Fig. 7
From: Atg5 deficiency in macrophages protects against kidney fibrosis via the CCR6-CCL20 axis
Macrophage autophagy-related 5 (Atg5) deletion decreased chemotactic responses to CCL20 in BMDMs in vitro. BMDMs were isolated from MΦ atg5−/− mice and WT mice and immediately used for in vitro Transwell migration assays. Chemotactic responses to 10% FBS, CXCL3, and CCL20 in MΦ atg5−/− and WT BMDMs. Data are presented as the mean ± SEM. *** P < 0.001, **** P < 0.0001 for WT BMDMs versus MΦ atg5−/− BMDMs (n = 5 per group). Two-way ANOVA with Sidak’s multiple-comparison test