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  1. Relapsed leukemia following initial therapeutic response and remission is difficult to treat and causes high patient mortality. Leukemia relapse is due to residual quiescent leukemia cells that escape conventi...

    Authors: Bi Liu, Yunzhu Shen, Huafang Huang, Kimiko Della Croce, Min Wu, Yingjuan Fan, Yang Liu, Jianhua Xu and Guang Yao

    Citation: Cell Communication and Signaling 2020 18:159

    Content type: Research

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  2. Extracellular vesicles (EVs) are lipid-bound particles that are naturally released from cells and mediate cell-cell communication. Integrin adhesion receptors are enriched in small EVs (SEVs) and SEV-carried i...

    Authors: Wanessa F. Altei, Bianca C. Pachane, Patty K. dos Santos, Lígia N. M. Ribeiro, Bong Hwan Sung, Alissa M. Weaver and Heloisa S. Selistre-de-Araújo

    Citation: Cell Communication and Signaling 2020 18:158

    Content type: Research

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  3. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in China. The lack of an effective treatment for this disease results in a high recurrence rate in patients who undergo radic...

    Authors: Benfan Wang, Qinyan Li, Jinyan Wang, Siting Zhao, Bayaer Nashun, Li Qin and Xiaoping Chen

    Citation: Cell Communication and Signaling 2020 18:157

    Content type: Research

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  4. Targeted therapy with BRAF and MEK inhibitors has improved the survival of patients with BRAF-mutated metastatic melanoma, but most patients relapse upon the onset of drug resistance induced by mechanisms incl...

    Authors: Elisabetta Vergani, Matteo Dugo, Mara Cossa, Simona Frigerio, Lorenza Di Guardo, Gianfrancesco Gallino, Ilaria Mattavelli, Barbara Vergani, Luca Lalli, Elena Tamborini, Barbara Valeri, Chiara Gargiuli, Eriomina Shahaj, Marina Ferrarini, Elisabetta Ferrero, Macarena Gomez Lira…

    Citation: Cell Communication and Signaling 2020 18:156

    Content type: Research

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  5. Thrombospondin-1 (TSP-1), a Ca2+-binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical conditions. Signaling involving TSP-1, through its co...

    Authors: Rosi Bissinger, Polina Petkova-Kirova, Olga Mykhailova, Per-Arne Oldenborg, Elena Novikova, David A. Donkor, Thomas Dietz, Abdulla Al Mamun Bhuyan, William P. Sheffield, Marijke Grau, Ferruh Artunc, Lars Kaestner, Jason P. Acker and Syed M. Qadri

    Citation: Cell Communication and Signaling 2020 18:155

    Content type: Research

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  6. Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable meta...

    Authors: Shaymaa Bahnassy, Hariprasad Thangavel, Maram Quttina, Ashfia Fatima Khan, Dhanya Dhanyalayam, Joan Ritho, Samaneh Karami, Jing Ren and Tasneem Bawa-Khalfe

    Citation: Cell Communication and Signaling 2020 18:154

    Content type: Research

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  7. Rabies virus (RABV) is reported to encode five phosphoproteins (P), which are involved in viral genomic replication, axonal transport, oxidative stress, interferon antagonism, and autophagy induction. However,...

    Authors: Juan Liu, Min Liao, Yan Yan, Hui Yang, Hailong Wang and Jiyong Zhou

    Citation: Cell Communication and Signaling 2020 18:153

    Content type: Research

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  8. Radioresistance is a major challenge in lung cancer radiotherapy, and new radiosensitizers are urgently needed. Estrogen receptor β (ERβ) is involved in the progression of non-small cell lung cancer (NSCLC), h...

    Authors: Hang Li, Jun Che, Mian Jiang, Ming Cui, Guoxing Feng, Jiali Dong, Shuqin Zhang, Lu Lu, Weili Liu and Saijun Fan

    Citation: Cell Communication and Signaling 2020 18:152

    Content type: Research

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  9. Hepatic fibrosis is a pathological response of the liver to a variety of chronic stimuli. Hepatic stellate cells (HSCs) are the major source of myofibroblasts in the liver. Follistatin like 1 (Fstl1) is a secr...

