LeBien TW, Tedder TF: B lymphocytes: how they develop and function. Blood. 2008, 112 (5): 1570-1580. 10.1182/blood-2008-02-078071.
Article
PubMed
PubMed Central
Google Scholar
Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B: Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Sci (New York, NY. 1998, 282 (5396): 2085-2088. 10.1126/science.282.5396.2085.
Article
Google Scholar
Browne EP: Regulation of B-cell responses by Toll-like receptors. Immunology. 2012, 136 (4): 370-379. 10.1111/j.1365-2567.2012.03587.x.
Article
PubMed
PubMed Central
Google Scholar
Beutler B, Poltorak A: Sepsis and evolution of the innate immune response. Crit Care Med. 2001, 29 (7 Suppl): S2-6. 10.1097/00003246-200107001-00002. discussion S6-7
Article
PubMed
Google Scholar
Ianaro A, Tersigni M, D'Acquisto F: New insight in LPS antagonist. Mini Rev Med Chem. 2009, 9 (3): 306-317. 10.2174/1389557510909030306.
Article
PubMed
Google Scholar
Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK: Innate response activator B cells protect against microbial sepsis. Sci (New York, NY. 2012, 335 (6068): 597-601. 10.1126/science.1215173.
Article
Google Scholar
Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF: B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008, 223: 284-299. 10.1111/j.1600-065X.2008.00646.x.
Article
PubMed
Google Scholar
Martinez-Hernandez E, Horvath J, Shiloh-Malawsky Y, Sangha N, Martinez-Lage M, Dalmau J: Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis. Neurology. 2011, 77 (6): 589-593. 10.1212/WNL.0b013e318228c136.
Article
PubMed
PubMed Central
Google Scholar
Danysz W, Parsons CG: Alzheimer's disease, beta-amyloid, glutamate, NMDA receptors and memantine–searching for the connections. Br J Pharmacol. 2012, 167 (2): 324-352. 10.1111/j.1476-5381.2012.02057.x.
Article
PubMed
PubMed Central
Google Scholar
Cunningham C: Microglia and neurodegeneration: the role of systemic inflammation. Glia. 2013, 61 (1): 71-90. 10.1002/glia.22350.
Article
PubMed
Google Scholar
Engelke M, Engels N, Dittmann K, Stork B, Wienands J: Ca(2+) signaling in antigen receptor-activated B lymphocytes. Immunol Rev. 2007, 218: 235-246. 10.1111/j.1600-065X.2007.00539.x.
Article
PubMed
Google Scholar
Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A: Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007, 42 (2): 145-156. 10.1016/j.ceca.2007.03.007.
Article
PubMed
Google Scholar
Baba Y, Matsumoto M, Kurosaki T: Calcium signaling in B cells: regulation of cytosolic Ca increase and its sensor molecules, STIM1 and STIM2. Mol Immunol. 2014, 62 (2): 339-343. 10.1016/j.molimm.2013.10.006.
Article
PubMed
Google Scholar
Chuvpilo S, Jankevics E, Tyrsin D, Akimzhanov A, Moroz D, Jha MK, Schulze-Luehrmann J, Santner-Nanan B, Feoktistova E, Konig T, Avots A, Schmitt E, Berberich-Siebelt F, Schimpl A, Serfling E: Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis. Immunity. 2002, 16 (6): 881-895. 10.1016/S1074-7613(02)00329-1.
Article
PubMed
Google Scholar
Shaw PJ, Qu B, Hoth M, Feske S: Molecular regulation of CRAC channels and their role in lymphocyte function. Cell Mol Life Sci. 2013, 70 (15): 2637-2656. 10.1007/s00018-012-1175-2.
Article
PubMed
PubMed Central
Google Scholar
Okkenhaug K, Vanhaesebroeck B: PI3K in lymphocyte development, differentiation and activation. Nat Rev. 2003, 3 (4): 317-330.
Google Scholar
Engels N, Engelke M, Wienands J: Conformational plasticity and navigation of signaling proteins in antigen-activated B lymphocytes. Adv Immunol. 2008, 97: 251-281. 10.1016/S0065-2776(08)00005-9.
