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  1. Content type: Research

    We previously showed that caveolin-1 (cav-1), an integral membrane protein, is required for the synthesis of matrix proteins by glomerular mesangial cells (MC). In a previous study to understand how cav-1 is i...

    Authors: Neel Mehta, Dan Zhang, Renzhong Li, Tony Wang, Agata Gava, Pavithra Parthasarathy, Bo Gao and Joan C. Krepinsky

    Citation: Cell Communication and Signaling 2019 17:37

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  2. Content type: Research

    The human positive cofactor 4 (PC4) is initially identified as a transcriptional cofactor and has an important role in embryonic development and malignant transformation. However, the clinical significance and...

    Authors: Peng Luo, Chi Zhang, Fengying Liao, Long Chen, Zhenyu Liu, Lei Long, Zhongyong Jiang, Yawei Wang, Ziwen Wang, Zujuan Liu, Hongming Miao and Chunmeng Shi

    Citation: Cell Communication and Signaling 2019 17:36

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  3. Content type: Review

    Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition and M phase progression in the cell cycle, plays a principal role in many physiological and pathological processes. A growing nu...

    Authors: Yumei Li, Feng Wu, Qi Tan, Mengfei Guo, Pei Ma, Xuan Wang, Shuai Zhang, Juanjuan Xu, Ping Luo and Yang Jin

    Citation: Cell Communication and Signaling 2019 17:35

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  4. Content type: Research

    Male and female hearts have many structural and functional differences. Here, we investigated the role of estrogen (E2) in the mechanisms of sex differences in contraction through the cAMP-L-type Ca2+channel path...

    Authors: Jeremiah Ong’achwa Machuki, Hong-Yuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Li Kexue, Zhiwei Zhao and Hong Sun

    Citation: Cell Communication and Signaling 2019 17:34

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  5. Content type: Research

    Vascular dysfunction is commonly seen during severe viral infections. Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in regulating vascular homeostasis as well as propa...

    Authors: Stephen R. Koch, Hyehun Choi, Eric H. Mace and Ryan J. Stark

    Citation: Cell Communication and Signaling 2019 17:33

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  6. Content type: Research

    A major challenge in the development of effective cancer immunotherapy is the ability of tumors and their microenvironment to suppress immune cells through immunosuppressive cells such as myeloid -derived supp...

    Authors: Dickson Adah, Yijun Yang, Quan Liu, Kranthi Gadidasu, Zhu Tao, Songlin Yu, Linglin Dai, Xiaofen Li, Siting Zhao, Limei Qin, Li Qin and Xiaoping Chen

    Citation: Cell Communication and Signaling 2019 17:32

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  7. Content type: Research

    p21-activated kinase 1 (PAK1) plays a fundamental role in promoting the development and progression of several cancers and is a potential therapeutic target. However, the biological function and underlying mec...

    Authors: Liang Chen, Shuning Bi, Jiuzhou Hou, Zhijun Zhao, Chaojie Wang and Songqiang Xie

    Citation: Cell Communication and Signaling 2019 17:31

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  8. Content type: Research

    The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation...

    Authors: Yi Qin, Qiangsheng Hu, Jin Xu, Shunrong Ji, Weixing Dai, Wensheng Liu, Wenyan Xu, Qiqing Sun, Zheng Zhang, Quanxing Ni, Bo Zhang, Xianjun Yu and Xiaowu Xu

    Citation: Cell Communication and Signaling 2019 17:30

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  9. Content type: Review

    EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role durin...

    Authors: Sheng-an Su, Yao Xie, Yuhao Zhang, Yutao Xi, Jie Cheng and Meixiang Xiang

    Citation: Cell Communication and Signaling 2019 17:29

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  10. Content type: Research

    Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is neces...

    Authors: Ting Lu, Zhou Zhu, Junchao Wu, Hua She, Rong Han, Haidong Xu and Zheng-Hong Qin

    Citation: Cell Communication and Signaling 2019 17:28

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  11. Content type: Research

    Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αvβ3 integrin an...

