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  1. Glioma is the most commonly diagnosed malignant and aggressive brain cancer in adults. Traditional researches mainly explored the expression profile of glioma at cell-population level, but ignored the heteroge...

    Authors: Dongsheng Yuan, Yiran Tao, Geng Chen and Tieliu Shi
    Citation: Cell Communication and Signaling 2019 17:48
    Content type: Research Published on:

  3. Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalli...

    Authors: Heike Reeh, Nadine Rudolph, Ulrike Billing, Henrike Christen, Stefan Streif, Eric Bullinger, Monica Schliemann-Bullinger, Rolf Findeisen, Fred Schaper, Heinrich J. Huber and Anna Dittrich
    Citation: Cell Communication and Signaling 2019 17:46
    Content type: Research Published on:

  4. Endometriosis, characterized by the presence of functional endometrial tissues outside the uterus, is one of the most common gynecological disorders. Endometrial mesenchymal stem cells (MSCs) are crucial for t...

    Authors: Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu, Guiping Wan and Xiaodong Han
    Citation: Cell Communication and Signaling 2019 17:45
    Content type: Research Published on:

  5. Over-activation of phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signaling pathway is one of important mechanisms to promote castration resistant prostate cancer, the final stag...

    Authors: Guang Yan, Yi Ru, Fengqi Yan, Xin Xiong, Wei Hu, Tao Pan, Jianming Sun, Chi Zhang, Qinhao Wang and Xia Li
    Citation: Cell Communication and Signaling 2019 17:44
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2019 17:130

  6. Following publication of the original article [1], the authors reported an error in

    Authors: Mingming Zhang, Yida Pan, Dehua Tang, Robert Gregory Dorfman, Lei Xu, Qian Zhou, Lixing Zhou, Yuming Wang, Yang Li, Yuyao Yin, Bo Kong, Helmut Friess, Shimin Zhao, Jian-lin Wu, Lei Wang and Xiaoping Zou
    Citation: Cell Communication and Signaling 2019 17:43
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2019 17:23

  7. Autophagy and ER stress are involved in maintaining some well-orchestrated mechanisms aimed at either restoring cellular homeostasis or performing cell death. Autophagy is a well-defined process which governs ...

    Authors: Wei Zheng, Weiwei Xie, Danyang Yin, Rui Luo, Min Liu and Fengjin Guo
    Citation: Cell Communication and Signaling 2019 17:42
    Content type: Research Published on:

  8. The flaviviridae family comprises single-stranded RNA viruses that enter cells via clathrin-mediated pH-dependent endocytosis. Although the initial events of the virus entry have been already identified, data reg...

    Authors: Katarzyna Owczarek, Yuliya Chykunova, Christian Jassoy, Beata Maksym, Zenon Rajfur and Krzysztof Pyrc
    Citation: Cell Communication and Signaling 2019 17:41
    Content type: Research Published on:

  9. Retinoic acid (RA) is the active metabolite of vitamin A and essential for many physiological processes, particularly the induction of cell differentiation. In addition to regulating genomic transcriptional ac...

    Authors: Thabat Khatib, Pietro Marini, Sudheer Nunna, David R. Chisholm, Andrew Whiting, Christopher Redfern, Iain R. Greig and Peter McCaffery
    Citation: Cell Communication and Signaling 2019 17:40
    Content type: Research Published on:

  10. In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates f...

    Authors: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca and Ciro Isidoro
    Citation: Cell Communication and Signaling 2019 17:39
    Content type: Research Published on:

  11. The NOV gene product, CCN3, has been reported in a diverse range of tumors to serve as a negative growth regulator, while acting as a tumor suppressor in Chronic Myelogenous Leukemia (CML). However, the precis...

    Authors: Mousa Vatanmakanian, Mahmood Tavallaie and Shirin Ghadami
    Citation: Cell Communication and Signaling 2019 17:38
    Content type: Research Published on:

  12. We previously showed that caveolin-1 (cav-1), an integral membrane protein, is required for the synthesis of matrix proteins by glomerular mesangial cells (MC). In a previous study to understand how cav-1 is i...

