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  1. Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate...

    Authors: Gernot Posselt, Maria Wiesauer, Bianca E. Chichirau, Daniela Engler, Linda M. Krisch, Gabriele Gadermaier, Peter Briza, Sabine Schneider, Francesco Boccellato, Thomas F. Meyer, Cornelia Hauser-Kronberger, Daniel Neureiter, Anne Müller and Silja Wessler
    Citation: Cell Communication and Signaling 2019 17:10
    Content type: Research Published on:

  2. To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway.

    Authors: Yu-hong Yuan, Han-yu Wang, Yu Lai, Wa Zhong, Wei-ling Liang, Fu-de Yan, Zhong Yu, Jun-kai Chen and Ying Lin
    Citation: Cell Communication and Signaling 2019 17:9
    Content type: Research Published on:

  3. Ghrelin modulates many physiological processes. However, the effects of intestinal ghrelin on hepatic glucose production (HGP) are still unclear. The current study was to explore the roles of intestinal ghreli...

    Authors: Yao Lin, Zerong Liang, Liping He, Mengliu Yang, Dongfang Liu, Harvest F. Gu, Hua Liu, Zhiming Zhu, Hongting Zheng, Ling Li and Gangyi Yang
    Citation: Cell Communication and Signaling 2019 17:8
    Content type: Research Published on:

  4. Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that are known to play a role in the ca...

    Authors: Huihui Xu, Tianshu Fang, Hongbo Yan and Linghuo Jiang
    Citation: Cell Communication and Signaling 2019 17:7
    Content type: Short report Published on:

  6. Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxic...

    Authors: Theresa Lowinus, Florian H. Heidel, Tanima Bose, Subbaiah Chary Nimmagadda, Tina Schnöder, Clemens Cammann, Ingo Schmitz, Ulrike Seifert, Thomas Fischer, Burkhart Schraven and Ursula Bommhardt
    Citation: Cell Communication and Signaling 2019 17:5
    Content type: Research Published on:

  7. As the first member of the metastasis-associated protein (MTA) family, MTA1 and another MTA family member, MTA2, have both been reported to promote breast cancer progression and metastasis. However, the differ...

    Authors: Long Zhang, Qi Wang, Yuzhen Zhou, Qianwen Ouyang, Weixing Dai, Jianfeng Chen, Peipei Ding, Ling Li, Xin Zhang, Wei Zhang, Xinyue Lv, Luying Li, Pingzhao Zhang, Guoxiang Cai and Weiguo Hu
    Citation: Cell Communication and Signaling 2019 17:4
    Content type: Research Published on:

  8. Despite therapeutic advancements (e.g. B-RAF inhibitors) targeting cutaneous melanoma, many cellular processes, including inducible heme oxygenase 1 (HO-1), counteract treatments for malignancies. So there is ...

    Authors: Liu Liu, Yan Wu, Chunxiang Bian, Muhammad Farrukh Nisar, Mei Wang, Xiangyu Hu, Qingchun Diao, Weiqi Nian, Enwen Wang, Wei Xu and Julia Li Zhong
    Citation: Cell Communication and Signaling 2019 17:3
    Content type: Research Published on:

  9. Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2), a key antioxidant transcription factor...

    Authors: Hongming Lv, Lihua Hong, Ye Tian, Changjiu Yin, Chao Zhu and Haihua Feng
    Citation: Cell Communication and Signaling 2019 17:2
    Content type: Research Published on:

  10. Exosomes are a class of extracellular vesicles released by multiple cells types including tumor cells, with a size range of 30-100 nm and a lipid bilayer membrane. Recently, the role of exosomes in cell-to-cel...

    Authors: Rui Chen, Xin Xu, Yuquan Tao, Zijun Qian and Yongchun Yu
    Citation: Cell Communication and Signaling 2019 17:1
    Content type: Review Published on:

  11. Megakaryopoiesis allows platelet formation, which is necessary for coagulation, also playing an important role in different pathologies. However, this process remains to be fully characterized. C3G, an activat...

