Figure 2
From: Hypoxia-inducible factor (HIF) network: insights from mathematical models
Molecular interaction map (MIM) for the HIF network. An example of the MIM used by our group for modelling the HIF response. The cellular localisation of the various moieties of HIF (free HIF, prolyl-hydroxylated pOH and asparaginyl-hydroxylated aOH), VHL, PHD and FIH are described to be either cytoplasmic or nuclear. Model reactions are numbered in red. Output of the MIM is the Gaussia luciferase signal under the control of HRE. Figure is reproduced from[31] with permission.