Article
PubMed
Google Scholar
Bhattacharyya S, Deb J, Patra AK, Thuy Pham DA, Chen W, Vaeth M, Berberich-Siebelt F, Klein-Hessling S, Lamperti ED, Reifenberg K, Jellusova J, Schweizer A, Nitschke L, Leich E, Rosenwald A, Brunner C, Engelmann S, Bommhardt U, Avots A, Muller MR, Kondo E, Serfling E: NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network. J Exp Med. 2011, 208 (4): 823-839. 10.1084/jem.20100945.
Article
PubMed
PubMed Central
Google Scholar
Pierau M, Na SY, Simma N, Lowinus T, Marx A, Schraven B, Bommhardt UH: Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function. Eur J Immunol. 2012, 42 (12): 3381-3393. 10.1002/eji.201242397.
Article
PubMed
Google Scholar
Castello A, Gaya M, Tucholski J, Oellerich T, Lu KH, Tafuri A, Pawson T, Wienands J, Engelke M, Batista FD: Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. Nat Immunol. 2013, 14 (9): 966-975. 10.1038/ni.2685.
Article
PubMed
Google Scholar
Geppert TD, Whitehurst CE, Thompson P, Beutler B: Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway. Mol Med. 1994, 1 (1): 93-103.
PubMed
PubMed Central
Google Scholar
Vivarelli MS, McDonald D, Miller M, Cusson N, Kelliher M, Geha RS: RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med. 2004, 200 (3): 399-404. 10.1084/jem.20040446.
Article
PubMed
PubMed Central
Google Scholar
Over B, Ziegler S, Foermer S, Weber AN, Bode KA, Heeg K, Bekeredjian-Ding I: IRAK4 turns IL-10+ phospho-FOXO+ monocytes into pro-inflammatory cells by suppression of protein kinase B. Eur J Immunol. 2013, 43 (6): 1630-1642. 10.1002/eji.201243217.
Article
PubMed
Google Scholar
Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF: A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity. 2008, 28 (5): 639-650. 10.1016/j.immuni.2008.03.017.
Article
PubMed
Google Scholar
Fillatreau S, Gray D, Anderton SM: Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev. 2008, 8 (5): 391-397.
Google Scholar
Candando KM, Lykken JM, Tedder TF: B10 cell regulation of health and disease. Immunol Rev. 2014, 259 (1): 259-272. 10.1111/imr.12176.
Article
PubMed
PubMed Central
Google Scholar
Madan R, Demircik F, Surianarayanan S, Allen JL, Divanovic S, Trompette A, Yogev N, Gu Y, Khodoun M, Hildeman D, Boespflug N, Fogolin MB, Grobe L, Greweling M, Finkelman FD, Cardin R, Mohrs M, Muller W, Waisman A, Roers A, Karp CL: Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol. 2009, 183 (4): 2312-2320. 10.4049/jimmunol.0900185.
Article
PubMed
PubMed Central
Google Scholar
Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF: The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. 2009, 182 (12): 7459-7472. 10.4049/jimmunol.0900270.
Article
PubMed
PubMed Central
Google Scholar
Blair PA, Chavez-Rueda KA, Evans JG, Shlomchik MJ, Eddaoudi A, Isenberg DA, Ehrenstein MR, Mauri C: Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J Immunol. 2009, 182 (6): 3492-3502. 10.4049/jimmunol.0803052.
Article
PubMed
PubMed Central
Google Scholar
Poe JC, Smith SH, Haas KM, Yanaba K, Tsubata T, Matsushita T, Tedder TF: Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS One. 2011, 6 (7): e22464-10.1371/journal.pone.0022464.
Article
PubMed
PubMed Central
Google Scholar
DiLillo DJ, Matsushita T, Tedder TF: B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Ann N Y Acad Sci. 2010, 1183: 38-57. 10.1111/j.1749-6632.2009.05137.x.
Article
PubMed
Google Scholar
Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, Spolski R, Poe JC, Leonard WJ, Tedder TF: Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature. 2012, 491 (7423): 264-268. 10.1038/nature11501.
Article
PubMed
PubMed Central
Google Scholar
Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM: B cells regulate autoimmunity by provision of IL-10. Nat Immunol. 2002, 3 (10): 944-950. 10.1038/ni833.
Article
PubMed
Google Scholar
Matsushita T, Yanaba K, Bouaziz JD, Fujimoto M, Tedder TF: Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest. 2008, 118 (10): 3420-3430.
PubMed
PubMed Central
Google Scholar
Mauri C, Gray D, Mushtaq N, Londei M: Prevention of arthritis by interleukin 10-producing B cells. J Exp Med. 2003, 197 (4): 489-501. 10.1084/jem.20021293.
