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  1. Candida albicans is the most common opportunistic human fungal pathogen. The chemokine ligand CXCL1 plays a protective role in fungal infection through the recruitment of neutrophils. TRAF1 (tumor necrosis factor...

    Authors: Wenjuan Bai, Qingqing Wang, Zihou Deng, Tiantian Li, Hui Xiao and Zhiyuan Wu
    Citation: Cell Communication and Signaling 2020 18:30
    Content type: Research Published on:

  3. Excessive light exposure is a detrimental environmental factor that plays a critical role in the pathogenesis of retinal degeneration. However, the mechanism of light-induced death of retina/photoreceptor cell...

    Authors: Yi-Ran Pan, Jing-Yao Song, Bin Fan, Ying Wang, Lin Che, Si-Ming Zhang, Yu-Xin Chang, Chang He and Guang-Yu Li
    Citation: Cell Communication and Signaling 2020 18:27
    Content type: Research Published on:

  4. The limited options to treat obesity and its complications result from an incomplete understanding of the underlying molecular mechanisms regulating white adipose tissue development, including adipocyte hypert...

    Authors: Nida Haider and Louise Larose
    Citation: Cell Communication and Signaling 2020 18:26
    Content type: Research Published on:

  5. Eukaryotic elongation factor-2 kinase (eEF2K) is a Ca 2+ /calmodulin (CaM)-dependent protein kinase that inhibits protein synthesis. However, the role of eEF2K in cancer development was reported paradoxically ...

    Authors: Min Xiao, Jianling Xie, Yu Wu, Genzhu Wang, Xin Qi, Zailiang Liu, Yuying Wang, Xuemin Wang, Ashfaqul Hoque, Jon Oakhill, Christopher G. Proud and Jing Li
    Citation: Cell Communication and Signaling 2020 18:25
    Content type: Research Published on:

  6. Nuclear translocation of several oncogenic proteins have previously been reported, but neither the translocation of doublecortin (DCX) nor the mechanism involved has been studied. DCX is a neuronal microtubule...

    Authors: Abiola Abdulrahman Ayanlaja, Guanquan Ji, Jie Wang, Yue Gao, Bo Cheng, Kouminin Kanwore, Lin Zhang, Ye Xiong, Piniel Alphayo Kambey and Dianshuai Gao
    Citation: Cell Communication and Signaling 2020 18:24
    Content type: Research Published on:

  7. Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome, and is associated with a number of other diseases. PCV2 is widely distributed in most developed swine indu...

    Authors: Shuai Zhang, Chunxiao Mou, Yanan Cao, En Zhang and Qian Yang
    Citation: Cell Communication and Signaling 2020 18:23
    Content type: Research Published on:

  8. Glioblastoma and Alzheimer’s disease (AD) are the most common and devastating diseases in the central nervous system. The dysfunction of Presenilin1 is the main reason for AD pathogenesis. However, the molecul...

    Authors: Wei Yang, Peng-fei Wu, Jian-xing Ma, Mao-jun Liao, Lun-shan Xu, Min-hui Xu and Liang Yi
    Citation: Cell Communication and Signaling 2020 18:22
    Content type: Methodology Published on:

  9. Glioblastoma multiforme is an aggressive primary brain tumor that is characterized by local invasive growth and resistance to therapy. The role of the microenvironment in glioblastoma invasiveness remains uncl...

    Authors: Nicholas W. Colangelo and Edouard I. Azzam
    Citation: Cell Communication and Signaling 2020 18:21
    Content type: Research Published on:

  11. Neutrophils form the first line of innate host defense against invading microorganisms. We previously showed that F0F1 ATP synthase (F-ATPase), which is widely known as mitochondrial respiratory chain complex ...

    Authors: Baoyi Zhu, Zhengfu Feng, Yan Guo, Tian Zhang, Ai Mai, Zhanfang Kang, Ting Weijen, Dai Wang, Dazhong Yin, Dongxing Zhu and Jun Gao
    Citation: Cell Communication and Signaling 2020 18:19
    Content type: Research Published on:

  12. Vascular endothelial cell alignment in the direction of flow is an adaptive response that protects against aortic diseases such as atherosclerosis. The RhoGTPases are known to regulate this alignment. We have ...

