Figure 1
From: Nck adapter proteins: functional versatility in T cells
Modular composition of Nck adapter proteins. Nck adapters are proteins of 47 kDa that are built of three SH3 domains and a C-terminal SH2 domain linked by small spacer regions. Nck1 displays 68% amino acid identity to Nck2. As indicated in the figure, the differences are mainly located in the linker regions between the interaction modules, whereas the individual SH2 and SH3 domains show a high degree of homology. Modular domains of Nck1 (NP_006140) and Nck2 (AAH07195) have been assigned using the simple modular architecture research tool SMART http://smart.embl-heidelberg.de. The sequence homology between the interaction modules and the linker regions was determined using the SIM alignment tool for protein sequences http://www.expasy.ch/tools/sim-prot.html. Percent values indicate the degree of identity of the respective regions.