Buday L, Wunderlich L, Tamas P: The Nck family of adapter proteins: regulators of actin cytoskeleton. Cell Signal. 2002, 14: 723-731. 10.1016/S0898-6568(02)00027-X.
Article
CAS
PubMed
Google Scholar
Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T: The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003, 23: 4586-4597. 10.1128/MCB.23.13.4586-4597.2003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chen M, She H, Kim A, Woodley DT, Li W: Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb. Mol Cell Biol. 2000, 20: 7867-7880. 10.1128/MCB.20.21.7867-7880.2000.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kempiak SJ, Yamaguchi H, Sarmiento C, Sidani M, Ghosh M, Eddy RJ, Desmarais V, Way M, Condeelis J, Segall JE: A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. J Biol Chem. 2005, 280: 5836-5842. 10.1074/jbc.M410713200.
Article
CAS
PubMed
Google Scholar
Pramatarova A, Ochalski PG, Chen K, Gropman A, Myers S, Min KT, Howell BW: Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons. Mol Cell Biol. 2003, 23: 7210-7221. 10.1128/MCB.23.20.7210-7221.2003.
Article
PubMed Central
CAS
PubMed
Google Scholar
Guan S, Chen M, Woodley D, Li W: Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level. Mol Cell Biol. 2007, 27: 6001-6011. 10.1128/MCB.01807-06.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li W, Fan J, Woodley DT: Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton. Oncogene. 2001, 20: 6403-6417. 10.1038/sj.onc.1204782.
Article
CAS
PubMed
Google Scholar
Li W, Hu P, Skolnik EY, Ullrich A, Schlessinger J: The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol Cell Biol. 1992, 12: 5824-5833.
Article
PubMed Central
CAS
PubMed
Google Scholar
Park D, Rhee SG: Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP. Mol Cell Biol. 1992, 12: 5816-5823.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kroll J, Waltenberger J: The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997, 272: 32521-32527. 10.1074/jbc.272.51.32521.
Article
CAS
PubMed
Google Scholar
Ito N, Wernstedt C, Engstrom U, Claesson-Welsh L: Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules. J Biol Chem. 1998, 273: 23410-23418. 10.1074/jbc.273.36.23410.
Article
CAS
PubMed
Google Scholar
Igarashi K, Isohara T, Kato T, Shigeta K, Yamano T, Uno I: Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2. Biochem Biophys Res Commun. 1998, 246: 95-99. 10.1006/bbrc.1998.8578.
Article
CAS
PubMed
Google Scholar
Lamalice L, Houle F, Huot J: Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF. J Biol Chem. 2006, 281: 34009-34020. 10.1074/jbc.M603928200.
Article
CAS
PubMed
Google Scholar
Nishimura R, Li W, Kashishian A, Mondino A, Zhou M, Cooper J, Schlessinger J: Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor. Mol Cell Biol. 1993, 13: 6889-6896.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rivera GM, Antoku S, Gelkop S, Shin NY, Hanks SK, Pawson T, Mayer BJ: Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Proc Natl Acad Sci USA. 2006, 103: 9536-9541. 10.1073/pnas.0603786103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kochhar KS, Iyer AP: Hepatocyte growth factor induces activation of Nck and phospholipase C-gamma in lung carcinoma cells. Cancer Lett. 1996, 104: 163-169. 10.1016/0304-3835(96)04244-9.
Article
CAS
PubMed
Google Scholar
Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO: Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. J Biol Chem. 1998, 273: 1303-1308. 10.1074/jbc.273.3.1303.
Article
CAS
PubMed
Google Scholar
Vindis C, Teli T, Cerretti DP, Turner CE, Huynh-Do U: EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118. J Biol Chem. 2004, 279: 27965-27970. 10.1074/jbc.M401295200.
Article
CAS
PubMed
Google Scholar
Lock P, Casagranda F, Dunn AR: Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck. J Biol Chem. 1999, 274: 22775-22784. 10.1074/jbc.274.32.22775.
Article
CAS
PubMed
Google Scholar
Becker E, Huynh-Do U, Holland S, Pawson T, Daniel TO, Skolnik EY: Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. Mol Cell Biol. 2000, 20: 1537-1545. 10.1128/MCB.20.5.1537-1545.2000.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lemay S, Davidson D, Latour S, Veillette A: Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. Mol Cell Biol. 2000, 20: 2743-2754. 10.1128/MCB.20.8.2743-2754.2000.
