Fig. 5
IL-10 enhance VM via JAK1/STAT3 pathway. A IL-10 associated networks predicted by STING (https://cn.string-db.org/); B The protein expression of VE-Cadherin, E-Cadherin, Vimentin and JAK1/STAT3 pathway in Ishhikawa and KLE after treated with IL-10 and IL-10 antibody; C The growth curve of Ishikawa after treated with concentration gradient niclosamide; D The growth curve of KLE after treated with concentration gradient niclosamide; E The protein expression of VE-Cadherin, E-Cadherin, Vimentin and JAK1/STAT3 pathway in Ishhikawa and KLE after treated with IL-10 and niclosamide; F The binding sites of STAT3 and CDH5 were predicted by the JASPAR database (https://jaspar.genereg.net/#). G ChIP assay verified that STAT3 could bind to CDH5 promoter in Ishikawa cells which could be stimulated by IL-10