    Authors: Paul R. Coleman, Angelina J. Lay, Ka Ka Ting, Yang Zhao, Jia Li, Sorour Jarrah, Mathew A. Vadas and Jennifer R. Gamble
    Citation: Cell Communication and Signaling 2020 18:18
    Content type: Research Published on:

  13. Esophageal squamous cell cancer (ESCC) is one kind of frequent digestive tumor. The inflammatory environment plays an important role in the tumorigenesis and development of ESCC. Cancer stem cells are a small ...

    Authors: Fengkai Xu, Zhonghe Liu, Ronghua Liu, Chunlai Lu, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Kunpeng Zhang, Yin Li, Yiwei Chu, Jie Gu and Di Ge
    Citation: Cell Communication and Signaling 2020 18:17
    Content type: Research Published on:

  14. The role and mechanism of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in cancer cell proliferation is poorly understood. Nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamid...

    Authors: Chenyang Ye, Lina Qi, Xiaofen Li, Ji Wang, Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen and Shu Zheng
    Citation: Cell Communication and Signaling 2020 18:16
    Content type: Research Published on:

  15. We have previously shown that the zinc finger transcription repressor SNAI2 (SLUG) represses tumor suppressor BRCA2-expression in non-dividing cells by binding to the E2-box upstream of the transcription start si...

    Authors: Marshall Ellison, Mukul Mittal, Minu Chaudhuri, Gautam Chaudhuri and Smita Misra
    Citation: Cell Communication and Signaling 2020 18:15
    Content type: Research Published on:

  16. CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirecti...

    Authors: Ao-Xiang Guo, Jia-Jia Cui, Lei-Yun Wang and Ji-Ye Yin
    Citation: Cell Communication and Signaling 2020 18:14
    Content type: Review Published on:

  17. Triple negative breast cancer (TNBC) accounts for 16% of breast cancers and represents an aggressive subtype that lacks targeted therapeutic options. In this study, mass spectrometry (MS)-based tyrosine phosph...

    Authors: Nicole J. Chew, Elizabeth V. Nguyen, Shih-Ping Su, Karel Novy, Howard C. Chan, Lan K. Nguyen, Jennii Luu, Kaylene J. Simpson, Rachel S. Lee and Roger J. Daly
    Citation: Cell Communication and Signaling 2020 18:13
    Content type: Research Published on:

  18. Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. To gain more in...

    Authors: Paula Lindner, Søren Brøgger Christensen, Poul Nissen, Jesper Vuust Møller and Nikolai Engedal
    Citation: Cell Communication and Signaling 2020 18:12
    Content type: Research Published on:

  19. Androgen receptor targeted therapies have emerged as an effective tool to manage advanced prostate cancer (PCa). Nevertheless, frequent occurrence of therapy resistance represents a major challenge in the clin...

    Authors: Hannes Neuwirt, Jan Bouchal, Gvantsa Kharaishvili, Christian Ploner, Karin Jöhrer, Florian Pitterl, Anja Weber, Helmut Klocker and Iris E. Eder
    Citation: Cell Communication and Signaling 2020 18:11
    Content type: Research Published on:

  20. The establishment of parasitic infection is dependent on the development of efficient strategies to evade the host defense mechanisms. Phosphatidylserine (PS) molecules are pivotal for apoptotic cell recogniti...

    Authors: João Luiz Mendes Wanderley, Renato Augusto DaMatta and Marcello André Barcinski
    Citation: Cell Communication and Signaling 2020 18:10
    Content type: Review Published on:

  21. Dysfunction in survival and differentiation of osteoblasts commonly occurs in patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major receptor of endocannabinoid system that is crucial for bo...

    Authors: Aihua Xu, Yang Yang, Yang Shao, Meng Wu and Yongxin Sun
    Citation: Cell Communication and Signaling 2020 18:9
    Content type: Research Published on:

  22. NR2F6 has been proposed as an alternative cancer immune checkpoint in the effector T cell compartment. However, a realistic assessment of the in vivo therapeutic potential of NR2F6 requires acute depletion.