    Authors: Sara Ortiz-Rivero, Cristina Baquero, Luis Hernández-Cano, Juan José Roldán-Etcheverry, Sara Gutiérrez-Herrero, Cristina Fernández-Infante, Víctor Martín-Granado, Eduardo Anguita, José María de Pereda, Almudena Porras and Carmen Guerrero
    Citation: Cell Communication and Signaling 2018 16:101
    Content type: Research Published on:

  12. Adipocytes make up the major component of breast tissue, accounting for 90% of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a critical role in cancer progression. Adi...

    Authors: Jin-Yong He, Xiao-Hui Wei, Si-Jing Li, Yang Liu, Hao-Lin Hu, Zheng-Zheng Li, Xin-Hong Kuang, Lai Wang, Xin Shi, Sheng-Tao Yuan and Li Sun
    Citation: Cell Communication and Signaling 2018 16:100
    Content type: Research Published on:

  13. The molecular signaling events involving in high malignancy and poor prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade of currently known targets has not yet led to successful cli...

    Authors: Bin Dai, Xuan Zhang, Runze Shang, Jianlin Wang, Xisheng Yang, Hong Zhang, Qi Liu, Desheng Wang, Lin Wang and Kefeng Dou
    Citation: Cell Communication and Signaling 2018 16:99
    Content type: Research Published on:

  14. Previously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood.

    Authors: Junsong Zhou, Aizhen Yang, Yucan Wang, Fengwu Chen, Zhenzhen Zhao, Viralkumar Davra, Katsue Suzuki-Inoue, Yukio Ozaki, Raymond B. Birge, Qingxian Lu and Yi Wu
    Citation: Cell Communication and Signaling 2018 16:98
    Content type: Research Published on:

  15. Transforming growth factor beta 1 (TGF-β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration and muscle function in skeletal muscle diseases. Skeleta...

    Authors: Xiaofan Yang, Pingping Xue, Xin Liu, Xiang Xu and Zhenbing Chen
    Citation: Cell Communication and Signaling 2018 16:97
    Content type: Research Published on:

  16. Human pluripotent stem cells (PSCs) open new windows for basic research and regenerative medicine due to their remarkable properties, i.e. their ability to self-renew indefinitely and being pluripotent. There ...

    Authors: Fereshteh Haghighi, Julia Dahlmann, Saeideh Nakhaei-Rad, Alexander Lang, Ingo Kutschka, Martin Zenker, George Kensah, Roland P. Piekorz and Mohammad Reza Ahmadian
    Citation: Cell Communication and Signaling 2018 16:96
    Content type: Research Published on:

  17. The regulatory mechanisms of hematopoiesis and cellular immunity show a high degree of similarity between insects and mammals, and Drosophila has become a good model for investigating cellular immune responses. J...

    Authors: Yangguang Hao, Shichao Yu, Fangzhou Luo and Li Hua Jin
    Citation: Cell Communication and Signaling 2018 16:95
    Content type: Research Published on:

  18. TP53 mutations in cancer cells often evoke cell invasiveness, whereas fibroblasts show invasiveness in the presence of intact TP53. AMAP1 (also called DDEF1 or ASAP1) is a downstream effector of ARF6 and is essen...

    Authors: Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Tsukasa Oikawa and Hisataka Sabe
    Citation: Cell Communication and Signaling 2018 16:94
    Content type: Research Published on:

  19. Platelet-derived growth factor receptor α (PDGFRα) expression is increased in activated hepatic stellate cells (HSCs) in cirrhotic liver, while normal hepatocytes express PDGFRα at a negligible level. However, ca...

    Authors: Beom Jin Lim, Woon-Kyu Lee, Hyun Woong Lee, Kwan Sik Lee, Ja Kyung Kim, Hye Young Chang and Jung Il Lee
    Citation: Cell Communication and Signaling 2018 16:93
    Content type: Research Published on:

  20. Chemotherapy is the primary established systemic treatment for patients with breast cancer, especially those with the triple-negative subtype. Simultaneously, the resistance of triple-negative breast cancer (T...

    Authors: Peng Huang, Deng-jie Ouyang, Shi Chang, Mo-yun Li, Lun Li, Qian-ying Li, Rong Zeng, Qiong-yan Zou, Juan Su, Piao Zhao, Lei Pei and Wen-jun Yi
    Citation: Cell Communication and Signaling 2018 16:92
    Content type: Research Published on:

  21. The link between cardiac diseases and cognitive deterioration has been accepted from the concept of “cardiogenic dementia”, which was proposed in the late 1970s. However, the molecular mechanism is unclarified.

