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  1. Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. A minority of affected patients develops inflammation, subsequently f...

    Authors: Marco Raffaele, Kristina Kovacovicova, Jan Frohlich, Oriana Lo Re, Sebastiano Giallongo, Jude A. Oben, Martin Faldyna, Lenka Leva, Antonino Giulio Giannone, Daniela Cabibi and Manlio Vinciguerra

    Citation: Cell Communication and Signaling 2021 19:44

    Content type: Short report

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  2. Phosphotyrosine kinase (PTK)-mediated phospholipase C-γ1 (PLC-γ1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for sever...

    Authors: Helena M. Stricker, Nadine Rommerswinkel, Silvia Keil, Sandina A. Gnoth, Bernd Niggemann and Thomas Dittmar

    Citation: Cell Communication and Signaling 2021 19:43

    Content type: Research

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  3. Progesterone receptor membrane component 1 (Pgrmc1) is a non-classical progesterone receptor associated with the development of the mammary gland and xenograft-induced breast cancer. Importantly, Pgrmc1 is ass...

    Authors: Sang R. Lee, Young Ho Lee, Seong Lae Jo, Jun H. Heo, Globinna Kim, Geun-Shik Lee, Beum-Soo An, In-Jeoung Baek and Eui-Ju Hong

    Citation: Cell Communication and Signaling 2021 19:42

    Content type: Research

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  4. The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a sca...

    Authors: Yu Fang, Angelina Olegovna Zekiy, Farhoodeh Ghaedrahmati, Anton Timoshin, Maryam Farzaneh, Amir Anbiyaiee and Seyed Esmaeil Khoshnam

    Citation: Cell Communication and Signaling 2021 19:41

    Content type: Review

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  5. Lysosome-associated membrane protein type 2A (LAMP-2A) is the key component of chaperone-mediated autophagy (CMA), a cargo-selective lysosomal degradation pathway. Aberrant LAMP-2A expression and CMA activatio...

    Authors: Yongjie Wang, Buyi Zhang, Jianli Wang, Haijian Wu, Shenbin Xu, Jianmin Zhang and Lin Wang

    Citation: Cell Communication and Signaling 2021 19:40

    Content type: Research

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  6. Tumor angiogenesis, an essential process for cancer proliferation and metastasis, has a critical role in prognostic of kidney renal clear cell carcinoma (KIRC), as well as a target in guiding treatment with an...

    Authors: Wenzhong Zheng, Shiqiang Zhang, Huan Guo, Xiaobao Chen, Zhangcheng Huang, Shaoqin Jiang and Mengqiang Li

    Citation: Cell Communication and Signaling 2021 19:39

    Content type: Research

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  7. CP12 is a small chloroplast protein that is widespread in various photosynthetic organisms and is an actor of the redox signaling pathway involved in the regulation of the Calvin Benson Bassham (CBB) cycle. Th...

    Authors: Hui Shao, Wenmin Huang, Luisana Avilan, Véronique Receveur-Bréchot, Carine Puppo, Rémy Puppo, Régine Lebrun, Brigitte Gontero and Hélène Launay

    Citation: Cell Communication and Signaling 2021 19:38

    Content type: Research

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  8. The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various g...

    Authors: Zhen Zhang, Puhua Zeng, Wenhui Gao, Qing Zhou, Ting Feng and Xuefei Tian

    Citation: Cell Communication and Signaling 2021 19:37

    Content type: Review

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  9. The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type pl...

    Authors: Daisuke Ito, Hiroyasu Ito, Takayasu Ideta, Ayumu Kanbe, Soranobu Ninomiya and Masahito Shimizu

    Citation: Cell Communication and Signaling 2021 19:36

    Content type: Research

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  10. The mechanism underlying endothelial dysfunction leading to cardiovascular disease in type 2 diabetes mellitus (T2DM) remains unclear. Here, we show that inhibition of histone deacetylase 3 (HDAC3) reduced inf...

    Authors: Shuai Huang, Gen Chen, Jia Sun, Yunjie Chen, Nan Wang, Yetong Dong, Enzhao Shen, Zhicheng Hu, Wenjie Gong, Litai Jin and Weitao Cong

    Citation: Cell Communication and Signaling 2021 19:35

    Content type: Research

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  11. Prostate cancer (PCa) is one of the most commonly diagnosed human cancers in males. Nearly 191,930 new cases and 33,330 new deaths of PCa are estimated in 2020. Androgen and androgen receptor pathways played e...

