Table 3 Bacteriocins in cancer therapy

Bovicin HC5

Streptococcus bovis

2.4

22 amino acids

Only at concentrations higher than the concentration required for its biological activity did bovicin HC5 exhibit cytotoxic effects

[262, 263]

Colicins

E. coli

40 to 80 kDa

Colicin Z (151 amino acids)

Modifying the target cell's electric charge distribution (which causes it to die)

[259, 264,265,266]

Nisin A

Lactococcus lactis

3.3

34 amino acids

Through destabilizing cell membranes, inhibiting tumor cell development, pore deformation, changing cell membranes, and increasing ion penetration that tampers with phospholipid organization, it demonstrates its antitumor and anti-metastasis effect

[264, 267,268,269,270]

Pediocins

Bacterium pediococcus acidilactici MTCC 5101

4.6

44 amino acids

preventing tumor cells from proliferating by upsetting the cycle of cell division

[271,272,273]

Fermenticin HV6b

Bacterium Lactobacillus fermentum HV6b MTCC 10,770

6.7

––––

Its ability to induce vascular endothelial cells to undergo apoptosis, break down DNA, and contract cells exhibits its anti-cancer effect

[264, 274, 275]

S2 Pyocin

Pseudomonas aeruginosa 42A

73.9

777 amino acids

It inhibits the production of lipids in cells and interferes with DNA replication to demonstrate its anti-cancer properties

[276,277,278]