRNAs, DNA and others) ...

    Authors: Giulia Cesi, Geoffroy Walbrecq, Christiane Margue and Stephanie Kreis

    Citation: Cell Communication and Signaling 2016 14:13

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  22. Content type: Research

    Antigen (Ag)/IgE-mediated mast cell (MC) responses play detrimental roles in allergic diseases. MC activation via the high-affinity receptor for IgE (FcεRI) is controlled by the Src family kinase Lyn. Lyn-defi...

    Authors: Susana M. Nunes de Miranda, Thomas Wilhelm, Michael Huber and Carolin N. Zorn

    Citation: Cell Communication and Signaling 2016 14:12

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  23. Content type: Research

    Cyclic nucleotides have been shown to play important signaling roles in many physiological processes in plants including photosynthesis and defence. Despite this, little is known about cyclic nucleotide-depend...

    Authors: Lara Donaldson, Stuart Meier and Christoph Gehring

    Citation: Cell Communication and Signaling 2016 14:10

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  24. Content type: Review

    RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RN...

    Authors: Aino I. Järvelin, Marko Noerenberg, Ilan Davis and Alfredo Castello

    Citation: Cell Communication and Signaling 2016 14:9

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  25. Content type: Review

    Protein-protein interactions (PPI) are involved in virtually every cellular process and thus represent an attractive target for therapeutic interventions. A significant number of protein interactions are frequ...

    Authors: Carles Corbi-Verge and Philip M. Kim

    Citation: Cell Communication and Signaling 2016 14:8

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  26. Content type: Erratum

    Authors: Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Lucia Demkova, Jan Gursky and Lucia Kucerova

    Citation: Cell Communication and Signaling 2016 14:7

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    The original article was published in Cell Communication and Signaling 2016 14:4

  27. Content type: Short report

    Chronic myeloid leukemia (CML) is driven by the fusion kinase Bcr-Abl. Bcr-Abl tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), revolutionized CML therapy. Nevertheless, about 20 % of CMLs di...

    Authors: Sebastian Halbach, Zehan Hu, Christine Gretzmeier, Julia Ellermann, Franziska U. Wöhrle, Jörn Dengjel and Tilman Brummer

    Citation: Cell Communication and Signaling 2016 14:6

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  28. Content type: Research

    Growth factors induce a characteristically short-lived Ras activation in cells emerging from quiescence. Extensive work has shown that transient as opposed to sustained Ras activation is critical for the induc...

    Authors: Anne Hennig, Robby Markwart, Katharina Wolff, Katja Schubert, Yan Cui, Ian A. Prior, Manuel A. Esparza-Franco, Graham Ladds and Ignacio Rubio

    Citation: Cell Communication and Signaling 2016 14:5

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  29. Content type: Review

    Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are...

    Authors: Matheus de Castro Fonseca, Carla J. Aguiar, Joao Antônio da Rocha Franco, Rafael N. Gingold and M. Fatima Leite

    Citation: Cell Communication and Signaling 2016 14:3

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  30. Content type: Methodology

    Human mesenchymal stromal cells (hMSC) are multipotent cells with both regenerative and immunomodulatory activities making them an attractive tool for cellular therapy. In the last few years it has been shown ...

    Authors: Teresa L. Ramos, Luis Ignacio Sánchez-Abarca, Sandra Muntión, Silvia Preciado, Noemí Puig, Guillermo López-Ruano, Ángel Hernández-Hernández, Alba Redondo, Rebeca Ortega, Concepción Rodríguez, Fermín Sánchez-Guijo and Consuelo del Cañizo

    Citation: Cell Communication and Signaling 2016 14:2

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  31. Content type: Research

    Cells of the tumor microenvironment are recognized as important determinants of the tumor biology. The adjacent non-malignant cells can regulate drug responses of the cancer cells by secreted paracrine factors...

    Authors: Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Lucia Demkova, Jan Gursky and Lucia Kucerova

    Citation: Cell Communication and Signaling 2016 14:4

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    The Erratum to this article has been published in Cell Communication and Signaling 2016 14:7

  32. Content type: Review

    A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordere...

