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Fig. 4. | Cell Communication and Signaling

Fig. 4.

From: High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast

Fig. 4.

p66Shc and ATG5 co-regulate senescence of trophoblast cells. A Western blot images of protein levels of ATG5, p16, p21 and LC3 in control and ATG5-KD cells. B SA-β-gal staining showing cell senescence of control and ATG5-KD cells. C Gene set enrichment analysis of SASP gene signature in control and ATG5-KD cells. D Venn diagram illustrates the number of differentially expressed genes overlapped between p66Shc-KD and ATG5-KD cells. E K-means clustering heatmap shows expressions patterns of differentially expressed genes upon p66Shc-KD. F Gene ontology enrichment analysis of genes in cluster C

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Cell Communication and Signaling

ISSN: 1478-811X