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Cell Communication and Signaling


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  1. Content type: Review

    Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio ...

    Authors: Gabriela Basile Carballo, Jéssica Ribeiro Honorato, Giselle Pinto Farias de Lopes and Tania Cristina Leite de Sampaio e Spohr

    Citation: Cell Communication and Signaling 2018 16:11

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  2. Content type: Research

    Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how...

    Authors: Sheng Liu, Josephine Iaria, Richard J. Simpson and Hong-Jian Zhu

    Citation: Cell Communication and Signaling 2018 16:10

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  3. Content type: Research

    The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances i...

    Authors: Yuanyuan Tang, Joshua Berlind and Nirmala Mavila

    Citation: Cell Communication and Signaling 2018 16:9

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  4. Content type: Research

    5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal ...

    Authors: Haizhou Liu, Hui Liu, Zhiyi Zhou, Robert A. Parise, Edward Chu and John C. Schmitz

    Citation: Cell Communication and Signaling 2018 16:7

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  5. Content type: Research

    High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown.

    Authors: Deyuan Fu, Jing Li, Jinli Wei, Zhengquan Zhang, Yulin Luo, Haosheng Tan and Chuanli Ren

    Citation: Cell Communication and Signaling 2018 16:8

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  6. Content type: Research

    Despite the implications for tumor growth and cancer drug resistance, the mechanisms underlying differences in energy metabolism among cells remain unclear.

    Authors: Li Wu, Jiayu Zhao, Kexin Cao, Xiao Liu, Hao Cai, Jiaqi Wang, Weidong Li and Zhipeng Chen

    Citation: Cell Communication and Signaling 2018 16:6

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  7. Content type: Research

    Long non-coding RNAs (lncRNAs) have emerged as a new and crucial layer of gene regulation in recent years and regulate various biological processes such as carcinogenesis and metastasis. LncRNA HOTAIR, an onco...

    Authors: Peng Zheng, Ze Yin, Ying Wu, Yao Xu, Ying Luo and Tong-Cun Zhang

    Citation: Cell Communication and Signaling 2018 16:5

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  8. Content type: Research

    Notch signaling controls many cellular processes, including cell fate determination, cell differentiation, proliferation and apoptosis. In mammals, four Notch receptors (Notch 1–4) can interact with five disti...

    Authors: Sylvain Pagie, Nathalie Gérard and Béatrice Charreau

    Citation: Cell Communication and Signaling 2018 16:4

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  9. Content type: Research

    Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are exp...

    Authors: Syeda Kiran Riaz, Jahangir Sarwar Khan, Syed Tahir Abbas Shah, Fen Wang, Lin Ye, Wen G. Jiang and Muhammad Faraz Arshad Malik

    Citation: Cell Communication and Signaling 2018 16:3

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  10. Content type: Research

    Fusion of breast cancer cells with tumor-associated populations of the microenvironment including mesenchymal stroma/stem-like cells (MSC) represents a rare event in cell communication whereby the metastatic c...

    Authors: Catharina Melzer, Juliane von der Ohe and Ralf Hass

    Citation: Cell Communication and Signaling 2018 16:2

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  11. Content type: Short report

    The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRK...

    Authors: Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, Shigeru Hashimoto, Haruka Handa, Hiroki Yamamoto, Ari Hashimoto and Hisataka Sabe

    Citation: Cell Communication and Signaling 2018 16:1

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  12. Content type: Research

    The left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to the premenstrual/menstrual repertoire in human endometrium, but little is known about its functional role...

    Authors: Wu Fei, Daiki Kijima, Mami Hashimoto, Miki Hashimura, Yasuko Oguri, Sabine Kajita, Toshihide Matsumoto, Ako Yokoi and Makoto Saegusa

    Citation: Cell Communication and Signaling 2017 15:56

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  13. Content type: Research

    Glioblastoma multiformae (GBM) is the most aggressive type of malignant brain tumor with complex molecular profile. Overexpression of Na+/H+ Exchanger isoform 9 (NHE9) promotes tumor progression and correlates po...