    Authors: Xin-Yi Xu, Yan Du, Xue Liu, Yilin Ren, Yingying Dong, Hong-Yu Xu, Jin-Song Shi, Dianhua Jiang, Xin Xu, Lian Li, Zheng-Hong Xu and Yan Geng

    Citation: Cell Communication and Signaling 2020 18:151

    Content type: Research

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  10. Target therapies based on BRAF and MEK inhibitors (MAPKi) have changed the therapeutic landscape for metastatic melanoma patients bearing mutations in the BRAF kinase. However, the emergence of drug resistance...

    Authors: Luigi Fattore, Debora Malpicci, Ciro Milite, Sabrina Castellano, Gianluca Sbardella, Gerardo Botti, Paolo A. Ascierto, Rita Mancini and Gennaro Ciliberto

    Citation: Cell Communication and Signaling 2020 18:150

    Content type: Short report

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  11. Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are wid...

    Authors: Kasra Asgarpour, Zahra Shojaei, Fatemeh Amiri, Jafar Ai, Maryam Mahjoubin-Tehran, Faezeh Ghasemi, Reza ArefNezhad, Michael R. Hamblin and Hamed Mirzaei

    Citation: Cell Communication and Signaling 2020 18:149

    Content type: Review

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  12. LOX-like 1 (LOXL1) is a lysyl oxidase, and emerging evidence has revealed its effect on malignant cancer progression. However, its role in colorectal cancer (CRC) and the underlying molecular mechanisms have n...

    Authors: Lin Hu, Jing Wang, Yunliang Wang, Linpeng Wu, Chao Wu, Bo Mao, E. Maruthi Prasad, Yuhong Wang and Y. Eugene Chin

    Citation: Cell Communication and Signaling 2020 18:148

    Content type: Research

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  13. Deficiency of mitochondrial sirtuin 3 (SIRT3), a NAD+-dependent protein deacetylase that maintains redox status and lipid homeostasis, contributes to hepatic steatosis. In this study, we investigated additional m...

    Authors: Emma Barroso, Rosalía Rodríguez-Rodríguez, Mohammad Zarei, Javier Pizarro-Degado, Anna Planavila, Xavier Palomer, Francesc Villarroya and Manuel Vázquez-Carrera

    Citation: Cell Communication and Signaling 2020 18:147

    Content type: Research

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  14. Lung cancer is the second most commonly occurring cancer. The ability to metastasize and spread to distant locations renders the tumor more aggressive. Members of the Rho subfamily of small GTP-binding protein...

    Authors: Maria Al Haddad, Rayane El-Rif, Samer Hanna, Leila Jaafar, Rayanne Dennaoui, Sandra Abdellatef, Veronika Miskolci, Dianne Cox, Louis Hodgson and Mirvat El-Sibai

    Citation: Cell Communication and Signaling 2020 18:144

    Content type: Research

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  15. Mesenchymal-like stemness is characterized by epithelial-mesenchymal transition (EMT). Breast cancer (BC) cell mesenchymal-like stemness is responsible for distal lung metastasis. Interrogation of databases sh...

    Authors: Ping Yin, Yu Bai, Zhuo Wang, Yu Sun, Jian Gao, Lei Na, Zhongbo Zhang, Wei Wang and Chenghai Zhao

    Citation: Cell Communication and Signaling 2020 18:143

    Content type: Research

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  16. Inhibitors targeting immune checkpoint were proved effective in cancer immunotherapy, such as PD-1/PD-L1 blockade. The novel immune checkpoint TIGIT/PVR plays critical roles in suppressing the anti-tumor effec...

    Authors: Xiuman Zhou, Jiangfeng Du, Hongfei Wang, Chunxia Chen, Ling Jiao, Xiangrui Cheng, Xiaowen Zhou, Shaomeng Chen, Shanshan Gou, Wenshan Zhao, Wenjie Zhai, Junhui Chen and Yanfeng Gao

    Citation: Cell Communication and Signaling 2020 18:142

    Content type: Research

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  17. Low molecular weight carrageenan (Cg) is a seaweed-derived sulfated polysaccharide widely used as inflammatory stimulus in preclinical studies. However, the molecular mechanisms of Cg-induced inflammation are ...

