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  1. To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors.

    Authors: Jin Qian, Zi-chen Gong, Yi-na Zhang, Hong-hua Wu, Jing Zhao, Li-ting Wang, Li-juan Ye, Da Liu, Wei Wang, Xia Kang, Jun Sheng, Wei Xu, Xi-lin Liu, Juan Wu and Wei Zheng

    Citation: Cell Communication and Signaling 2021 19:9

    Content type: Research

    Published on:

  2. First identified as a regulator of neuronal axon guidance, Slit/Robo signaling has since been implicated in additional physiologic and pathologic processes, such as angiogenesis, organogenesis and cancer progr...

    Authors: Emmanuelle Martinot and Derek Boerboom

    Citation: Cell Communication and Signaling 2021 19:8

    Content type: Research

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  3. The cytokine release syndrome or cytokine storm, which is the hyper-induction of inflammatory responses has a central role in the mortality rate of COVID-19 and some other viral infections. Interleukin-6 (IL-6...

    Authors: László Földvári-Nagy, Tamás Schnabel, Gabriella Dörnyei, Tamás Korcsmáros and Katalin Lenti

    Citation: Cell Communication and Signaling 2021 19:7

    Content type: Hypothesis

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  4. Androgen receptor (AR) and polycomb repressive complex 2 (PRC2) are known to co-occupy the loci of genes that are downregulated by androgen-stimulus. Long intergenic non-coding RNA (lincRNA) PVT1 is an overexpres...

    Authors: Alexandre Videira, Felipe C. Beckedorff, Lucas F. daSilva and Sergio Verjovski-Almeida

    Citation: Cell Communication and Signaling 2021 19:5

    Content type: Research

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  5. Probiotics are beneficial bacteria that exist within the human gut, and which are also present in different food products and supplements. They have been investigated for some decades, due to their potential b...

    Authors: Amirhossein Davoodvandi, Havva Marzban, Pouya Goleij, Amirhossein Sahebkar, Korosh Morshedi, Samaneh Rezaei, Maryam Mahjoubin-Tehran, Hossein Tarrahimofrad, Michael R. Hamblin and Hamed Mirzaei

    Citation: Cell Communication and Signaling 2021 19:4

    Content type: Review

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  6. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is overexpressed or activated in several advanced-stage solid cancers. It is known to play both kinase-dependent and -independent roles in pro...

    Authors: Ioanna Antoniades, Maria Kyriakou, Anna Charalambous, Katerina Kalalidou, Andri Christodoulou, Maria Christoforou and Paris A. Skourides

    Citation: Cell Communication and Signaling 2021 19:3

    Content type: Research

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  7. Signal fidelity depends on protein–protein interaction–‘hubs’ integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-h...

    Authors: Lasse Staby, Katrine Bugge, Rasmus Greve Falbe-Hansen, Edoardo Salladini, Karen Skriver and Birthe B. Kragelund

    Citation: Cell Communication and Signaling 2021 19:2

    Content type: Commentary

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  8. Bone marrow derived endothelial progenitor cells (EPCs) are immature endothelial cells (ECs) involved in neo-angiogenesis and endothelial homeostasis and are considered as a circulating reservoir for endotheli...

    Authors: Mahsa Nouri Barkestani, Sara Shamdani, Mazdak Afshar Bakshloo, Nassim Arouche, Bijan Bambai, Georges Uzan and Sina Naserian

    Citation: Cell Communication and Signaling 2021 19:1

    Content type: Research

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  9. The electromechanical function of myocardial tissue depends on the intercellular communication between cardiomyocytes (CMs) as well as their crosstalk with other cell types. Cell injury, and subsequent death t...

    Authors: Krishna Chander Sridhar, Nils Hersch, Georg Dreissen, Rudolf Merkel and Bernd Hoffmann

    Citation: Cell Communication and Signaling 2020 18:191

    Content type: Research

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  10. The rapid ability of SARS-CoV-2 to spread among humans, along with the clinical complications of coronavirus disease 2019—COVID-19, have represented a significant challenge to the health management systems wor...

