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  1. Content type: Research

    Cancer cells undergo global reprogramming of cellular metabolism to satisfy demands of energy and biomass during proliferation and metastasis. Computational modeling of genome-scale metabolic models is an effe...

    Authors: Ziwei Dai, Shiyu Yang, Liyan Xu, Hongrong Hu, Kun Liao, Jianghuang Wang, Qian Wang, Shuaishi Gao, Bo Li and Luhua Lai

    Citation: Cell Communication and Signaling 2019 17:124

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  2. Content type: Research

    The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular ...

    Authors: Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Groß, Anette Kaiser and Simone Prömel

    Citation: Cell Communication and Signaling 2019 17:123

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  3. Content type: Research

    Prostate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease. ABI1, a memb...

    Authors: Disharee Nath, Xiang Li, Claudia Mondragon, Dawn Post, Ming Chen, Julie R. White, Anita Hryniewicz-Jankowska, Tiffany Caza, Vladimir A. Kuznetsov, Heidi Hehnly, Tamara Jamaspishvili, David M. Berman, Fan Zhang, Sonia H. Y. Kung, Ladan Fazli, Martin E. Gleave…

    Citation: Cell Communication and Signaling 2019 17:120

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  4. Content type: Research

    The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα, part of the GPIb-IX-V complex, has several physiolog...

    Authors: Stephanie Makhoul, Katharina Trabold, Stepan Gambaryan, Stefan Tenzer, Daniele Pillitteri, Ulrich Walter and Kerstin Jurk

    Citation: Cell Communication and Signaling 2019 17:122

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  5. Content type: Review

    Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate of metastasis and low rate of survival. Despite the advances in understanding this devastating disease, PC still accounts for 3% o...

    Authors: Jiang-Jiang Qin, Xiang-Dong Cheng, Jia Zhang and Wei-Dong Zhang

    Citation: Cell Communication and Signaling 2019 17:121

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  6. Content type: Research

    Stromal-derived CXCL12 play an important role which influence the proliferation and invasiveness of colon cancer in microenvironment. The present study aimed to analyze the underlying mechanism by which CXCL12...

    Authors: Jiachi Ma, Xiaowen Sun, Yimin Wang, Bangling Chen, Liyu Qian and Yaguo Wang

    Citation: Cell Communication and Signaling 2019 17:119

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  7. Content type: Research

    Mechanisms driving the progression of castration-resistant prostate cancer are believed to relate substantially to the tumor microenvironment. However, the cross-talks between tumor epithelial cell, stromal ce...

    Authors: Yongning Lu, Baijun Dong, Fan Xu, Yunze Xu, Jiahua Pan, Jiajia Song, Jin Zhang, Yiran Huang and Wei Xue

    Citation: Cell Communication and Signaling 2019 17:118

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  8. Content type: Short report

    Cryptococcus neoformans (C. neoformans) is an encapsulated budding yeast that causes life-threatening meningoencephalitis in immunocompromised individuals, especially those with acquired immunodeficiency syndrome...

    Authors: Xiaofan Yang, Huijuan Wang, Fan Hu, Xichen Chen and Mingshun Zhang

    Citation: Cell Communication and Signaling 2019 17:117

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  9. Content type: Review

    Ventricular Zone Expressed PH Domain-Containing 1 (VEPH1) is an 833-amino acid protein encoded by an evolutionarily conserved single-copy gene that emerged with pseudocoelomates. This gene has no paralog in an...

    Authors: Theodore J. Brown, Alexandra Kollara, Premalatha Shathasivam and Maurice J. Ringuette

    Citation: Cell Communication and Signaling 2019 17:116

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  10. Content type: Research

    Gastric cancer (GC) has high incidence and mortality worldwide. However, the underlying mechanisms that regulate gastric carcinogenesis are largely undefined. 4.1B is an adaptor protein found at the interface ...

    Authors: Fumin Xue, Chao An, Lixiang Chen, Gang Liu, Feifei Ren, Xinhua Guo, Haibin Sun, Lu Mei, Xiangdong Sun, Jinpeng Li, Youcai Tang, Xiuli An and Pengyuan Zheng

    Citation: Cell Communication and Signaling 2019 17:115

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  11. Content type: Research

    KIT tyrosine kinase is expressed in mast cells, interstitial cells of Cajal, and hematopoietic cells. Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leu...