    Authors: Taís M. Danilucci, Patty K. Santos, Bianca C. Pachane, Graziéle F. D. Pisani, Rafael L. B. Lino, Bruna C. Casali, Wanessa F. Altei and Heloisa S. Selistre-de-Araujo

    Citation: Cell Communication and Signaling 2019 17:27

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  12. Content type: Review

    Pericytes, as a key cellular part of the blood-brain barrier, play an important role in the maintenance of brain neurovascular unit. These cells participate in brain homeostasis by regulating vascular developm...

    Authors: Mohammad Hossein Geranmayeh, Reza Rahbarghazi and Mehdi Farhoudi

    Citation: Cell Communication and Signaling 2019 17:26

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  13. Content type: Research

    Flavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including prostate cancer. However, the molecular targets o...

    Authors: Xuesen Li, Victor Pham, Matthew Tippin, Dongjun Fu, Raymond Rendon, Liankun Song, Edward Uchio, Bang H. Hoang and Xiaolin Zi

    Citation: Cell Communication and Signaling 2019 17:25

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  14. Content type: Research

    Epithelial-to-mesenchymal transition (EMT) results in changes that promote de-differentiation, migration, and invasion in non-small cell lung cancer (NSCLC). While it is recognized that EMT promotes altered en...

    Authors: Szymon J. Szymura, Jacob P. Zaemes, David F. Allison, Sheena H. Clift, Jaclyn M. D’Innocenzi, Lisa G. Gray, Brian D. McKenna, Benjamin B. Morris, Stefan Bekiranov, Robin D. LeGallo, David R. Jones and Marty W. Mayo

    Citation: Cell Communication and Signaling 2019 17:24

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  15. Content type: Research

    Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has ofte...

    Authors: Mingming Zhang, Yida Pan, Dehua Tang, Robert Gregory Dorfman, Lei Xu, Qian Zhou, Lixing Zhou, Yuming Wang, Yang Li, Yuyao Yin, Bo Kong, Helmut Friess, Shimin Zhao, Jian-lin Wu, Lei Wang and Xiaoping Zou

    Citation: Cell Communication and Signaling 2019 17:23

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  16. Content type: Research

    Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of evidence indicate that it is through G protein coupled estrogen receptor (GPER) sig...

    Authors: Yiran Li, Yuanhui Jia, Yiding Bian, Huan Tong, Junjie Qu, Kai Wang and Xiao-Ping Wan

    Citation: Cell Communication and Signaling 2019 17:22

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  17. Content type: Research

    Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others, the modulation of cytokine expression patterns. The p...

    Authors: Geneviève Hamel-Côté, Fanny Lapointe, Daniel Gendron, Marek Rola-Pleszczynski and Jana Stankova

    Citation: Cell Communication and Signaling 2019 17:21

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  18. Content type: Research

    Shp1, a tyrosine-phosphatase-1 containing the Src-homology 2 (SH2) domain, is involved in inflammatory and immune reactions, where it regulates diverse signalling pathways, usually by limiting cell responses t...

    Authors: Alessia Varone, Stefania Mariggiò, Manpreet Patheja, Vincenzo Maione, Antonio Varriale, Mariangela Vessichelli, Daniela Spano, Fabio Formiggini, Matteo Lo Monte, Nadia Brancati, Maria Frucci, Pompea Del Vecchio, Sabato D’Auria, Angela Flagiello, Clara Iannuzzi, Alberto Luini…

    Citation: Cell Communication and Signaling 2019 17:20

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  19. Content type: Short report

    Oncogenic KRAS plays a vital role in controlling tumor metabolism by enhancing aerobic glycolysis. Obesity driven by chronic consumption of high-fat diet (HFD) is a major risk factor for oncogenic KRAS-mediate...

    Authors: Dan Wang, Yawei Bi, Lianghao Hu, Yongde Luo, Juntao Ji, Albert Z. Mao, Craig D. Logsdon, Ellen Li, James L. Abbruzzese, Zhaoshen Li, Vincent W. Yang and Weiqin Lu

    Citation: Cell Communication and Signaling 2019 17:19

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  20. Content type: Research

    Oral lichen planus (OLP) is known as a chronic inflammatory disease. Our recent studies have suggested that vitamin D/vitamin D receptor (VDR) signaling exerts its protective effects on oral keratinocyte apopt...

