Fig. 6
From: Melanoma stimulates the proteolytic activity of HaCaT keratinocytes
Influence of melanoma on keratinocytes’ expression of TIMPs. Real-time PCR analysis of TIMP1, TIMP2, and TIMP3 expression. Cells were cultured in the presence of melanoma on Transwell inserts (INS) or with melanoma-conditioned media (CM). Control (CTRL) constitutes of cells cultured in kDMEM: mDMEM (1:1 ratio) media analogously to tested cells. The mean of at least three biological repetitions ± SD is shown. Asterisks indicate statistically important differences between control cells and CAKs or between different type of CAKs. The significance level was set at p ≤ 0.05 (*), p ≤ 0.01 (**) and p ≤ 0.001 (***)