    Authors: Yuuki Obata, Yasushi Hara, Isamu Shiina, Takatsugu Murata, Yasutaka Tasaki, Kyohei Suzuki, Keiichi Ito, Shou Tsugawa, Kouhei Yamawaki, Tsuyoshi Takahashi, Koji Okamoto, Toshirou Nishida and Ryo Abe

    Citation: Cell Communication and Signaling 2019 17:114

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  12. Content type: Research

    C-Type Lectin Domain Family 3 Member B (CLEC3B), is down-regulated in serum and tumor tissues in different cancers including hepatocellular carcinoma (HCC). However, the functions of CLEC3B in HCC remains eluc...

    Authors: Wenjuan Dai, Yilin Wang, Tianxiao Yang, Jing Wang, Weicheng Wu and Jianxin Gu

    Citation: Cell Communication and Signaling 2019 17:113

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  13. Content type: Correction

    Following publication of the original article [1], the authors reported that the given name of Liqing Wang was incorrectly published as Liqiang Wang. The original article has been updated.

    Authors: Yueying Zheng, Liqing Wang, Manli Chen, Lu Liu, Aijie Pei, Rong Zhang, Shuyuan Gan and Shengmei Zhu

    Citation: Cell Communication and Signaling 2019 17:112

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    The original article was published in Cell Communication and Signaling 2019 17:103

  14. Content type: Research

    Overexpression of ATP-binding cassette (ABC) transporters, such as ABCB1 and ABCG2, has been proved to be a major trigger for multidrug resistance (MDR) in certain types of cancer. A promising approach to reve...

    Authors: Zhiqiang Zhang, Chunling Ma, Peng Li, Min Wu, Shengnan Ye, Liwu Fu and Jianhua Xu

    Citation: Cell Communication and Signaling 2019 17:110

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  15. Content type: Research

    Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) cells rely on an un...

    Authors: Weiguang Sun, Shanshan Luan, Changxing Qi, Qingyi Tong, Shan Yan, Hua Li and Yonghui Zhang

    Citation: Cell Communication and Signaling 2019 17:111

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  16. Content type: Research

    Breast cancer is the leading cause of cancer-related death in women worldwide. Metastatic disease remains the primary cause of death in patients with breast cancer. Basal-like breast cancer (BLBC) is associate...

    Authors: Shaojie Jiang, Miaofeng Zhang, Yanhua Zhang, Weiping Zhou, Tao Zhu, Qing Ruan, Hui Chen, Jie Fang, Fei Zhou, Jihong Sun and Xiaoming Yang

    Citation: Cell Communication and Signaling 2019 17:109

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  17. Content type: Research

    Glioma is the most common and primary brain tumors in adults. Despite the available multimodal therapies, glioma patients appear to have a poor prognosis. The Hedgehog (Hh) signaling is involved in tumorigenes...

    Authors: Giuseppina D’Alessandro, Deborah Quaglio, Lucia Monaco, Clotilde Lauro, Francesca Ghirga, Cinzia Ingallina, Michela De Martino, Sergio Fucile, Alessandra Porzia, Maria Amalia Di Castro, Federica Bellato, Francesca Mastrotto, Mattia Mori, Paola Infante, Paola Turano, Stefano Salmaso…

    Citation: Cell Communication and Signaling 2019 17:108

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  18. Content type: Research

    Ligands of the C-type lectin CLEC10A such as Tn and sialyl-Tn representing early intermediates of O-glycosylation are hallmarks of many human malignancies. A variety of regulatory mechanisms underlying their e...

    Authors: Anna-Katharina Kurze, Sophia Buhs, Dennis Eggert, Leticia Oliveira-Ferrer, Volkmar Müller, Axel Niendorf, Christoph Wagener and Peter Nollau

    Citation: Cell Communication and Signaling 2019 17:107

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  19. Content type: Research

    HER3/ErbB3 receptor deletion or blockade leads to tumor cell apoptosis, whereas its overexpression confers anti-cancer drug resistance through upregulation of protective mechanisms against apoptosis. We produc...

    Authors: Christophe Le Clorennec, Yassamine Lazrek, Olivier Dubreuil, Carla Sampaio, Christel Larbouret, Romain Lanotte, Marie-Alix Poul, Jean-Marc Barret, Jean-François Prost, André Pèlegrin and Thierry Chardès

    Citation: Cell Communication and Signaling 2019 17:106

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  20. Content type: Research

    Breast cancer is a life-threatening disease in females and the leading cause of mortality among the female population, presenting huge challenges for prognosis and treatment. ITM2A is a member of the BRICHOS s...

