Fig. 4
From: A promising frontier: targeting NETs for stroke treatment breakthroughs
The administration of tPA led to a notable increase in the expression of LRP-1 and NETs within the ischaemic cortex of mice. Following tPA injection, it interacts with LRP-1 in various cells, thereby fostering the generation of NETs in neutrophils. Consequently, this process induces the expression of cGAS in microglia and stimulates the expression of IFN-B and IL-6 through STING, TBK1, and IRF-3. The infusion of regulatory T cells has been shown to ameliorate TPA-induced intracerebral haemorrhage by inhibiting the expression of NLRP3, MMP-9, MMP-3, and MIP-1α in microglia. These factors are known to contribute to an inflammatory response, blood‒brain barrier disruption, vascular endothelium damage, and subsequent cerebral haemorrhage