    Authors: Daniela M. Gomez Zubieta, Mohamed A. Hamood, Rami Beydoun, Ashley E. Pall and Kalyan C. Kondapalli

    Citation: Cell Communication and Signaling 2017 15:55

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  14. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the cancer types with poor prognosis. To effectively treat HCC, new molecular targets and therapeutic approaches must be identified. 5-aminoimidazole-4-carboxamide ribo...

    Authors: Minjing Li, Changzhu Jin, Maolei Xu, Ling Zhou, Defang Li and Yancun Yin

    Citation: Cell Communication and Signaling 2017 15:52

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  15. Content type: Research

    Prostate cancer (PCa), the second most common cancer affecting men worldwide, shows a broad spectrum of biological and clinical behaviour representing the epiphenomenon of an extreme heterogeneity. Androgen de...

    Authors: Nicoletta Ferrari, Ilaria Granata, Matteo Capaia, Marina Piccirillo, Mario Rosario Guarracino, Roberta Venè, Antonella Brizzolara, Andrea Petretto, Elvira Inglese, Martina Morini, Simonetta Astigiano, Adriana Agnese Amaro, Francesco Boccardo, Cecilia Balbi and Paola Barboro

    Citation: Cell Communication and Signaling 2017 15:51

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  16. Content type: Research

    The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses. This is often justified by the complex regulation showed by Smad pro...

    Authors: Eva María García-Vizcaíno, Sergio Liarte, José Luis Alonso-Romero and Francisco José Nicolás

    Citation: Cell Communication and Signaling 2017 15:50

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  17. Content type: Correction

    Unfortunately, following publication of this article [1], it was noticed that the key in Figure 5c incorrectly showed ‘0 h’, ‘5 h’ and ‘10 h’. The corrected version, showing ‘0 h’, ‘12 h’ and ‘24 h’, can be se...

    Authors: Yue Pang, Changzhi Li, Shiyue Wang, Wei Ba, Tao Yu, Guangying Pei, Dan Bi, Hongfang Liang, Xiong Pan, Ting Zhu, Meng Gou, Yinglun Han and Qingwei Li

    Citation: Cell Communication and Signaling 2017 15:49

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    The original article was published in Cell Communication and Signaling 2017 15:42

  18. Content type: Research

    Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Of the three, HAS1 is found to be localized more into the cytoplasmic space wher...

    Authors: Nguyet Nguyen, Awanit Kumar, Simi Chacko, Rodney J. Ouellette and Anirban Ghosh

    Citation: Cell Communication and Signaling 2017 15:48

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  19. Content type: Methodology

    Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. V...

    Authors: Venugopal Thayanithy, Patrick O’Hare, Phillip Wong, Xianda Zhao, Clifford J. Steer, Subbaya Subramanian and Emil Lou

    Citation: Cell Communication and Signaling 2017 15:46

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  20. Content type: Research

    One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not...

    Authors: Angela Lombardi, Bruno Trimarco, Guido Iaccarino and Gaetano Santulli

    Citation: Cell Communication and Signaling 2017 15:47

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  21. Content type: Research

    We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate ...

    Authors: Allal Ouhtit, Mohammed E. Abdraboh, Andrew D. Hollenbach, Hatem Zayed and Madhwa H. G. Raj

    Citation: Cell Communication and Signaling 2017 15:45

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  22. Content type: Research

    Vascular progenitor cells (VPCs) derived from embryonic stem cells (ESCs) are a valuable source for cell- and tissue-based therapeutic strategies. During the optimization of endothelial cell (EC) inductions fr...

    Authors: Simar J. Singh, William Turner, Drew E. Glaser, Kara E. McCloskey and Fabian V. Filipp

    Citation: Cell Communication and Signaling 2017 15:44

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  23. Content type: Research

    We evaluated the therapeutic effect and fate of high doses of human umbilical cord Wharton jelly cells (hUCWJCs) after IP administration to streptozotocin (STZ)-induced diabetic mice.

    Authors: Martin Maldonado, Tianhua Huang, Lujun Yang, Lan Xu and Lian Ma

    Citation: Cell Communication and Signaling 2017 15:43

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