    Authors: Cefan Zhou, Ming Wang, Jing Yang, Hui Xiong, Yefu Wang and Jingfeng Tang

    Citation: Cell Communication and Signaling 2019 17:105

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  21. Content type: Research

    Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase complex and is associated with hepatic lipid accumulation...

    Authors: Dong Hun Lee, Mi Hee Park, Chul Ju Hwang, Youngsoo Kim, Dae Yeon Hwang, Sang Bae Han and Jin Tae Hong

    Citation: Cell Communication and Signaling 2019 17:104

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  22. Content type: Research

    The T cell Ig domain and mucin domain (TIM)-1 protein expressed on the surface of Th2 cells regulates the immune response by modulating cytokine production. The present study aimed to investigate the role and ...

    Authors: Yueying Zheng, Liqing Wang, Manli Chen, Lu Liu, Aijie Pei, Rong Zhang, Shuyuan Gan and Shengmei Zhu

    Citation: Cell Communication and Signaling 2019 17:103

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    The Correction to this article has been published in Cell Communication and Signaling 2019 17:112

  23. Content type: Research

    How high-salt intake leads to the occurrence of many cardiovascular diseases such as atherosclerosis is a fundamental question in pathology. Here we postulated that high-salt-induced NFAT5 controls the inflamm...

    Authors: Pingping Ma, Shenfang Zha, Xinkun Shen, Yulan Zhao, Li Li, Li Yang, Mingxing Lei and Wanqian Liu

    Citation: Cell Communication and Signaling 2019 17:102

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  24. Content type: Research

    Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits.

    Authors: Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu and Yan-Qing Ma

    Citation: Cell Communication and Signaling 2019 17:101

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  25. Content type: Research

    Androgen receptor (AR) plays important role in the development, progression, and metastasis of prostate cancer (PCa). Caffeic acid phenethyl ester (CAPE) is the main component of honey bee propolis. We determi...

    Authors: Ying-Yu Kuo, Chieh Huo, Ching-Yu Lin, Hui-Ping Lin, Jai-Shin Liu, Wen-Ching Wang, Chuang-Rung Chang and Chih-Pin Chuu

    Citation: Cell Communication and Signaling 2019 17:100

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  26. Content type: Research

    Excessive estrogen exposure is an important pathogenic factor in uterine endometrial cancer (UEC). Recent studies have reported the metabolic propertie...

    Authors: Wen-Jie Zhou, Jie Zhang, Hui-Li Yang, Ke Wu, Feng Xie, Jiang-Nan Wu, Yan Wang, Li Yao, Yan Zhuang, Jiang-Dong Xiang, Ai-Jun Zhang, Yin-Yan He and Ming-Qing Li

    Citation: Cell Communication and Signaling 2019 17:99

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  27. Content type: Research

    Autophagy is a macromolecular degradation process playing a pivotal role in the maintenance of stem-like features and in the morpho-functional remodeling of the tissues undergoing differentiation. In this work...

    Authors: Chiara Vidoni, Alessandra Ferraresi, Eleonora Secomandi, Letizia Vallino, Chiara Gardin, Barbara Zavan, Carmen Mortellaro and Ciro Isidoro

    Citation: Cell Communication and Signaling 2019 17:98

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  28. Content type: Review

    Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of disability. Characterized by degradation of articular cartilage, synovial inflammation, and changes in periarticular and su...

    Authors: Yudan Wang, Xinhao Fan, Lei Xing and Faming Tian

    Citation: Cell Communication and Signaling 2019 17:97

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  29. Content type: Short report

    Neural stem/progenitor cells (NPCs) are known to have potent therapeutic effects in neurological disorders through secreting exosomes. The limited numbers of NPCs in adult brain and the decline of NPC pool in ...

    Authors: Yizhao Ma, Chunhong Li, Yunlong Huang, Yi Wang, Xiaohuan Xia and Jialin C. Zheng

    Citation: Cell Communication and Signaling 2019 17:96

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  30. Content type: Research

    Extracellular vesicles (EVs) play important roles in intercellular communication by delivering RNA, lipid, and proteins to neighboring or distant cells. Identification and classification of EVs secreted from d...

