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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Frizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1

Fig. 6

ALDH1A1 is a downstream effector of FZD5. A Active β-catenin expression in OC cells detected by western blot. B Active β-catenin expression in OVCAR3 cells detected by immunofluorescence staining; scale bar: 50 μm. C ALDH1A1 and active β-catenin expression in OC cells detected by real-time PCR and western blot (mean ± SD, n = 3). D ALDH1A1, BRCA1, and RAD51 expression in OVCAR3 cells with FZD5 knocked down detected by western blot. E γ-H2AX expression in OVCAR3 cells with FZD5 knocked down detected by immunofluorescence staining 24 h after treatment with cisplatin (5 µM) (mean ± SD, n = 3); scale bar: 100 μm. F Viability of OVCAR3 cells with FZD5 knocked down 48 h after treatment with cisplatin or olaparib analyzed by CCK8 assay (mean ± SD, n = 3)

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Cell Communication and Signaling

ISSN: 1478-811X