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  1. Saccharomyces cerevisiae ScGdt1 and mammalian TMEM165 are two members of the UPF0016 membrane protein family that is likely to form a new group of Ca2+/H+ antiporter and/or a Mn2+ transporter in the Golgi apparat...

    Authors: Linghuo Jiang, Junjun Wang, Faiza Asghar, Nathan Snyder and Kyle W. Cunningham
    Citation: Cell Communication and Signaling 2018 16:33
    Content type: Research Published on:

  2. To determine whether adipocyte-derived lipids could be transferred into breast cancer cells and investigate the underlying mechanisms of subsequent lipolysis and fatty acid trafficking in breast cancer cells.

    Authors: Dejuan Yang, Yunhai Li, Lei Xing, Yiqing Tan, Jiazheng Sun, Beilei Zeng, Tingxiu Xiang, Jinxiang Tan, Guosheng Ren and Yuanyuan Wang
    Citation: Cell Communication and Signaling 2018 16:32
    Content type: Research Published on:

  3. The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phos...

    Authors: Min Yang, En Liu, Li Tang, Yuanyuan Lei, Xuemei Sun, Jiaxi Hu, Hui Dong, Shi-Ming Yang, Mingfa Gao and Bo Tang
    Citation: Cell Communication and Signaling 2018 16:31
    Content type: Review Published on:

  4. In this study, we investigated the role of microRNA-644a (miR-644a) in the growth and survival of hepatocellular carcinoma (HCC) cells. MiR-644a levels were lower in HCC tissues than in adjacent peri-cancerous...

    Authors: Wenjin Liang, Yong Liao, Zeming Li, Yan Wang, Siqi Zheng, Xiaochen Xu, Fulin Ran, Bo Tang and Zhenran Wang
    Citation: Cell Communication and Signaling 2018 16:30
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2022 20:151

  5. TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP va...

    Authors: Sungjin Park, Hyunji Lee, Minhee Kim, Jisoo Park, Seon-Hwan Kim and Jongsun Park
    Citation: Cell Communication and Signaling 2018 16:29
    Content type: Review Published on:

  6. SOD1 is an abundant enzyme that has been studied as a regulator of the antioxidant defence system, and this enzyme is well known for catalyzing the dismutation of superoxide into hydrogen peroxide. However the...

    Authors: Shuai Li, Lanyan Fu, Tian Tian, Liwen Deng, Huangbin Li, Weixiong Xia and Qing Gong
    Citation: Cell Communication and Signaling 2018 16:28
    Content type: Research Published on:

  7. Altered expression of Solute Carrier Family 12 Member 7 (SLC12A7) is implicated to promote malignant behavior in multiple cancer types through an incompletely understood mechanism. Recent studies have shown re...

    Authors: Taylor C. Brown, Timothy D. Murtha, Jill C. Rubinstein, Reju Korah and Tobias Carling
    Citation: Cell Communication and Signaling 2018 16:27
    Content type: Research Published on:

  8. Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers, including colorectal cancer. Recent years have witnessed the im...

    Authors: Qingguo Li, Yaqi Li, Lei Liang, Jing Li, Dakui Luo, Qi Liu, Sanjun Cai and Xinxiang Li
    Citation: Cell Communication and Signaling 2018 16:26
    Content type: Research Published on:

  9. Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fract...

    Authors: Jiangfeng Du, Yaping Qin, Yahong Wu, Wenshan Zhao, Wenjie Zhai, Yuanming Qi, Chuchu Wang and Yanfeng Gao
    Citation: Cell Communication and Signaling 2018 16:25
    Content type: Research Published on:

  10. The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens. Recently it became clear tha...

    Authors: Omar Elaskalani, Norbaini Binti Abdol Razak and Pat Metharom
    Citation: Cell Communication and Signaling 2018 16:24
    Content type: Research Published on:

  11. Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, c...

    Authors: Shaojie Jiang, Miaofeng Zhang, Jihong Sun and Xiaoming Yang
    Citation: Cell Communication and Signaling 2018 16:23
    Content type: Review Published on:

  12. SDF1/CXCR4 and AnnexinA7 play important roles in many physiological and pathological conditions, but the molecular association between them in cancer cells has not been studied thus far.