    Authors: Ming-Jing Duan, Mei-Ling Yan, Qin Wang, Meng Mao, Dan Su, Lin-Lin Sun, Ke-Xin Li, Yang Qu, Qiang Sun, Xin-Yu Zhang, Si-Yu Huang, Ji-Chao Ma, Tao Ban and Jing Ai
    Citation: Cell Communication and Signaling 2018 16:91
    Content type: Research Published on:

  22. Following publication of the original article [1], the authors reported an error in the name of the 11th author. The author’s name was incorrectly published as “Vincenzo Calautti”, instead of “Enzo Calautti”.

    Authors: Maria del Pilar Camacho Leal, Andrea Costamagna, Beatrice Tassone, Stefania Saoncella, Matilde Simoni, Dora Natalini, Aurora Dadone, Marianna Sciortino, Emilia Turco, Paola Defilippi, Enzo Calautti and Sara Cabodi
    Citation: Cell Communication and Signaling 2018 16:90
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2018 16:73

  23. Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by the histopathological pattern of usual interstitial pneumonia and is associated with a high mortality rate. Recently, lung resident...

    Authors: Jiwei Hou, Jingyan Shi, Ling Chen, Zhongyang Lv, Xiang Chen, Honghui Cao, Zou Xiang and Xiaodong Han
    Citation: Cell Communication and Signaling 2018 16:89
    Content type: Research Published on:

  24. Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer ...

    Authors: Petr Tomek, Shanti K. Gore, Chloe L. Potts, Cristin G. Print, Michael A. Black, Ariane Hallermayr, Michael Kilian, Evelyn Sattlegger and Lai-Ming Ching
    Citation: Cell Communication and Signaling 2018 16:88
    Content type: Research Published on:

  25. Deregulated metabolism is a hallmark of cancer and recent evidence underlines that targeting tumor energetics may improve therapy response and patient outcome. Despite the general attitude of cancer cells to e...

    Authors: Elena Andreucci, Silvia Pietrobono, Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini, Alessio Biagioni, Barbara Stecca and Lido Calorini
    Citation: Cell Communication and Signaling 2018 16:87
    Content type: Research Published on:

  26. MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-mediated gene expression. The activity of MRTF-A is critically dependent on the dissociation of G-actin from N-terminal RPEL motifs. M...

    Authors: Franziska Kluge, Julia Weissbach, Anja Weber, Theresia Stradal and Guido Posern
    Citation: Cell Communication and Signaling 2018 16:86
    Content type: Research Published on:

  27. Rapamycin is a potent inhibitor of the highly conserved TOR kinase, the nutrient-sensitive controller of growth and aging. It has been utilised as a chemotherapeutic agent due to its anti-proliferative propert...

    Authors: Duygu Dikicioglu, Elif Dereli Eke, Serpil Eraslan, Stephen G. Oliver and Betul Kirdar
    Citation: Cell Communication and Signaling 2018 16:85
    Content type: Research Published on:

  28. Impaired wound healing frequently occurs in diabetes mellitus (DM) and is implicated in impaired angiogenesis. Long non-coding RNA (lncRNA) H19 has been reported as being reduced in DM and played a critical ro...

    Authors: Jian-Rong Guo, Lei Yin, Yong-Quan Chen, Xiao-Ju Jin, Xun Zhou, Na-Na Zhu, Xiao-Qian Liu, Han-Wei Wei and Li-Shuang Duan
    Citation: Cell Communication and Signaling 2018 16:84
    Content type: Research Published on:

  29. P2X7 is ubiquitously expressed in myeloid cells and regulates the pathophysiology of inflammatory diseases. Since mitochondrial function in microglia is highly associated with microglial functions in controlli...

    Authors: Ponarulselvam Sekar, Duen-Yi Huang, Shie-Liang Hsieh, Shwu-Fen Chang and Wan-Wan Lin
    Citation: Cell Communication and Signaling 2018 16:83
    Content type: Research Published on:

  30. Knockdown of Akt1 promotes Epithelial-to-Mesenchymal Transition in breast cancer cells. However, the mechanisms are not completely understood.