    Authors: Neel Mehta, Dan Zhang, Renzhong Li, Tony Wang, Agata Gava, Pavithra Parthasarathy, Bo Gao and Joan C. Krepinsky
    Citation: Cell Communication and Signaling 2019 17:37
    Content type: Research Published on:

  13. The human positive cofactor 4 (PC4) is initially identified as a transcriptional cofactor and has an important role in embryonic development and malignant transformation. However, the clinical significance and...

    Authors: Peng Luo, Chi Zhang, Fengying Liao, Long Chen, Zhenyu Liu, Lei Long, Zhongyong Jiang, Yawei Wang, Ziwen Wang, Zujuan Liu, Hongming Miao and Chunmeng Shi
    Citation: Cell Communication and Signaling 2019 17:36
    Content type: Research Published on:

  14. Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition and M phase progression in the cell cycle, plays a principal role in many physiological and pathological processes. A growing nu...

    Authors: Yumei Li, Feng Wu, Qi Tan, Mengfei Guo, Pei Ma, Xuan Wang, Shuai Zhang, Juanjuan Xu, Ping Luo and Yang Jin
    Citation: Cell Communication and Signaling 2019 17:35
    Content type: Review Published on:

  15. Male and female hearts have many structural and functional differences. Here, we investigated the role of estrogen (E2) in the mechanisms of sex differences in contraction through the cAMP-L-type Ca2+channel path...

    Authors: Jeremiah Ong’achwa Machuki, Hong-Yuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Li Kexue, Zhiwei Zhao and Hong Sun
    Citation: Cell Communication and Signaling 2019 17:34
    Content type: Research Published on:

  16. Vascular dysfunction is commonly seen during severe viral infections. Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in regulating vascular homeostasis as well as propa...

    Authors: Stephen R. Koch, Hyehun Choi, Eric H. Mace and Ryan J. Stark
    Citation: Cell Communication and Signaling 2019 17:33
    Content type: Research Published on:

  17. A major challenge in the development of effective cancer immunotherapy is the ability of tumors and their microenvironment to suppress immune cells through immunosuppressive cells such as myeloid -derived supp...

    Authors: Dickson Adah, Yijun Yang, Quan Liu, Kranthi Gadidasu, Zhu Tao, Songlin Yu, Linglin Dai, Xiaofen Li, Siting Zhao, Limei Qin, Li Qin and Xiaoping Chen
    Citation: Cell Communication and Signaling 2019 17:32
    Content type: Research Published on:

  18. p21-activated kinase 1 (PAK1) plays a fundamental role in promoting the development and progression of several cancers and is a potential therapeutic target. However, the biological function and underlying mec...

    Authors: Liang Chen, Shuning Bi, Jiuzhou Hou, Zhijun Zhao, Chaojie Wang and Songqiang Xie
    Citation: Cell Communication and Signaling 2019 17:31
    Content type: Research Published on:

  19. The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation...

    Authors: Yi Qin, Qiangsheng Hu, Jin Xu, Shunrong Ji, Weixing Dai, Wensheng Liu, Wenyan Xu, Qiqing Sun, Zheng Zhang, Quanxing Ni, Bo Zhang, Xianjun Yu and Xiaowu Xu
    Citation: Cell Communication and Signaling 2019 17:30
    Content type: Research Published on:

  20. EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role durin...

    Authors: Sheng-an Su, Yao Xie, Yuhao Zhang, Yutao Xi, Jie Cheng and Meixiang Xiang
    Citation: Cell Communication and Signaling 2019 17:29
    Content type: Review Published on:

  21. Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is neces...

    Authors: Ting Lu, Zhou Zhu, Junchao Wu, Hua She, Rong Han, Haidong Xu and Zheng-Hong Qin
    Citation: Cell Communication and Signaling 2019 17:28
    Content type: Research Published on:

  22. Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αvβ3 integrin an...