    Authors: Xuejun Ge, Lixiang Wang, Mengdi Li, Na Xu, Feiyan Yu, Fang Yang, Ran Li, Fang Zhang, Bin Zhao and Jie Du

    Citation: Cell Communication and Signaling 2019 17:18

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  21. Content type: Research

    Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, th...

    Authors: Zhengxiao Ouyang, Sisi Wang, Ming Zeng, Zhihong Li, Qing Zhang, Wanchun Wang and Tang Liu

    Citation: Cell Communication and Signaling 2019 17:17

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  22. Content type: Research

    The periodic growth of hair follicles is regulated by the balance of activators and inhibitors. The BMP signaling pathway plays an important role during hair follicle regeneration, but the exact BMP protein th...

    Authors: Pan Wu, Yiming Zhang, Yizhan Xing, Wei Xu, Haiying Guo, Fang Deng, Xiaogen Ma and Yuhong Li

    Citation: Cell Communication and Signaling 2019 17:16

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  23. Content type: Research

    ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of Erb...

    Authors: Jinrui Zhang, Qiong Li, Yueguang Wu, Duchuang Wang, Lu Xu, Yang Zhang, Shanshan Wang, Taishu Wang, Fang Liu, Mohamed Y. Zaky, Shuai Hou, Shuyan Liu, Kun Zou, Haixin Lei, Lijuan Zou, Yingqiu Zhang…

    Citation: Cell Communication and Signaling 2019 17:15

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  24. Content type: Research

    Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering hormone insulin. This metabolic activation is ass...

    Authors: Jaime Santo-Domingo, Antonio Núñez Galindo, Ornella Cominetti, Umberto De Marchi, Pedro Cutillas, Loïc Dayon and Andreas Wiederkehr

    Citation: Cell Communication and Signaling 2019 17:14

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  25. Content type: Research

    Exosomes are small membrane-bound vesicles that contribute to tumor progression and metastasis by mediating cell-to-cell communication and modifying the tumor microenvironment at both local and distant sites. ...

    Authors: Bethany N. Hannafon, Amy L. Gin, Yi-Fan Xu, Matthew Bruns, Cameron L. Calloway and Wei-Qun Ding

    Citation: Cell Communication and Signaling 2019 17:13

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  26. Content type: Research

    The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroi...

    Authors: Neha Kaushik, Min-Jung Kim, Nagendra Kumar Kaushik, Jae Kyung Myung, Mi-Young Choi, Jae-Hyeok Kang, Hyuk-Jin Cha, Cha-Soon Kim, Seon-Young Nam and Su-Jae Lee

    Citation: Cell Communication and Signaling 2019 17:12

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  27. Content type: Research

    Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC...

    Authors: Feixia Wang, Yan Jia, Mengmeng Li, Ling Wang, Jiangjuan Shao, Qinglong Guo, Shanzhong Tan, Hai Ding, Anping Chen, Feng Zhang and Shizhong Zheng

    Citation: Cell Communication and Signaling 2019 17:11

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  28. Content type: Research

    Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate...

    Authors: Gernot Posselt, Maria Wiesauer, Bianca E. Chichirau, Daniela Engler, Linda M. Krisch, Gabriele Gadermaier, Peter Briza, Sabine Schneider, Francesco Boccellato, Thomas F. Meyer, Cornelia Hauser-Kronberger, Daniel Neureiter, Anne Müller and Silja Wessler

    Citation: Cell Communication and Signaling 2019 17:10

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  29. Content type: Research

    To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway.

    Authors: Yu-hong Yuan, Han-yu Wang, Yu Lai, Wa Zhong, Wei-ling Liang, Fu-de Yan, Zhong Yu, Jun-kai Chen and Ying Lin

    Citation: Cell Communication and Signaling 2019 17:9

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  30. Content type: Research

    Ghrelin modulates many physiological processes. However, the effects of intestinal ghrelin on hepatic glucose production (HGP) are still unclear. The current study was to explore the roles of intestinal ghreli...