Article
PubMed Central
CAS
PubMed
Google Scholar
Frese S, Schubert WD, Findeis AC, Marquardt T, Roske YS, Stradal TE, Heinz DW: The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains. J Biol Chem. 2006, 281: 18236-18245. 10.1074/jbc.M512917200.
Article
CAS
PubMed
Google Scholar
Brown MC, Cary LA, Jamieson JS, Cooper JA, Turner CE: Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell. 2005, 16: 4316-4328. 10.1091/mbc.E05-02-0131.
Article
PubMed Central
CAS
PubMed
Google Scholar
Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB: Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest. 2006, 116: 1346-1359. 10.1172/JCI27414.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T, Quaggin SE, Pawson T: Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature. 2006, 440: 818-823. 10.1038/nature04662.
Article
CAS
PubMed
Google Scholar
Wunderlich L, Farago A, Downward J, Buday L: Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes. Eur J Immunol. 1999, 29: 1068-1075. 10.1002/(SICI)1521-4141(199904)29:04<1068::AID-IMMU1068>3.0.CO;2-P.
Article
CAS
PubMed
Google Scholar
Cowan CA, Henkemeyer M: The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature. 2001, 413: 174-179. 10.1038/35093123.
Article
CAS
PubMed
Google Scholar
Houtman JC, Higashimoto Y, Dimasi N, Cho S, Yamaguchi H, Bowden B, Regan C, Malchiodi EL, Mariuzza R, Schuck P, Appella E, Samelson LE: Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences. Biochemistry. 2004, 43: 4170-4178. 10.1021/bi0357311.
Article
CAS
PubMed
Google Scholar
Wunderlich L, Goher A, Farago A, Downward J, Buday L: Requirement of multiple SH3 domains of Nck for ligand binding. Cell Signal. 1999, 11: 253-262. 10.1016/S0898-6568(98)00054-0.
Article
CAS
PubMed
Google Scholar
Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC: Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains. Mol Cell Biol. 1995, 15: 5725-5731.
Article
PubMed Central
CAS
PubMed
Google Scholar
Anton IM, Lu W, Mayer BJ, Ramesh N, Geha RS: The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. J Biol Chem. 1998, 273: 20992-20995. 10.1074/jbc.273.33.20992.
Article
CAS
PubMed
Google Scholar
Badour K, Zhang J, Siminovitch KA: Involvement of the Wiskott-Aldrich syndrome protein and other actin regulatory adaptors in T cell activation. Semin Immunol. 2004, 16: 395-407. 10.1016/j.smim.2004.08.019.
Article
CAS
PubMed
Google Scholar
Zhong JL, Poghosyan Z, Pennington CJ, Scott X, Handsley MM, Warn A, Gavrilovic J, Honert K, Kruger A, Span PN, Sweep FC, Edwards DR: Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. Mol Cancer Res. 2008, 6: 383-394. 10.1158/1541-7786.MCR-07-2028.
Article
CAS
PubMed
Google Scholar
Gil D, Schamel WW, Montoya M, Sanchez-Madrid F, Alarcon B: Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell. 2002, 109: 901-912. 10.1016/S0092-8674(02)00799-7.
Article
CAS
PubMed
Google Scholar
Liu J, Li M, Ran X, Fan JS, Song J: Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins. Biochemistry. 2006, 45: 7171-7184. 10.1021/bi060091y.
Article
CAS
PubMed
Google Scholar
Hake MJ, Choowongkomon K, Kostenko O, Carlin CR, Sonnichsen FD: Specificity determinants of a novel Nck interaction with the juxtamembrane domain of the epidermal growth factor receptor. Biochemistry. 2008, 47: 3096-3108. 10.1021/bi701549a.
Article
CAS
PubMed
Google Scholar
Kebache S, Cardin E, Nguyen DT, Chevet E, Larose L: Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation. J Biol Chem. 2004, 279: 9662-9671. 10.1074/jbc.M310535200.