    Authors: Jingwen Wang, Yuhong Huang, Jun Zhang, Boyi Xing, Wei Xuan, Honghai Wang, He Huang, Jiayu Yang and Jianwu Tang
    Citation: Cell Communication and Signaling 2018 16:22
    Content type: Research Published on:

  13. The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine – receptor interaction between neoplastic cells and their microenvironmen...

    Authors: Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen and Jenny Potratz
    Citation: Cell Communication and Signaling 2018 16:21
    Content type: Research Published on:

  14. Histone deacetylases (HDACs) are involved in epigenetic gene regulation via deacetylation of acetylated lysine residues of both histone and non-histone proteins. Among the 18 HDACs identified in humans, HDAC8,...

    Authors: G. R. Vanaja, Hemalatha Golaconda Ramulu and Arunasree M. Kalle
    Citation: Cell Communication and Signaling 2018 16:20
    Content type: Research Published on:

  15. Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the significance of golgin-97 in human diseases such as cancer rem...

    Authors: Rae-Mann Hsu, Cai-Yan Zhong, Chih-Liang Wang, Wei-Chao Liao, Chi Yang, Shih-Yu Lin, Jia-Wei Lin, Hsiao-Yun Cheng, Po-Yu Li and Chia-Jung Yu
    Citation: Cell Communication and Signaling 2018 16:19
    Content type: Research Published on:

  16. Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact ...

    Authors: Zhaoping Qin, Wei Xia, Gary J. Fisher, John J. Voorhees and Taihao Quan
    Citation: Cell Communication and Signaling 2018 16:18
    Content type: Research Published on:

  17. Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influen...

    Authors: Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē and Una Riekstiņa
    Citation: Cell Communication and Signaling 2018 16:17
    Content type: Short report Published on:

  18. Gain-of-function mutations and overexpression of KIT are characteristic features of gastrointestinal stromal tumor (GIST). Dysregulation in miRNA expression may lead to KIT overexpression and tumorigenesis.

    Authors: Yu Wang, Jun Li, Dong Kuang, Xiaoyan Wang, Yuanli Zhu, Sanpeng Xu, Yaobing Chen, Henghui Cheng, Qiu Zhao, Yaqi Duan and Guoping Wang
    Citation: Cell Communication and Signaling 2018 16:16
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2023 21:360

  19. In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonic...

    Authors: Juvenal A. Ríos, Juan A. Godoy and Nibaldo C. Inestrosa
    Citation: Cell Communication and Signaling 2018 16:15
    Content type: Research Published on:

  20. In addition to physiological events such as fertilisation, placentation, osteoclastogenesis, or tissue regeneration/wound healing, cell fusion is involved in pathophysiological conditions such as cancer. Cell ...

    Authors: Julian Weiler, Marieke Mohr, Kurt S. Zänker and Thomas Dittmar
    Citation: Cell Communication and Signaling 2018 16:14
    Content type: Research Published on:

  21. Osteosarcoma (OS) is the representative primary malignant bone tumor with the highest incidence. It is known that malignant phenotypes of OS, such as proliferation, invasion, and metastasis, are significantly ...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki and Hiroshi Tsumura
    Citation: Cell Communication and Signaling 2018 16:13
    Content type: Research Published on:

  23. Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio ...

    Authors: Gabriela Basile Carballo, Jéssica Ribeiro Honorato, Giselle Pinto Farias de Lopes and Tania Cristina Leite de Sampaio e Spohr
    Citation: Cell Communication and Signaling 2018 16:11
    Content type: Review Published on:

  24. Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how...

    Authors: Sheng Liu, Josephine Iaria, Richard J. Simpson and Hong-Jian Zhu
    Citation: Cell Communication and Signaling 2018 16:10
    Content type: Research Published on:

  25. The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances i...

    Authors: Yuanyuan Tang, Joshua Berlind and Nirmala Mavila
    Citation: Cell Communication and Signaling 2018 16:9
    Content type: Research Published on:

  26. High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown.

    Authors: Deyuan Fu, Jing Li, Jinli Wei, Zhengquan Zhang, Yulin Luo, Haosheng Tan and Chuanli Ren
    Citation: Cell Communication and Signaling 2018 16:8
    Content type: Research Published on:

  27. 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal ...

    Authors: Haizhou Liu, Hui Liu, Zhiyi Zhou, Robert A. Parise, Edward Chu and John C. Schmitz
    Citation: Cell Communication and Signaling 2018 16:7
    Content type: Research Published on:

  28. Despite the implications for tumor growth and cancer drug resistance, the mechanisms underlying differences in energy metabolism among cells remain unclear.

