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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Melanoma stimulates the proteolytic activity of HaCaT keratinocytes

Fig. 4

Influence of melanoma on keratinocytes’ proteolytic properties. Secreted by CAKs proteases were identified in conditioned media using proteases array (A). Based on obtained signals quantitative analysis was conducted. Results were normalized to reference spots and are shown in a form of heatmap, where darker red indicates a higher intensity of a signal. CAKs’ proteolytic activity was examined also in gelatin-FITC degradation assay (B). Cells were cultured in the presence of melanoma on Transwell inserts (INS) or with melanoma-conditioned media (CM). Abbreviations: ADAM, a disintegrin and metalloproteinase; MMPs, matrix metalloproteinases

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