    Authors: Victoria Klepsch, Maria Pommermayr, Dominik Humer, Natascha Brigo, Natascha Hermann-Kleiter and Gottfried Baier
    Citation: Cell Communication and Signaling 2020 18:8
    Content type: Research Published on:

  23. Low expression of FOXE1, a member of Forkhead box (FOX) transcription factor family that plays vital roles in cancers, contributes to poor prognosis of colorectal cancer (CRC) patients. However, the underlying...

    Authors: Weixing Dai, Xianke Meng, Shaobo Mo, Wenqiang Xiang, Ye Xu, Long Zhang, Renjie Wang, Qingguo Li and Guoxiang Cai
    Citation: Cell Communication and Signaling 2020 18:7
    Content type: Research Published on:

  25. Following publication of the original article [1], the authors reported that they would like to correct the second last sentence of “Authors’ information” section as PW is an undergraduate, but was incorrectly...

    Authors: Pan Wu, Yiming Zhang, Yizhan Xing, Wei Xu, Haiying Guo, Fang Deng, Xiaogen Ma and Yuhong Li
    Citation: Cell Communication and Signaling 2020 18:4
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2019 17:16

  26. Ras are small cellular GTPases which regulate diverse cellular processes. It has three isoforms: H-Ras, K-Ras, and N-Ras. Owing to the N-terminus (1–165 residues) sequence homology these isoforms were thought ...

    Authors: Arathi Nair, Sushmita Chakraborty, Late Anirban Banerji, Ankita Srivastava, Charudutta Navare and Bhaskar Saha
    Citation: Cell Communication and Signaling 2020 18:3
    Content type: Research Published on:

  27. Gliomas are the most common and malignant brain tumors. The standard therapy is surgery combined with radiotherapy, chemotherapy, and/or other comprehensive methods. However, the emergence of chemoresistance i...

    Authors: Fan Zeng, Kuanyu Wang, Xiu Liu and Zheng Zhao
    Citation: Cell Communication and Signaling 2020 18:2
    Content type: Research Published on:

  28. The calcium/calcineurin signaling pathway is mediated by the transcription factors NFAT (nuclear factor of activated T cells) in mammals and Crz1 (calcineurin-responsive zinc finger 1) in yeasts and other lowe...

    Authors: Huihui Xu, Tianshu Fang, Raha Parvizi Omran, Malcolm Whiteway and Linghuo Jiang
    Citation: Cell Communication and Signaling 2020 18:1
    Content type: Research Published on:

  29. LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important com...

    Authors: Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Weidong Zhu, Yong Fang and Dan-ni Ren
    Citation: Cell Communication and Signaling 2019 17:174
    Content type: Research Published on:

  30. Accumulation of immunosuppressive protein programmed death-ligand 1 (PD-L1) has been documented in several cancers and contributes to the evasion of the host immune system. However, cancer cell-intrinsic signa...

    Authors: Dan Yu, Xueshibojie Liu, Guanghong Han, Yan Liu, Xue Zhao, Di Wang, Xiaomin Bian, Tingting Gu and Lianji Wen
    Citation: Cell Communication and Signaling 2019 17:173
    Content type: Research Published on:

  31. Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is a potent oncogenic driver signal promoting numerous cancer hallmarks such as proliferation, survival, angiogenesis, metast...

    Authors: Sandra Grund-Gröschke, Georg Stockmaier and Fritz Aberger
    Citation: Cell Communication and Signaling 2019 17:172
    Content type: Review Published on:

  32. Lymphotoxin β receptor (LTβR) plays important roles in the development of the immune system and immune response. At the cellular level, ligand-bound LTβR activates the pro-inflammatory NF-κB pathway but the de...

    Authors: Magdalena Banach-Orłowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb and Marta Miączyńska
    Citation: Cell Communication and Signaling 2019 17:171
    Content type: Research Published on:

  33. Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose...

