Skip to main content
Figure 4 | Cell Communication and Signaling

Figure 4

From: NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells

Figure 4

NMDAR antagonists affect B-cell migration and Ig production. A) Ifenprodil impairs chemokine-induced B-cell migration. The migration of splenic B cells towards SDF-1α and CCL21 in the absence or presence of ifenprodil (30 μM) was determined and the relative + SD migration was calculated from three experiments. Migration of B cells in the absence of ifenprodil was set as 100%. B) Ifenprodil blocks Ig production. B cells were activated with LPS or LPS plus IL-4 in the presence or absence of ifenprodil (10 μM) and IgM and IgG secretion was determined at day 4 with ELISA. Ifenprodil was added at day 1, day 2 or day 3. Data are representative for two experiments.

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X