Fig. 7
From: mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors
PARP-1/mTOR inhibition attenuates retina light injury. The mice were intraperitoneally injected with 20 mg/kg 3AB or 15 mg/kg rapamycin for 7 days following 7000 lx light exposure for 12 h. Retinal function was evaluated with ERG analyses 5 days after the light exposure. a ERG waves. b, c Quantification of the A- and B-wave values. All experiments were repeated in triplicate, and the results are shown as the means ± SEM (*: P < 0.05, **: P < 0.01, ***: P < 0.001)