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  1. Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the ...

    Authors: Yuan Yan Sin, Tamara P Martin, Lauren Wills, Susan Currie and George S Baillie
    Citation: Cell Communication and Signaling 2015 13:16
    Content type: Research Published on:

  2. The mechanistic target of rapamycin, (mTOR) kinase plays a pivotal role in controlling critical cellular growth and survival pathways, and its aberrant induction is implicated in cancer pathogenesis. Therefore...

    Authors: Krystyna Mazan-Mamczarz, Raymond J Peroutka, James J Steinhardt, Moriah Gidoni, Yongqing Zhang, Elin Lehrmann, Ari L Landon, Bojie Dai, Simone Houng, Parameswary A Muniandy, Sol Efroni, Kevin G Becker and Ronald B Gartenhaus
    Citation: Cell Communication and Signaling 2015 13:15
    Content type: Research Published on:

  3. Expression of programmed cell death ligand 1 (PD-L1) is an important process by which tumor cells suppress antitumor immunity in the tumor microenvironment. Bone marrow (BM)–derived immune cells are an importa...

    Authors: Hyangsoon Noh, Jiemiao Hu, Xiaohong Wang, Xueqing Xia, Arun Satelli and Shulin Li
    Citation: Cell Communication and Signaling 2015 13:14
    Content type: Research Published on:

  4. We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection triggers an interleukin-1 (IL-1) activat...

    Authors: Ichiro Murakami, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Yasushi Horie, Kazuhiko Hayashi, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert, Katsuyoshi Takata, Takashi Oka and Tadashi Yoshino
    Citation: Cell Communication and Signaling 2015 13:13
    Content type: Review Published on:

  5. The RAS/MAPK signaling pathway can regulate gene expression by phosphorylating and altering the function of some, but not all, ETS transcription factors. ETS family transcription factors bind similar DNA seque...

    Authors: Nagarathinam Selvaraj, Vivekananda Kedage and Peter C Hollenhorst
    Citation: Cell Communication and Signaling 2015 13:12
    Content type: Research Published on:

  6. The viral G protein-coupled receptor (vGPCR) is proposed to act as one of the predominant mediators of Kaposi’s sarcoma (KS), a human herpes virus 8 (HHV8)-elicited disease. The actions of vGPCR manifest patho...

    Authors: Julie Dwyer, Sandy Azzi, Héloïse M Leclair, Steven Georges, Agnès Carlotti, Lucas Treps, Eva M Galan-Moya, Catherine Alexia, Nicolas Dupin, Nicolas Bidère and Julie Gavard
    Citation: Cell Communication and Signaling 2015 13:11
    Content type: Short report Published on:

  7. Chronic myeloid leukemia (CML) is driven by the expression of the BCR-ABL oncoprotein. STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylation in CML cells. Activated STAT5 (pSTAT5)...

    Authors: Dirk Fahrenkamp, Hildegard Schmitz-Van de Leur, Andrea Küster, Nicolas Chatain and Gerhard Müller-Newen
    Citation: Cell Communication and Signaling 2015 13:10
    Content type: Research Published on:

  9. Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder in which leukemic cells display a reciprocal t(9:22) chromosomal translocation that results in the formation of the chimeric BCR-ABL ...

    Authors: Stefania Raimondo, Laura Saieva, Chiara Corrado, Simona Fontana, Anna Flugy, Aroldo Rizzo, Giacomo De Leo and Riccardo Alessandro
    Citation: Cell Communication and Signaling 2015 13:8
    Content type: Research Published on:

  10. Phosphatidylinositol 3-Kinases (PI3Ks) are a family of lipid kinases that phosphorylate the D3-hydroxyls of the inositol ring of phosphoinositides, and are responsible for coordinating a diverse range of cellu...

    Authors: Vivek K Gupta, Ammaji Rajala and Raju VS Rajala
    Citation: Cell Communication and Signaling 2015 13:7
    Content type: Research Published on:

  11. The Rho GTPase RhoB has been proposed to be a tumor suppressor in cancer and is downregulated in various tumors including prostate. RhoB has different effects on cell migration depending on the cell type and c...

    Authors: Francisco M Vega, Mairian Thomas, Nicolas Reymond and Anne J Ridley
    Citation: Cell Communication and Signaling 2015 13:6
    Content type: Research Published on:

  12. The growth factor heregulin (HRG) potently stimulates epithelial cell survival and proliferation through the binding of its cognate receptor ErbB3 (also known as HER3). ErbB3-dependent signal transmission reli...