    Authors: Sang-Soo Lee, Jong-Hoon Won, Gippeum J. Lim, Jeongran Han, Ji Youn Lee, Kyung-Ok Cho and Young-Kyung Bae

    Citation: Cell Communication and Signaling 2019 17:95

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  31. Content type: Research

    Increased human endogenous retroviruses E clone 4–1 (HERV-E clone 4–1) mRNA expression is observed in systemic lupus erythematosus (SLE) patients and associates with the disease activity. In this study, we wan...

    Authors: Xin Wang, Chaoshuai Zhao, Chengzhong Zhang, Xingyu Mei, Jun Song, Yue Sun, Zhouwei Wu and Weimin Shi

    Citation: Cell Communication and Signaling 2019 17:94

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  32. Content type: Research

    Breast cancer is the leading cause of cancer death in women worldwide which is closely related to metastasis. But the exact molecular mechanism of ERα-36 and STAT3 on metastasis is still not fully understood.

    Authors: Yuan Xiang, Jia Peng Li, Wei Guo, Dan-Qun Wang, Ao Yao, Hui-Min Zhang, Feng Huang, Han-Han Li, Zhou-Tong Dai, Zi-Jiang Zhang, Hui Li, Yao Tan, Kun Chen, Le-Yuan Bao and Xing-Hua Liao

    Citation: Cell Communication and Signaling 2019 17:93

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  33. Content type: Research

    This study aimed to confirm that blocking RasGRP4 can effectively slow down the growth of DLBCL both in vitro and in vivo and ascertain the role of RasGRP4 in the prognosis of DLBCL clinically.

    Authors: Lin Zhu, Chunyan Xia, Lin Wu, Yuxuan Zhang, Junling Liu, Yinan Chen, Jing Liu, Yongxin Xiao, Kai Nie, Liyu Huang, Ning Qu and Hong Yu

    Citation: Cell Communication and Signaling 2019 17:92

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  34. Content type: Research

    Protein phosphorylation & dephosphorylation are ubiquitous cellular processes that allow for the nuanced and reversible regulation of protein activity. Protein phosphatase 2A (PP2A) is a multifunction phosphat...

    Authors: Xiujuan Zhu, Yuhong Ye, Chengxian Xu, Cunji Gao, Yingying Zhang, Jing Zhou, Weiqiang Lin and Jianhua Mao

    Citation: Cell Communication and Signaling 2019 17:91

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  35. Content type: Research

    Binding of tumor necrosis factor (TNF) to TNF-receptor 1 (TNF-R1) can induce either cell survival or cell death. The selection between these diametrically opposed effects depends on the subcellular location of...

    Authors: Philipp Zingler, Vinzenz Särchen, Timo Glatter, Lotta Caning, Carina Saggau, Rahul S. Kathayat, Bryan C. Dickinson, Dieter Adam, Wulf Schneider-Brachert, Stefan Schütze and Jürgen Fritsch

    Citation: Cell Communication and Signaling 2019 17:90

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  36. Content type: Research

    Escape from immune control must be important in the natural course of B-cell lymphomas, especially for those with activation of NF-κB. The pre-clinical LMP1/CD40-expressing transgenic mouse model is characteri...

    Authors: Christelle Vincent-Fabert, Lilian Roland, Ursula Zimber-Strobl, Jean Feuillard and Nathalie Faumont

    Citation: Cell Communication and Signaling 2019 17:89

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  37. Content type: Research

    Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiqui...

    Authors: Eun Ji Ro, Yong-Hee Cho, Woo-Jeong Jeong, Jong-Chan Park, Do Sik Min and Kang-Yell Choi

    Citation: Cell Communication and Signaling 2019 17:88

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  38. Content type: Research

    The understanding of lysosomes has been expanded in recent research way beyond their view as cellular trash can. Lysosomes are pivotal in regulating metabolism, endocytosis and autophagy and are implicated in ...

    Authors: Karin Bartel, Helmut Pein, Bastian Popper, Sabine Schmitt, Sudha Janaki-Raman, Almut Schulze, Florian Lengauer, Andreas Koeberle, Oliver Werz, Hans Zischka, Rolf Müller, Angelika M. Vollmar and Karin von Schwarzenberg

    Citation: Cell Communication and Signaling 2019 17:87

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  39. Content type: Research

    To clarify the effects of cylcin E1 expression on HCC tumor progression, we studied the expression of cyclin E1 and inhibitory efficacy of regorafenib and sorafenib in HCC cells, and investigated a potential t...

