Fig. 5
From: The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels
TRPM2-S increased the susceptibility to apoptosis of RPLS cells under oxidative stress. a Representative images of PI staining (upper panels), the analysis indicated that the apoptosis rate was significantly higher in TRPM2-H2O2 cells than control-H2O2 cells and had a concentration-dependence property (down panels). b ROS kit assays showed that ROS was gently increased in TRPM2-S-expressing cells but was sharply elevated in TRPM2-H2O2 cells compared with control cells and control-H2O2 cells respectively. c Western blotting revealed that cleaved caspase 3 was upregulated in TRPM2-S-H2O2 RPLS cells compared with control-H2O2 cells