    Authors: Annabell Bischoff, Michaela Bayerlová, Michaela Strotbek, Simone Schmid, Tim Beissbarth and Monilola A Olayioye
    Citation: Cell Communication and Signaling 2015 13:5
    Content type: Research Published on:

  13. Elevated levels of the inflammatory cytokine TNF-α are common in chronic diseases or inherited or degenerative muscle disorders and can lead to muscle wasting. By contrast, IGF1 has a growth promoting effect o...

    Authors: Swanhild U Meyer, Christian Thirion, Anna Polesskaya, Stefan Bauersachs, Sebastian Kaiser, Sabine Krause and Michael W Pfaffl
    Citation: Cell Communication and Signaling 2015 13:4
    Content type: Research Published on:

  14. Homeodomain interacting protein kinases (HIPKs) function as modulators of cellular stress responses and regulate cell differentiation, proliferation and apoptosis. The HIPK family includes HIPK1, HIPK2 and HIP...

    Authors: Jan van der Laden, Ulf Soppa and Walter Becker
    Citation: Cell Communication and Signaling 2015 13:3
    Content type: Research Published on:

  15. The WNT/planar-cell-polarity (PCP) pathway is a key regulator of cell polarity and directional cell movements. Core PCP proteins such as Van Gogh-like2 (VANGL2) are evolutionarily highly conserved; however, th...

    Authors: Markéta Kaucká, Julian Petersen, Pavlína Janovská, Tomasz Radaszkiewicz, Lucie Smyčková, Avais M Daulat, Jean-Paul Borg, Gunnar Schulte and Vitezslav Bryja
    Citation: Cell Communication and Signaling 2015 13:2
    Content type: Methodology Published on:

  16. Many receptors function by binding to multiple ligands, each eliciting a distinct biological output. The extracellular domain of the human prolactin receptor (hPRL-R) uses an identical epitope to bind to both ...

    Authors: Shahir S Rizk, Jean-Louis K Kouadio, Anna Szymborska, Erica M Duguid, Somnath Mukherjee, Jiamao Zheng, Charles V Clevenger and Anthony A Kossiakoff
    Citation: Cell Communication and Signaling 2015 13:1
    Content type: Short report Published on:

  17. Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in sever...

    Authors: Carla J Aguiar, João A Rocha-Franco, Pedro A Sousa, Anderson K Santos, Marina Ladeira, Cibele Rocha-Resende, Luiz O Ladeira, Rodrigo R Resende, Fernando A Botoni, Marcos Barrouin Melo, Cristiano X Lima, José M Carballido, Thiago M Cunha, Gustavo B Menezes, Silvia Guatimosim and M Fatima Leite
    Citation: Cell Communication and Signaling 2014 12:78
    Content type: Research Published on:

  18. TGFβ1 (Transforming Growth Factor-beta1) is a versatile regulator of T cell immune responses. Depending on its context in the immunological environment, TGFβ1 guides T cells toward specific activation programs...

    Authors: Thomas Harder, Karina Guttek, Lars Philipsen, Luca Simeoni, Burkhart Schraven and Dirk Reinhold
    Citation: Cell Communication and Signaling 2014 12:74
    Content type: Research Published on:

  19. IRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-κB activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocyt...

    Authors: Jiangfeng Du, Gerry AF Nicolaes, Danielle Kruijswijk, Miranda Versloot, Tom van der Poll and Cornelis van ’t Veer
    Citation: Cell Communication and Signaling 2014 12:77
    Content type: Research Published on:

  20. B cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation ...

    Authors: Narasimhulu Simma, Tanima Bose, Sascha Kahlfuß, Judith Mankiewicz, Theresa Lowinus, Fred Lühder, Thomas Schüler, Burkhart Schraven, Martin Heine and Ursula Bommhardt
    Citation: Cell Communication and Signaling 2014 12:75
    Content type: Research Published on:

  21. Epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 is one of well-recognized factors contributing to renal fibrosis. However, the underlying molecular mechanisms of EMT are not fully understood. Brac...