    Authors: Kateřina Hanáková, Ondřej Bernatík, Marek Kravec, Miroslav Micka, Jitender Kumar, Jakub Harnoš, Petra Ovesná, Petra Paclíková, Matěj Rádsetoulal, David Potěšil, Konstantinos Tripsianes, Lukáš Čajánek, Zbyněk Zdráhal and Vítězslav Bryja
    Citation: Cell Communication and Signaling 2019 17:170
    Content type: Research Published on:

  34. Tumor endothelial cells (TECs) perform tumor angiogenesis, which is essential for tumor growth and metastasis. Tumor cells produce large amounts of lactic acid from glycolysis; however, the mechanism underlyin...

    Authors: Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida and Kyoko Hida
    Citation: Cell Communication and Signaling 2019 17:169
    Content type: Research Published on:

  35. Our previous study has demonstrated that NAD(P)H: quinone oxidoreductase 1 (NQO1) is significantly upregulated in human liver cancer where it potentiates the apoptosis evasion of liver cancer cell. However, th...

    Authors: Hong-Zhong Zhou, Han-Qing Zeng, Ding Yuan, Ji-Hua Ren, Sheng-Tao Cheng, Hai-Bo Yu, Fang Ren, Qing Wang, Yi-Ping Qin, Ai-Long Huang and Juan Chen
    Citation: Cell Communication and Signaling 2019 17:168
    Content type: Research Published on:

  36. Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor differentiation, cancer stemness, and enhanced malignancy of non-small cell lung cancer (NSCLC). Herein, we investigated ...

    Authors: Keqiang Zhang, Lu Yang, Jinhui Wang, Ting Sun, Yuming Guo, Rebecca Nelson, Tommy R. Tong, Rajendra Pangeni, Ravi Salgia and Dan J. Raz
    Citation: Cell Communication and Signaling 2019 17:167
    Content type: Research Published on:

  37. In vitro chondrogenesis depends on the concerted action of numerous signalling pathways, many of which are sensitive to the changes of intracellular Ca2+ concentration. N-methyl-D-aspartate (NMDA) glutamate recep...

    Authors: Csaba Matta, Tamás Juhász, János Fodor, Tibor Hajdú, Éva Katona, Csilla Szűcs-Somogyi, Roland Takács, Judit Vágó, Tamás Oláh, Ádám Bartók, Zoltan Varga, Gyorgy Panyi, László Csernoch and Róza Zákány
    Citation: Cell Communication and Signaling 2019 17:166
    Content type: Research Published on:

  38. Non-targeting effects of radiotherapy have become as clinical concern due to secondary tumorigenesis in the patients receiving radiotherapy. Radiotherapy also affects non-tumoral cells present in the tumor mic...

    Authors: Nasrollah Jabbari, Muhammad Nawaz and Jafar Rezaie
    Citation: Cell Communication and Signaling 2019 17:165
    Content type: Research Published on:

  39. Carcinoma cells shift between epithelial and mesenchymal phenotypes during cancer progression, as defined by surface presentation of the cell-cell cohesion molecule E-cadherin, affecting dissemination, progres...

    Authors: Bo Ma, Ahmad Khazali, Hanshuang Shao, Yuhan Jiang and Alan Wells
    Citation: Cell Communication and Signaling 2019 17:164
    Content type: Research Published on:

  40. Recent evidence has suggested that the 1,25(OH)2D3/Vitamin D receptor (VDR) acts to suppress the immune response associated with systemic lupus erythematosus (SLE), a serious multisystem autoimmune disease. Hence...

    Authors: Dan Liu, Yu-Xuan Fang, Xia Wu, Wei Tan, Wei Zhou, Yu Zhang, Yan-Qing Liu and Guo-Qing Li
    Citation: Cell Communication and Signaling 2019 17:163
    Content type: Research Published on:

  41. Interleukin-22 (IL-22) belongs to the IL-10 cytokine family and is mainly produced by activated Th1 cells. Although IL-22 expression is reported to be elevated in many cancers, and increased IL-22 expression c...