    Authors: Wei Li, Jiu-Zhou Hou, Jie Niu, Zhuo-Qing Xi, Chang Ma, Hua Sun, Chao-Jie Wang, Dong Fang, Qin Li and Song-Qiang Xie
    Citation: Cell Communication and Signaling 2018 16:82
    Content type: Research Published on:

  31. Four-octyl itaconate (OI), the itaconate’s cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective functi...

    Authors: Hua Liu, Yu Feng, Min Xu, Jian Yang, Zhichun Wang and Guangfu Di
    Citation: Cell Communication and Signaling 2018 16:81
    Content type: Research Published on:

  32. Following publication of the original article [1], the authors reported an error in Table 3. The correct version of Table 3 is shown below:

    Authors: Julianna Kardos, László Héja, Ágnes Simon, István Jablonkai, Richard Kovács and Katalin Jemnitz
    Citation: Cell Communication and Signaling 2018 16:80
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2018 16:71

  33. Insulin signaling pathway in β-cell is essential to promote β-cells proliferation and survival, while Nodal–ALK7–Smad3 signaling involves β-cells apoptosis. We attempted to address inter-relationship between N...

    Authors: Junfeng Li, Zhihong Wang, Liwei Ren, Linling Fan, Wenjuan Liu, Yaojing Jiang, Harry K. Lau, Rui Liu and Qinghua Wang
    Citation: Cell Communication and Signaling 2018 16:79
    Content type: Research Published on:

  34. Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis....

    Authors: Suryakant Niture, Maxwell A. Gyamfi, Habib Kedir, Elena Arthur, Habtom Ressom, Gagan Deep and Deepak Kumar
    Citation: Cell Communication and Signaling 2018 16:78
    Content type: Research Published on:

  35. The deubiquitinase USP17 is overexpressed in NSCLC and has been shown to be required for the growth and motility of EGFR wild-type (WT) NSCLC cells. USP17 is also required for clathrin-mediated endocytosis of EGF...

    Authors: Aidan P. McCann, Peter Smyth, Francesco Cogo, William J. McDaid, Lai Jiang, Jia Lin, Emma Evergren, Roberta E. Burden, Sandra Van Schaeybroeck, Christopher J. Scott and James F. Burrows
    Citation: Cell Communication and Signaling 2018 16:77
    Content type: Research Published on:

  36. Tunnelling nanotubes (TNTs), also known as membrane nanochannels, are actin-based structures that facilitate cytoplasmic connections for rapid intercellular transfer of signals, organelles and membrane compone...

    Authors: Eshna Jash, Peeyush Prasad, Naveen Kumar, Taruna Sharma, Aaron Goldman and Seema Sehrawat
    Citation: Cell Communication and Signaling 2018 16:76
    Content type: Review Published on:

  37. Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers for treatment selection. P-cadherin is frequently ov...

    Authors: Ana Sofia Ribeiro, Ana Rita Nobre, Nuno Mendes, João Almeida, André Filipe Vieira, Bárbara Sousa, Filomena A. Carvalho, Joana Monteiro, António Polónia, Martina Fonseca, João Miguel Sanches, Nuno C. Santos, Raquel Seruca and Joana Paredes
    Citation: Cell Communication and Signaling 2018 16:75
    Content type: Research Published on:

  38. We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environm...

    Authors: R. Betten, B. Scharner, S. Probst, B. Edemir, N. A. Wolff, C. Langelueddecke, W.-K. Lee and F. Thévenod
    Citation: Cell Communication and Signaling 2018 16:74
    Content type: Research Published on:

  39. p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracell...

    Authors: Maria del Pilar Camacho Leal, Andrea Costamagna, Beatrice Tassone, Stefania Saoncella, Matilde Simoni, Dora Natalini, Aurora Dadone, Marianna Sciortino, Emilia Turco, Paola Defilippi, Enzo Calautti and Sara Cabodi
    Citation: Cell Communication and Signaling 2018 16:73
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2018 16:90

  40. The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK...

    Authors: Sachith Gallolu Kankanamalage, Aroon S. Karra and Melanie H. Cobb
    Citation: Cell Communication and Signaling 2018 16:72
    Content type: Review Published on:

  41. Copper-containing enzymes perform fundamental functions by activating dioxygen (O2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O2 transport, metabolism and pr...

