Fig. 1
From: The role of Bach2 in regulating CD8 + T cell development and function
Effect of Bach2 on different types of CD8+ T cells. In the absence of Bach2, murine effector CTLs activated in vitro exhibited enhanced proliferative and killing capacities. Through PRDM1, Bach2 encourages the growth and recall proliferation of memory CD8+ T cells. IL-7 increased the expression of Bach2, a key transcription factor produced by long-lived memory T cells. Bach2 promotes the proliferation of memory CD8+ T cells through PRDM1 and KLRG1. Bach2 may influence CD8+ T cell development by affecting PRDM1 expression and the RUNX3 pathway, which prevents terminal exhaustion. Bach2 promotes exhaustion by limiting the function of IRF4 and the AP-1 family of transcription factors when it is overexpressed