    Authors: Alexandre H. Lopes, Rangel L. Silva, Miriam D. Fonseca, Francisco I. Gomes, Alexandre G. Maganin, Lucas S. Ribeiro, Lucas Maciel Mauriz Marques, Fernando Q. Cunha, Jose C. Alves-Filho, Dario S. Zamboni, Norberto P. Lopes, Bernardo S. Franklin, Aurélie Gombault, Fernando Silva Ramalho, Valerie F. J. Quesniaux, Isabelle Couillin…

    Citation: Cell Communication and Signaling 2020 18:141

    Content type: Research

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  18. Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a toxic “gain-of-function” inflammation in the liver associated with intracellular retention of mutant alpha-1 antitrypsin. The clinical presenta...

    Authors: Nazli Khodayari, Regina Oshins, L. Shannon Holliday, Virginia Clark, Qiang Xiao, George Marek, Borna Mehrad and Mark Brantly

    Citation: Cell Communication and Signaling 2020 18:140

    Content type: Research

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  19. Venous malformations (VMs), most of which associated with activating mutations in the endothelial cells (ECs) tyrosine kinase receptor TIE2, are characterized by dilated and immature veins with scarce smooth m...

    Authors: Yameng Si, Jiadong Huang, Xiang Li, Yu Fu, Rongyao Xu, Yifei Du, Jie Cheng and Hongbing Jiang

    Citation: Cell Communication and Signaling 2020 18:139

    Content type: Research

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  20. Polycystin-2 (TRPP2) is a Ca2+ permeable nonselective cationic channel essential for maintaining physiological function in live cells. Stromal interaction molecule 1 (STIM1) is an important Ca2+ sensor in store-o...

    Authors: Jizheng Guo, Ren Zhao, Muyao Zhou, Jie Li, Xiaoqiang Yao, Juan Du, Jiexia Chen and Bing Shen

    Citation: Cell Communication and Signaling 2020 18:138

    Content type: Research

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  21. The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates. These substrates include, but are not limited to...

    Authors: Trevor P. Creamer

    Citation: Cell Communication and Signaling 2020 18:137

    Content type: Review

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  22. Metabolites produced via traditional biochemical processes affect intracellular communication, inflammation, and malignancy. Unexpectedly, acetyl-CoA, α-ketoglutarate and palmitic acid, which are chemical spec...

    Authors: Ioannis Skalidis, Christian Tüting and Panagiotis L. Kastritis

    Citation: Cell Communication and Signaling 2020 18:136

    Content type: Review

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  23. Glioma stem cells (GSCs) are glioma cells with stemness and are responsible for a variety of malignant behaviors of glioma. Evidence has shown that signals from tumor microenvironment (TME) enhance stemness of...

    Authors: Jian Zang, Min-Hua Zheng, Xiu-Li Cao, Yi-Zhe Zhang, Yu-Fei Zhang, Xiang-Yu Gao, Yuan Cao, Mei Shi, Hua Han and Liang Liang

    Citation: Cell Communication and Signaling 2020 18:135

    Content type: Research

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  24. Chimeric Antigen Receptor (CAR) immunotherapy utilizes genetically-engineered immune cells that express a unique cell surface receptor that combines tumor antigen specificity with immune cell activation. In re...

    Authors: Dongfang Liu, Saiaditya Badeti, Gianpietro Dotti, Jie-gen Jiang, He Wang, James Dermody, Patricia Soteropoulos, Deanna Streck, Raymond B. Birge and Chen Liu

    Citation: Cell Communication and Signaling 2020 18:134

    Content type: Review

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  25. Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the inside of cells. Remarkably, they orchestrate key biological processes...

    Authors: Pernille Seiffert, Katrine Bugge, Mads Nygaard, Gitte W. Haxholm, Jacob H. Martinsen, Martin N. Pedersen, Lise Arleth, Wouter Boomsma and Birthe B. Kragelund

    Citation: Cell Communication and Signaling 2020 18:132

    Content type: Research

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  26. Metabolic reprogramming, in which energetic metabolism changes from oxidative phosphorylation to glycolysis, is well-accepted as a hallmark of cancers including hepatocellular carcinoma (HCC). A growing body o...