    Authors: Julianna Kardos, László Héja, Ágnes Simon, István Jablonkai, Richard Kovács and Katalin Jemnitz
    Citation: Cell Communication and Signaling 2018 16:71
    Content type: Review Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2018 16:80

  42. Benign Lymphoepithelial Lesion (BLEL) is a rare disease observed in the adult population. Despite the growing numbers of people suffering from BLEL, the etiology and mechanisms underlying its pathogenesis rema...

    Authors: Yao Mawulikplimi Adzavon, Pengxiang Zhao, Jianmin Ma, Xujuan Zhang, Xin Zhang, Mingzi Zhang, Mengyu Liu, Limin Wang, Danying Chen, Tarekegn Gebreyesus Abisso, Baobei Lv, Lei Wang, Fei Xie and Xuemei Ma
    Citation: Cell Communication and Signaling 2018 16:70
    Content type: Research Published on:

  43. Transmissible gastroenteritis virus (TGEV), the etiologic agent of transmissible gastroenteritis, infects swine of all ages causing vomiting and diarrhea, in newborn piglets the mortality rate is near 100%. In...

    Authors: Shuai Zhang, Weiwei Hu, Lvfeng Yuan and Qian Yang
    Citation: Cell Communication and Signaling 2018 16:69
    Content type: Research Published on:

  44. Myeloma bone disease (MBD) can cause bone destruction and increase the level of Ca2+ concentration in the bone marrow microenvironment by stimulating osteoclastic differentiation. Nevertheless, the relationships ...

    Authors: Hua Bai, Huayuan Zhu, Qing Yan, Xuxing Shen, Xiupan Lu, Juejin Wang, Jianyong Li and Lijuan Chen
    Citation: Cell Communication and Signaling 2018 16:68
    Content type: Research Published on:

  45. The tumor microenvironment enables important cellular interactions between cancer cells and recruited adjacent populations including mesenchymal stroma/stem cells (MSC). In vivo cellular interactions of primar...

    Authors: Catharina Melzer, Juliane von der Ohe and Ralf Hass
    Citation: Cell Communication and Signaling 2018 16:67
    Content type: Short report Published on:

  46. By allowing intercellular communication between cells, tunneling nanotubes (TNTs) could play critical role in cancer progression. If TNT formation is known to require cytoskeleton remodeling, key mechanism con...

    Authors: Fatéméh Dubois, Bastien Jean-Jacques, Hélène Roberge, Magalie Bénard, Ludovic Galas, Damien Schapman, Nicolas Elie, Didier Goux, Maureen Keller, Elodie Maille, Emmanuel Bergot, Gérard Zalcman and Guénaëlle Levallet
    Citation: Cell Communication and Signaling 2018 16:66
    Content type: Research Published on:

  47. Our previous work revealed that rhomboid domain-containing protein 1 (RHBDD1) participates in the modulation of cell growth and apoptosis in colorectal cancer cells. This study aimed to investigate the functio...

    Authors: Xin Zhang, Yuechao Zhao, Changjun Wang, Hongge Ju, Wenjie Liu, Xiaohui Zhang, Shiying Miao, Linfang Wang, Qiang Sun and Wei Song
    Citation: Cell Communication and Signaling 2018 16:65
    Content type: Research Published on:

  48. Mammalian target of rapamycin (mTOR) is a master regulator of various cellular responses by forming two functional complexes, mTORC1 and mTORC2. mTOR signaling is frequently dysregulated in pancreatic neuroend...

    Authors: Masoud Razmara, Azita Monazzam and Britt Skogseid
    Citation: Cell Communication and Signaling 2018 16:64
    Content type: Research Published on:

  50. TEM8 is a cell membrane protein predominantly expressed in tumor endothelium, which serves as a receptor for the protective antigen (PA) of anthrax toxin. However, the physiological ligands for TEM8 remain unk...

    Authors: Lian-Cheng Zhang, Yong Shao, Li-Hua Gao, Jin Liu, Yong-Yi Xi, Yin Xu, Chutse Wu, Wei Chen, Hui-Peng Chen, You-Liang Wang, Hai-Feng Duan and Xian-Wen Hu
    Citation: Cell Communication and Signaling 2018 16:62
    Content type: Research Published on:
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