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  1. Olanzapine (OLZ) reverses chronic stress-induced anxiety. Chronic stress promotes cancer development via abnormal neuro-endocrine activation. However, how intervention of brain-body interaction reverses chroni...

    Authors: Jinxin Lu, Xiaoyu Zhang, Keyu Su, Huandong Luo, Congcong Liu, Yuqing Yang, Bin He, Cenxin Wang, Zhuoran Zhao, Xianxian Liu, Xu Wang, Peixuan Meng, Dekang Lv, Chunli Wang, Keith W. Kelley, Ling Wang…
    Citation: Cell Communication and Signaling 2024 22:375
  2. High-altitude cerebral edema (HACE) is considered an end-stage acute mountain sickness (AMS) that typically occurs in people after rapid ascent to 2500 m or more. While hypoxia is a fundamental feature of the ...

    Authors: Xiufang Jiang, Jiayue Gao, Xuechao Fei, Yanan Geng, Xiangpei Yue, Zibi Shi, Xiang Cheng, Tong Zhao, Ming Fan, Haitao Wu, Ming Zhao and Lingling Zhu
    Citation: Cell Communication and Signaling 2024 22:374
  3. Many DNA viruses develop various strategies to inhibit cell death to facilitate their replication. However, whether influenza A virus (IAV), a fast-replicating RNA virus, attenuates cell death remains unknown....

    Authors: Yuling Sun, Lei Ji, Wei Liu, Jing Sun, Penggang Liu, Xiaoquan Wang, Xiufan Liu and Xiulong Xu
    Citation: Cell Communication and Signaling 2024 22:372
  4. Protein kinase A (PKA) enhances neurotransmission at the neuromuscular junction (NMJ), which is retrogradely regulated by nerve-induced muscle contraction to promote Acetylcholine (ACh) release through the pho...

    Authors: Aleksandra Polishchuk, Víctor Cilleros-Mañé, Marta Balanyà-Segura, Laia Just-Borràs, Anton Forniés-Mariné, Carolina Silvera-Simón, Marta Tomàs, Meryem Jami El Hirchi, Erica Hurtado, Josep Tomàs and Maria A. Lanuza
    Citation: Cell Communication and Signaling 2024 22:371
  5. Stroke is a leading cause of mortality and long-term disability globally, with acute ischemic stroke (AIS) being the most common subtype. Despite significant advances in reperfusion therapies, their limited ti...

    Authors: Jiahao Song, Da Zhou, Lili Cui, Chuanjie Wu, Lina Jia, Mengqi Wang, Jingrun Li, Jingyuan Ya, Xunming Ji and Ran Meng
    Citation: Cell Communication and Signaling 2024 22:369
  6. Painful diabetic neuropathy (PDN) is closely linked to inflammation, which has been demonstrated to be associated with pyroptosis. Emerging evidence has implicated TANK-binding kinase 1 (TBK1) in various infla...

    Authors: Qinming Liao, Yimei Yang, Yilu Li, Jun Zhang, Keke Fan, Yihao Guo, Jun Chen, Yinhao Chen, Pian Zhu, Lijin Huang and Zhongjie Liu
    Citation: Cell Communication and Signaling 2024 22:368
  7. Colorectal cancer (CRC) is a common gastrointestinal malignancy with higher incidence and mortality rates in men compared to women, potentially due to the effects of estrogen signaling. There is substantial ev...

    Authors: Zihong Wu, Chong Xiao, Jiamei Wang, Min Zhou, Fengming You and Xueke Li
    Citation: Cell Communication and Signaling 2024 22:367
  8. Z-DNA binding protein 1 (ZBP1) is a nucleic acid sensor that is involved in multiple inflammatory diseases, but whether and how it contributes to osteoarthritis (OA) are unclear.

    Authors: Kai Sun, Fan Lu, Liangcai Hou, Xiong Zhang, Chunran Pan, Haigang Liu, Zehang Zheng, Zhou Guo, Zhaoxuan Ruan, Yanjun Hou, Jinming Zhang, Fengjing Guo and Wentao Zhu
    Citation: Cell Communication and Signaling 2024 22:366
  9. The homing of human mesenchymal stem cells (hMSCs) is crucial for their therapeutic efficacy and is characterized by the orchestrated regulation of multiple signaling modules. However, the principal upstream r...