    Authors: Taís M. Danilucci, Patty K. Santos, Bianca C. Pachane, Graziéle F. D. Pisani, Rafael L. B. Lino, Bruna C. Casali, Wanessa F. Altei and Heloisa S. Selistre-de-Araujo
    Citation: Cell Communication and Signaling 2019 17:27
    Content type: Research Published on:

  23. Pericytes, as a key cellular part of the blood-brain barrier, play an important role in the maintenance of brain neurovascular unit. These cells participate in brain homeostasis by regulating vascular developm...

    Authors: Mohammad Hossein Geranmayeh, Reza Rahbarghazi and Mehdi Farhoudi
    Citation: Cell Communication and Signaling 2019 17:26
    Content type: Review Published on:

  24. Flavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including prostate cancer. However, the molecular targets o...

    Authors: Xuesen Li, Victor Pham, Matthew Tippin, Dongjun Fu, Raymond Rendon, Liankun Song, Edward Uchio, Bang H. Hoang and Xiaolin Zi
    Citation: Cell Communication and Signaling 2019 17:25
    Content type: Research Published on:

  25. Epithelial-to-mesenchymal transition (EMT) results in changes that promote de-differentiation, migration, and invasion in non-small cell lung cancer (NSCLC). While it is recognized that EMT promotes altered en...

    Authors: Szymon J. Szymura, Jacob P. Zaemes, David F. Allison, Sheena H. Clift, Jaclyn M. D’Innocenzi, Lisa G. Gray, Brian D. McKenna, Benjamin B. Morris, Stefan Bekiranov, Robin D. LeGallo, David R. Jones and Marty W. Mayo
    Citation: Cell Communication and Signaling 2019 17:24
    Content type: Research Published on:

  26. Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has ofte...

    Authors: Mingming Zhang, Yida Pan, Dehua Tang, Robert Gregory Dorfman, Lei Xu, Qian Zhou, Lixing Zhou, Yuming Wang, Yang Li, Yuyao Yin, Bo Kong, Helmut Friess, Shimin Zhao, Jian-lin Wu, Lei Wang and Xiaoping Zou
    Citation: Cell Communication and Signaling 2019 17:23
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2019 17:43

  27. Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of evidence indicate that it is through G protein coupled estrogen receptor (GPER) sig...

    Authors: Yiran Li, Yuanhui Jia, Yiding Bian, Huan Tong, Junjie Qu, Kai Wang and Xiao-Ping Wan
    Citation: Cell Communication and Signaling 2019 17:22
    Content type: Research Published on:

  28. Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others, the modulation of cytokine expression patterns. The p...

    Authors: Geneviève Hamel-Côté, Fanny Lapointe, Daniel Gendron, Marek Rola-Pleszczynski and Jana Stankova
    Citation: Cell Communication and Signaling 2019 17:21
    Content type: Research Published on:

  29. Shp1, a tyrosine-phosphatase-1 containing the Src-homology 2 (SH2) domain, is involved in inflammatory and immune reactions, where it regulates diverse signalling pathways, usually by limiting cell responses t...

    Authors: Alessia Varone, Stefania Mariggiò, Manpreet Patheja, Vincenzo Maione, Antonio Varriale, Mariangela Vessichelli, Daniela Spano, Fabio Formiggini, Matteo Lo Monte, Nadia Brancati, Maria Frucci, Pompea Del Vecchio, Sabato D’Auria, Angela Flagiello, Clara Iannuzzi, Alberto Luini…
    Citation: Cell Communication and Signaling 2019 17:20
    Content type: Research Published on:

  30. Oncogenic KRAS plays a vital role in controlling tumor metabolism by enhancing aerobic glycolysis. Obesity driven by chronic consumption of high-fat diet (HFD) is a major risk factor for oncogenic KRAS-mediate...

