Fig. 7
From: DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis
Mouse alveolar epithelial cell specific knockout of DEC1 attenuated ATII cell senescence in bleomycin-induced mouse pulmonary fibrosis. (A) Representative immunofluorescence images of p21 protein expression in pulmonary fibrosis models constructed in mice with or without DEC1 knockout. Original magnification, ×400. Green: p21, red: SFTPC. (B) qRT-PCR was performed to detect mRNA levels of the senescence-associated secretory phenotype (SASP) factors, including IL-1α, IL-6, TNF-α, and MMP-9 in mouse lung tissues (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001. P values were determined by the one-way ANOVA followed by the Bonferroni’s test