    Authors: Kim Van Roey and Norman E. Davey

    Citation: Cell Communication and Signaling 2015 13:45

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  33. Content type: Review

    Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) ...

    Authors: Norman E. Davey, Martha S. Cyert and Alan M. Moses

    Citation: Cell Communication and Signaling 2015 13:43

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  34. Content type: Review

    It has become clear in outline though not yet in detail how cellular regulatory and signalling systems are constructed. The essential machines are protein complexes that effect regulatory decisions by undergoi...

    Authors: Toby J. Gibson, Holger Dinkel, Kim Van Roey and Francesca Diella

    Citation: Cell Communication and Signaling 2015 13:42

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  35. Content type: Research

    Abl interactor (Abi) family proteins play significant roles in actin cytoskeleton organization through participation in the WAVE complex. Mammals possess three Abi proteins: Abi-1, Abi-2, and NESH/Abi-3. Abi-1...

    Authors: Saki Sekino, Yuriko Kashiwagi, Hitoshi Kanazawa, Kazuki Takada, Takashi Baba, Seiichi Sato, Hiroki Inoue, Masaki Kojima and Katsuko Tani

    Citation: Cell Communication and Signaling 2015 13:41

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  36. Content type: Review

    Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called “redox signaling” includes the H2O2-mediated reversible oxidation of redox sens...

    Authors: Claudia Lennicke, Jette Rahn, Rudolf Lichtenfels, Ludger A. Wessjohann and Barbara Seliger

    Citation: Cell Communication and Signaling 2015 13:39

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  37. Content type: Research

    Pasteurella multocida toxin (PMT) is a potent inducer of osteoclast formation. Pigs suffering from an infection with toxigenic Pasteurella multocida strains develop atrophic rhinitis c...

    Authors: Bianca Kloos, Sushmita Chakraborty, Sonja G. Lindner, Katrin Noack, Ulrike Harre, Georg Schett, Oliver H. Krämer and Katharina F. Kubatzky

    Citation: Cell Communication and Signaling 2015 13:40

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  38. Content type: Research

    Mitochondria are key regulators of apoptosis. In response to stress, BH3-only proteins activate pro-apoptotic Bcl2 family proteins Bax and Bak, which induce mitochondrial outer membrane permeabilization (MOMP)...

    Authors: Sehyo Charley Choe, Anne Hamacher-Brady and Nathan Ryan Brady

    Citation: Cell Communication and Signaling 2015 13:37

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  39. Content type: Research Article

    The consideration of lactate as an active metabolite is a newly emerging and attractive concept. Recently, lactate has been reported to regulate gene transcription via the inhibition of histone deacetylases (H...

    Authors: Waldemar Wagner, Wojciech M. Ciszewski and Katarzyna D. Kania

    Citation: Cell Communication and Signaling 2015 13:36

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  40. Content type: Research Article

    The complex of Dock180/ELMO1 that functions as a bipartite guanine nucleotide exchange factor for Rac is essential for diverse physiological and pathological processes of cells such as cell migration, phagocyt...

    Authors: Yoshinori Makino, Masumi Tsuda, Yusuke Ohba, Hiroshi Nishihara, Hirofumi Sawa, Kazuo Nagashima and Shinya Tanaka

    Citation: Cell Communication and Signaling 2015 13:35

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  41. Content type: Research Article

    Connexin37 (Cx37) and Cx40 are crucial for endothelial cell-cell communication and homeostasis. Both connexins interact with endothelial nitric oxide synthase (eNOS). The exact contribution of these interactio...

    Authors: Merlijn J Meens, Florian Alonso, Loïc Le Gal, Brenda R Kwak and Jacques-Antoine Haefliger

    Citation: Cell Communication and Signaling 2015 13:34

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  42. Content type: Research Article

    Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar syndrome protein Tks4 resulted in aberrant intracellular...

    Authors: Csaba Ádám, Anna Fekete, Gábor Bőgel, Zsuzsanna Németh, Natália Tőkési, Judit Ovádi, Károly Liliom, Szabolcs Pesti, Miklós Geiszt and László Buday

    Citation: Cell Communication and Signaling 2015 13:33

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