    Authors: Gustavo A. Argañaraz, Julys da Fonseca Palmeira and Enrique R. Argañaraz

    Citation: Cell Communication and Signaling 2020 18:190

    Content type: Review

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  11. G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins plays an important role in the cellular regulation of responses to external stimuli. Despite intensive structural research, the mechani...

    Authors: Agnieszka Polit, Beata Rysiewicz, Paweł Mystek, Ewa Błasiak and Marta Dziedzicka-Wasylewska

    Citation: Cell Communication and Signaling 2020 18:189

    Content type: Research

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  12. Pyroptosis is a recently identified pathway of caspase-mediated cell death in response to microbes, lipopolysaccharide, or chemotherapy in certain types of cells. However, the mechanism of how pyroptosis is re...

    Authors: Ruiyuan Yao, Yuhao Chen, Huifang Hao, Zhixin Guo, Xiaoou Cheng, Yuze Ma, Qiang Ji, Xiaoru Yang, Yanfeng Wang, Xihe Li and Zhigang Wang

    Citation: Cell Communication and Signaling 2020 18:187

    Content type: Research

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  13. The matrix metalloproteinase-9 (MMP-9) is up-regulated by several proinflammatory mediators in the central nervous system (CNS) diseases. Increasing reports show that MMP-9 expression is an inflammatory biomar...

    Authors: Tsong-Hai Lee, Pei-Shan Liu, Ming-Ming Tsai, Jiun-Liang Chen, Su-Jane Wang and Hsi-Lung Hsieh

    Citation: Cell Communication and Signaling 2020 18:185

    Content type: Research

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  14. Vascular leakage is an important pathophysiological process of critical conditions such as shock and ischemia–reperfusion (I/R)-induced lung injury. Microparticles (MPs), including endothelial cell-derived mic...

    Authors: Jie Zhang, Yu Zhu, Yue Wu, Qing-Guang Yan, Xiao-Yong Peng, Xin-Ming Xiang, Ming-Ying Xue, Qing-Hui Li, Liang-Ming Liu and Tao Li

    Citation: Cell Communication and Signaling 2020 18:184

    Content type: Research

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  15. Upon engagement of the T-cell receptor (TCR), the Src-family protein tyrosine kinase p56Lck phosphorylates components of the TCR (e.g. the TCRζ chains), thereby initiating T-cell activation. The enzymatic acti...

    Authors: Matthias Kästle, Camilla Merten, Roland Hartig, Thilo Kaehne, Ardiyanto Liaunardy-Jopeace, Nadine M. Woessner, Wolfgang W. Schamel, John James, Susana Minguet, Luca Simeoni and Burkhart Schraven

    Citation: Cell Communication and Signaling 2020 18:183

    Content type: Research

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  16. The circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced organismal survival by facilitating the anticipation of the day/night cycl...

    Authors: Jacqueline F. Pelham, Jay C. Dunlap and Jennifer M. Hurley

    Citation: Cell Communication and Signaling 2020 18:181

    Content type: Review

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  17. The Drosophila melanogaster Germ cell-expressed protein (GCE) is a paralog of the juvenile hormone (JH) receptor - Methoprene tolerant protein (MET). Both proteins mediate JH function, preventing precocious diffe...

    Authors: Marta Kolonko, Dominika Bystranowska, Michał Taube, Maciej Kozak, Mark Bostock, Grzegorz Popowicz, Andrzej Ożyhar and Beata Greb-Markiewicz

    Citation: Cell Communication and Signaling 2020 18:180

    Content type: Research

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  18. Phase three clinical trial evidence suggests that colorectal cancers with the KRAS G13D mutation may benefit from EGFR inhibitors, like cetuximab, in contrast to the other most common KRAS mutations. A mechani...

    Authors: Thomas McFall, Noah K. Schomburg, Kent L. Rossman and Edward C. Stites

    Citation: Cell Communication and Signaling 2020 18:179

    Content type: Short report

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  19. Fibroblasts are the powerhouses responsible for the production and assembly of extracellular matrix (ECM). Their activity needs to be tightly controlled especially within the musculoskeletal system, where chan...

