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  1. Research

    DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion

    Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms hav...

    You-Take Oh, Ping Yue and Shi-Yong Sun

    Cell Communication and Signaling 2017 15:18

    Published on: 8 May 2017

  2. Research

    Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line

    There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attr...

    Paola Ortiz-Montero, Arturo Londoño-Vallejo and Jean-Paul Vernot

    Cell Communication and Signaling 2017 15:17

    Published on: 4 May 2017

  3. Research

    The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

    Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One import...

    Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher and Sebastian Heikaus

    Cell Communication and Signaling 2017 15:16

    Published on: 2 May 2017

  4. Review

    From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases

    Infections with the human pathogen Helicobacter pylori (H. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. Drastic changes in...

    Silja Wessler, Linda M. Krisch, Dominik P. Elmer and Fritz Aberger

    Cell Communication and Signaling 2017 15:15

    Published on: 20 April 2017

  5. Research

    TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells

    Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA se...

    Fabia Fricke, Jennifer Lee, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Meggy Suarez-Carmona, Niels Halama, Martina Schnölzer, Jürgen Kopitz and Johannes Gebert

    Cell Communication and Signaling 2017 15:14

    Published on: 4 April 2017

  6. Review

    The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation

    Hypomethylating agents (HMAs) have been widely used over the last decade, approved for use in myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). The propos...

    Florian Wolff, Michael Leisch, Richard Greil, Angela Risch and Lisa Pleyer

    Cell Communication and Signaling 2017 15:13

    Published on: 31 March 2017

  7. Review

    Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?

    Cancer represents heterogeneous and aberrantly proliferative manifestations composed of (epi)genetically and phenotypically distinct cells with a common clonal origin. Cancer stem cells (CSC) make up a rare su...

    Wolfgang Gruber, Tamara Scheidt, Fritz Aberger and Christian G. Huber

    Cell Communication and Signaling 2017 15:12

    Published on: 29 March 2017

  8. Research

    Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin

    Translationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. TCTP may be involved in protec...

    Ulrich-Axel Bommer, Kara L. Vine, Prianka Puri, Martin Engel, Lisa Belfiore, Karen Fildes, Marijka Batterham, Alistair Lochhead and Morteza Aghmesheh

    Cell Communication and Signaling 2017 15:9

    Published on: 1 February 2017

  9. Review

    The Id-protein family in developmental and cancer-associated pathways

    Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif. During development, th...

    Cornelia Roschger and Chiara Cabrele

    Cell Communication and Signaling 2017 15:7

    Published on: 25 January 2017

  10. Review

    Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling

    Treatment of acute myeloid leukemia (AML), an aggressive and heterogeneous hematological malignancy, remains a challenge. Despite advances in our understanding of the complex genetics and biology of AML pathop...

    Fritz Aberger, Evelyn Hutterer, Christina Sternberg, Pedro J. del Burgo and Tanja N. Hartmann

    Cell Communication and Signaling 2017 15:8

    Published on: 25 January 2017

  11. Research

    Unraveling the regulation of mTORC2 using logical modeling

    The mammalian target of rapamycin (mTOR) is a regulator of cell proliferation, cell growth and apoptosis working through two distinct complexes: mTORC1 and mTORC2. Although much is known about the activation a...

    Kirsten Thobe, Christine Sers and Heike Siebert

    Cell Communication and Signaling 2017 15:6

    Published on: 19 January 2017

  12. Research

    HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures

    Cell migration including collective cell movement and individual cell migration are crucial factors in embryogenesis. During the spreading/migration of cells, several types of adhesive structures physically in...

    Xiaoli Shen, Zanhui Jia, Donato D’Alonzo, Xinggang Wang, Elisabeth Bruder, Fabienne Hélène Emch, Christian De Geyter and Hong Zhang

    Cell Communication and Signaling 2017 15:2

    Published on: 5 January 2017

  13. Review

    T cell exhaustion: from pathophysiological basics to tumor immunotherapy

    The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoi...

    Kemal Catakovic, Eckhard Klieser, Daniel Neureiter and Roland Geisberger

    Cell Communication and Signaling 2017 15:1

    Published on: 5 January 2017

  14. Research

    Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations

    Uric acid (UA) is an antioxidant found in human serum. However, high UA levels may also have pro-oxidant functions. According to previous research, aldose reductase (AR) plays a vital role in the oxidative str...

    Zhiyong Huang, Quan Hong, Xueguang Zhang, Wenzhen Xiao, Liyuan Wang, Shaoyuan Cui, Zhe Feng, Yang Lv, Guangyan Cai, Xiangmei Chen and Di Wu

    Cell Communication and Signaling 2017 15:3

    Published on: 5 January 2017

  15. Research

    Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3

    STAT3 is increasingly becoming known for its non-transcriptional regulation of mitochondrial bioenergetic function upon activation of its S727 residue (S727-STAT3). Lengthy mitochondrial dysfunction can lead t...

    Nishant P. Visavadiya, Matthew P. Keasey, Vladislav Razskazovskiy, Kalpita Banerjee, Cuihong Jia, Chiharu Lovins, Gary L. Wright and Theo Hagg

    Cell Communication and Signaling 2016 14:32

    Published on: 15 December 2016

    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:11

  16. Research

    Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28

    Some herpesviruses like human cytomegalovirus (HCMV) encode viral G protein-coupled receptors that cause reprogramming of cell signaling to facilitate dissemination of the virus, prevent immune surveillance an...

    Theresa Frank, Anna Reichel, Olav Larsen, Anne-Charlotte Stilp, Mette M. Rosenkilde, Thomas Stamminger, Takeaki Ozawa and Nuska Tschammer

    Cell Communication and Signaling 2016 14:31

    Published on: 12 December 2016

  17. Research

    HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens

    The serine proteases HtrA/DegP secreted by the human gastrointestinal pathogens Helicobacter pylori (H. pylori) and Campylobacter jejuni (C. jejuni) cleave the mammalian cell adhesion protein E-cadherin to open i...

    Carmen M. Abfalter, Maria Schubert, Camilla Götz, Thomas P. Schmidt, Gernot Posselt and Silja Wessler

    Cell Communication and Signaling 2016 14:30

    Published on: 8 December 2016

  18. Review

    The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection

    Mycobacterium avium subsp. paratuberculosis (MAP) is an intracellular pathogen and is the causative agent of Johne’s disease of domestic and wild ruminants. Johne’s disease is characteriz...

    Tariq Hussain, Syed Zahid Ali Shah, Deming Zhao, Srinand Sreevatsan and Xiangmei Zhou

    Cell Communication and Signaling 2016 14:29

    Published on: 1 December 2016

  19. Short report

    High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue

    Squamous cell carcinoma of the tongue (tongue SCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer under current therapeutics. ARF6 and its effector AMAP1 ar...

    Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Kiyoshi Fukunaga, Kanako C. Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Satoshi Fukuda and Hisataka Sabe

    Cell Communication and Signaling 2016 14:28

    Published on: 21 November 2016

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