The role of Bach2 in regulating CD8 + T cell development and function

Table 1 Summary of Bach2 modulation of CD8 + T cells in immune diseases

Immune diseases	Related area	Funtion of Bach2	Source/Methods	Ref
Chronic lymphocytic leukemia	Immune senescence	Bach2 downregulate with aging and reduced cytotoxic activity of CD8 + T cells	Human lymphocyte subsets	[31]
Cancer	Immunosuppression	Bach2 restricts the development of CD8 + effector T cells	Bach2-deficient mice	[34]
Tuberculosis	Vaccine and immune protection	The combination of Bach2 and IL-7 by the vaccine promoted CD8 + T cell development	C57BL/6 mice	[21]
Ulcerative colitis	Immune responses	Bach2-mediated differentially expressed genes and CD8 + T cell aggregation are associated with acquired immune responses	DEGs and DETFs from GEO database	[33]
Ulcerative colitis	Sustained T cell responses	Long-term stimulation is a feature of CD8 + effector T cells	Single-cell transcriptomics of human colonic CD8+ T cells	[36]

ISSN: 1478-811X