    Authors: Shiren Sun, Wenjuan Sun, Lin Xia, Limin Liu, Rui Du, Lijie He, Rong Li, Hanmin Wang and Chen Huang
    Citation: Cell Communication and Signaling 2014 12:76
    Content type: Research Published on:

  22. Adrenogonadal cell growth and differentiation are controlled by nuclear receptor NR5A1 (Ad4BP/SF-1) that regulates the expression of adrenal and gonadal genes. In addition, SF-1 also resides in the centrosome ...

    Authors: Chia-Yih Wang, Pao-Yen Lai, Ting-Yu Chen and Bon-chu Chung
    Citation: Cell Communication and Signaling 2014 12:55
    Content type: Research Published on:

  23. Increased activity or expression of integrin-linked kinase (ILK), which regulates cell adhesion, migration, and proliferation, leads to oncogenesis. We identified the molecular basis for the regulation of ILK ...

    Authors: Po-Chun Tseng, Chia-Ling Chen, Yan-Shen Shan, Wen-Teng Chang, Hsiao-Sheng Liu, Tse-Ming Hong, Chia-Yuan Hsieh, Sheng-Hsiang Lin and Chiou-Feng Lin
    Citation: Cell Communication and Signaling 2014 12:69
    Content type: Research Published on:

  25. The nuclear factor κB (NF-κB) family members regulate several biological processes as cell proliferation and differentiation, inflammation, immunity and tumor progression. Ubiquitination plays a key role in NF...

    Authors: Naima Zemirli, Marie Pourcelot, Neslihan Dogan, Aimé Vazquez and Damien Arnoult
    Citation: Cell Communication and Signaling 2014 12:72
    Content type: Short report Published on:

  26. One of the most insidious characteristics of cancer is its spread to and ability to compromise distant organs via the complex process of metastasis. Communication between cancer cells and organ-resident cells ...

    Authors: Alexandra Koch, Shashank Saran, Doan Duy Hai Tran, Sabine Klebba-Färber, Hauke Thiesler, Katherina Sewald, Susann Schindler, Armin Braun, Robert Klopfleisch and Teruko Tamura
    Citation: Cell Communication and Signaling 2014 12:73
    Content type: Methodology Published on:

  27. Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes and its use as a substrate for glycolysis and mitoch...

    Authors: Tomás Gutiérrez, Valentina Parra, Rodrigo Troncoso, Christian Pennanen, Ariel Contreras-Ferrat, César Vasquez-Trincado, Pablo E Morales, Camila Lopez-Crisosto, Cristian Sotomayor-Flores, Mario Chiong, Beverly A Rothermel and Sergio Lavandero
    Citation: Cell Communication and Signaling 2014 12:68
    Content type: Research Published on:

  28. G protein-coupled receptors (GPCRs) represent a physiologically and pharmacologically important family of receptors that upon coupling to GαS stimulate cAMP production catalyzed by adenylyl cyclase. Thus, develop...

    Authors: Ashutosh Trehan, Emmi Rotgers, Eleanor T Coffey, Ilpo Huhtaniemi and Adolfo Rivero-Müller
    Citation: Cell Communication and Signaling 2014 12:70
    Content type: Methodology Published on:

  30. The rod photoreceptor cGMP-gated cation channel, consisting of three α- and one β subunit, controls ion flow into the rod outer segment (ROS). In addition to the β-subunit, the Cngb1 locus encodes an abundant sol...

    Authors: Shanta Sarfare, Alex S McKeown, Jeffrey Messinger, Glen Rubin, Hongjun Wei, Timothy W Kraft and Steven J Pittler
    Citation: Cell Communication and Signaling 2014 12:67
    Content type: Research Published on:

  31. Iron transport across the blood-brain barrier (BBB) involves the cooperation of brain microvascular endothelial cells (BMVEC) and their neighboring astrocytes. Astrocytes secrete a soluble form of ceruloplasmi...

    Authors: Ryan C McCarthy and Daniel J Kosman
    Citation: Cell Communication and Signaling 2014 12:65
    Content type: Research Published on:

  32. Human cells release nano-sized vesicles called exosomes, containing mRNA, miRNA and specific proteins. Exosomes from one cell can be taken up by another cell, which is a recently discovered cell-to-cell commun...

