ERK and Akt response to EGF using different time delays for the negative feedback. The Boolean model given in Figure 2B was transferred to an ODE model using HillCubes. All Hill coefficients were set to 3, all parameters k to 0.3, and all parameters τ to 1, except the parameter τ describing the life time of SOS and thus the delay of the downregulating effect of the negative feedback loop. (A) Parameter τ_SOS set to 80. (B) Parameter τ_SOS set to 40. (C) Parameter τ_SOS set to 1.