    Authors: Li Wu, Jiayu Zhao, Kexin Cao, Xiao Liu, Hao Cai, Jiaqi Wang, Weidong Li and Zhipeng Chen
    Citation: Cell Communication and Signaling 2018 16:6
    Content type: Research Published on:

  29. Long non-coding RNAs (lncRNAs) have emerged as a new and crucial layer of gene regulation in recent years and regulate various biological processes such as carcinogenesis and metastasis. LncRNA HOTAIR, an onco...

    Authors: Peng Zheng, Ze Yin, Ying Wu, Yao Xu, Ying Luo and Tong-Cun Zhang
    Citation: Cell Communication and Signaling 2018 16:5
    Content type: Research Published on:

  30. Notch signaling controls many cellular processes, including cell fate determination, cell differentiation, proliferation and apoptosis. In mammals, four Notch receptors (Notch 1–4) can interact with five disti...

    Authors: Sylvain Pagie, Nathalie Gérard and Béatrice Charreau
    Citation: Cell Communication and Signaling 2018 16:4
    Content type: Research Published on:

  31. Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are exp...

    Authors: Syeda Kiran Riaz, Jahangir Sarwar Khan, Syed Tahir Abbas Shah, Fen Wang, Lin Ye, Wen G. Jiang and Muhammad Faraz Arshad Malik
    Citation: Cell Communication and Signaling 2018 16:3
    Content type: Research Published on:

  32. Fusion of breast cancer cells with tumor-associated populations of the microenvironment including mesenchymal stroma/stem-like cells (MSC) represents a rare event in cell communication whereby the metastatic c...

    Authors: Catharina Melzer, Juliane von der Ohe and Ralf Hass
    Citation: Cell Communication and Signaling 2018 16:2
    Content type: Research Published on:

  33. The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRK...

    Authors: Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, Shigeru Hashimoto, Haruka Handa, Hiroki Yamamoto, Ari Hashimoto and Hisataka Sabe
    Citation: Cell Communication and Signaling 2018 16:1
    Content type: Short report Published on:

  34. The left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to the premenstrual/menstrual repertoire in human endometrium, but little is known about its functional role...

    Authors: Wu Fei, Daiki Kijima, Mami Hashimoto, Miki Hashimura, Yasuko Oguri, Sabine Kajita, Toshihide Matsumoto, Ako Yokoi and Makoto Saegusa
    Citation: Cell Communication and Signaling 2017 15:56
    Content type: Research Published on:

  35. Glioblastoma multiformae (GBM) is the most aggressive type of malignant brain tumor with complex molecular profile. Overexpression of Na+/H+ Exchanger isoform 9 (NHE9) promotes tumor progression and correlates po...

    Authors: Daniela M. Gomez Zubieta, Mohamed A. Hamood, Rami Beydoun, Ashley E. Pall and Kalyan C. Kondapalli
    Citation: Cell Communication and Signaling 2017 15:55
    Content type: Research Published on:

  38. Hepatocellular carcinoma (HCC) is one of the cancer types with poor prognosis. To effectively treat HCC, new molecular targets and therapeutic approaches must be identified. 5-aminoimidazole-4-carboxamide ribo...

    Authors: Minjing Li, Changzhu Jin, Maolei Xu, Ling Zhou, Defang Li and Yancun Yin
    Citation: Cell Communication and Signaling 2017 15:52
    Content type: Research Published on:

  39. Prostate cancer (PCa), the second most common cancer affecting men worldwide, shows a broad spectrum of biological and clinical behaviour representing the epiphenomenon of an extreme heterogeneity. Androgen de...

    Authors: Nicoletta Ferrari, Ilaria Granata, Matteo Capaia, Marina Piccirillo, Mario Rosario Guarracino, Roberta Venè, Antonella Brizzolara, Andrea Petretto, Elvira Inglese, Martina Morini, Simonetta Astigiano, Adriana Agnese Amaro, Francesco Boccardo, Cecilia Balbi and Paola Barboro
    Citation: Cell Communication and Signaling 2017 15:51
    Content type: Research Published on:

  40. The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses. This is often justified by the complex regulation showed by Smad pro...

