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Figure 4 | Cell Communication and Signaling

Figure 4

From: Modeling approaches for qualitative and semi-quantitative analysis of cellular signaling networks

Figure 4

Discrete dynamic simulation of the Boolean EGF/NRG1 example model (Figure 2B) using synchronous updating. (A) Response to EGF stimulation. The inputs in Figure 2B were set as follows: EGF = 1, NRG1 = 0, ErbB1 = ErbB2 = ErbB3 = 1. (B) Response to EGF stimulation in presence of MEK inhibitor blocking the catalytic site of MEK. The inputs were set as in Figure 4A. In addition, the edge MEK → ERK was removed from the model in Figure 2B.

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