    Authors: Wei Li, Fen Li, Weiwei Lei and Zezhang Tao
    Citation: Cell Communication and Signaling 2019 17:162
    Content type: Research Published on:

  42. Serine protease HtrA exhibits both proteolytic and chaperone activities, which are involved in cellular protein quality control. Moreover, HtrA is an important virulence factor in many pathogens including Helicob...

    Authors: Urszula Zarzecka, Aileen Harrer, Anna Zawilak-Pawlik, Joanna Skorko-Glonek and Steffen Backert
    Citation: Cell Communication and Signaling 2019 17:161
    Content type: Research Published on:

  43. Decondesation of the highly compacted chromatin architecture is essential for efficient DNA repair, but how this is achieved remains largely unknown. Here, we report that microrchidia family CW-type zinc finge...

    Authors: Hong-Yan Xie, Tai-Mei Zhang, Shu-Yuan Hu, Zhi-Ming Shao and Da-Qiang Li
    Citation: Cell Communication and Signaling 2019 17:160
    Content type: Research Published on:

  44. Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of kar...

    Authors: Elisabeth Drucker, Kerstin Holzer, Stefan Pusch, Juliane Winkler, Diego F. Calvisi, Eva Eiteneuer, Esther Herpel, Benjamin Goeppert, Stephanie Roessler, Alessandro Ori, Peter Schirmacher, Kai Breuhahn and Stephan Singer
    Citation: Cell Communication and Signaling 2019 17:159
    Content type: Research Published on:

  45. Following publication of the original article [1], the authors reported that Figs. 3 and 6 are incorrect.

    Authors: Jinsoo Song, Dongkyun Kim, Churl-Hong Chun and Eun-Jung Jin
    Citation: Cell Communication and Signaling 2019 17:158
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2013 11:66

  46. Patients with advanced gastric cancer usually have a poor prognosis and limited therapeutic options. Overcoming this challenge requires novel targets and effective drugs. The Hedgehog (Hh) signaling pathway pl...

    Authors: Yan Xu, Shumei Song, Zhenning Wang and Jaffer A. Ajani
    Citation: Cell Communication and Signaling 2019 17:157
    Content type: Review Published on:

  47. The numerous and diverse biological roles of Phosphatidylserine (PtdSer) are featured in this special issue. This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK – compr...

    Authors: Tal Burstyn-Cohen and Avi Maimon
    Citation: Cell Communication and Signaling 2019 17:156
    Content type: Review Published on:

  48. E-cadherin has been awarded a key role in the aetiology of both sporadic and hereditary forms of gastric cancer. In this study, we aimed to identify molecular interactors that influence the expression and func...

    Authors: Patrícia Carneiro, Ana Margarida Moreira, Joana Figueiredo, Rita Barros, Patrícia Oliveira, Maria Sofia Fernandes, Anabela Ferro, Raquel Almeida, Carla Oliveira, Fátima Carneiro, Fernando Schmitt, Joana Paredes, Sérgia Velho and Raquel Seruca
    Citation: Cell Communication and Signaling 2019 17:155
    Content type: Research Published on:

  49. Abnormal reactivation of androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) mainly results from overexpression and down-regulation of AR. Sumoylation of AR can influence its functi...

    Authors: Nanyang Yang, Sitong Liu, Tian Qin, Xintong Liu, Nobumoto Watanabe, Kevin H. Mayo, Jiang Li and Xiaomeng Li
    Citation: Cell Communication and Signaling 2019 17:153
    Content type: Research Published on:

  50. Overexpression of erythropoietin (EPO) and EPO receptor (EPO-R) is associated with poor prognosis in non-small-cell lung carcinoma (NSCLC). Hypoxia, a potent EPO inducer, is a major stimulating factor in the g...

    Authors: Tianhong Su, Pi Liu, Xinyu Ti, Shouzhen Wu, Xiaochang Xue, Zenglu Wang, Elhardji Dioum and Qiuyang Zhang
    Citation: Cell Communication and Signaling 2019 17:152
    Content type: Research Published on:
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