    Authors: Dayeon Kang, Taehwan Kim, Ga-Eun Choi, Arum Park, Jin Yoon, Jinho Yu and Nayoung Suh
    Citation: Cell Communication and Signaling 2024 22:365
  10. Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide, characterized by persistent respiratory symptoms and airflow limitation. The involvement of C–C motif ...

    Authors: Yue Dong, Ying Dong, Chengyue Zhu, Lan Yang, Hanlin Wang, Junqing Li, Zixuan Zheng, Hanwei Zhao, Wanji Xie, Meiting Chen, Zhijun Jie, Jia Li, Yi Zang and Jindong Shi
    Citation: Cell Communication and Signaling 2024 22:364
  11. We previously identified Il17RB, a member of the IL17 superfamily, as a candidate marker gene for endometrial aging. While IL17RB has been linked to inflammation and malignancies in several organ systems, its ...

    Authors: Keiko Kawamura, Yumiko Matsumura, Teruhiko Kawamura, Hiromitsu Araki, Norio Hamada, Kazutaka Kuramoto, Hiroshi Yagi, Ichiro Onoyama, Kazuo Asanoma and Kiyoko Kato
    Citation: Cell Communication and Signaling 2024 22:363

    The Correction to this article has been published in Cell Communication and Signaling 2024 22:370

  12. Dihydroorotase (DHOase) is the third enzyme in the six enzymatic reaction steps of the endogenous pyrimidine nucleotide de novo biosynthesis pathway, which is a metabolic pathway conserved in both bacteria and...

    Authors: Jing-Yi Wang, Ying-Ying Cai, Lin Li, Xue-Ming Zhu, Zi-Fang Shen, Zi-He Wang, Jian Liao, Jian-Ping Lu, Xiao-Hong Liu and Fu-Cheng Lin
    Citation: Cell Communication and Signaling 2024 22:362
  13. Breast cancer is one of the most lethal cancers in women. Despite significant advances in the diagnosis and treatment of breast cancer, many patients still succumb to this disease, and thus, novel effective tr...

    Authors: Sujie Zhu, Wenjing Zhu, Kaihua Zhao, Jie Yu, Wenxia Lu, Rui Zhou, Shule Fan, Weikaixin Kong, Feifei Yang and Peipei Shan
    Citation: Cell Communication and Signaling 2024 22:361
  14. Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for activation of the autoimmunity checkpo...

    Authors: Patrick A. H. Ehm, Stefan Horn, Konstantin Hoffer, Malte Kriegs, Michael Horn, Susanne Giehler, Marcus Nalaskowski, Christoph Rehbach, Martin A. Horstmann and Manfred Jücker
    Citation: Cell Communication and Signaling 2024 22:360
  15. Bietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease caused by mutations in the CYP4V2 gene. Currently, there is no clinical therapy approach available for BCD patients. Previous resear...

    Authors: Chang Shen, Qianjie Yang, Kuangqi Chen, Huiling Ma, Xiawei Wang, Jianping Tong, Ye Shen and Hongguang Cui
    Citation: Cell Communication and Signaling 2024 22:359
  16. O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic post-translational modification (PTM) involving the covalent binding of serine and/or threonine residues, which regulates bone c...

    Authors: Shengqian Li, Wenhao Ren, Jingjing Zheng, Shaoming Li, Keqian Zhi and Ling Gao
    Citation: Cell Communication and Signaling 2024 22:358
  17. Chronic kidney disease (CKD) is highly prevalent worldwide, and its global burden is substantial and growing. CKD displays a number of features of accelerated senescence. Tubular cell senescence is a common bi...

    Authors: Qing Yin, Tao-Tao Tang, Xiao-Yu Lu, Wei-Jie Ni, Di Yin, Yi-Lin Zhang, Wei Jiang, Yue Zhang, Zuo-Lin Li, Yi Wen, Wei-Hua Gan, Ai-Qing Zhang, Lin-Li Lv, Bin Wang and Bi-Cheng Liu
    Citation: Cell Communication and Signaling 2024 22:357
  18. Stem cell-derived extracellular vesicles (EVs) are an emerging class of therapeutics with excellent biocompatibility, bioactivity and pro-regenerative capacity. One of the potential targets for EV-based medici...