    Authors: Ching-Yan Chloé Yeung, Erwin M. Schoof, Michal Tamáš, Abigail L. Mackey and Michael Kjaer

    Citation: Cell Communication and Signaling 2020 18:177

    Content type: Research

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  20. Lymphotoxin β receptor (LTβR) is a member of tumor necrosis factor receptor (TNFR) superfamily which regulates the immune response. At the cellular level, upon ligand binding, the receptor activates the pro-in...

    Authors: Małgorzata Maksymowicz, Marta Miączyńska and Magdalena Banach-Orłowska

    Citation: Cell Communication and Signaling 2020 18:176

    Content type: Research

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  21. The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for gene expression, and occurs principally at the initiation phase which is mainly regulated by eukaryotic initiation ...

    Authors: Peiqi Hao, Jiaojiao Yu, Richard Ward, Yin Liu, Qiao Hao, Su An and Tianrui Xu

    Citation: Cell Communication and Signaling 2020 18:175

    Content type: Review

    Published on:

  22. In this study, we comprehensively analyzed genes related to ferroptosis and iron metabolism to construct diagnostic and prognostic models and explore the relationship with the immune microenvironment in HCC.

    Authors: Bufu Tang, Jinyu Zhu, Jie Li, Kai Fan, Yang Gao, Shimiao Cheng, Chunli Kong, Liyun Zheng, Fazong Wu, Qiaoyou Weng, Chenying Lu and Jiansong Ji

    Citation: Cell Communication and Signaling 2020 18:174

    Content type: Research

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  23. Skeletal muscle is essential for glucose and lipid metabolism. Growing evidence reveals the importance of long non-coding RNAs (LncRNAs) in metabolism. This study aimed to investigate the function of LncRNA H1...

    Authors: Weiwei Gui, Wei Fen Zhu, Yiyi Zhu, Shengjie Tang, Fenping Zheng, Xueyao Yin, Xihua Lin and Hong Li

    Citation: Cell Communication and Signaling 2020 18:173

    Content type: Research

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  24. Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious in...

    Authors: Yue Guo, Ruiping Gu, Dekang Gan, Fangyuan Hu, Gang Li and Gezhi Xu

    Citation: Cell Communication and Signaling 2020 18:172

    Content type: Research

    Published on:

  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yongxin Li, Yu Meng, Xiangyang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Alfonso Eirin and Lilach O. Lerman

    Citation: Cell Communication and Signaling 2020 18:171

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2020 18:124

  26. Receptor for advanced glycation end products (RAGE) is a multi-ligand transmembrane receptor of the immunoglobulin superfamily. Lysophosphatidic acid (LPA) is a ligand for RAGE and is involved in physiological...

    Authors: Rashmi Ray, Nitish Jangde, Satyendra Kumar Singh, Sunita Sinha and Vivek Rai

    Citation: Cell Communication and Signaling 2020 18:170

    Content type: Research

    Published on:

  27. Jumonji AT-rich interactive domain 1B(JARID1B) has been shown to be upregulated in many human cancers and plays a critical role in the development of cancers cells. Nevertheless, its functional role in colorec...

    Authors: Da Huang, Fan Xiao, Haibin Hao, Fuzhou Hua, Zhenzhong Luo, Zhaoxia Huang, Qing Li, Sha Chen, Xiuzhi Cheng, Xinyue Zhang, Weilan Fang, Xiaoyun Hu and Fanrong Liu

    Citation: Cell Communication and Signaling 2020 18:169

    Content type: Research

    Published on:

  28. Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression o...

    Authors: Omid Reza Tamtaji, Mohammad Behnam, Mohammad Ali Pourattar, Michael R. Hamblin, Maryam Mahjoubin-Tehran, Hamed Mirzaei and Zatollah Asemi

    Citation: Cell Communication and Signaling 2020 18:168

    Content type: Review

    Published on:

  29. Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung c...

    Authors: Qi Dong, Chenkang Zhou, Haodong Ren, Zhijian Zhang, Feng Cheng, Zhenkai Xiong, Chuantao Chen, Jianke Yang, Jiguang Gao, Yao Zhang, Lei Xu, Jian Fang, Yuxiang Cao, Huijun Wei and Zhihao Wu

    Citation: Cell Communication and Signaling 2020 18:167

    Content type: Research

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  30. Overexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular carcinoma (HCC) via cell autonomous mechanisms. Howe...