    Authors: Yao Lin, Zerong Liang, Liping He, Mengliu Yang, Dongfang Liu, Harvest F. Gu, Hua Liu, Zhiming Zhu, Hongting Zheng, Ling Li and Gangyi Yang

    Citation: Cell Communication and Signaling 2019 17:8

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  31. Content type: Short report

    Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that are known to play a role in the ca...

    Authors: Huihui Xu, Tianshu Fang, Hongbo Yan and Linghuo Jiang

    Citation: Cell Communication and Signaling 2019 17:7

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  32. Content type: Research

    Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxic...

    Authors: Theresa Lowinus, Florian H. Heidel, Tanima Bose, Subbaiah Chary Nimmagadda, Tina Schnöder, Clemens Cammann, Ingo Schmitz, Ulrike Seifert, Thomas Fischer, Burkhart Schraven and Ursula Bommhardt

    Citation: Cell Communication and Signaling 2019 17:5

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  33. Content type: Research

    As the first member of the metastasis-associated protein (MTA) family, MTA1 and another MTA family member, MTA2, have both been reported to promote breast cancer progression and metastasis. However, the differ...

    Authors: Long Zhang, Qi Wang, Yuzhen Zhou, Qianwen Ouyang, Weixing Dai, Jianfeng Chen, Peipei Ding, Ling Li, Xin Zhang, Wei Zhang, Xinyue Lv, Luying Li, Pingzhao Zhang, Guoxiang Cai and Weiguo Hu

    Citation: Cell Communication and Signaling 2019 17:4

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  34. Content type: Research

    Despite therapeutic advancements (e.g. B-RAF inhibitors) targeting cutaneous melanoma, many cellular processes, including inducible heme oxygenase 1 (HO-1), counteract treatments for malignancies. So there is ...

    Authors: Liu Liu, Yan Wu, Chunxiang Bian, Muhammad Farrukh Nisar, Mei Wang, Xiangyu Hu, Qingchun Diao, Weiqi Nian, Enwen Wang, Wei Xu and Julia Li Zhong

    Citation: Cell Communication and Signaling 2019 17:3

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  35. Content type: Research

    Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor...

    Authors: Hongming Lv, Lihua Hong, Ye Tian, Changjiu Yin, Chao Zhu and Haihua Feng

    Citation: Cell Communication and Signaling 2019 17:2

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  36. Content type: Review

    Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cel...

    Authors: Rui Chen, Xin Xu, Yuquan Tao, Zijun Qian and Yongchun Yu

    Citation: Cell Communication and Signaling 2019 17:1

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  37. Content type: Research

    Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activat...

    Authors: Sara Ortiz-Rivero, Cristina Baquero, Luis Hernández-Cano, Juan José Roldán-Etcheverry, Sara Gutiérrez-Herrero, Cristina Fernández-Infante, Víctor Martín-Granado, Eduardo Anguita, José María de Pereda, Almudena Porras and Carmen Guerrero

    Citation: Cell Communication and Signaling 2018 16:101

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  38. Content type: Research

    Adipocytes make up the major component of breast tissue, accounting for 90% of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a critical role in cancer progression. Adi...

    Authors: Jin-Yong He, Xiao-Hui Wei, Si-Jing Li, Yang Liu, Hao-Lin Hu, Zheng-Zheng Li, Xin-Hong Kuang, Lai Wang, Xin Shi, Sheng-Tao Yuan and Li Sun

    Citation: Cell Communication and Signaling 2018 16:100

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  39. Content type: Research

    The molecular signaling events involving in high malignancy and poor prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade of currently known targets has not yet led to successful cli...

    Authors: Bin Dai, Xuan Zhang, Runze Shang, Jianlin Wang, Xisheng Yang, Hong Zhang, Qi Liu, Desheng Wang, Lin Wang and Kefeng Dou

    Citation: Cell Communication and Signaling 2018 16:99

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  40. Content type: Research

    Previously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood.