    Authors: Jianliang Xu, Fei Huang, Zhicheng Yao, Changchang Jia, Zhiyong Xiong, Hao Liang, Nan Lin and Meihai Deng

    Citation: Cell Communication and Signaling 2019 17:85

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  40. Content type: Research

    miR-449a, an intronic miRNA, is highly down-regulated in the skeletal muscle during diabetes. Its levels are epigenetically regulated by altered acetylation/deacetylation on the promoter that it shares with it...

    Authors: Shagun Poddar, Devesh Kesharwani and Malabika Datta

    Citation: Cell Communication and Signaling 2019 17:84

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  41. Content type: Research

    Growth factors, such as EGF, activate the PI3K/Akt/mTORC1 signalling pathway, which regulates a distinct program of protein synthesis leading to cell growth. This pathway relies on mTORC1 sensing sufficient le...

    Authors: Blake K. Zhang, Anne M. Moran, Charles G. Bailey, John E. J. Rasko, Jeff Holst and Qian Wang

    Citation: Cell Communication and Signaling 2019 17:83

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  42. Content type: Research

    The SUMO-activating enzyme SAE1 is indispensable for protein SUMOylation. A dysregulation of SAE1 expression involves in progression of several human cancers. However, its biological roles of SAE1 in glioma ar...

    Authors: Yanfang Yang, Ziwei Liang, Zijing Xia, Xixi Wang, Yanni Ma, Zenghua Sheng, Qingjia Gu, Guobo Shen, Liangxue Zhou, Hongxia Zhu, Ningzhi Xu and Shufang Liang

    Citation: Cell Communication and Signaling 2019 17:82

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  43. Content type: Research

    Inflammatory reaction in the dysfunction of retinal endotheliocytes has been considered to play a vital role in diabetic retinopathy (DR). Anti-inflammatory therapy so far gains poor outcome as DR treatment. T...

    Authors: Ning Wang, Cheng Zhang, Yu Xu, Sha Li, Hor-Yue Tan, Wen Xia and Yibin Feng

    Citation: Cell Communication and Signaling 2019 17:81

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  44. Content type: Research

    Expression of CD44 receptor is associated with the onset of several tumors. The intracellular domain of CD44 (CD44-ICD) has been implicated as a co-transcription factor for RUNX2 in the regulation of expressio...

    Authors: Linda T. Senbanjo, Hanan AlJohani, Sunipa Majumdar and Meenakshi A. Chellaiah

    Citation: Cell Communication and Signaling 2019 17:80

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  45. Content type: Research

    Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis than patients with microsatellite stable (MSS) CRC. However, some MSI-H CRC patients do not gain ...

    Authors: Wangxiong Hu, Yanmei Yang, Lina Qi, Jiani Chen, Weiting Ge and Shu Zheng

    Citation: Cell Communication and Signaling 2019 17:79

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  46. Content type: Research

    The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) a...

    Authors: Engin Baturcam, Stefan Vollmer, Holger Schlüter, Rose A. Maciewicz, Nisha Kurian, Outi Vaarala, Stephan Ludwig and Danen Mootoosamy Cunoosamy

    Citation: Cell Communication and Signaling 2019 17:78

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  47. Content type: Research

    Lipogenesis is required for the optimal growth of many types of cancer cells, it is shown to control the biosynthesis of the lipid bilayer membrane during rapid proliferation and metastasis, provides cancer ce...

    Authors: Yinfang Wang, Xiaohong Wan, Yilong Hao, Yuanyuan Zhao, Lanlan Du, Yitong Huang, Zongjun Liu, Ying Wang, Nanping Wang and Peng Zhang

    Citation: Cell Communication and Signaling 2019 17:77

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  48. Content type: Research

    Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its...

    Authors: Pei-Yi Chou, Sing-Ru Lin, Ming-Hui Lee, Lori Schultz, Chun-I Sze and Nan-Shan Chang

    Citation: Cell Communication and Signaling 2019 17:76

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  49. Content type: Research

    The major limitation of organ transplantation is the shortage of available organs. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection is a major hurdle for the su...

    Authors: Hanchao Gao, Mengtao Cao, Pengfei Chen, David K. C. Cooper, Yanli Zhao, Ling Wei, Jia Xu, Zhiming Cai, Changchun Zeng, Shaodong Luan and Lisha Mou

    Citation: Cell Communication and Signaling 2019 17:75

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