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Editor's profile

Stephan FellerStephan Feller, Editor-in-Chief

Stephan Feller holds a professorship in Tumor Biology at the Institute of Molecular Medicine of the Martin-Luther-University Halle-Wittenberg, Germany. Prior to this appointment, he was a Principal Investigator at the Weatherall Instuitute of Molecular Medicine (WIMM) in Oxford and a Lecturer at the University of Oxford for over a decade.

Stephan graduated in 1989 with a Diploma in Biology after studying at Kaiserlautern and Heidelberg. In 1994 he obtained a PhD in biochemistry and cell biology from The Rockefeller University, New York. He then stayed on for another year as a postdoctoral fellow, again in the laboratory of renowned cancer virologist Hidesaburo Hanafusa, before moving to Würzburg University, where he established an independent junior research group. Starting with his doctoral research, Stephan has been interested in the molecular signaling mechanisms that allow cancer cells to develop and persist.

In 2001 he moved to Oxford to continue and extend his cancer cell research into structural biology and other biophysical studies. In Oxford he also started to dissect the molecular differences that underlie the development of individual human cancers, with a focus on protein kinases and related signaling proteins. For this, the research team analyses large panels of tumor cell lines derived from colorectal cancers and head and neck squamous cell carcinomas.

His most recent work aims to understand the molecular architecture of signaling protein complexes and networks. He has put forward the N-terminal folding nucleation (NFN) hypothesis, which would seem to explain how complex signals are molecularly computed in a highly coordinated manner within multi-protein complexes assembled on intrinsically disordered proteins.

STS/CCS Honorary Medal

In 2010 the Signal Transduction Society, together with Cell Communication and Signaling, introduced the STS/CCS Honorary Medal that celebrates the accomplishments of world leaders in cell signaling research.

Recipients of this Honorary Medal are so far:

  • Mina Bissell (2015)
  • Jules A. Hoffmann (2014)
  • Klaus Rajewsky (2013)
  • Carl-Henrik (Calle) Heldin (2012)
  • Anthony (Tony) R. Hunter (2011)
  • Anthony (Tony) J. Pawson (2010)