Fig. 8
From: Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis
Macrophage autophagy-related 5 (Atg5) deletion inhibited the PI3K-AKT pathway. BMDMs from MΦ atg5−/− and WT mice were treated with 200 ng/mL CXCL3 or CCL20 for 0–30 min. Western blot analysis of the activation of the AKT, PI3K, and ERK pathways in WT and MΦ atg5−/− BMDMs following (A) CXCL3 and (B) CCL20 treatment. Data are presented as the mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001 for 0 versus 30 min treatment in WT BMDMs, #P < 0.05, ## P < 0.01 for 0 versus 30 min treatment in MΦ atg5−/− BMDMs (n = 3 per group). Two-way ANOVA with Sidak’s multiple-comparison test