    Authors: Dexin Shen, Lingao Ju, Fenfang Zhou, Mengxue Yu, Haoli Ma, Yi Zhang, Tongzu Liu, Yu Xiao, Xinghuan Wang and Kaiyu Qian

    Citation: Cell Communication and Signaling 2021 19:34

    Content type: Review

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  12. Hepatitis B virus (HBV) X protein (HBX) has been reported to be responsible for the epithelial-mesenchymal transition (EMT) in HBV-related hepatocellular carcinoma (HCC). Vimentin is an EMT-related molecular m...

    Authors: Hongjuan You, Dongchen Yuan, Yanwei Bi, Ning Zhang, Qi Li, Tao Tu, Xiao Wei, Qi Lian, Tong Yu, Delong Kong, Xiaoying Yang, Xiangye Liu, Xiaomei Liu, Fanyun Kong, Kuiyang Zheng and Renxian Tang

    Citation: Cell Communication and Signaling 2021 19:33

    Content type: Research

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  13. Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique chara...

    Authors: Jason D. Domogauer, Sonia M. de Toledo, Roger W. Howell and Edouard I. Azzam

    Citation: Cell Communication and Signaling 2021 19:30

    Content type: Research

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  14. Neurodegeneration, an early event in the pathogenesis of diabetic retinopathy (DR), precedes clinically detectable microvascular damage. Autophagy dysregulation is considered a potential cause of neuronal cell...

    Authors: Sanjar Batirovich Madrakhimov, Jin Young Yang, Jin Ha Kim, Jung Woo Han and Tae Kwann Park

    Citation: Cell Communication and Signaling 2021 19:29

    Content type: Research

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  15. Alzheimer’s disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal transduction in neurons and other glia cells. The pathologica...

    Authors: Smita Eknath Desale and Subashchandrabose Chinnathambi

    Citation: Cell Communication and Signaling 2021 19:28

    Content type: Review

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  16. The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy. Abl also is a critical regulator of normal development, playing c...

    Authors: Edward M. Rogers, S. Colby Allred and Mark Peifer

    Citation: Cell Communication and Signaling 2021 19:27

    Content type: Research

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  17. Over the past years, Human Amnion Epithelial Cells (hAECs), a placental stem cell, are gaining higher attention from the scientific community as they showed several advantages over other types of stem cells, i...

    Authors: Meriem Bejaoui, Farhana Ferdousi, Yun-Wen Zheng, Tatsuya Oda and Hiroko Isoda

    Citation: Cell Communication and Signaling 2021 19:26

    Content type: Short report

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  18. Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found. No pharmaceutical treatment is available today and r...

    Authors: Matthias Schürmann, Felix Oppel, Senyao Shao, Verena Volland-Thurn, Christian Kaltschmidt, Barbara Kaltschmidt, Lars-Uwe Scholtz and Holger Sudhoff

    Citation: Cell Communication and Signaling 2021 19:25

    Content type: Research

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  19. The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance. Inhibition of the Otub1/c-Maf axis is a promising therape...

    Authors: Tong Sun, Yujia Xu, Zhuan Xu, Biyin Cao, Zubin Zhang, Qi Wang, Yan Kong and Xinliang Mao

    Citation: Cell Communication and Signaling 2021 19:24

    Content type: Research

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  20. Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysio...

    Authors: Zhu Liang, Andreas Damianou, Elena Di Daniel and Benedikt M. Kessler

    Citation: Cell Communication and Signaling 2021 19:23

    Content type: Review

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  21. Metastasis is the predominant cause for cancer morbidity and mortality accounting for approximatively 90% of cancer deaths. The actin-bundling protein L-plastin has been proposed as a metastatic marker and pho...

    Authors: Raquel A. C. Machado, Dunja Stojevski, Sébastien De Landtsheer, Philippe Lucarelli, Alexandre Baron, Thomas Sauter and Elisabeth Schaffner-Reckinger

    Citation: Cell Communication and Signaling 2021 19:22

    Content type: Research

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  22. Frizzled (FZD) proteins function as receptors for WNT ligands. Members in FZD family including FZD2, FZD4, FZD7, FZD8 and FZD10 have been demonstrated to mediate cancer cell epithelial-mesenchymal transition (...

    Authors: Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao and Wei Wang

    Citation: Cell Communication and Signaling 2021 19:21

    Content type: Research

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  23. Intercellular communication is crucial for breast cancer progression and metastasis. However, the role of cancer-derived exosomes and their crucial microRNA (miRNA) cargoes mediating intercellular communicatio...

    Authors: Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou and Qiang Sun

    Citation: Cell Communication and Signaling 2021 19:20

    Content type: Research

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  24. Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and more aggressive clones that contri...

    Authors: Yuan Li, Zhenning Wang, Jaffer A. Ajani and Shumei Song

    Citation: Cell Communication and Signaling 2021 19:19

    Content type: Review

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  25. Our previous studies have shown that the E3 ubiquitin ligase of HMG-CoA reductase degradation 1 (HRD1) functions as a tumor suppressor, as overexpression of HRD1 suppressed breast cancer proliferation and inva...