Article
CAS
PubMed
Google Scholar
Russell JH, Ley TJ: Lymphocyte-mediated cytotoxicity. Annu Rev Immunol. 2002, 20: 323-370. 10.1146/annurev.immunol.20.100201.131730.
Article
CAS
PubMed
Google Scholar
Burkhardt JK, Carrizosa E, Shaffer MH: The actin cytoskeleton in T cell activation. Annu Rev Immunol. 2008, 26: 233-259. 10.1146/annurev.immunol.26.021607.090347.
Article
CAS
PubMed
Google Scholar
Depoil D, Zaru R, Guiraud M, Chauveau A, Harriague J, Bismuth G, Utzny C, Muller S, Valitutti S: Immunological synapses are versatile structures enabling selective T cell polarization. Immunity. 2005, 22: 185-194. 10.1016/j.immuni.2004.12.010.
Article
CAS
PubMed
Google Scholar
Wiedemann A, Depoil D, Faroudi M, Valitutti S: Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses. Proc Natl Acad Sci USA. 2006, 103: 10985-10990. 10.1073/pnas.0600651103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fuller CL, Braciale VL, Samelson LE: All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton. Immunol Rev. 2003, 191: 220-236. 10.1034/j.1600-065X.2003.00004.x.
Article
CAS
PubMed
Google Scholar
Pitcher LA, van Oers NS: T-cell receptor signal transmission: who gives an ITAM?. Trends Immunol. 2003, 24: 554-560. 10.1016/j.it.2003.08.003.
Article
CAS
PubMed
Google Scholar
Mustelin T, Tasken K: Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem J. 2003, 371: 15-27. 10.1042/BJ20021637.
Article
PubMed Central
CAS
PubMed
Google Scholar
Horejsi V, Zhang W, Schraven B: Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat Rev Immunol. 2004, 4: 603-616. 10.1038/nri1414.
Article
CAS
PubMed
Google Scholar
Takenawa T, Suetsugu S: The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat Rev Mol Cell Biol. 2007, 8: 37-48. 10.1038/nrm2069.
Article
CAS
PubMed
Google Scholar
Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ: Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J Biol Chem. 2001, 276: 26448-26452. 10.1074/jbc.M103856200.
Article
CAS
PubMed
Google Scholar
Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, Samelson LE: Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat Immunol. 2005, 6: 80-89. 10.1038/ni1143.
Article
CAS
PubMed
Google Scholar
Zeng R, Cannon JL, Abraham RT, Way M, Billadeau DD, Bubeck-Wardenberg J, Burkhardt JK: SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol. 2003, 171: 1360-1368.
Article
CAS
PubMed
Google Scholar
Szymczak AL, Workman CJ, Gil D, Dilioglou S, Vignali KM, Palmer E, Vignali DA: The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function. J Immunol. 2005, 175: 270-275.
Article
CAS
PubMed
Google Scholar
Minguet S, Swamy M, Alarcon B, Luescher IF, Schamel WW: Full activation of the T cell receptor requires both clustering and conformational changes at CD3. Immunity. 2007, 26: 43-54. 10.1016/j.immuni.2006.10.019.
Article
CAS
PubMed
Google Scholar
Risueno RM, Schamel WW, Alarcon B: T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation. PLoS ONE. 2008, 3: e1747-10.1371/journal.pone.0001747.
Article
PubMed Central
PubMed
CAS
Google Scholar
Risueno RM, Gil D, Fernandez E, Sanchez-Madrid F, Alarcon B: Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses. Blood. 2005, 106: 601-608. 10.1182/blood-2004-12-4763.
Article
CAS
PubMed
Google Scholar
Risueno RM, van Santen HM, Alarcon B: A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection. Proc Natl Acad Sci USA. 2006, 103: 9625-9630. 10.1073/pnas.0601785103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tailor P, Tsai S, Shameli A, Serra P, Wang J, Robbins S, Nagata M, Szymczak-Workman AL, Vignali DA, Santamaria P: The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling. J Immunol. 2008, 181: 243-255.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kesti T, Ruppelt A, Wang JH, Liss M, Wagner R, Tasken K, Saksela K: Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon. J Immunol. 2007, 179: 878-885.