    Authors: Junsong Zhou, Aizhen Yang, Yucan Wang, Fengwu Chen, Zhenzhen Zhao, Viralkumar Davra, Katsue Suzuki-Inoue, Yukio Ozaki, Raymond B. Birge, Qingxian Lu and Yi Wu

    Citation: Cell Communication and Signaling 2018 16:98

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  41. Content type: Research

    Transforming growth factor beta 1 (TGF-β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration and muscle function in skeletal muscle diseases. Skeleta...

    Authors: Xiaofan Yang, Pingping Xue, Xin Liu, Xiang Xu and Zhenbing Chen

    Citation: Cell Communication and Signaling 2018 16:97

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  42. Content type: Research

    Human pluripotent stem cells (PSCs) open new windows for basic research and regenerative medicine due to their remarkable properties, i.e. their ability to self-renew indefinitely and being pluripotent. There ...

    Authors: Fereshteh Haghighi, Julia Dahlmann, Saeideh Nakhaei-Rad, Alexander Lang, Ingo Kutschka, Martin Zenker, George Kensah, Roland P. Piekorz and Mohammad Reza Ahmadian

    Citation: Cell Communication and Signaling 2018 16:96

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  43. Content type: Research

    The regulatory mechanisms of hematopoiesis and cellular immunity show a high degree of similarity between insects and mammals, and Drosophila has become a good model for investigating cellular immune responses. J...

    Authors: Yangguang Hao, Shichao Yu, Fangzhou Luo and Li Hua Jin

    Citation: Cell Communication and Signaling 2018 16:95

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  44. Content type: Research

    TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essen...

    Authors: Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa and Hisataka Sabe

    Citation: Cell Communication and Signaling 2018 16:94

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  45. Content type: Research

    Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, ca...

    Authors: Beom Jin Lim, Woon-Kyu Lee, Hyun Woong Lee, Kwan Sik Lee, Ja Kyung Kim, Hye Young Chang and Jung Il Lee

    Citation: Cell Communication and Signaling 2018 16:93

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  46. Content type: Research

    Chemotherapy is the primary established systemic treatment for patients with breast cancer, especially those with the triple-negative subtype. Simultaneously, the resistance of triple-negative breast cancer (T...

    Authors: Peng Huang, Deng-jie Ouyang, Shi Chang, Mo-yun Li, Lun Li, Qian-ying Li, Rong Zeng, Qiong-yan Zou, Juan Su, Piao Zhao, Lei Pei and Wen-jun Yi

    Citation: Cell Communication and Signaling 2018 16:92

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  47. Content type: Research

    The link between cardiac diseases and cognitive deterioration has been accepted from the concept of “cardiogenic dementia”, which was proposed in the late 1970s. However, the molecular mechanism is unclarified.

    Authors: Ming-Jing Duan, Mei-Ling Yan, Qin Wang, Meng Mao, Dan Su, Lin-Lin Sun, Ke-Xin Li, Yang Qu, Qiang Sun, Xin-Yu Zhang, Si-Yu Huang, Ji-Chao Ma, Tao Ban and Jing Ai

    Citation: Cell Communication and Signaling 2018 16:91

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  48. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the name of the 11th author. The author’s name was incorrectly published as “Vincenzo Calautti”, instead of “Enzo Calautti”.

    Authors: Maria del Pilar Camacho Leal, Andrea Costamagna, Beatrice Tassone, Stefania Saoncella, Matilde Simoni, Dora Natalini, Aurora Dadone, Marianna Sciortino, Emilia Turco, Paola Defilippi, Enzo Calautti and Sara Cabodi

    Citation: Cell Communication and Signaling 2018 16:90

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    The original article was published in Cell Communication and Signaling 2018 16:73

  49. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the histopathological pattern of usual interstitial pneumonia and is associated with a high mortality rate. Recently, lung resident...

    Authors: Jiwei Hou, Jingyan Shi, Ling Chen, Zhongyang Lv, Xiang Chen, Honghui Cao, Zou Xiang and Xiaodong Han

    Citation: Cell Communication and Signaling 2018 16:89

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