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  1. Research

    Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

    Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel invol...

    Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, F. Kelly Galbraith Kawabata, David Horgen, Toshihiko Kawamori, Reinhold Penner and Andrea Fleig

    Cell Communication and Signaling 2017 15:30

    Published on: 15 August 2017

  2. Research

    Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

    C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-termina...

    Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin and Heung-Chin Cheng

    Cell Communication and Signaling 2017 15:29

    Published on: 7 August 2017

  3. Research

    Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia

    Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunit...

    Kirsten Bucher, Fee Schmitt, Benedikt Mothes, Carolin Blumendeller, Daniel Schäll, Roland Piekorz, Emilio Hirsch, Bernd Nürnberg and Sandra Beer-Hammer

    Cell Communication and Signaling 2017 15:28

    Published on: 19 July 2017

  4. Review

    Viral manipulation of the cellular sumoylation machinery

    Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has em...

    Angela J. Lowrey, Wyatt Cramblet and Gretchen L. Bentz

    Cell Communication and Signaling 2017 15:27

    Published on: 14 July 2017

  5. Research

    Glyceollins trigger anti-proliferative effects through estradiol-dependent and independent pathways in breast cancer cells

    Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract....

    Sylvain Lecomte, Frederic Chalmel, François Ferriere, Frederic Percevault, Nicolas Plu, Christian Saligaut, Claire Surel, Marie Lelong, Theo Efstathiou and Farzad Pakdel

    Cell Communication and Signaling 2017 15:26

    Published on: 30 June 2017

  6. Research

    Fibroblast growth factor 2 supports osteoblastic niche cells during hematopoietic homeostasis recovery after bone marrow suppression

    Hematopoietic stem cell (HSC) maintenance requires a specific microenvironment. HSC niches can be activated by tissue damaging chemotherapeutic drugs and various cell signaling molecules such as SDF-1 and FGF,...

    Kyung-Ae Yoon, YeonSung Son, Young-Jin Choi, Joo-Hyun Kim and Je-Yoel Cho

    Cell Communication and Signaling 2017 15:25

    Published on: 29 June 2017

  7. Review

    The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells

    The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarizati...

    Farhad Seif, Majid Khoshmirsafa, Hossein Aazami, Monireh Mohsenzadegan, Gholamreza Sedighi and Mohammadali Bahar

    Cell Communication and Signaling 2017 15:23

    Published on: 21 June 2017

  8. Research

    Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells

    In mammalian intestines, Notch signaling plays a critical role in mediating cell fate decisions; it promotes the absorptive (or enterocyte) cell fate, while concomitantly inhibiting the secretory cell fate (i....

    Shaiya C. Robinson, Kristina Klobucar, Christina C. Pierre, Amna Ansari, Svetlana Zhenilo, Egor Prokhortchouk and Juliet M. Daniel

    Cell Communication and Signaling 2017 15:24

    Published on: 21 June 2017

  9. Short report

    Identification of EGF-NF-κB-FOXC1 signaling axis in basal-like breast cancer

    The pathogenesis of human basal-like breast cancer (BLBC) is not well understood and patients with BLBC have a poor prognosis. Expression of the epidermal growth factor receptor (EGFR) and nuclear factor-κB (N...

    Stacey Chung, Yanli Jin, Bingchen Han, Ying Qu, Bowen Gao, Armando E. Giuliano and Xiaojiang Cui

    Cell Communication and Signaling 2017 15:22

    Published on: 19 June 2017

  13. Research

    DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion

    Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms hav...

    You-Take Oh, Ping Yue and Shi-Yong Sun

    Cell Communication and Signaling 2017 15:18

    Published on: 8 May 2017

  14. Research

    Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line

    There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attr...

    Paola Ortiz-Montero, Arturo Londoño-Vallejo and Jean-Paul Vernot

    Cell Communication and Signaling 2017 15:17

    Published on: 4 May 2017

  15. Research

    The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

    Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One import...

    Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher and Sebastian Heikaus

    Cell Communication and Signaling 2017 15:16

    Published on: 2 May 2017

  16. Review

    From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases

    Infections with the human pathogen Helicobacter pylori (H. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. Drastic changes in...

    Silja Wessler, Linda M. Krisch, Dominik P. Elmer and Fritz Aberger

    Cell Communication and Signaling 2017 15:15

    Published on: 20 April 2017

  17. Research

    TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells

    Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA se...

    Fabia Fricke, Jennifer Lee, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Meggy Suarez-Carmona, Niels Halama, Martina Schnölzer, Jürgen Kopitz and Johannes Gebert

    Cell Communication and Signaling 2017 15:14

    Published on: 4 April 2017

  18. Review

    The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation

    Hypomethylating agents (HMAs) have been widely used over the last decade, approved for use in myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). The propos...

    Florian Wolff, Michael Leisch, Richard Greil, Angela Risch and Lisa Pleyer

    Cell Communication and Signaling 2017 15:13

    Published on: 31 March 2017

  19. Review

    Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?

    Cancer represents heterogeneous and aberrantly proliferative manifestations composed of (epi)genetically and phenotypically distinct cells with a common clonal origin. Cancer stem cells (CSC) make up a rare su...

    Wolfgang Gruber, Tamara Scheidt, Fritz Aberger and Christian G. Huber

    Cell Communication and Signaling 2017 15:12

    Published on: 29 March 2017

  22. Research

    Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin

    Translationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. TCTP may be involved in protec...

    Ulrich-Axel Bommer, Kara L. Vine, Prianka Puri, Martin Engel, Lisa Belfiore, Karen Fildes, Marijka Batterham, Alistair Lochhead and Morteza Aghmesheh

    Cell Communication and Signaling 2017 15:9

    Published on: 1 February 2017

  23. Review

    Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling

    Treatment of acute myeloid leukemia (AML), an aggressive and heterogeneous hematological malignancy, remains a challenge. Despite advances in our understanding of the complex genetics and biology of AML pathop...

    Fritz Aberger, Evelyn Hutterer, Christina Sternberg, Pedro J. del Burgo and Tanja N. Hartmann

    Cell Communication and Signaling 2017 15:8

    Published on: 25 January 2017

  24. Review

    The Id-protein family in developmental and cancer-associated pathways

    Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif. During development, th...

    Cornelia Roschger and Chiara Cabrele

    Cell Communication and Signaling 2017 15:7

    Published on: 25 January 2017

  25. Research

    Unraveling the regulation of mTORC2 using logical modeling

    The mammalian target of rapamycin (mTOR) is a regulator of cell proliferation, cell growth and apoptosis working through two distinct complexes: mTORC1 and mTORC2. Although much is known about the activation a...

    Kirsten Thobe, Christine Sers and Heike Siebert

    Cell Communication and Signaling 2017 15:6

    Published on: 19 January 2017

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