Article
CAS
PubMed
Google Scholar
Takeuchi K, Yang H, Ng E, Park SY, Sun ZY, Reinherz EL, Wagner G: Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity. J Mol Biol. 2008, 380: 704-716. 10.1016/j.jmb.2008.05.037.
Article
PubMed Central
CAS
PubMed
Google Scholar
Borroto A, Lama J, Niedergang F, utry-Varsat A, Alarcon B, Alcover A: The CD3 epsilon subunit of the TCR contains endocytosis signals. J Immunol. 1999, 163: 25-31.
CAS
PubMed
Google Scholar
Mingueneau M, Sansoni A, Gregoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B: The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nat Immunol. 2008, 9: 522-532. 10.1038/ni.1608.
Article
CAS
PubMed
Google Scholar
Bonifacino JS, McCarthy SA, Maguire JE, Nakayama T, Singer DS, Klausner RD, Singer A: Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4. Nature. 1990, 344: 247-251. 10.1038/344247a0.
Article
CAS
PubMed
Google Scholar
Nakayama T, June CH, Munitz TI, Sheard M, McCarthy SA, Sharrow SO, Samelson LE, Singer A: Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. Science. 1990, 249: 1558-1561. 10.1126/science.2120773.
Article
CAS
PubMed
Google Scholar
Wiest DL, Yuan L, Jefferson J, Benveniste P, Tsokos M, Klausner RD, Glimcher LH, Samelson LE, Singer A: Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J Exp Med. 1993, 178: 1701-1712. 10.1084/jem.178.5.1701.
Article
CAS
PubMed
Google Scholar
Myers MD, Dragone LL, Weiss A: Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation. J Cell Biol. 2005, 170: 285-294. 10.1083/jcb.200501164.
Article
PubMed Central
CAS
PubMed
Google Scholar
Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H, Weiss A: Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol. 2006, 7: 57-66. 10.1038/ni1291.
Article
CAS
PubMed
Google Scholar
Roehm N, Herron L, Cambier J, DiGuisto D, Haskins K, Kappler J, Marrack P: The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells. Cell. 1984, 38: 577-584. 10.1016/0092-8674(84)90512-9.
Article
CAS
PubMed
Google Scholar
Bubeck WJ, Pappu R, Bu JY, Mayer B, Chernoff J, Straus D, Chan AC: Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. Immunity. 1998, 9: 607-616. 10.1016/S1074-7613(00)80658-5.
Article
Google Scholar
Yablonski D, Kane LP, Qian D, Weiss A: A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK. EMBO J. 1998, 17: 5647-5657. 10.1093/emboj/17.19.5647.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chu P, Pardo J, Zhao H, Li CC, Pali E, Shen MM, Qu K, Yu SX, Huang BC, Yu P, Masuda ES, Molineaux SM, Kolbinger F, Aversa G, de VJ, Payan DG, Liao XC: Systematic identification of regulatory proteins critical for T-cell activation. J Biol. 2003, 2: 21-10.1186/1475-4924-2-21.
Article
PubMed Central
PubMed
Google Scholar
Chu PC, Wu J, Liao XC, Pardo J, Zhao H, Li C, Mendenhall MK, Pali E, Shen M, Yu S, Taylor VC, Aversa G, Molineaux S, Payan DG, Masuda ES: A novel role for p21-activated protein kinase 2 in T cell activation. J Immunol. 2004, 172: 7324-7334.
Article
CAS
PubMed
Google Scholar
Bokoch GM: Biology of the p21-activated kinases. Annu Rev Biochem. 2003, 72: 743-781. 10.1146/annurev.biochem.72.121801.161742.
Article
CAS
PubMed
Google Scholar
Ku GM, Yablonski D, Manser E, Lim L, Weiss A: A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J. 2001, 20: 457-465. 10.1093/emboj/20.3.457.
Article
PubMed Central
CAS
PubMed
Google Scholar
Galisteo ML, Chernoff J, Su YC, Skolnik EY, Schlessinger J: The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J Biol Chem. 1996, 271: 20997-21000. 10.1074/jbc.271.35.20997.
Article
CAS
PubMed
Google Scholar
Bokoch GM, Wang Y, Bohl BP, Sells MA, Quilliam LA, Knaus UG: Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J Biol Chem. 1996, 271: 25746-25749. 10.1074/jbc.271.42.25746.