    Authors: Sylwia Bobis-Wozowicz, Milena Paw, Michał Sarna, Sylwia Kędracka-Krok, Kinga Nit, Natalia Błażowska, Anna Dobosz, Ruba Hammad, Toni Cathomen, Ewa Zuba-Surma, Małgorzata Tyszka-Czochara and Zbigniew Madeja
    Citation: Cell Communication and Signaling 2024 22:356
  19. FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a common mutation type in acute myeloid leukemia (AML) and is usually associated with poor patient prognosis. With advancements in molecular...

    Authors: Chuhong Hu, Yvyin Zhang, Jie Yang, Yanli Xu, Tingfen Deng, Yumiao Li, Shilin Xu, Shunqing Wang and Peihong Wang
    Citation: Cell Communication and Signaling 2024 22:355
  20. Hyperactive neutrophil extracellular traps (NETs) formation plays a crucial role in active severe systemic lupus erythematosus (SLE). However, what triggers the imbalance in dysregulated NETs formation in SLE ...

    Authors: Yi-Ming Chen, Kuo-Tung Tang, Hung-Jen Liu, Shih-Ting Huang and Tsai-Ling Liao
    Citation: Cell Communication and Signaling 2024 22:354
  21. Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation...

    Authors: Thi Thuy Tien Vo, Tzu-Yu Peng, Thi Hong Nguyen, Trang Ngoc Huyen Bui, Ching-Shuen Wang, Wei-Ju Lee, Yuh-Lien Chen, Yang-Che Wu and I-Ta Lee
    Citation: Cell Communication and Signaling 2024 22:353
  22. In triple-negative breast cancer (TNBC) therapy, insufficient tumor infiltration by lymphocytes significantly hinders the efficacy of immune checkpoint inhibitors. We have previously demonstrated that Hainanen...

    Authors: Xiaoxi Li, Nan Su, Haining Yu, Xiaoyan Li and Shu-lan Sun
    Citation: Cell Communication and Signaling 2024 22:352
  23. Accompanied by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP release is situated upstream of inflammasome assembly and inflammation an...

    Authors: C. L. Cliff, P. E. Squires and C. E. Hills
    Citation: Cell Communication and Signaling 2024 22:351
  24. T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in growth and development but are also involved in immunity, cancer initiation, and pr...

    Authors: Siwen Li, Xiangyuan Luo, Mengyu Sun, Yijun Wang, Zerui Zhang, Junqing Jiang, Dian Hu, Jiaqian Zhang, Zhangfan Wu, Yufei Wang, Wenjie Huang and Limin Xia
    Citation: Cell Communication and Signaling 2024 22:350
  25. T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and lymphopenia were found to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While lym...

    Authors: Shaimaa Shouman, Nada El-Kholy, Alaa E. Hussien, Azza M. El-Derby, Shireen Magdy, Ahmed M. Abou-Shanab, Ahmed O. Elmehrath, Ahmad Abdelwaly, Mohamed Helal and Nagwa El-Badri
    Citation: Cell Communication and Signaling 2024 22:349
  26. Primary cilia on the surface of eukaryotic cells serve as sensory antennas for the reception and transmission in various cell signaling pathways. They are dynamic organelles that rapidly form during differenti...

    Authors: Batchingis Chinbold, Hyug Moo Kwon and Raekil Park
    Citation: Cell Communication and Signaling 2024 22:348
  27. PIWI-interacting RNA (piRNA) is the most abundant small non-coding RNA in animal cells, typically 26–31 nucleotides in length and it binds with PIWI proteins, a subfamily of Argonaute proteins. Initially disco...

    Authors: Mingye Jiang, Xiaoning Hong, Yunfei Gao, Alvin T. Kho, Kelan G. Tantisira and Jiang Li
    Citation: Cell Communication and Signaling 2024 22:347
  28. Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells that represent the interface between blood cells on one side and hepatocytes on the other side. LSECs not only form a barrier...

    Authors: Qiongyao He, Wu He, Hui Dong, Yujin Guo, Gang Yuan, Xiaoli Shi, Dingkun Wang and Fuer Lu
    Citation: Cell Communication and Signaling 2024 22:346
  29. The neonatal mammalian heart exhibits considerable regenerative potential following injury through cardiomyocyte proliferation, whereas mature cardiomyocytes withdraw from the cell cycle and lose regenerative ...