    Authors: Chuanzong Zhao, Ben Wang, Enyu Liu and Zongli Zhang

    Citation: Cell Communication and Signaling 2020 18:131

    Content type: Research

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  27. Exosomes are extracellular vesicles containing a variety of biological molecules including microRNAs (miRNAs). We have recently demonstrated that certain miRNA species are selectively and highly enriched in pa...

    Authors: Yi-Fan Xu, Xiaohui Xu, Amy Gin, Jean D. Nshimiyimana, Blaine H. M. Mooers, Massimo Caputi, Bethany N. Hannafon and Wei-Qun Ding

    Citation: Cell Communication and Signaling 2020 18:130

    Content type: Research

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  28. Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage both αvβ3 integrin and Syndecan-4 expressed on the su...

    Authors: Alejandra Valdivia, Areli Cárdenas, Marianne Brenet, Horacio Maldonado, Milene Kong, Jorge Díaz, Keith Burridge, Pascal Schneider, Alejandra San Martín, Rafael García-Mata, Andrew F. G. Quest and Lisette Leyton

    Citation: Cell Communication and Signaling 2020 18:129

    Content type: Research

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  29. The activation of the NF-κB pathway plays a crucial role in the progression of breast cancer (BCa) and also involved in endocrine therapy resistance. On the contrary to the canonical NF-κB pathway, the effect ...

    Authors: Mei Wang, Yanyan Zhang, Zhi Xu, Peipei Qian, Wenbo Sun, Xiumei Wang, Zhang Jian, Tiansong Xia, Yong Xu and Jinhai Tang

    Citation: Cell Communication and Signaling 2020 18:128

    Content type: Research

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  30. Bladder cancer (BCa) is a frequent urothelial malignancy with a high ratio of morbidity and mortality. Various genetic and environmental factors are involved in BCa progression. Since, majority of BCa cases ar...

    Authors: Amir Sadra Zangouei, Amir Hossein Barjasteh, Hamid Reza Rahimi, Majid Mojarrad and Meysam Moghbeli

    Citation: Cell Communication and Signaling 2020 18:127

    Content type: Review

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  31. Current pharmacological therapies and treatments targeting pancreatic neuroendocrine tumors (PNETs) have proven ineffective, far too often. Therefore, there is an urgent need for alternative therapeutic approa...

    Authors: Dexter L. Puckett, Mohammed Alquraishi, Dina Alani, Samah Chahed, Dallas Donohoe, Brynn Voy, Jay Whelan and Ahmed Bettaieb

    Citation: Cell Communication and Signaling 2020 18:126

    Content type: Research

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  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang and Yong-gang Shi

    Citation: Cell Communication and Signaling 2020 18:125

    Content type: Correction

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    The original article was published in Cell Communication and Signaling 2019 17:142

  33. The metabolic syndrome (MetS) is a combination of cardiovascular risk-factors, including obesity, hypertension, hyperglycemia, and insulin resistance. MetS may induce senescence in mesenchymal stem/stromal cel...

    Authors: Yongxin Li, Yu Meng, Xiangyang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Alfonso Eirin and Lilach O. Lerman

    Citation: Cell Communication and Signaling 2020 18:124

    Content type: Research

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  34. Neurodegeneration is a representative phenotype of patients with chronic alcoholism. Ethanol-induced calcium overload causes NOD-like receptor protein 3 (NLRP3) inflammasome formation and an imbalance in mitoc...

    Authors: Jae Ryong Lim, Hyun Jik Lee, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Seo Yihl Kim and Ho Jae Han

    Citation: Cell Communication and Signaling 2020 18:123

    Content type: Research

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  35. Multivesicular bodies (MVBs) are endosome organelles that are gradually attracting research attention. Initially, MVBs were considered as important components of the endosomal-lysosomal degradation pathway. In...

    Authors: Xueqiang Peng, Liang Yang, Yingbo Ma, Yan Li and Hangyu Li

    Citation: Cell Communication and Signaling 2020 18:122

    Content type: Review

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  36. The PIM family kinases promote cancer cell survival and motility as well as metastatic growth in various types of cancer. We have previously identified several PIM substrates, which support cancer cell migrati...