Article
CAS
PubMed
Google Scholar
Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L: PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol Cell. 1998, 1: 183-192. 10.1016/S1097-2765(00)80019-2.
Article
CAS
PubMed
Google Scholar
Bagrodia S, Taylor SJ, Jordon KA, Van AL, Cerione RA: A novel regulator of p21-activated kinases. J Biol Chem. 1998, 273: 23633-23636. 10.1074/jbc.273.37.23633.
Article
CAS
PubMed
Google Scholar
Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, Premont RT, Taylor SJ, Cerione RA: A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Biol Chem. 1999, 274: 22393-22400. 10.1074/jbc.274.32.22393.
Article
CAS
PubMed
Google Scholar
Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S, Leventhal PS: Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. J Cell Biol. 1999, 145: 851-863. 10.1083/jcb.145.4.851.
Article
PubMed Central
CAS
PubMed
Google Scholar
Daniels RH, Hall PS, Bokoch GM: Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells. EMBO J. 1998, 17: 754-764. 10.1093/emboj/17.3.754.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bokoch GM, Reilly AM, Daniels RH, King CC, Olivera A, Spiegel S, Knaus UG: A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids. J Biol Chem. 1998, 273: 8137-8144. 10.1074/jbc.273.14.8137.
Article
CAS
PubMed
Google Scholar
Turner CE, West KA, Brown MC: Paxillin-ARF GAP signaling and the cytoskeleton. Curr Opin Cell Biol. 2001, 13: 593-599. 10.1016/S0955-0674(00)00256-8.
Article
CAS
PubMed
Google Scholar
Phee H, Abraham RT, Weiss A: Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol. 2005, 6: 608-617. 10.1038/ni1199.
Article
CAS
PubMed
Google Scholar
Veillette A: Immune regulation by SLAM family receptors and SAP-related adaptors. Nat Rev Immunol. 2006, 6: 56-66. 10.1038/nri1761.
Article
CAS
PubMed
Google Scholar
Li C, Iosef C, Jia CY, Gkourasas T, Han VK, Shun-Cheng LS: Disease-causing SAP mutants are defective in ligand binding and protein folding. Biochemistry. 2003, 42: 14885-14892. 10.1021/bi034798l.
Article
CAS
PubMed
Google Scholar
Li C, Iosef C, Jia CY, Han VK, Li SS: Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. J Biol Chem. 2003, 278: 3852-3859. 10.1074/jbc.M206649200.
Article
CAS
PubMed
Google Scholar
Latour S, Roncagalli R, Chen R, Bakinowski M, Shi X, Schwartzberg PL, Davidson D, Veillette A: Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat Cell Biol. 2003, 5: 149-154. 10.1038/ncb919.
Article
CAS
PubMed
Google Scholar
Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ: SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. 2003, 5: 155-160. 10.1038/ncb920.
Article
CAS
PubMed
Google Scholar
Gu C, Tangye SG, Sun X, Luo Y, Lin Z, Wu J: The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation. Proc Natl Acad Sci USA. 2006, 103: 14447-14452. 10.1073/pnas.0606624103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lettau M, Schmidt H, Kabelitz D, Janssen O: Secretory lysosomes and their cargo in T and NK cells. Immunol Lett. 2007, 108: 10-19. 10.1016/j.imlet.2006.10.001.
Article
CAS
PubMed
Google Scholar
Lettau M, Paulsen M, Kabelitz D, Janssen O: Storage, expression and function of Fas ligand, the key death factor of immune cells. Curr Med Chem. 2008, 15: 1684-1696. 10.2174/092986708784872384.
Article
CAS
PubMed
Google Scholar
Lettau M, Qian J, Linkermann A, Latreille M, Larose L, Kabelitz D, Janssen O: The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse. Proc Natl Acad Sci USA. 2006, 103: 5911-5916. 10.1073/pnas.0508562103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O: Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. FEBS Lett. 2001, 509: 255-262. 10.1016/S0014-5793(01)03174-X.
Article
CAS
PubMed
Google Scholar
Kremer BE, Adang LA, Macara IG: Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Cell. 2007, 130: 837-850. 10.1016/j.cell.2007.06.053.
