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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice

Fig. 1

Effect of sleep deprivation (SD) on prostate in ICR mice. SD results in the simultaneous reduction of melatonin (MT) and dihydrotestosterone (DHT), which leads to an accumulation of reactive oxygen species (ROS) and the release of mitochondrial DNA (mt-DNA), activating the cGAS-STING pathway. The activated cGAS-STING pathway in turn recruits inflammatory cells into prostatic stroma and subsequently promotes the development of prostatitis

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Cell Communication and Signaling

ISSN: 1478-811X