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  1. Content type: Research

    To determine whether adipocyte-derived lipids could be transferred into breast cancer cells and investigate the underlying mechanisms of subsequent lipolysis and fatty acid trafficking in breast cancer cells.

    Authors: Dejuan Yang, Yunhai Li, Lei Xing, Yiqing Tan, Jiazheng Sun, Beilei Zeng, Tingxiu Xiang, Jinxiang Tan, Guosheng Ren and Yuanyuan Wang

    Citation: Cell Communication and Signaling 2018 16:32

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  2. Content type: Review

    The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phos...

    Authors: Min Yang, En Liu, Li Tang, Yuanyuan Lei, Xuemei Sun, Jiaxi Hu, Hui Dong, Shi-Ming Yang, Mingfa Gao and Bo Tang

    Citation: Cell Communication and Signaling 2018 16:31

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  3. Content type: Research

    In this study, we investigated the role of microRNA-644a (miR-644a) in the growth and survival of hepatocellular carcinoma (HCC) cells. MiR-644a levels were lower in HCC tissues than in adjacent peri-cancerous...

    Authors: Wenjin Liang, Yong Liao, Zeming Li, Yan Wang, Siqi Zheng, Xiaochen Xu, Fulin Ran, Bo Tang and Zhenran Wang

    Citation: Cell Communication and Signaling 2018 16:30

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  4. Content type: Research

    SOD1 is an abundant enzyme that has been studied as a regulator of the antioxidant defence system, and this enzyme is well known for catalyzing the dismutation of superoxide into hydrogen peroxide. However the...

    Authors: Shuai Li, Lanyan Fu, Tian Tian, Liwen Deng, Huangbin Li, Weixiong Xia and Qing Gong

    Citation: Cell Communication and Signaling 2018 16:28

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  5. Content type: Review

    TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP va...

    Authors: Sungjin Park, Hyunji Lee, Minhee Kim, Jisoo Park, Seon-Hwan Kim and Jongsun Park

    Citation: Cell Communication and Signaling 2018 16:29

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  6. Content type: Research

    Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers, including colorectal cancer. Recent years have witnessed the im...

    Authors: Qingguo Li, Yaqi Li, Lei Liang, Jing Li, Dakui Luo, Qi Liu, Sanjun Cai and Xinxiang Li

    Citation: Cell Communication and Signaling 2018 16:26

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  7. Content type: Research

    Altered expression of Solute Carrier Family 12 Member 7 (SLC12A7) is implicated to promote malignant behavior in multiple cancer types through an incompletely understood mechanism. Recent studies have shown re...

    Authors: Taylor C. Brown, Timothy D. Murtha, Jill C. Rubinstein, Reju Korah and Tobias Carling

    Citation: Cell Communication and Signaling 2018 16:27

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  8. Content type: Research

    Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fract...

    Authors: Jiangfeng Du, Yaping Qin, Yahong Wu, Wenshan Zhao, Wenjie Zhai, Yuanming Qi, Chuchu Wang and Yanfeng Gao

    Citation: Cell Communication and Signaling 2018 16:25

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  9. Content type: Research

    The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens. Recently it became clear tha...

    Authors: Omar Elaskalani, Norbaini Binti Abdol Razak and Pat Metharom

    Citation: Cell Communication and Signaling 2018 16:24

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  10. Content type: Review

    Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, c...

    Authors: Shaojie Jiang, Miaofeng Zhang, Jihong Sun and Xiaoming Yang

    Citation: Cell Communication and Signaling 2018 16:23

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  11. Content type: Research

    SDF1/CXCR4 and AnnexinA7 play important roles in many physiological and pathological conditions, but the molecular association between them in cancer cells has not been studied thus far.

    Authors: Jingwen Wang, Yuhong Huang, Jun Zhang, Boyi Xing, Wei Xuan, Honghai Wang, He Huang, Jiayu Yang and Jianwu Tang

    Citation: Cell Communication and Signaling 2018 16:22

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  12. Content type: Research

    The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine – receptor interaction between neoplastic cells and their microenvironmen...

