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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: RETRACTED ARTICLE: Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway

Fig. 2

KOR knockdown promotes ESCC cell proliferation, invasion and migration. A KOR protein levels in KYSE30 and KYSE180 decreased after transfection with the small interfering RNA against KOR (si-KOR-1, 2), as comparing with the negative control si-RNA (NC). B Gene Ontology (GO) analysis of dysregulated genes in KOR knockdown cells comparing with control. C–D Down-regulation of KOR enhanced the proliferation of KYSE30 and KYSE180 cells. E Down-regulation of KOR enhanced the invasive ability of KYSE30 and KYSE180 cells. F–G Down-regulation of KOR enhanced the migration of KYSE30 and KYSE180 cells

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Cell Communication and Signaling

ISSN: 1478-811X