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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: RETRACTED ARTICLE: Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway

Fig. 3

KOR downregulation activates pPDK1-mediated-pAKT(S473) phosphorylation. A KEGG analysis of pathways enriched for genes up-regulated following KOR knockdown. The results showed that these genes were involved in the PI3K-Akt pathway, ECM-receptor interaction and regulation of actin cytoskeleton. B KOR knockdown elevated the phosphorylation level of pPDK1 and pAKT (S473), in ESCC cells, in the absence of changes in total protein expression of PDK1/AKT

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Cell Communication and Signaling

ISSN: 1478-811X