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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: RETRACTED ARTICLE: Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway

Fig. 6

The AKT kinase inhibitor (HY-10249A) reverses KOR knockdown-mediated enhancement of proliferation, invasion and migration. A Levels of pAKT (S473) in KYSE30 and KYSE180 cells were decreased after treatment with HY-10249A (0.5 μM). B, C HY-10249A inhibited the proliferation of KYSE30 and KYSE180 cells, as reversing the effect of KOR knockdown. D. HY-10249A inhibited the invasive ability of KYSE30 and KYSE180 cells, as reversing the effect of KOR knockdown. E–F HY-10249A inhibited the migratory ability of KYSE30 and KYSE180 cells, as reversing the effect of KOR knockdown

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Cell Communication and Signaling

ISSN: 1478-811X