    Authors: Ya Fan, Jia Wang, Yuemei Xu, Yipin Wang, Tao Song, Xiubin Liang, Feng Jin and Dongming Su

    Citation: Cell Communication and Signaling 2021 19:18

    Content type: Research

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  26. Vascular endothelial barrier function is maintained by cell-to-cell junctional proteins and contributes to vascular homeostasis. Various risk factors such as inflammation disrupt barrier function through down-...

    Authors: Kayo Kunimura, Satomi Miki, Miyuki Takashima and Jun-ichiro Suzuki

    Citation: Cell Communication and Signaling 2021 19:17

    Content type: Research

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  27. Amyloid aggregate deposition is the key feature of Alzheimer’s disease. The proteinaceous aggregates found in the afflicted brain are the intra-neuronal neurofibrillary tangles formed by the microtubule-associ...

    Authors: Shweta Kishor Sonawane, Vladimir N. Uversky and Subashchandrabose Chinnathambi

    Citation: Cell Communication and Signaling 2021 19:16

    Content type: Research

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  28. Colorectal familial adenomatous polyposis (FAP) adenomas exhibit a uniform pathogenetic basis caused by a germline mutation in the adenomatous polyposis gene (APC), but the molecular changes leading to their deve...

    Authors: Christoph Roser, Csaba Tóth, Marcus Renner, Esther Herpel and Peter Schirmacher

    Citation: Cell Communication and Signaling 2021 19:15

    Content type: Research

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  29. Abnormal neovascularization is the most common cause of blindness, and hypoxia alters tissue metabolism, function, and morphology. HIF-1α, the transcriptional activator of VEGF, has intricate mechanisms of nuc...

    Authors: Lijie Dong, Wenbo Li, Tingting Lin, Boshi Liu, Yaru Hong, Xiaomin Zhang and Xiaorong Li

    Citation: Cell Communication and Signaling 2021 19:14

    Content type: Research

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  30. Epimedii Folium (EF) is commonly used for treating bone fractures and joint diseases, but the potential hepatotoxicity of EF limits its clinical application. Our previous study confirms that EF could lead to i...

    Authors: Yuan Gao, Guang Xu, Li Ma, Wei Shi, Zhilei Wang, Xiaoyan Zhan, Nan Qin, Tingting He, Yuming Guo, Ming Niu, Jiabo Wang, Zhaofang Bai and Xiaohe Xiao

    Citation: Cell Communication and Signaling 2021 19:13

    Content type: Research

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  31. TIGIT, as a novel immune checkpoint molecule involved in T cell and NK cell anergy, could induce the immune tolerance and escape through binding with its ligand PVR. Blockade of TIGIT/PVR is considered as a pr...

    Authors: Xiaowen Zhou, Jiangfeng Du, Xiuman Zhou, Xiaoshuang Niu, Wanqiong Li, Chunxia Chen, Sifan Lv, Aijun Wu, Shanshan Gou, Yixuan Sun, Wenjie Zhai, Lu Qiu, Yuanming Qi, Wenshan Zhao and Yanfeng Gao

    Citation: Cell Communication and Signaling 2021 19:12

    Content type: Research

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  32. Tyro3, Axl, and Mertk (TAM) receptors are a subfamily of receptor tyrosine kinases. TAM receptors have been implicated in mediating efferocytosis, regulation of immune cells, secretion of inflammatory factors,...

    Authors: Yunxiang Zhou, Yali Wang, Hailong Chen, Yanyan Xu, Yi Luo, Yongchuan Deng, Jianmin Zhang and Anwen Shao

    Citation: Cell Communication and Signaling 2021 19:11

    Content type: Review

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  33. Over the past 2 decades, pattern recognition receptors (PRRs) have been shown to be on the front line of many illnesses such as autoimmune, inflammatory, and neurodegenerative diseases as well as allergies and...

    Authors: Valérie Lannoy, Anthony Côté-Biron, Claude Asselin and Nathalie Rivard

    Citation: Cell Communication and Signaling 2021 19:10

    Content type: Review

    Published on:

  34. To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors.

    Authors: Jin Qian, Zi-chen Gong, Yi-na Zhang, Hong-hua Wu, Jing Zhao, Li-ting Wang, Li-juan Ye, Da Liu, Wei Wang, Xia Kang, Jun Sheng, Wei Xu, Xi-lin Liu, Juan Wu and Wei Zheng

    Citation: Cell Communication and Signaling 2021 19:9

    Content type: Research

    Published on:

  35. First identified as a regulator of neuronal axon guidance, Slit/Robo signaling has since been implicated in additional physiologic and pathologic processes, such as angiogenesis, organogenesis and cancer progr...

