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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns

Fig. 5

Difference of immune microenvironments between MEN1/DAXXmut and MEN1/DAXXwild groups. A The graphs depict the distributions of immune cell biomarker levels in the PM (Primary MEN1/DAXXmut), PW (Primary MEN1/DAXXwild), MM (Metastatic MEN1/DAXXmut), and MW (Metastatic MEN1/DAXXwild) groups. The vertical axes show biomarker levels, with orange bars indicating stromal levels and blue bars indicating tumor levels. Each dot on the graph represents one sample, and the name of each biomarker is provided at the top of the plots. B The graph illustrates the counts of tertiary lymphoid structures (TLS) in the PM, PW, MM, and MW groups. The vertical axes indicate TLS counts, and the horizontal axes categorize the groups. Each dot on the graph represents one sample. C The graphs present the distributions of PD-1 levels in the PM, PW, MM, and MW groups. The vertical axes represent PD-1 levels, while the horizontal axes denote the groups. Orange bars indicate PD-1 levels in the stroma, and blue bars represent PD-1 levels in the tumor. Each dot on the graph corresponds to one sample

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Cell Communication and Signaling

ISSN: 1478-811X