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Figure 2 | Cell Communication and Signaling

Figure 2

From: Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cell

Figure 2

Key characteristics of horizontal and vertical receptors. The differences in structural changes on activation by binding the ligand are indicated schematically. The striking feature of horizontal receptors is that they associate and form dimers or multimers upon activation, whereas activation of vertical receptors does not involve quaternary structure changes of the already associated, preformed oligomer. This figure was originally reproduced from R.M. Stroud and J. A. Wells. 2004. Mechanistic Diversity of Cytokine Receptor Signalling across Cell Membranes, and the journal, Science STKE.2004.Re: 7, pps: 1-17, with approval of the authors and the AAAS in my forthcoming book in German: <Von Molekülen zu Zellen. 100 Jahre experimentelle Biologie. Betrachtungen eines Biochemikers>. It is shown here with permission of the GNT Verlag für Geschichte der Naturwissenschaften und der Technik. Diepholz. Stuttgart, Berlin.

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Cell Communication and Signaling

ISSN: 1478-811X