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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns

Fig. 4

Clinically actionable somatic alterations observed in our and the MSK-MET cohort. A Utilize the OncoKB dataset to annotate clinically actionable somatic alterations within both the MSK-MET dataset (above) and our cohort (below), and subsequently present the findings in an oncoplot. B Investigate the variation in the proportion of clinically actionable somatic alterations between patients with and without MEN1/DAXX/ATRX mutations in the MSK-MET dataset. No significant difference is identified in the overall ratio (left graph, p = 0.158). However, individuals with MEN1/DAXX/ATRX mutations manifest significantly elevated mutation rates in PTEN (p = 0.0004) and TSC2 (p = 0.0036) compared to those lacking these mutations

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Cell Communication and Signaling

ISSN: 1478-811X