    Authors: Chao Su, Jinzheng Ma, Xuyang Yao, Wei Hao, Shihu Gan, Yixiang Gao, Jinlong He, Yuanyuan Ren, Xingjie Gao, Yi Zhu, Jie Yang and Minxin Wei
    Citation: Cell Communication and Signaling 2024 22:345
  30. Tumor cells release extracellular vesicles (EVs) that contribute to the polarization of macrophages towards tumor-associated macrophages (TAMs). High expression levels of the RNA binding protein IGF2BP2/IMP2 a...

    Authors: Vida Mashayekhi, Annika Schomisch, Sari Rasheed, Ernesto Aparicio-Puerta, Timo Risch, Daniela Yildiz, Marcus Koch, Simon Both, Nicole Ludwig, Thierry M. Legroux, Andreas Keller, Rolf Müller, Gregor Fuhrmann, Jessica Hoppstädter and Alexandra K. Kiemer
    Citation: Cell Communication and Signaling 2024 22:344
  31. Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in regulating mitochondrial transcription and oxidative phospho...

    Authors: Meng-Jia Huan, Ping-ping Fu, Xia Chen, Zhao-Xia Wang, Zhou-rui Ma, Shi-zhong Cai, Qin Jiang and Qian Wang
    Citation: Cell Communication and Signaling 2024 22:343
  32. Mechanical unloading of the knee articular cartilage results in cartilage matrix atrophy, signifying the osteoarthritic-inductive potential of mechanical unloading. In contrast, mechanical loading stimulates c...

    Authors: Zhiyao Ma, David Xinzheyang Li, Xiaoyi Lan, Adam Bubelenyi, Margaret Vyhlidal, Melanie Kunze, Mark Sommerfeldt and Adetola B. Adesida
    Citation: Cell Communication and Signaling 2024 22:342
  33. Pseudomonas aeruginosa (PA) is an opportunistic pathogen that can cause sight threatening infections in the eye and fatal infections in the cystic fibrosis airway. Extracellular vesicles (EVs) are released by hos...

    Authors: Rajalakshmy Ayilam Ramachandran, Andrew Lemoff and Danielle M. Robertson
    Citation: Cell Communication and Signaling 2024 22:341
  34. Triple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breast cancer. A high circulating neutrophil-to-lymphocyte ratio (NLR) is strongly linked to...

    Authors: Chenghui Yang, Lili Li, Zhiqiang Ye, Anqi Zhang, Yunjia Bao, Xue Wu, Guohong Ren, Chao Jiang, Ouchen Wang and Zhen Wang
    Citation: Cell Communication and Signaling 2024 22:340
  35. Endocrine resistance driven by sustained activation of androgen receptor (AR) signaling pathway in advanced prostate cancer (PCa) is fatal. Characterization of mechanisms underlying aberrant AR pathway activat...

    Authors: Jiajia Wang, Hui Liu, Zeyuan Yu, Qianqian Zhou, Feifei Sun, Jingying Han, Lin Gao, Baokai Dou, Hanwen Zhang, Jiawei Fu, Wenqiao Jia, Weiwen Chen, Jing Hu and Bo Han
    Citation: Cell Communication and Signaling 2024 22:339
  36. Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor expressed predominantly in NK and T-cell subsets that downregulates the activation and proliferation of immune cells and participate...

    Authors: Yakun Zhang, Shuang Chen, Xinyi Tang, Yu Peng, Tingting Jiang, Xiaomei Zhang, Jun Li, Yao Liu and Zailin Yang
    Citation: Cell Communication and Signaling 2024 22:337
  37. Excessive scar formation such as hypertrophic scars and keloids, resulting from trauma or surgical procedures, present a widespread concern for causing disfigurement, discomfort, and functional limitations. Ma...

    Authors: Julei Zhang, Zeliang He, Chenlu Xiong, Yuanyuan Yao, Chengliang Zhang, Wende Yao, Sihan Yang, Xiaodong Li and Yan Han
    Citation: Cell Communication and Signaling 2024 22:336
  38. Kappa opioid receptor (KOR) signaling is involved in joint development and inflammation in Osteoarthritis (OA), while the biochemical mechanism remains unclarified. This study aims to investigate downstream mo...