Article
PubMed
PubMed Central
Google Scholar
Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK: Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity. 2002, 16 (2): 219-230. 10.1016/S1074-7613(02)00274-1.
Article
PubMed
Google Scholar
Lancaster E, Martinez-Hernandez E, Dalmau J: Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology. 2011, 77 (2): 179-189. 10.1212/WNL.0b013e318224afde.
Article
PubMed
PubMed Central
Google Scholar
Kleopa KA: Autoimmune channelopathies of the nervous system. Curr Neuropharmacol. 2011, 9 (3): 458-467. 10.2174/157015911796557966.
Article
PubMed
PubMed Central
Google Scholar
Rogers SW, Andrews PI, Gahring LC, Whisenand T, Cauley K, Crain B, Hughes TE, Heinemann SF, McNamara JO: Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis. Sci (New York, NY. 1994, 265 (5172): 648-651. 10.1126/science.8036512.
Article
Google Scholar
Lennon VA, Kryzer TJ, Griesmann GE, O'Suilleabhain PE, Windebank AJ, Woppmann A, Miljanich GP, Lambert EH: Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes. N Engl J Med. 1995, 332 (22): 1467-1474. 10.1056/NEJM199506013322203.
Article
PubMed
Google Scholar
Sansing LH, Tuzun E, Ko MW, Baccon J, Lynch DR, Dalmau J: A patient with encephalitis associated with NMDA receptor antibodies. Nat Clin Pract Neurol. 2007, 3 (5): 291-296. 10.1038/ncpneuro0493.
Article
PubMed
PubMed Central
Google Scholar
Ramanathan S, Mohammad SS, Brilot F, Dale RC: Autoimmune encephalitis: recent updates and emerging challenges. J Clin Neurosci. 2014, 21 (5): 722-730. 10.1016/j.jocn.2013.07.017.
Article
PubMed
Google Scholar
Rawlings DJ, Schwartz MA, Jackson SW, Meyer-Bahlburg A: Integration of B cell responses through Toll-like receptors and antigen receptors. Nat Rev. 2012, 12 (4): 282-294.
Google Scholar
Peri F, Piazza M: Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists. Biotechnol Adv. 2012, 30 (1): 251-260. 10.1016/j.biotechadv.2011.05.014.
Article
PubMed
Google Scholar
Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R: Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010, 62 (3): 405-496. 10.1124/pr.109.002451.
Article
PubMed
PubMed Central
Google Scholar
Parsons CG, Danysz W, Dekundy A, Pulte I: Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease. Neurotox Res. 2013, 24 (3): 358-369. 10.1007/s12640-013-9398-z.
Article
PubMed
PubMed Central
Google Scholar
Murrough JW, Iosifescu DV, Chang LC, Al Jurdi RK, Green CE, Perez AM, Iqbal S, Pillemer S, Foulkes A, Shah A, Charney DS, Mathew SJ: Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry. 2013, 170 (10): 1134-1142. 10.1176/appi.ajp.2013.13030392.
Article
PubMed
PubMed Central
Google Scholar
Lipton SA: Pathologically activated therapeutics for neuroprotection. Nat Rev Neurosci. 2007, 8 (10): 803-808. 10.1038/nrn2229.
Article
PubMed
Google Scholar
Santangelo RM, Acker TM, Zimmerman SS, Katzman BM, Strong KL, Traynelis SF, Liotta DC: Novel NMDA receptor modulators: an update. Expert Opin Ther Pat. 2012, 22 (11): 1337-1352. 10.1517/13543776.2012.728587.
Article
PubMed
PubMed Central
Google Scholar
Dang VD, Hilgenberg E, Ries S, Shen P, Fillatreau S: From the regulatory functions of B cells to the identification of cytokine-producing plasma cell subsets. Curr Opin Immunol. 2014, 28C: 77-83. 10.1016/j.coi.2014.02.009.
Article
Google Scholar
Kacimi R, Giffard RG, Yenari MA: Endotoxin-activated microglia injure brain derived endothelial cells via NF-kappaB, JAK-STAT and JNK stress kinase pathways. J Inflamm (Lond). 2011, 8: 7-10.1186/1476-9255-8-7.