    Authors: Hui Xiao, Cecilia Lässer, Ganesh Vilas Shelke, Juan Wang, Madeleine Rådinger, Taral Rameshchand Lunavat, Carina Malmhäll, Li Hui Lin, Jia Li, Li Li and Jan Lötvall
    Citation: Cell Communication and Signaling 2014 12:64
    Content type: Research Published on:

  33. The TIR domain-containing proteins BtpA/Btp1/TcpB and BtpB are translocated into host cells by the facultative intracellular bacterial pathogen Brucella. Here, they interfere with Toll like receptor signalling to...

    Authors: Christine Felix, Burcu Kaplan Türköz, Sebastien Ranaldi, Thomas Koelblen, Laurent Terradot, David O’Callaghan and Annette Caroline Vergunst
    Citation: Cell Communication and Signaling 2014 12:53
    Content type: Research Published on:

  34. Accelerated cell cycle progression is the common feature of most cancers. MiRNAs can act as oncogenes or tumor suppressors by directly modulating cell cycle machinery. It has been shown that miR-188 is upregul...

    Authors: Jiangbin Wu, Qing Lv, Jie He, Haoxiang Zhang, Xueshuang Mei, Kai Cui, Nunu Huang, Weidong Xie, Naihan Xu and Yaou Zhang
    Citation: Cell Communication and Signaling 2014 12:66
    Content type: Research Published on:

  35. The myotonic dystrophy kinase-related CDC42-binding kinases MRCKβ and MRCKβ regulate actin-myosin contractility and have been implicated in cancer metastasis. Along with the related ROCK1 and ROCK2 kinases, th...

    Authors: Mathieu Unbekandt, Daniel R Croft, Diane Crighton, Mokdad Mezna, Duncan McArthur, Patricia McConnell, Alexander W Schüttelkopf, Simone Belshaw, Andrew Pannifer, Mairi Sime, Justin Bower, Martin Drysdale and Michael F Olson
    Citation: Cell Communication and Signaling 2014 12:54
    Content type: Research Published on:

  36. Hepatocellular carcinoma (HCC) typically relies on tumor transformation and angiogenesis for its malignant behavior, including growth and metastasis. Previously, we reported that Vasohibin2 (VASH2) is preferen...

    Authors: Xiaofeng Xue, Ye Zhang, Qiaoming Zhi, Min Tu, Yue Xu, Jie Sun, Jishu Wei, Zipeng Lu, Yi Miao and Wentao Gao
    Citation: Cell Communication and Signaling 2014 12:62
    Content type: Research Published on:

  37. Mesenchymal stem cells (MSCs) are increasingly considered to be used as biological immunosuppressants in hematopoietic stem cell transplantation (HSCT). In the early reconstitution phase following HSCT, natura...

    Authors: Debanjana Chatterjee, Nicole Marquardt, Dejene Milkessa Tufa, Guillaume Beauclair, Hui Zhi Low, Tim Hatlapatka, Ralf Hass, Cornelia Kasper, Constantin von Kaisenberg, Reinhold Ernst Schmidt and Roland Jacobs
    Citation: Cell Communication and Signaling 2014 12:63
    Content type: Research Published on:

  38. Inositol 1,4,5-trisphosphate receptor (IP3R) plays a pivotal role in the Ca2+ release process in a variety of cell types. Additionally, IP3R is distributed in ventricular intercalated discs, but its function(s) i...

    Authors: Man Kang, Na Lin, Chen Li, Qingli Meng, Yuanyuan Zheng, Xinxin Yan, Jianxin Deng, Yang Ou, Chao Zhang, Junqi He and Dali Luo
    Citation: Cell Communication and Signaling 2014 12:58
    Content type: Research Published on:

  39. INPP4B and PTEN dual specificity phosphatases are frequently lost during progression of prostate cancer to metastatic disease. We and others have previously shown that loss of INPP4B expression correlates with...

    Authors: Myles C Hodgson, Elena I Deryugina, Egla Suarez, Sandra M Lopez, Dong Lin, Hui Xue, Ivan P Gorlov, Yuzhuo Wang and Irina U Agoulnik
    Citation: Cell Communication and Signaling 2014 12:61
    Content type: Research Published on:

  40. A number of receptor kinases contain guanylate cyclase (GC) catalytic centres encapsulated in the cytosolic kinase domain. A prototypical example is the phytosulfokine receptor 1 (PSKR1) that is involved in re...