    Authors: Emmanuelle Martinot and Derek Boerboom

    Citation: Cell Communication and Signaling 2021 19:8

    Content type: Research

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  36. The cytokine release syndrome or cytokine storm, which is the hyper-induction of inflammatory responses has a central role in the mortality rate of COVID-19 and some other viral infections. Interleukin-6 (IL-6...

    Authors: László Földvári-Nagy, Tamás Schnabel, Gabriella Dörnyei, Tamás Korcsmáros and Katalin Lenti

    Citation: Cell Communication and Signaling 2021 19:7

    Content type: Hypothesis

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  37. Androgen receptor (AR) and polycomb repressive complex 2 (PRC2) are known to co-occupy the loci of genes that are downregulated by androgen-stimulus. Long intergenic non-coding RNA (lincRNA) PVT1 is an overexpres...

    Authors: Alexandre Videira, Felipe C. Beckedorff, Lucas F. daSilva and Sergio Verjovski-Almeida

    Citation: Cell Communication and Signaling 2021 19:5

    Content type: Research

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  38. Probiotics are beneficial bacteria that exist within the human gut, and which are also present in different food products and supplements. They have been investigated for some decades, due to their potential b...

    Authors: Amirhossein Davoodvandi, Havva Marzban, Pouya Goleij, Amirhossein Sahebkar, Korosh Morshedi, Samaneh Rezaei, Maryam Mahjoubin-Tehran, Hossein Tarrahimofrad, Michael R. Hamblin and Hamed Mirzaei

    Citation: Cell Communication and Signaling 2021 19:4

    Content type: Review

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  39. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is overexpressed or activated in several advanced-stage solid cancers. It is known to play both kinase-dependent and -independent roles in pro...

    Authors: Ioanna Antoniades, Maria Kyriakou, Anna Charalambous, Katerina Kalalidou, Andri Christodoulou, Maria Christoforou and Paris A. Skourides

    Citation: Cell Communication and Signaling 2021 19:3

    Content type: Research

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  40. Signal fidelity depends on protein–protein interaction–‘hubs’ integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-h...

    Authors: Lasse Staby, Katrine Bugge, Rasmus Greve Falbe-Hansen, Edoardo Salladini, Karen Skriver and Birthe B. Kragelund

    Citation: Cell Communication and Signaling 2021 19:2

    Content type: Commentary

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  41. Bone marrow derived endothelial progenitor cells (EPCs) are immature endothelial cells (ECs) involved in neo-angiogenesis and endothelial homeostasis and are considered as a circulating reservoir for endotheli...

    Authors: Mahsa Nouri Barkestani, Sara Shamdani, Mazdak Afshar Bakshloo, Nassim Arouche, Bijan Bambai, Georges Uzan and Sina Naserian

    Citation: Cell Communication and Signaling 2021 19:1

    Content type: Research

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  42. The electromechanical function of myocardial tissue depends on the intercellular communication between cardiomyocytes (CMs) as well as their crosstalk with other cell types. Cell injury, and subsequent death t...

    Authors: Krishna Chander Sridhar, Nils Hersch, Georg Dreissen, Rudolf Merkel and Bernd Hoffmann

    Citation: Cell Communication and Signaling 2020 18:191

    Content type: Research

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  43. The rapid ability of SARS-CoV-2 to spread among humans, along with the clinical complications of coronavirus disease 2019—COVID-19, have represented a significant challenge to the health management systems wor...

    Authors: Gustavo A. Argañaraz, Julys da Fonseca Palmeira and Enrique R. Argañaraz

    Citation: Cell Communication and Signaling 2020 18:190

    Content type: Review

    Published on:

  44. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins plays an important role in the cellular regulation of responses to external stimuli. Despite intensive structural research, the mechani...

    Authors: Agnieszka Polit, Beata Rysiewicz, Paweł Mystek, Ewa Błasiak and Marta Dziedzicka-Wasylewska

    Citation: Cell Communication and Signaling 2020 18:189

    Content type: Research

    Published on:

  45. Pyroptosis is a recently identified pathway of caspase-mediated cell death in response to microbes, lipopolysaccharide, or chemotherapy in certain types of cells. However, the mechanism of how pyroptosis is re...

    Authors: Ruiyuan Yao, Yuhao Chen, Huifang Hao, Zhixin Guo, Xiaoou Cheng, Yuze Ma, Qiang Ji, Xiaoru Yang, Yanfeng Wang, Xihe Li and Zhigang Wang

    Citation: Cell Communication and Signaling 2020 18:187

    Content type: Research

    Published on:

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