Article
PubMed Central
CAS
PubMed
Google Scholar
Matuoka K, Miki H, Takahashi K, Takenawa T: A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. Biochem Biophys Res Commun. 1997, 239: 488-492. 10.1006/bbrc.1997.7492.
Article
CAS
PubMed
Google Scholar
Martens N, Wery M, Wang P, Braet F, Gertler A, Hooghe R, Vandenhaute J, Hooghe-Peters EL: The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. Exp Cell Res. 2004, 298: 239-248. 10.1016/j.yexcr.2004.04.002.
Article
CAS
PubMed
Google Scholar
Lawe DC, Hahn C, Wong AJ: The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Oncogene. 1997, 14: 223-231. 10.1038/sj.onc.1200821.
Article
CAS
PubMed
Google Scholar
Najib S, Martin-Romero C, Gonzalez-Yanes C, Sanchez-Margalet V: Role of Sam68 as an adaptor protein in signal transduction. Cell Mol Life Sci. 2005, 62: 36-43. 10.1007/s00018-004-4309-3.
Article
CAS
PubMed
Google Scholar
Cote J, Boisvert FM, Boulanger MC, Bedford MT, Richard S: Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell. 2003, 14: 274-287. 10.1091/mbc.E02-08-0484.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ishidate T, Yoshihara S, Kawasaki Y, Roy BC, Toyoshima K, Akiyama T: Identification of a novel nuclear localization signal in Sam68. FEBS Lett. 1997, 409: 237-241. 10.1016/S0014-5793(97)00455-9.
Article
CAS
PubMed
Google Scholar
Hu Q, Milfay D, Williams LT: Binding of NCK to SOS and activation of ras-dependent gene expression. Mol Cell Biol. 1995, 15: 1169-1174.
Article
PubMed Central
CAS
PubMed
Google Scholar
Okada S, Pessin JE: Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. J Biol Chem. 1996, 271: 25533-25538. 10.1074/jbc.271.41.25533.
Article
CAS
PubMed
Google Scholar
Wunderlich L, Farago A, Buday L: Characterization of interactions of Nck with Sos and dynamin. Cell Signal. 1999, 11: 25-29. 10.1016/S0898-6568(98)00027-8.
Article
CAS
PubMed
Google Scholar
Wang B, Zou JX, Ek-Rylander B, Ruoslahti E: R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. J Biol Chem. 2000, 275: 5222-5227. 10.1074/jbc.275.7.5222.
Article
CAS
PubMed
Google Scholar
Cardin E, Latreille M, Khoury C, Greenwood MT, Larose L: Nck-1 selectively modulates eIF2alphaSer51 phosphorylation by a subset of eIF2alpha-kinases. FEBS J. 2007, 274: 5865-5875. 10.1111/j.1742-4658.2007.06110.x.
Article
CAS
PubMed
Google Scholar
Cardin E, Larose L: Nck-1 interacts with PKR and modulates its activation by dsRNA. Biochem Biophys Res Commun. 2008, 377: 231-235. 10.1016/j.bbrc.2008.09.112.
Article
CAS
PubMed
Google Scholar
Kebache S, Zuo D, Chevet E, Larose L: Modulation of protein translation by Nck-1. Proc Natl Acad Sci USA. 2002, 99: 5406-5411. 10.1073/pnas.082483399.
Article
PubMed Central
CAS
PubMed
Google Scholar
Latreille M, Larose L: Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. J Biol Chem. 2006, 281: 26633-26644. 10.1074/jbc.M513556200.
Article
CAS
PubMed
Google Scholar
Ren R, Ye ZS, Baltimore D: Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. Genes Dev. 1994, 8: 783-795. 10.1101/gad.8.7.783.
Article
CAS
PubMed
Google Scholar
Teo M, Tan L, Lim L, Manser E: The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors. J Biol Chem. 2001, 276: 18392-18398. 10.1074/jbc.M008795200.
Article
CAS
PubMed
Google Scholar
Coutinho S, Jahn T, Lewitzky M, Feller S, Hutzler P, Peschel C, Duyster J: Characterization of Ggrb4, an adapter protein interacting with Bcr-Abl. Blood. 2000, 96: 618-624.