    Authors: Eva María García-Vizcaíno, Sergio Liarte, José Luis Alonso-Romero and Francisco José Nicolás
    Citation: Cell Communication and Signaling 2017 15:50
    Content type: Research Published on:

  41. Unfortunately, following publication of this article [1], it was noticed that the key in Figure 5c incorrectly showed ‘0 h’, ‘5 h’ and ‘10 h’. The corrected version, showing ‘0 h’, ‘12 h’ and ‘24 h’, can be se...

    Authors: Yue Pang, Changzhi Li, Shiyue Wang, Wei Ba, Tao Yu, Guangying Pei, Dan Bi, Hongfang Liang, Xiong Pan, Ting Zhu, Meng Gou, Yinglun Han and Qingwei Li
    Citation: Cell Communication and Signaling 2017 15:49
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2017 15:42

  42. Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Of the three, HAS1 is found to be localized more into the cytoplasmic space wher...

    Authors: Nguyet Nguyen, Awanit Kumar, Simi Chacko, Rodney J. Ouellette and Anirban Ghosh
    Citation: Cell Communication and Signaling 2017 15:48
    Content type: Research Published on:

  43. One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not...

    Authors: Angela Lombardi, Bruno Trimarco, Guido Iaccarino and Gaetano Santulli
    Citation: Cell Communication and Signaling 2017 15:47
    Content type: Research Published on:

  44. Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. V...

    Authors: Venugopal Thayanithy, Patrick O’Hare, Phillip Wong, Xianda Zhao, Clifford J. Steer, Subbaya Subramanian and Emil Lou
    Citation: Cell Communication and Signaling 2017 15:46
    Content type: Methodology Published on:

  45. We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate ...

    Authors: Allal Ouhtit, Mohammed E. Abdraboh, Andrew D. Hollenbach, Hatem Zayed and Madhwa H. G. Raj
    Citation: Cell Communication and Signaling 2017 15:45
    Content type: Research Published on:

  46. Vascular progenitor cells (VPCs) derived from embryonic stem cells (ESCs) are a valuable source for cell- and tissue-based therapeutic strategies. During the optimization of endothelial cell (EC) inductions fr...

    Authors: Simar J. Singh, William Turner, Drew E. Glaser, Kara E. McCloskey and Fabian V. Filipp
    Citation: Cell Communication and Signaling 2017 15:44
    Content type: Research Published on:

  47. We evaluated the therapeutic effect and fate of high doses of human umbilical cord Wharton jelly cells (hUCWJCs) after IP administration to streptozotocin (STZ)-induced diabetic mice.

    Authors: Martin Maldonado, Tianhua Huang, Lujun Yang, Lan Xu and Lian Ma
    Citation: Cell Communication and Signaling 2017 15:43
    Content type: Research Published on:

  48. In previous research, we found that cell secretion from the adult lamprey supraneural body tissues possesses cytocidal activity against tumor cells, but the protein with cytocidal activity was unidentified.

    Authors: Yue Pang, Changzhi Li, Shiyue Wang, Wei Ba, Tao Yu, Guangying Pei, Dan Bi, Hongfang Liang, Xiong Pan, Ting Zhu, Meng Gou, Yinglun Han and Qingwei Li
    Citation: Cell Communication and Signaling 2017 15:42
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2017 15:49

  49. Human cancer cells often exhibit impaired IGF2 expression and the underlying mechanisms are multifaceted and complex. Besides the well-known imprinting control region IGF2/H19-ICR, the involvement of a differenti...

    Authors: Undraga Schagdarsurengin, Angela Lammert, Natalie Schunk, Diana Sheridan, Stefan Gattenloehner, Klaus Steger, Florian Wagenlehner and Temuujin Dansranjavin
    Citation: Cell Communication and Signaling 2017 15:40
    Content type: Research Published on:

  50. Chronic inflammation is causally linked to the carcinogenesis and progression of most solid tumors. LPTS is a well-identified tumor suppressor by inhibiting telomerase activity and cancer cell growth. However,...

    Authors: Dongbo Liu, Hongping Miao, Yuanyin Zhao, Xia Kang, Shenglan Shang, Wei Xiang, Rongchen Shi, Along Hou, Rui Wang, Kun Zhao, Yingzhe Liu, Yue Ma, Huan Luo, Hongming Miao and Fengtian He
    Citation: Cell Communication and Signaling 2017 15:39
    Content type: Research Published on:
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ISSN: 1478-811X