Article
Google Scholar
Cull-Candy S, Brickley S, Farrant M: NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol. 2001, 11 (3): 327-335. 10.1016/S0959-4388(00)00215-4.
Article
PubMed
Google Scholar
Kahlfuss S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M, Bommhardt U: Immunosuppression by N-Methyl-D-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells. Mol Cell Biol. 2014, 34 (5): 820-831. 10.1128/MCB.01273-13.
Article
PubMed
PubMed Central
Google Scholar
Lam J, Wulff H: The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression. Drug Dev Res. 2011, 72 (7): 573-584. 10.1002/ddr.20467.
Article
PubMed
PubMed Central
Google Scholar
Cahalan MD, Chandy KG: Ion channels in the immune system as targets for immunosuppression. Curr Opin Biotechnol. 1997, 8 (6): 749-756. 10.1016/S0958-1669(97)80130-9.
Article
PubMed
Google Scholar
Amigorena S, Choquet D, Teillaud JL, Korn H, Fridman WH: Ion channel blockers inhibit B cell activation at a precise stage of the G1 phase of the cell cycle. Possible involvement of K+ channels. J Immunol. 1990, 144 (6): 2038-2045.
PubMed
Google Scholar
Partiseti M, Choquet D, Diu A, Korn H: Differential regulation of voltage- and calcium-activated potassium channels in human B lymphocytes. J Immunol. 1992, 148 (11): 3361-3368.
PubMed
Google Scholar
Partiseti M, Korn H, Choquet D: Pattern of potassium channel expression in proliferating B lymphocytes depends upon the mode of activation. J Immunol. 1993, 151 (5): 2462-2470.
PubMed
Google Scholar
Wulff H, Knaus HG, Pennington M, Chandy KG: K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity. J Immunol. 2004, 173 (2): 776-786. 10.4049/jimmunol.173.2.776.
Article
PubMed
Google Scholar
Lewis RS, Cahalan MD: Potassium and calcium channels in lymphocytes. Annu Rev Immunol. 1995, 13: 623-653. 10.1146/annurev.iy.13.040195.003203.
Article
PubMed
Google Scholar
Ackermann JA, Radtke D, Maurberger A, Winkler TH, Nitschke L: Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling. EMBO J. 2011, 30 (8): 1621-1633. 10.1038/emboj.2011.74.
Article
PubMed
PubMed Central
Google Scholar
Hock M, Vaeth M, Rudolf R, Patra AK, Pham DA, Muhammad K, Pusch T, Bopp T, Schmitt E, Rost R, Berberich-Siebelt F, Tyrsin D, Chuvpilo S, Avots A, Serfling E, Klein-Hessling S: NFATc1 induction in peripheral T and B lymphocytes. J Immunol. 2013, 190 (5): 2345-2353. 10.4049/jimmunol.1201591.
Article
PubMed
Google Scholar
Matsumoto M, Fujii Y, Baba A, Hikida M, Kurosaki T, Baba Y: The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity. 2011, 34 (5): 703-714. 10.1016/j.immuni.2011.03.016.
Article
PubMed
Google Scholar
Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL: Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol. 2001, 167 (2): 1081-1089. 10.4049/jimmunol.167.2.1081.
Article
PubMed
Google Scholar
Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galan JE, Harhaj E, Flavell RA: Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity. 2006, 25 (6): 941-952. 10.1016/j.immuni.2006.09.013.
Article
PubMed
Google Scholar
Cahalan MD, Chandy KG: The functional network of ion channels in T lymphocytes. Immunol Rev. 2009, 231 (1): 59-87. 10.1111/j.1600-065X.2009.00816.x.
Article
PubMed
PubMed Central
Google Scholar
Agrawal A, Dillon S, Denning TL, Pulendran B: ERK1−/− mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J Immunol. 2006, 176 (10): 5788-5796. 10.4049/jimmunol.176.10.5788.
Article
PubMed
Google Scholar
Qian C, Jiang X, An H, Yu Y, Guo Z, Liu S, Xu H, Cao X: TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation. Blood. 2006, 108 (7): 2307-2315. 10.1182/blood-2006-03-005595.
Article
PubMed
Google Scholar
Jin G, Hamaguchi Y, Matsushita T, Hasegawa M, Le Huu D, Ishiura N, Naka K, Hirao A, Takehara K, Fujimoto M: B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells. J Allergy Clin Immunol. 2013, 131 (6): 1674-1682. 10.1016/j.jaci.2013.01.044.