    Authors: Victor Muleya, Janet I Wheeler, Oziniel Ruzvidzo, Lubna Freihat, David T Manallack, Chris Gehring and Helen R Irving
    Citation: Cell Communication and Signaling 2014 12:60
    Content type: Short report Published on:

  41. Adhesion and migration are relevant physiological functions that must be regulated by the cell under both normal and pathological conditions. The dioxin receptor (AhR) has emerged as a transcription factor reg...

    Authors: Javier Rey-Barroso, Alberto Alvarez-Barrientos, Eva Rico-Leo, María Contador-Troca, José M Carvajal-Gonzalez, Asier Echarri, Miguel A del Pozo and Pedro M Fernandez-Salguero
    Citation: Cell Communication and Signaling 2014 12:57
    Content type: Research Published on:

  42. It is well established that inflammation promotes cancer, including melanoma, although the exact mechanisms involved are less known. In this study, we tested the hypothesis that inflammatory factors affect the...

    Authors: Pauline Ostyn, Raja El Machhour, Severine Begard, Nuria Kotecki, Jerome Vandomme, Pilar Flamenco, Pascaline Segard, Bernadette Masselot, Pierre Formstecher, Yasmine Touil and Renata Polakowska
    Citation: Cell Communication and Signaling 2014 12:52
    Content type: Research Published on:

  43. Autophagy is a vesicle-mediated pathway for lysosomal degradation, essential under basal and stressed conditions. Various cellular components, including specific proteins, protein aggregates, organelles and in...

    Authors: Christoph S Börlin, Verena Lang, Anne Hamacher-Brady and Nathan R Brady
    Citation: Cell Communication and Signaling 2014 12:56
    Content type: Research Published on:

  44. Cryptococcus neoformans is the most common cause of fungal meningitis among individuals with HIV/AIDS, which is uniformly fatal without proper treatment. The underlying mechanism of disease development in the bra...

    Authors: Tong-Bao Liu, Selvakumar Subbian, Weihua Pan, Eliseo Eugenin, Jianping Xie and Chaoyang Xue
    Citation: Cell Communication and Signaling 2014 12:51
    Content type: Research Published on:

  45. Exocytosis of sperm’s single secretory granule or acrosome (acrosome reaction, AR) is a highly regulated event essential for fertilization. The AR begins with an influx of calcium from the extracellular milieu...

    Authors: María C Ruete, Ornella Lucchesi, Matías A Bustos and Claudia N Tomes
    Citation: Cell Communication and Signaling 2014 12:43
    Content type: Research Published on:

  47. Platelet-derived growth factor-BB (PDGF-BB) has been implicated in the proliferation, migration and synthetic activities of smooth muscle cells that characterize physiologic and pathologic tissue remodeling in...

    Authors: Wei Yang, Aruna Ramachandran, Sungyong You, HyoBin Jeong, Samantha Morley, Michelle D Mulone, Tanya Logvinenko, Jayoung Kim, Daehee Hwang, Michael R Freeman and Rosalyn M Adam
    Citation: Cell Communication and Signaling 2014 12:44
    Content type: Research Published on:

  48. The aryl hydrocarbon receptor (AhR) has gradually emerged as a regulator of inflammation in the lung and other tissues. AhR may interact with the p65-subunit of the nuclear factor (NF)-κB transcription factors...

    Authors: Johan Øvrevik, Marit Låg, Valerie Lecureur, David Gilot, Dominique Lagadic-Gossmann, Magne Refsnes, Per E Schwarze, Tonje Skuland, Rune Becher and Jørn A Holme
    Citation: Cell Communication and Signaling 2014 12:48
    Content type: Research Published on:

  49. Neuregulin 1 (NRG1) and NMDARs play important roles in various neuronal functions including neural development. NMDARs also promote many cellular events such as proliferation and survival of neuroblasts before...

    Authors: Chirayu D Pandya and Anilkumar Pillai
    Citation: Cell Communication and Signaling 2014 12:47
    Content type: Research Published on:

  50. The CARMA1-BCL10-MALT1 (CBM) complex bridges T cell receptor (TCR) signaling to the canonical IκB kinase (IKK)/NF-κB pathway. The CBM complex constitutes a signaling cluster of more than 1 Mio Dalton. Little i...

    Authors: Gisela Schimmack, Andrea C Eitelhuber, Michelle Vincendeau, Katrin Demski, Hisaaki Shinohara, Tomohiro Kurosaki and Daniel Krappmann
    Citation: Cell Communication and Signaling 2014 12:49
    Content type: Short report Published on:
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