    Authors: Dan Wang, Yawei Bi, Lianghao Hu, Yongde Luo, Juntao Ji, Albert Z. Mao, Craig D. Logsdon, Ellen Li, James L. Abbruzzese, Zhaoshen Li, Vincent W. Yang and Weiqin Lu
    Citation: Cell Communication and Signaling 2019 17:19
    Content type: Short report Published on:

  31. Oral lichen planus (OLP) is known as a chronic inflammatory disease. Our recent studies have suggested that vitamin D/vitamin D receptor (VDR) signaling exerts its protective effects on oral keratinocyte apopt...

    Authors: Xuejun Ge, Lixiang Wang, Mengdi Li, Na Xu, Feiyan Yu, Fang Yang, Ran Li, Fang Zhang, Bin Zhao and Jie Du
    Citation: Cell Communication and Signaling 2019 17:18
    Content type: Research Published on:

  32. Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, th...

    Authors: Zhengxiao Ouyang, Sisi Wang, Ming Zeng, Zhihong Li, Qing Zhang, Wanchun Wang and Tang Liu
    Citation: Cell Communication and Signaling 2019 17:17
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2023 21:40

  33. The periodic growth of hair follicles is regulated by the balance of activators and inhibitors. The BMP signaling pathway plays an important role during hair follicle regeneration, but the exact BMP protein th...

    Authors: Pan Wu, Yiming Zhang, Yizhan Xing, Wei Xu, Haiying Guo, Fang Deng, Xiaogen Ma and Yuhong Li
    Citation: Cell Communication and Signaling 2019 17:16
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2020 18:4

  34. ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of Erb...

    Authors: Jinrui Zhang, Qiong Li, Yueguang Wu, Duchuang Wang, Lu Xu, Yang Zhang, Shanshan Wang, Taishu Wang, Fang Liu, Mohamed Y. Zaky, Shuai Hou, Shuyan Liu, Kun Zou, Haixin Lei, Lijuan Zou, Yingqiu Zhang…
    Citation: Cell Communication and Signaling 2019 17:15
    Content type: Research Published on:

  35. Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering hormone insulin. This metabolic activation is ass...

    Authors: Jaime Santo-Domingo, Antonio Núñez Galindo, Ornella Cominetti, Umberto De Marchi, Pedro Cutillas, Loïc Dayon and Andreas Wiederkehr
    Citation: Cell Communication and Signaling 2019 17:14
    Content type: Research Published on:

  36. Exosomes are small membrane-bound vesicles that contribute to tumor progression and metastasis by mediating cell-to-cell communication and modifying the tumor microenvironment at both local and distant sites. ...

    Authors: Bethany N. Hannafon, Amy L. Gin, Yi-Fan Xu, Matthew Bruns, Cameron L. Calloway and Wei-Qun Ding
    Citation: Cell Communication and Signaling 2019 17:13
    Content type: Research Published on:

  37. The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroi...

    Authors: Neha Kaushik, Min-Jung Kim, Nagendra Kumar Kaushik, Jae Kyung Myung, Mi-Young Choi, Jae-Hyeok Kang, Hyuk-Jin Cha, Cha-Soon Kim, Seon-Young Nam and Su-Jae Lee
    Citation: Cell Communication and Signaling 2019 17:12
    Content type: Research Published on:

  38. Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC...

    Authors: Feixia Wang, Yan Jia, Mengmeng Li, Ling Wang, Jiangjuan Shao, Qinglong Guo, Shanzhong Tan, Hai Ding, Anping Chen, Feng Zhang and Shizhong Zheng
    Citation: Cell Communication and Signaling 2019 17:11
    Content type: Research Published on:

  39. Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate...

    Authors: Gernot Posselt, Maria Wiesauer, Bianca E. Chichirau, Daniela Engler, Linda M. Krisch, Gabriele Gadermaier, Peter Briza, Sabine Schneider, Francesco Boccellato, Thomas F. Meyer, Cornelia Hauser-Kronberger, Daniel Neureiter, Anne Müller and Silja Wessler
    Citation: Cell Communication and Signaling 2019 17:10
    Content type: Research Published on:

  40. To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway.

    Authors: Yu-hong Yuan, Han-yu Wang, Yu Lai, Wa Zhong, Wei-ling Liang, Fu-de Yan, Zhong Yu, Jun-kai Chen and Ying Lin
    Citation: Cell Communication and Signaling 2019 17:9
    Content type: Research Published on:

  41. Ghrelin modulates many physiological processes. However, the effects of intestinal ghrelin on hepatic glucose production (HGP) are still unclear. The current study was to explore the roles of intestinal ghreli...

