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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy

Fig. 1

Expression analysis of SIRPα and PD-L1 in colorectal cancer tissues. A Expression of SIRPα and PD-L1 in Normal (N), PBMC (P), and tumor (T) tissues of patients with colorectal cancer (http://crcleukocyte.cancer-pku.cn/). B Expression of SIRPα and PD-L1 in normal and tumor tissues of mice with colorectal cancer (http://crcleukocyte.cancer-pku.cn/). C The correlation of SIRPα and PD-L1 with CD14 and CD163, as well as PD-L1 and SIRPα in colorectal cancer patients analyzed using the TCGA database. D The relationship between SIRPα expression and patient survival in the TCGA database for colorectal cancer. E Alterations in CD47 and PD-L1 in normal human samples and colorectal cancer patients from the GEO database (GSE37182). Statistical significance was determined using the unpaired Student's t-test (***P < 0.001)

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Cell Communication and Signaling

ISSN: 1478-811X