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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Frizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1

Fig. 7

The FZD5-ALDH1A1 pathway activates Akt signaling. A pAkt, Akt, pJnk, Jnk, pErk, and Erk expression in OC cells detected by western blot. B pAkt and Akt expression in OVCAR3 cells with FZD5 knocked down detected by western blot. C pAkt, Akt, BRCA1, and RAD51 expression in OC cells 48 h after treatment with NCT-501 detected by western blot. D pAkt, Akt, BRCA1, and RAD51 expression in OC cells 48 h after treatment with MK-2206 detected by western blot. E γ-H2AX expression in OVCAR3 cells detected by immunofluorescence staining 24 h after treatment with cisplatin (5 µM) (mean ± SD, n = 3); scale bar: 100 μm. F Schematic showing the FZD5-ALDH1A1-Akt pathway

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Cell Communication and Signaling

ISSN: 1478-811X