    Authors: Simone Marquard, Stefan Thomann, Sofia M. E. Weiler, Michaela Bissinger, Teresa Lutz, Carsten Sticht, Marcell Tóth, Carolina de la Torre, Norbert Gretz, Beate K. Straub, Jens Marquardt, Peter Schirmacher and Kai Breuhahn

    Citation: Cell Communication and Signaling 2020 18:166

    Content type: Research

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  31. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Chenying Lu, Shiji Fang, Qiaoyou Weng, Xiuling Lv, Miaomiao Meng, Jinyu Zhu, Liyun Zheng, Yumin Hu, Yang Gao, Xulu Wu, Jianting Mao, Bufu Tang, Zhongwei Zhao, Li Huang and Jiansong Ji

    Citation: Cell Communication and Signaling 2020 18:165

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2020 18:97

  32. Chemotherapy is currently one of the most effective treatments for advanced breast cancer. Anti-microtubule agents, including taxanes, eribulin and vinca-alkaloids are one of the primary major anti-breast canc...

    Authors: Tsung-Ching Lai, Chih-Yeu Fang, Yi-Hua Jan, Hsiao-Ling Hsieh, Yi-Fang Yang, Chun-Yu Liu, Peter Mu-Hsin Chang and Michael Hsiao

    Citation: Cell Communication and Signaling 2020 18:164

    Content type: Research

    Published on:

  33. In recent years, it has been demonstrated that extracellular vesicles (EVs) can be released by almost all cell types, and detected in most body fluids. In the tumour microenvironment (TME), EVs serve as a tran...

    Authors: Shi-Cong Tao and Shang-Chun Guo

    Citation: Cell Communication and Signaling 2020 18:163

    Content type: Review

    Published on:

  34. Recent physiological and experimental data highlight the role of the sensory nervous system in bone repair, but its precise role on angiogenesis in a bone regeneration context is still unknown. Our previous wo...

    Authors: Alice Leroux, Bruno Paiva dos Santos, Jacques Leng, Hugo Oliveira and Joëlle Amédée

    Citation: Cell Communication and Signaling 2020 18:162

    Content type: Research

    Published on:

  35. Toll-like receptor 3 (TLR3) ligand which activates TLR3 signaling induces both cancer cell death and activates anti-tumor immunity. However, TLR3 signaling can also harbor pro-tumorigenic consequences. Therefo...

    Authors: Thanpisit Lomphithak, Swati Choksi, Apiwat Mutirangura, Rutaiwan Tohtong, Tewin Tencomnao, Hajime Usubuchi, Michiaki Unno, Hironobu Sasano and Siriporn Jitkaew

    Citation: Cell Communication and Signaling 2020 18:161

    Content type: Research

    Published on:

  36. Helicobacter pylori (H. pylori) is a gram-negative bacterium that chronically infects approximately 50% of the world’s human population. While in most cases the infection remains asymptomatic, 10% of infected ind...

    Authors: Muamera Sarajlic, Theresa Neuper, Julia Vetter, Susanne Schaller, Maria M. Klicznik, Iris K. Gratz, Silja Wessler, Gernot Posselt and Jutta Horejs-Hoeck

    Citation: Cell Communication and Signaling 2020 18:160

    Content type: Research

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  37. Relapsed leukemia following initial therapeutic response and remission is difficult to treat and causes high patient mortality. Leukemia relapse is due to residual quiescent leukemia cells that escape conventi...

    Authors: Bi Liu, Yunzhu Shen, Huafang Huang, Kimiko Della Croce, Min Wu, Yingjuan Fan, Yang Liu, Jianhua Xu and Guang Yao

    Citation: Cell Communication and Signaling 2020 18:159

    Content type: Research

    Published on:

  38. Extracellular vesicles (EVs) are lipid-bound particles that are naturally released from cells and mediate cell-cell communication. Integrin adhesion receptors are enriched in small EVs (SEVs) and SEV-carried i...