    Authors: Yao Lin, Zerong Liang, Liping He, Mengliu Yang, Dongfang Liu, Harvest F. Gu, Hua Liu, Zhiming Zhu, Hongting Zheng, Ling Li and Gangyi Yang
    Citation: Cell Communication and Signaling 2019 17:8
    Content type: Research Published on:

  42. Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that are known to play a role in the ca...

    Authors: Huihui Xu, Tianshu Fang, Hongbo Yan and Linghuo Jiang
    Citation: Cell Communication and Signaling 2019 17:7
    Content type: Short report Published on:

  44. Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxic...

    Authors: Theresa Lowinus, Florian H. Heidel, Tanima Bose, Subbaiah Chary Nimmagadda, Tina Schnöder, Clemens Cammann, Ingo Schmitz, Ulrike Seifert, Thomas Fischer, Burkhart Schraven and Ursula Bommhardt
    Citation: Cell Communication and Signaling 2019 17:5
    Content type: Research Published on:

  45. As the first member of the metastasis-associated protein (MTA) family, MTA1 and another MTA family member, MTA2, have both been reported to promote breast cancer progression and metastasis. However, the differ...

    Authors: Long Zhang, Qi Wang, Yuzhen Zhou, Qianwen Ouyang, Weixing Dai, Jianfeng Chen, Peipei Ding, Ling Li, Xin Zhang, Wei Zhang, Xinyue Lv, Luying Li, Pingzhao Zhang, Guoxiang Cai and Weiguo Hu
    Citation: Cell Communication and Signaling 2019 17:4
    Content type: Research Published on:

  46. Despite therapeutic advancements (e.g. B-RAF inhibitors) targeting cutaneous melanoma, many cellular processes, including inducible heme oxygenase 1 (HO-1), counteract treatments for malignancies. So there is ...

    Authors: Liu Liu, Yan Wu, Chunxiang Bian, Muhammad Farrukh Nisar, Mei Wang, Xiangyu Hu, Qingchun Diao, Weiqi Nian, Enwen Wang, Wei Xu and Julia Li Zhong
    Citation: Cell Communication and Signaling 2019 17:3
    Content type: Research Published on:

  47. Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor...

    Authors: Hongming Lv, Lihua Hong, Ye Tian, Changjiu Yin, Chao Zhu and Haihua Feng
    Citation: Cell Communication and Signaling 2019 17:2
    Content type: Research Published on:

  48. Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cel...

    Authors: Rui Chen, Xin Xu, Yuquan Tao, Zijun Qian and Yongchun Yu
    Citation: Cell Communication and Signaling 2019 17:1
    Content type: Review Published on:

  49. Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activat...

    Authors: Sara Ortiz-Rivero, Cristina Baquero, Luis Hernández-Cano, Juan José Roldán-Etcheverry, Sara Gutiérrez-Herrero, Cristina Fernández-Infante, Víctor Martín-Granado, Eduardo Anguita, José María de Pereda, Almudena Porras and Carmen Guerrero
    Citation: Cell Communication and Signaling 2018 16:101
    Content type: Research Published on:

  50. Adipocytes make up the major component of breast tissue, accounting for 90% of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a critical role in cancer progression. Adi...

    Authors: Jin-Yong He, Xiao-Hui Wei, Si-Jing Li, Yang Liu, Hao-Lin Hu, Zheng-Zheng Li, Xin-Hong Kuang, Lai Wang, Xin Shi, Sheng-Tao Yuan and Li Sun
    Citation: Cell Communication and Signaling 2018 16:100
    Content type: Research Published on:
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ISSN: 1478-811X