| Actin-dependent | Scale (vesicle diameter) | Canonical cargoes | Cholesterol-dependent | Dynamin-dependent | Cell type first described in |
---|---|---|---|---|---|---|
Clathrin-dependent endocytosis | Depends on cell type [2] | 35–200 nm [3] | Tfr [4] | Yes [5] | A. aegypti oocytes [8] | |
Caveolae-dependent endocytosis | 50–80 nm [12] | Unclear | Yes [13] | Yes [14] | Murine gall bladder epithelium [15] | |
CLIC/GEEC pathway endocytosis | Tubulovesicular, 40Â nm width [18] | CTxB, CD44 [19] | Yes [16] | No [20] | COS, CHO cells [21] | |
Flotillin-dependent endocytosis | Unclear [22] | Unclear | Unclear | Yes [23] | Unclear | HeLa cells [24] |
IL-2Rβ pathway endocytosis | Yes [25] | IL-2Rβ [26] | Yes [29] | IARC 301.5, YT2C2, CIAC cells [30] | ||
Arf6-dependent endocytosis | Yes [31] | 60–200 nm | MHC-I, CD59 [32] | Yes [32] | Unclear | CHO cells [33] |
Phagocytosis | Microbial pathogens | Yes [42] | Ranine phagocytes [43] | |||
Fast endophilin-mediated endocytosis (FEME) | Yes [44] | Tubulo-vesicular, 100 nm–μm length | Yes [44] | Yes [44] | BSC1, HEK293 cells [44] | |
Activity-dependent bulk endocytosis (ADBE) | 150Â nm | VAMP4 [48] | Yes [49] | Yes [50] | Murine cerebellar granule cells [51] | |
Ultrafast endocytosis (UFE) | Yes [52] | Unclear | Yes [54] | Yes [52] | Nematode neurons [55] | |
Massive endocytosis (MEND) |  < 100 nm [57] | Phospholemman, polypalmitoylated proteins [58] | Yes [59] | BHK, HEK293 cells [57] | ||
Macropinocytosis | 200 nm–20 μm | Non-selective | Unclear | Murine sarcoma cells [64] |