CAS
PubMed
Google Scholar
Lussier G, Larose L: A casein kinase I activity is constitutively associated with Nck. J Biol Chem. 1997, 272: 2688-2694. 10.1074/jbc.272.24.15527.
Article
CAS
PubMed
Google Scholar
Rivero-Lezcano OM, Sameshima JH, Marcilla A, Robbins KC: Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J Biol Chem. 1994, 269: 17363-17366.
CAS
PubMed
Google Scholar
Li X, Meriane M, Triki I, Shekarabi M, Kennedy TE, Larose L, Lamarche-Vane N: The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. J Biol Chem. 2002, 277: 37788-37797. 10.1074/jbc.M205428200.
Article
CAS
PubMed
Google Scholar
Tu Y, Kucik DF, Wu C: Identification and kinetic analysis of the interaction between Nck-2 and DOCK180. FEBS Lett. 2001, 491: 193-199. 10.1016/S0014-5793(01)02195-0.
Article
CAS
PubMed
Google Scholar
Oldenhof J, Vickery R, Anafi M, Oak J, Ray A, Schoots O, Pawson T, von ZM, Van Tol HH: SH3 binding domains in the dopamine D4 receptor. Biochemistry. 1998, 37: 15726-15736. 10.1021/bi981634+.
Article
CAS
PubMed
Google Scholar
Choudhury GG, Marra F, Abboud HE: Thrombin stimulates association of src homology domain containing adaptor protein Nck with pp125FAK. Am J Physiol. 1996, 270: F295-F300.
CAS
PubMed
Google Scholar
Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL, Wu C: Nck-2 interacts with focal adhesion kinase and modulates cell motility. Int J Biochem Cell Biol. 2002, 34: 791-805. 10.1016/S1357-2725(02)00002-X.
Article
CAS
PubMed
Google Scholar
Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS: GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem. 2003, 278: 34641-34653. 10.1074/jbc.M304594200.
Article
CAS
PubMed
Google Scholar
Zhao ZS, Manser E, Lim L: Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. Mol Cell Biol. 2000, 20: 3906-3917. 10.1128/MCB.20.11.3906-3917.2000.
Article
PubMed Central
CAS
PubMed
Google Scholar
Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM: The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene. 1998, 17: 1893-1901. 10.1038/sj.onc.1202108.
Article
CAS
PubMed
Google Scholar
Tu Y, Liang L, Frank SJ, Wu C: Src homology 3 domain-dependent interaction of Nck-2 with insulin receptor substrate-1. Biochem J. 2001, 354: 315-322. 10.1042/0264-6021:3540315.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yamamoto A, Suzuki T, Sakaki Y: Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease. Gene. 2001, 271: 159-169. 10.1016/S0378-1119(01)00521-2.
Article
CAS
PubMed
Google Scholar
Kitamura T, Kitamura Y, Yonezawa K, Totty NF, Gout I, Hara K, Waterfield MD, Sakaue M, Ogawa W, Kasuga M: Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. Biochem Biophys Res Commun. 1996, 219: 509-514. 10.1006/bbrc.1996.0264.
Article
CAS
PubMed
Google Scholar
Su YC, Han J, Xu S, Cobb M, Skolnik EY: NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 1997, 16: 1279-1290. 10.1093/emboj/16.6.1279.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bagrodia S, Taylor SJ, Creasy CL, Chernoff J, Cerione RA: Identification of a mouse p21Cdc42/Rac activated kinase. J Biol Chem. 1995, 270: 22731-22737. 10.1074/jbc.270.39.22731.
Article
CAS
PubMed
Google Scholar
Tu Y, Li F, Wu C: Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. Mol Biol Cell. 1998, 9: 3367-3382.
Article
PubMed Central
CAS
PubMed
Google Scholar
Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ: Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. J Biol Chem. 1996, 271: 28772-28776. 10.1074/jbc.271.46.28772.
Article
CAS
PubMed
Google Scholar
Rebhun JF, Chen H, Quilliam LA: Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. J Biol Chem. 2000, 275: 13406-13410. 10.1074/jbc.C000085200.
Article
CAS
PubMed
Google Scholar
Chou MM, Hanafusa H: A novel ligand for SH3 domains. The Nck adaptor protein binds to a serine/threonine kinase via an SH3 domain. J Biol Chem. 1995, 270: 7359-7364. 10.1074/jbc.270.13.7359.