    Authors: Niina M. Santio, Veera Vainio, Tuuli Hoikkala, Kwan Long Mung, Mirka Lång, Riitta Vahakoski, Justyna Zdrojewska, Eleanor T. Coffey, Elena Kremneva, Eeva-Marja Rainio and Päivi J. Koskinen

    Citation: Cell Communication and Signaling 2020 18:121

    Content type: Research

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  37. Malignant gliomas are the most common and deadly type of central nervous system tumors. Despite some advances in treatment, the mean survival time remains only about 1.25 years. Even after surgery, radiotherap...

    Authors: Amir B. Ghaemmaghami, Maryam Mahjoubin-Tehran, Ahmad Movahedpour, Korosh Morshedi, Amirhossein Sheida, Seyed Pouya Taghavi, Hamed Mirzaei and Michael R. Hamblin

    Citation: Cell Communication and Signaling 2020 18:120

    Content type: Review

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  38. Exosomes have been considered as novel and potent vehicles of intercellular communication, instead of “cell dust”. Exosomes are consistent with anucleate cells, and organelles with lipid bilayer consisting of ...

    Authors: Wei Wang, Neng Zhu, Tao Yan, Ya-Ning Shi, Jing Chen, Chan-Juan Zhang, Xue-Jiao Xie, Duan-Fang Liao and Li Qin

    Citation: Cell Communication and Signaling 2020 18:119

    Content type: Review

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  39. The term mesenchymal stromal cells (MSCs) designates an assorted cell population comprised of stem cells, progenitor cells, fibroblasts, and stromal cells. MSCs contribute to the homeostatic maintenance of man...

    Authors: Serife Ayaz-Guner, Nicola Alessio, Mustafa B. Acar, Domenico Aprile, Servet Özcan, Giovanni Di Bernardo, Gianfranco Peluso and Umberto Galderisi

    Citation: Cell Communication and Signaling 2020 18:118

    Content type: Research

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  40. Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within th...

    Authors: Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong and Masahiko Negishi

    Citation: Cell Communication and Signaling 2020 18:117

    Content type: Research

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  41. Aberrant activation of the Hedgehog (Hh) signaling pathway is frequently observed in hepatocellular carcinoma (HCC), nevertheless, the precise molecular mechanism remains unclear. Forkhead box M1 (FOXM1), a ta...

    Authors: Yiting Wang, Hailong Wang, Zhengwei Yan, Guohua Li, Guohui Hu, Hong Zhang, Dengliang Huang, Yao Wang, Xiang Zhang, Yehong Yan, Quqin Lu, Minzhang Cheng and Shiwen Luo

    Citation: Cell Communication and Signaling 2020 18:116

    Content type: Research

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  42. Colorectal cancer (CRC) is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies (both acquired and intrinsic), owing to the amplification or mutation of the KRAS oncogene. However...

    Authors: Hua Ye, Yi Liu, Kefeng Wu, Hui Luo and Liao Cui

    Citation: Cell Communication and Signaling 2020 18:115

    Content type: Research

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  43. Progression of Colorectal cancer (CRC) is influenced by single or compounded environmental factors. Accumulating evidence shows that microbiota can influence the outcome of cancer immunotherapy. T cell, one of...

    Authors: Hua Sui, Lu Zhang, Kaijuan Gu, Ni Chai, Qing Ji, Lihong Zhou, Yan Wang, Junze Ren, Limei Yang, Bimeng Zhang, Jing Hu and Qi Li

    Citation: Cell Communication and Signaling 2020 18:113

    Content type: Research

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  44. Many cancers evade immune surveillance by overexpressing PD-L1. PD-L1 interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation and thereafter cancer cell death mediated ...

    Authors: Yu Wang, Qingguo Sun, Ning Mu, Xiaoyang Sun, Yingying Wang, Songqing Fan, Ling Su and Xiangguo Liu

    Citation: Cell Communication and Signaling 2020 18:112

    Content type: Research

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  45. Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are both reversible processes, and regulation of phenotypical transition is very important for progression of several c...

    Authors: Hande Topel, Ezgi Bagirsakci, Dehan Comez, Gulsun Bagci, Gulcin Cakan-Akdogan and Nese Atabey

    Citation: Cell Communication and Signaling 2020 18:110

    Content type: Research

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