    Authors: Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen and Jenny Potratz

    Citation: Cell Communication and Signaling 2018 16:21

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  13. Content type: Research

    Histone deacetylases (HDACs) are involved in epigenetic gene regulation via deacetylation of acetylated lysine residues of both histone and non-histone proteins. Among the 18 HDACs identified in humans, HDAC8,...

    Authors: G. R. Vanaja, Hemalatha Golaconda Ramulu and Arunasree M. Kalle

    Citation: Cell Communication and Signaling 2018 16:20

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  14. Content type: Research

    Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the significance of golgin-97 in human diseases such as cancer rem...

    Authors: Rae-Mann Hsu, Cai-Yan Zhong, Chih-Liang Wang, Wei-Chao Liao, Chi Yang, Shih-Yu Lin, Jia-Wei Lin, Hsiao-Yun Cheng, Po-Yu Li and Chia-Jung Yu

    Citation: Cell Communication and Signaling 2018 16:19

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  15. Content type: Research

    Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact ...

    Authors: Zhaoping Qin, Wei Xia, Gary J. Fisher, John J. Voorhees and Taihao Quan

    Citation: Cell Communication and Signaling 2018 16:18

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  16. Content type: Short report

    Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influen...

    Authors: Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē and Una Riekstiņa

    Citation: Cell Communication and Signaling 2018 16:17

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  17. Content type: Research

    Gain-of-function mutations and overexpression of KIT are characteristic features of gastrointestinal stromal tumor (GIST). Dysregulation in miRNA expression may lead to KIT overexpression and tumorigenesis.

    Authors: Yu Wang, Jun Li, Dong Kuang, Xiaoyan Wang, Yuanli Zhu, Sanpeng Xu, Yaobing Chen, Henghui Cheng, Qiu Zhao, Yaqi Duan and Guoping Wang

    Citation: Cell Communication and Signaling 2018 16:16

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  18. Content type: Research

    In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonic...

    Authors: Juvenal A. Ríos, Juan A. Godoy and Nibaldo C. Inestrosa

    Citation: Cell Communication and Signaling 2018 16:15

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  19. Content type: Research

    In addition to physiological events such as fertilisation, placentation, osteoclastogenesis, or tissue regeneration/wound healing, cell fusion is involved in pathophysiological conditions such as cancer. Cell ...

    Authors: Julian Weiler, Marieke Mohr, Kurt S. Zänker and Thomas Dittmar

    Citation: Cell Communication and Signaling 2018 16:14

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  20. Content type: Research

    Osteosarcoma (OS) is the representative primary malignant bone tumor with the highest incidence. It is known that malignant phenotypes of OS, such as proliferation, invasion, and metastasis, are significantly ...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki and Hiroshi Tsumura

    Citation: Cell Communication and Signaling 2018 16:13

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  21. Content type: Review

    Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio ...

    Authors: Gabriela Basile Carballo, Jéssica Ribeiro Honorato, Giselle Pinto Farias de Lopes and Tania Cristina Leite de Sampaio e Spohr

    Citation: Cell Communication and Signaling 2018 16:11

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  22. Content type: Research

    Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how...

    Authors: Sheng Liu, Josephine Iaria, Richard J. Simpson and Hong-Jian Zhu

    Citation: Cell Communication and Signaling 2018 16:10

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  23. Content type: Research

    The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances i...

    Authors: Yuanyuan Tang, Joshua Berlind and Nirmala Mavila

    Citation: Cell Communication and Signaling 2018 16:9

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  24. Content type: Research

    High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown.

    Authors: Deyuan Fu, Jing Li, Jinli Wei, Zhengquan Zhang, Yulin Luo, Haosheng Tan and Chuanli Ren

    Citation: Cell Communication and Signaling 2018 16:8

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