Article
CAS
PubMed
Google Scholar
Fu CA, Shen M, Huang BC, Lasaga J, Payan DG, Luo Y: TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. J Biol Chem. 1999, 274: 30729-30737. 10.1074/jbc.274.43.30729.
Article
CAS
PubMed
Google Scholar
Sudol M: Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene. 1994, 9: 2145-2152.
CAS
PubMed
Google Scholar
Frischknecht F, Moreau V, Rottger S, Gonfloni S, Reckmann I, Superti-Furga G, Way M: Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling. Nature. 1999, 401: 926-929. 10.1038/44860.
Article
CAS
PubMed
Google Scholar
Galisteo ML, Yang Y, Urena J, Schlessinger J: Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli. Proc Natl Acad Sci USA. 2006, 103: 9796-9801. 10.1073/pnas.0603714103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sotgia F, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP: Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Biochemistry. 2001, 40: 14585-14592. 10.1021/bi011247r.
Article
CAS
PubMed
Google Scholar
Mizuno K, Tagawa Y, Mitomo K, Watanabe N, Katagiri T, Ogimoto M, Yakura H: Src homology region 2 domain-containing phosphatase 1 positively regulates B cell receptor-induced apoptosis by modulating association of B cell linker protein with Nck and activation of c-Jun NH2-terminal kinase. J Immunol. 2002, 169: 778-786.
Article
CAS
PubMed
Google Scholar
Minegishi M, Tachibana K, Sato T, Iwata S, Nojima Y, Morimoto C: Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes. J Exp Med. 1996, 184: 1365-1375. 10.1084/jem.184.4.1365.
Article
CAS
PubMed
Google Scholar
Lee H, Park DS, Wang XB, Scherer PE, Schwartz PE, Lisanti MP: Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1. J Biol Chem. 2002, 277: 34556-34567. 10.1074/jbc.M204367200.
Article
CAS
PubMed
Google Scholar
Noguchi T, Matozaki T, Inagaki K, Tsuda M, Fukunaga K, Kitamura Y, Kitamura T, Shii K, Yamanashi Y, Kasuga M: Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration. EMBO J. 1999, 18: 1748-1760. 10.1093/emboj/18.7.1748.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jones N, Dumont DJ: The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 1998, 17: 1097-1108. 10.1038/sj.onc.1202115.
Article
CAS
PubMed
Google Scholar
Jones N, Dumont DJ: Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation. Curr Biol. 1999, 9: 1057-1060. 10.1016/S0960-9822(99)80458-8.
Article
CAS
PubMed
Google Scholar
Lee CH, Li W, Nishimura R, Zhou M, Batzer AG, Myers MG Jr, White MF, Schlessinger J, Skolnik EY: Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci USA. 1993, 90: 11713-11717. 10.1073/pnas.90.24.11713.
Article
PubMed Central
CAS
PubMed
Google Scholar
Xu P, Jacobs AR, Taylor SI: Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins. J Biol Chem. 1999, 274: 15262-15270. 10.1074/jbc.274.21.15262.
Article
CAS
PubMed
Google Scholar
Schlaepfer DD, Broome MA, Hunter T: Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol. 1997, 17: 1702-1713.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bocciardi R, Mograbi B, Pasini B, Borrello MG, Pierotti MA, Bourget I, Fischer S, Romeo G, Rossi B: The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck. Oncogene. 1997, 15: 2257-2265. 10.1038/sj.onc.1201413.
Article
CAS
PubMed
Google Scholar
Sitko JC, Guevara CI, Cacalano NA: Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation. J Biol Chem. 2004, 279: 37662-37669. 10.1074/jbc.M404007200.
Article
CAS
PubMed
Google Scholar
Gruenheid S, DeVinney R, Bladt F, Goosney D, Gelkop S, Gish GD, Pawson T, Finlay BB: Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells. Nat Cell Biol. 2001, 3: 856-859. 10.1038/ncb0901-856.
Article
CAS
PubMed
Google Scholar
Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S: Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor. Biochem Biophys Res Commun. 2002, 294: 1087-1092. 10.1016/S0006-291X(02)00606-X.
Article
CAS
PubMed
Google Scholar