    Authors: Haixia Liu, Renhuan Huang, Ziang Zhuo, Xinru Zhang, Ling Wu, Zhen Guo, Fuping Wen, Liwei An, Hang Yuan, Yiming Zhang and Yuanzhi Xu
    Citation: Cell Communication and Signaling 2024 22:335
  39. Balloon flower root-derived exosome-like nanoparticles (BDEs) have recently been proposed as physiologically active molecules with no cytotoxicity. However, the therapeutic effects of drug-induced hepatotoxici...

    Authors: Jisu Kim, Chao Gao, Pengcheng Guo, Jianyong Sheng and Jianxin Wang
    Citation: Cell Communication and Signaling 2024 22:334
  40. Glioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis even under the current first-line treatment, with a 5-year survival rate less than 7%. Therefore, it is important to under...

    Authors: Tingyu Liang, Lingui Gu, Xiaoman Kang, Junlin Li, Yixuan Song, Yu Wang and Wenbin Ma
    Citation: Cell Communication and Signaling 2024 22:333
  41. HRASKO/NRASKO double knockout mice exhibit exceedingly high rates of perinatal lethality due to respiratory failure caused by a significant lung maturation delay. The few animals that reach adulthood have a norma...

    Authors: Rocío Fuentes-Mateos, Rósula García-Navas, Cristina Fernández-Infante, Luis Hernández-Cano, Nuria Calzada-Nieto, Andrea Olarte-San Juan, Carmen Guerrero, Eugenio Santos and Alberto Fernández-Medarde
    Citation: Cell Communication and Signaling 2024 22:332
  42. Biomechanical attributes have emerged as novel markers, providing a reliable means to characterize cellular and subcellular fractions. Numerous studies have identified correlations between these factors and pa...

    Authors: Behrouz Aghajanloo, Hanieh Hadady, Fatemeh Ejeian, David W. Inglis, Michael Pycraft Hughes, Alireza Fadaei Tehrani and Mohammad Hossein Nasr-Esfahani
    Citation: Cell Communication and Signaling 2024 22:331
  43. Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously inhibiting the opposite pathway. In mice, the WNT/β-catenin...

    Authors: Malene Lundgaard Riis, Gaspard Delpouve, John E. Nielsen, Cecilie Melau, Lea Langhoff Thuesen, Kristine Juul Hare, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Jakob Albrethsen, Hanne Frederiksen, Anders Juul, Paolo Giacobini and Anne Jørgensen
    Citation: Cell Communication and Signaling 2024 22:330
  44. Respiratory disorders are among the conditions that affect the respiratory system. The healthcare sector faces challenges due to the emergence of drug resistance to prescribed medications for these illnesses. ...

    Authors: Bashdar Mahmud Hussen, Zana Baqi Najmadden, Snur Rasool Abdullah, Mohammed Fatih Rasul, Suhad A. Mustafa, Soudeh Ghafouri-Fard and Mohammad Taheri
    Citation: Cell Communication and Signaling 2024 22:329
  45. Authors: Xiyue Huang, Xiao Yang, Jinglin Huang, Ling Wei, Yanhua Mao, Changjiang Li, Yingfeng Zhang, Qiuhong Chen, Shasha Wu, Lele Xie, Congcong Sun, Wenwen Zhang and Jia Wang
    Citation: Cell Communication and Signaling 2024 22:326

    The original article was published in Cell Communication and Signaling 2024 22:301

  46. Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will in...

    Authors: Qihong Yang, Kenneth Kin Wah To, Guilin Hu, Kai Fu, Chuan Yang, Shuangli Zhu, Can Pan, Fang Wang, Kewang Luo and Liwu Fu
    Citation: Cell Communication and Signaling 2024 22:325

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  • Citation Impact 2023
    Journal Impact Factor: 8.2
    5-year Journal Impact Factor: 8.0
    Source Normalized Impact per Paper (SNIP): 1.569
    SCImago Journal Rank (SJR): 2.308

    Speed 2023
    Submission to first editorial decision (median days): 5
    Submission to acceptance (median days): 83

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