Fig. 1

PTEN structures. A: Overall view of the PTEN crystal structure. The cartoon representation of the PTEN crystal structure (PDB ID: 7jvx) displays the phosphatase domain in pink and the C2 structural domain in blue-green. B: The domain architecture of PTEN. PTEN consists of 403 amino acids, and the protein has three functional domains: the N-terminal domain which binds and phosphatizes PI(4,5)P2, the C2 domain, and the carboxy-terminal tail domain (C-tail). The catalytically active site on the P-loop at the bottom of the active site pocket: HCxxGxxR (amino acids 123–130, red). The C2 domain plays a key role in membrane binding. PTEN also contains two PEST structural domains and a PDZ structural domain, PDZ binding domains can localize PTEN to specific cellular regions, and PEST sequences may be correlated with PTEN expression. there is a set of phosphorylation sites at the C-terminus that play an important role in maintaining PTEN stability and catalytic activity