    Authors: Wanessa F. Altei, Bianca C. Pachane, Patty K. dos Santos, Lígia N. M. Ribeiro, Bong Hwan Sung, Alissa M. Weaver and Heloisa S. Selistre-de-Araújo

    Citation: Cell Communication and Signaling 2020 18:158

    Content type: Research

    Published on:

  39. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death in China. The lack of an effective treatment for this disease results in a high recurrence rate in patients who undergo radic...

    Authors: Benfan Wang, Qinyan Li, Jinyan Wang, Siting Zhao, Bayaer Nashun, Li Qin and Xiaoping Chen

    Citation: Cell Communication and Signaling 2020 18:157

    Content type: Research

    Published on:

  40. Targeted therapy with BRAF and MEK inhibitors has improved the survival of patients with BRAF-mutated metastatic melanoma, but most patients relapse upon the onset of drug resistance induced by mechanisms incl...

    Authors: Elisabetta Vergani, Matteo Dugo, Mara Cossa, Simona Frigerio, Lorenza Di Guardo, Gianfrancesco Gallino, Ilaria Mattavelli, Barbara Vergani, Luca Lalli, Elena Tamborini, Barbara Valeri, Chiara Gargiuli, Eriomina Shahaj, Marina Ferrarini, Elisabetta Ferrero, Macarena Gomez Lira…

    Citation: Cell Communication and Signaling 2020 18:156

    Content type: Research

    Published on:

  41. Thrombospondin-1 (TSP-1), a Ca2+-binding trimeric glycoprotein secreted by multiple cell types, has been implicated in the pathophysiology of several clinical conditions. Signaling involving TSP-1, through its co...

    Authors: Rosi Bissinger, Polina Petkova-Kirova, Olga Mykhailova, Per-Arne Oldenborg, Elena Novikova, David A. Donkor, Thomas Dietz, Abdulla Al Mamun Bhuyan, William P. Sheffield, Marijke Grau, Ferruh Artunc, Lars Kaestner, Jason P. Acker and Syed M. Qadri

    Citation: Cell Communication and Signaling 2020 18:155

    Content type: Research

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  42. Hormone receptor positive (HR+) breast cancer (BCa) is the most frequently diagnosed subtype. Acquired and intrinsic resistance to conventional endocrine therapy (ET) commonly occurs and prompts incurable meta...

    Authors: Shaymaa Bahnassy, Hariprasad Thangavel, Maram Quttina, Ashfia Fatima Khan, Dhanya Dhanyalayam, Joan Ritho, Samaneh Karami, Jing Ren and Tasneem Bawa-Khalfe

    Citation: Cell Communication and Signaling 2020 18:154

    Content type: Research

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  43. Rabies virus (RABV) is reported to encode five phosphoproteins (P), which are involved in viral genomic replication, axonal transport, oxidative stress, interferon antagonism, and autophagy induction. However,...

    Authors: Juan Liu, Min Liao, Yan Yan, Hui Yang, Hailong Wang and Jiyong Zhou

    Citation: Cell Communication and Signaling 2020 18:153

    Content type: Research

    Published on:

  44. Radioresistance is a major challenge in lung cancer radiotherapy, and new radiosensitizers are urgently needed. Estrogen receptor β (ERβ) is involved in the progression of non-small cell lung cancer (NSCLC), h...

    Authors: Hang Li, Jun Che, Mian Jiang, Ming Cui, Guoxing Feng, Jiali Dong, Shuqin Zhang, Lu Lu, Weili Liu and Saijun Fan

    Citation: Cell Communication and Signaling 2020 18:152

    Content type: Research

    Published on:

  45. Target therapies based on BRAF and MEK inhibitors (MAPKi) have changed the therapeutic landscape for metastatic melanoma patients bearing mutations in the BRAF kinase. However, the emergence of drug resistance...

    Authors: Luigi Fattore, Debora Malpicci, Ciro Milite, Sabrina Castellano, Gianluca Sbardella, Gerardo Botti, Paolo A. Ascierto, Rita Mancini and Gennaro Ciliberto

    Citation: Cell Communication and Signaling 2020 18:150

    Content type: Short report

    Published on:

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