Article
PubMed
Google Scholar
Liu BS, Cao Y, Huizinga TW, Hafler DA, Toes RE: TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol. 2014, 44 (7): 2121-2129. 10.1002/eji.201344341.
Article
PubMed
Google Scholar
Saraiva M, O'Garra A: The regulation of IL-10 production by immune cells. Nat Rev. 2010, 10 (3): 170-181.
Google Scholar
Ziegler S, Gartner K, Scheuermann U, Zoeller T, Hantzschmann J, Over B, Foermer S, Heeg K, Bekeredjian-Ding I: Ca(2+) -related signaling events influence TLR9-induced IL-10 secretion in human B cells. Eur J Immunol. 2014, 44 (5): 1285-1298. 10.1002/eji.201343994.
Article
PubMed
Google Scholar
Iritani BM, Forbush KA, Farrar MA, Perlmutter RM: Control of B cell development by Ras-mediated activation of Raf. EMBO J. 1997, 16 (23): 7019-7031. 10.1093/emboj/16.23.7019.
Article
PubMed
PubMed Central
Google Scholar
Jacob A, Cooney D, Pradhan M, Coggeshall KM: Convergence of signaling pathways on the activation of ERK in B cells. J Biol Chem. 2002, 277 (26): 23420-23426. 10.1074/jbc.M202485200.
Article
PubMed
Google Scholar
Teixeira-Coelho M, Guedes J, Ferreirinha P, Howes A, Pedrosa J, Rodrigues F, Lai WS, Blackshear PJ, O'Garra A, Castro AG, Saraiva M: Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages. Eur J Immunol. 2014, 44 (3): 856-866. 10.1002/eji.201343734.
Article
PubMed
PubMed Central
Google Scholar
Maseda D, Smith SH, DiLillo DJ, Bryant JM, Candando KM, Weaver CT, Tedder TF: Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. J Immunol. 2012, 188 (3): 1036-1048. 10.4049/jimmunol.1102500.
Article
PubMed
PubMed Central
Google Scholar
Quintana A, Pasche M, Junker C, Al-Ansary D, Rieger H, Kummerow C, Nunez L, Villalobos C, Meraner P, Becherer U, Rettig J, Niemeyer BA, Hoth M: Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation. EMBO J. 2011, 30 (19): 3895-3912. 10.1038/emboj.2011.289.
Article
PubMed
PubMed Central
Google Scholar
Gocke AR, Lebson LA, Grishkan IV, Hu L, Nguyen HM, Whartenby KA, Chandy KG, Calabresi PA: Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis. J Immunol. 2012, 188 (12): 5877-5886. 10.4049/jimmunol.1103095.
Article
PubMed
PubMed Central
Google Scholar
Koshy S, Huq R, Tanner MR, Atik MA, Porter PC, Khan FS, Pennington MW, Hanania NA, Corry DB, Beeton C: Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma. J Biol Chem. 2014, 289 (18): 12623-12632. 10.1074/jbc.M113.517037.
Article
PubMed
PubMed Central
Google Scholar
Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H: The Ca(2)(+)-activated K(+) channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. PLoS One. 2013, 8 (11): e81006-10.1371/journal.pone.0081006.
Article
PubMed
PubMed Central
Google Scholar
Grgic I, Kiss E, Kaistha BP, Busch C, Kloss M, Sautter J, Muller A, Kaistha A, Schmidt C, Raman G, Wulf H, Strutz F, Grone HJ, Kohler R, Hoyer J: Renal fibrosis is attenuated by targeted disruption of KCa3.1 potassium channels. Proc Natl Acad Sci U S A. 2009, 106 (34): 14518-14523. 10.1073/pnas.0903458106.
Article
PubMed
PubMed Central
Google Scholar
Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt UH: Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation. J Immunol. 2009, 183 (10): 6124-6134. 10.4049/jimmunol.0900246.
Article
PubMed
Google Scholar
Vallejo-Gracia A, Bielanska J, Hernandez-Losa J, Castellvi J, Ruiz-Marcellan MC, Ramon Y, Cajal S, Condom E, Manils J, Soler C, Comes N, Ferreres JC, Felipe A: Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy. J Leukoc Biol. 2013, 94 (4): 779-789. 10.1189/jlb.0213094.
Article
PubMed
Google Scholar